Engagement Activities
the cilium in chondrocyte mechanotransduction
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Collaboration
Analysis of primary cilia in human cells
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Collaboration
Functional Conservation in Ciliary Trafficking
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Engagement Activities
the University of Southampton
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Engagement Activities
Mucociliary Interactions
Collaboration
PCD male fertility assessment
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
cilia to be resorbed and identified the pathway responsible
Engagement Activities
Hannah Mitchison
Engagement Activities
conference by Hannah Mitchison
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
Collaboration with molecular basis of disease and therapeutics
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
UK Cilia Network
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Engagement Activities
Network Meeting
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Engagement Activities
Takeover 3 - Fraser McPhie, PhD Student
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Engagement Activities
Polycystins in Chondrocyte Mechanotransuction
Collaboration
Role of primary cilia in cortical development
Engagement Activities
Takeover 2 - Dr Daniel Dodd,
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Engagement Activities
meeting Edinburgh 06/10/2024
Engagement Activities
meeting Edinburgh 06/10/2024
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Engagement Activities
years on - at EMBO Cilia 2022 in Cologne, Germany (4th October 2022)
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Collaboration
Primary cilia in Joubert Syndrome
Collaboration
Nordic Centrosome and Cilia Network
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...
Research Databases and Models
Paranasal sinuses are hollow spaces within the bones surrounding the nose. Of these, the largest...
Key Findings
functions such as mucociliary clearance in our airways and for sperm to swim. The molecular motors...
Further Funding
Quidwai, Title: WDR35/ IFT121 functions like COPI vesicles to transport cilia specific cargo to...
Key Findings
facility not a s[pecific project: Vaughan: 3-D organisation of the flagellar pocket in T....
Products Interventions & Clinical Trials
Cilia are small structures that protrude from the surface of most animal cells like antennae. Like...
Products Interventions & Clinical Trials
Cilia are small structures that protrude from the surface of most animal cells like antennae. Like...
Engagement Activities
Trinity Centre for Bioengineering
Key Findings
in which the dynein-2 microtubule motor works in the formation and function of primary cilia. This...
Key Findings
years research works we now can confirm that planar cell polarity is important in the skin,...
Key Findings
postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has...
Further Funding
structure and function (PhD Studentship)
Collaboration
COST Action BEAT-PCD
Impact Summary
understanding of the role of cilia related genes in male infertility and the unknown function of...