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Key Findings

We have found that the presence of blood and

extra fluid in the joint are the greatest risk factors identifiable at the time of the knee injury...

Key Findings

New methodologies have been developed that enable

whole cadaveric knees to be tested in a laboratory. The methods allow the performance of...

Key Findings

We have found that the presence of blood and

extra fluid in the joint are the greatest risk factors identifiable at the time of the knee injury...

Key Findings

Osteoarthritis is a degenerative disease of the

joints, where cartilage is destroyed. Around 8.5 million people in the UK having moderate to severe...

Key Findings

High Tibial Osteotomy (HTO) surgery is performed

as a treatment for people who have osteoarthritis (OA) affecting one side of their knee. It...

Policy Influence

classification criteria for early osteoarthritis of the knee

Membership of a guideline committee

Policy Influence

classification criteria for early osteoarthritis of the knee

Membership of a guideline committee

Key Findings

The project developed computer algorithms for

automatically matching (corresponding) and delineating (segmenting) anatomical structures in 3D...

Key Findings

We have developed substantial research capacity

and capability, in experimental and computational simulation systems, and fundamental knowledge of...

Impact Summary

As the work performed for this project has

demonstrated the potential of fibrillin-1 to enhance regeneration potential of ACL cells of both...

Artistic and Creative Products

Anatomy of Pain Sculpture

The 2.5-meter-tall, 200 kg sculpture is built on a sturdy wooden structure, wrapped in chicken...

Key Findings

With respect to important new research questions,

several new research networks, collaborations and partnerships have worked towards establishing new...

Collaboration

LANCASTER UNIVERSITY in collaboration with Lancaster University

Acoustic emissions in biomechanics & sports science

Collaboration

University of Warwick in collaboration with Royal Institute of Technology

KTH University - Bio-imaging

Key Findings

Please explain for a non-specialist audience what

has been discovered or achieved as a result of the work funded through this award. * A clinical...

Key Findings

Initially, dose-response curves across 2.5 -

20µM were conducted for 11 compounds (luteolin, isoliquiritigenin, curcumin, genistin,...

Impact Summary

Osteoarthritis (OA) represents an increasing

economic burden to the UK, both from direct and indirect costs. In 2010-2011 approximately 181,350...

Intellectual Property

SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a...

Impact Summary

Patient satisfaction after knee replacement is

poor, and this is a function of the replaced joint not replicating the biomechanics of the natural...

Key Findings

The main achievement of this project was that the

knee device prototypes were successfully tested and evaluated with human participants in the...

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

AUGMENT study (Universities of Bristol, Southampton, Aberdeen, Cardiff and Queensland)

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

AUGMENT study (Universities of Bristol, Southampton, Aberdeen, Cardiff and Queensland)

Collaboration

University of Bristol in collaboration with Erasmus MC

Genetics of Osteoarthritis Endophenotypes Working Group

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

Collaboration with Ben Faber

Key Findings

Defintion of a new wear law for polyethylene in

knee replacements Defintion of a novel computational model to predict wear of polyethylene in the...

Key Findings

A functional smart knee implant prototype was

made, giving additional evidence that smart knee implants could be introduced in future healthcare.

Impact Summary

[Impact Brochure to follow at the end of the

programme] CAMERA's impact is broad and far reaching; taking cutting-edge technologies from the...

Impact Summary

The PI's story as a research leader in this

technology development was published in the Further Together series at the University of Leeds,...

Key Findings

We have been developing a proof-of-concept

bio-inspired prosthetic knee joint based on the human bones dimensions. This novel bio-inspired...

Key Findings

This award facilitated the development of a new

method for investigating human knee and leg biomechanics. This method uses a robotic joint which...

Key Findings

A initial electronic sleeve (E-sleeve) prototype

has been developed for knee joint pain relief which includes a knee sleeve with dry fabric...

Key Findings

We have demonstrated that for bow-legged knees (a

common deformity in active people), the joint alignment can change, but there are specific...

Key Findings

Dogs with osteoarthritis have unregulated spinal

responses to tissue damaging stimuli indicative of central sensitisation - this provides additional...

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

UNIVERSITY OF SUSSEX in collaboration with University of Oxford

Professor Tonia Vincent

Collaboration

UNIVERSITY OF OXFORD in collaboration with Wellcome Sanger Institute

Genetics of Osteoarthritis Consortium member

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with Wellcome Sanger Institute

Genetics of Osteoarthritis Consortium member

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with Wellcome Sanger Institute

Genetics of Osteoarthritis Consortium member

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with University of Brighton

UCL and Andrew Pitsillides, Royal Veterinary College, Katherine Staines, University of Brighton....

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Royal Veterinary College (RVC)

UCL and Andrew Pitsillides, Royal Veterinary College, Katherine Staines, University of Brighton....

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Tonia Vincent

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Tonia Vincent

Impact Summary

This research project comprises of four primary

objectives, in priority order: 1. The development of a low-cost prosthesis that is suitable for use...

Policy Influence

Membership of a guideline committee on the safety of drug therapies in osteoarthritis - with ESCEO

Membership of a guideline committee

Research Tools and Methods

Knee contact pressure models to quantify the effects of medial knee osteoarthritis and associated surgical and noon-surgical interventions

The new model result from a collaboration with Cardiff University and KU Leuven and as funded by...

Research Tools and Methods

Knee contact pressure models to quantify the effects of medial knee osteoarthritis and associated surgical and noon-surgical interventions

The new model result from a collaboration with Cardiff University and KU Leuven and as funded by...

Impact Summary

Findings have been used commercially and

clinically to improve outcomes in orthopaedic surgery. the technology base has been used clinically...

Collaboration

ROYAL VETERINARY COLLEGE in collaboration with Reference Hospital The Equine

Arthrostem

Policy Influence

Wilkinson - NICE OA guideline committee

Participation in a guidance/advisory committee

Policy Influence

Member (since 2022) and incoming chair (April 2025) of OARSI's Strategic Alliance Committee

Participation in a guidance/advisory committee

Policy Influence

Member (since 2022) and incoming chair (April 2025) of OARSI's Strategic Alliance Committee

Participation in a guidance/advisory committee

Policy Influence

Member (since 2022) and incoming chair (April 2025) of OARSI's Strategic Alliance Committee

Participation in a guidance/advisory committee

Impact Summary

Improving performances of a para-triathlete: 1 -

Providing marginal gains to improve transition time 2 - Developing a human-like device to improve...

Impact Summary

A multi-modal sensing system with IMU, force, and

EMG sensors has been developed and integrated into the knee exoskeleton prototype to measure knee...

Impact Summary

My findings have been used and taken forward by

industries and NHS clinicians. NHS clinicians have also used one of my findings to provide...

Key Findings

New findings from using measurements taken on

patients at Denver have identified ways in which the hip joint moves in some patients that may...

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Key Findings

Key findings: -Significant new knowledge derived

directly from patient and healthcare providers that have driven the technical development of this...

Intellectual Property

A PROSTHETIC JOINT AND PROSTHETIC LIMB COMPRISING THE SAME

A design for a through knee prosthesis

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with National Institute for Health and Care Research

Imperial Patient Experience Research Centre (PERC)

Impact Summary

The coating that was characterised in this grant

is to be developed further for use on a Knee spacer implant

Key Findings

MeDe Innovation was created to lead the UK in the

innovative manufacture of implants, biomaterials and new regenerative devices for the treatment of...

Collaboration

QUEEN MARY UNIVERSITY OF LONDON in collaboration with University Hospital Magdeburg

jessica bertrand

Collaboration

QUEEN MARY UNIVERSITY OF LONDON in collaboration with University Hospital Magdeburg

jessica bertrand

Collaboration

CARDIFF UNIVERSITY in collaboration with InHealth Group

Pump Priming Project Governance Process Collaboration

Collaboration

CARDIFF UNIVERSITY in collaboration with Leeds Teaching Hospitals NHS Trust

Pump Priming Project Governance Process Collaboration

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Leeds

Pump Priming Project Governance Process Collaboration

Collaboration

UNIVERSITY OF EXETER in collaboration with Cardiff University

From Ultrastructure to Functionality: a New Paradigm on Cartilage Repair and Regeneration

Impact Summary

New methods developed that provide improved

preclinical analysis tools for new knee interventions. Methods are being used with industry and...

Collaboration

CARDIFF UNIVERSITY in collaboration with Arthritis UK

PhD Studentship

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Warwick

PhD Studentship

Policy Influence

International position on osteoarthritis treatment

Influenced training of practitioners or researchers

Policy Influence

International position on osteoarthritis treatment

Influenced training of practitioners or researchers

Key Findings

Critical factors in the surgeon's operative

technique that are most likely to determine the success of unicompartmental knee replacement have...

Impact Summary

Natural knee simulation system has been designed

, manufactured and sold by industry partner Simulation Solutions. Patent on acellular bone tendon...

Collaboration

University of Leeds in collaboration with University of Leeds

Collaboration with researchers in osteoarthritis

Research Tools and Methods

Knee joint simulator

artificial knee joint simulator

Research Tools and Methods

Knee joint simulator

artificial knee joint simulator

Research Tools and Methods

Knee joint simulator

artificial knee joint simulator

Research Tools and Methods

Knee joint simulator

artificial knee joint simulator

Research Tools and Methods

Knee joint simulator

artificial knee joint simulator

Research Tools and Methods

Knee joint simulator

artificial knee joint simulator

Policy Influence

Invited talk,British Society for Rheumatology Convergence, Manchester, UK, April 2023 April 2023

Influenced training of practitioners or researchers

Policy Influence

Invited talk,British Society for Rheumatology Convergence, Manchester, UK, April 2023 April 2023

Influenced training of practitioners or researchers

Collaboration

University of Liverpool in collaboration with Florida Atlantic University

Poulet - Florida Atlantic University New MMP13 inhibitor against osteoarthritis

Research Tools and Methods

Natural knee simulator