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Impact Summary

Substantial additional networks, publications and

grants despite the fact that ODA reduction cut us off at the knees, and GCRF was a one hit wonder....

Artistic and Creative Products

Supplementary material for 'The uncontrolled manifold theory can explain only part of the inter-trial variability of knee contact force during level walking'

This repository contains the supplementary material for the paper 'The uncontrolled manifold theory...

Impact Summary

Improved healthcare. The research has had several

publications and has contributed to better surgery for early correction of hip pathology - i.e. to...

Key Findings

New methods have been developed to predict user

intent during activities of daily living. Powered knee for transfemoral prosthetic devices has been...

Impact Summary

We are working to develop new projects utilising

the instruments developed during this project. In particular, we have established a collaboration...

Collaboration

University of Leeds in collaboration with European University of Madrid

Acquisition of Meniscus Geometries

Collaboration

University of Leeds in collaboration with University of Connecticut

Acquisition of Meniscus Geometries

Key Findings

With the aim of enhancing understanding of the

biomechanics of elite sprint running we discovered that in contrast to previous research related to...

Products Interventions & Clinical Trials

TOKA - Tailored Osteotomy Knee Alignment (TOKA®) is a patient specific surgical treatment for knee osteoarthritis specifically designed for young and active patinets

Image based evaluation for validation of a computer aided model of TOKA (3D-MP/Cardiff University...

Impact Summary

This project provided an versatile time-resolved

spectrophotometer that formed the basis for a series of instruments that we have developed and...

Key Findings

During this multidisciplinary research project,

we developed two portable fibre-optic probe-based instruments for in situ single point measurements...

Research Tools and Methods

Osteoarthritis TMJ mouse model

Creation of an osteoarthritis mouse model for the TMJ. Transgenic mouse develops OA over a period...

Research Tools and Methods

Validation study for use of routinely collected data for research into common hand conditions

External Validation study showing the positive predictive value of a prescribed set of codes...

Intellectual Property

miR-544a as therapeutic target for the treatment of osteoarthritis

We characterise the role of this new micro-RNA in the context of cartilage homeostasis and...

Key Findings

We have generated and characterised two zebrafish

mutant models of lmx1b - a gene associated both with Nail patella syndrome and more recently with...

Research Tools and Methods

Osteochondral graft tribological testing method

Natural knee joint simulator to evaluate the mechanical and tribological consequences of cartilage...

Collaboration

University of Sheffield in collaboration with Flinders University

Application of validated finite element models to assess the effect of osteoarthritis on the...

Key Findings

Some of the key principal achievements from this

award have been: First, it has generated preliminary new knowledge concerning the in vivo...

Impact Summary

The work has been publicized on websites and

newsletters to improve the awareness of the knee joint pain and how technologies might help. We...

Collaboration

UNIVERSITY OF EXETER in collaboration with Tokyo Medical and Dental University

Early Diagnosis of Osteoarthritis

Products Interventions & Clinical Trials

Low-cost polycentric prosthetic knee joint

The low-cost polycentric knee joint is a mechanical prosthetic knee that uses a unique polycentric...

Key Findings

We have developed a novel soft robotic knee

rehabilitation device for people who have had stroke. This medical device has received approval...

Collaboration

UNIVERSITY OF OXFORD in collaboration with University of Oxford

Centre for Osteoarthritis Pathogenesis Versus Arthritis

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

UK Biobank analysis of shift workers and osteoarthritis risk

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Centre for Osteoarthritis Pathogenesis Versus Arthritis

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Centre for Osteoarthritis Pathogenesis Versus Arthritis

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

UK Biobank analysis of shift workers and osteoarthritis risk

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

UK Biobank analysis of shift workers and osteoarthritis risk

Artistic and Creative Products

Mechanics of Life

With support from "Enhanced surgical treatments for hip osteoarthritis" and Royal Academy...

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with Erasmus MC

The World COACH Consortium (a Worldwide Collaboration in OsteoArthritis prediCtion of the Hip)

Research Tools and Methods

Histomorphometric assessment of osteoarthritis in mice

We have identified a more sensitive method to objectively quantify osteoarthritis in mice. This...

Research Tools and Methods

Histomorphometric assessment of osteoarthritis in mice

We have identified a more sensitive method to objectively quantify osteoarthritis in mice. This...

Key Findings

The advantage of Fast Field-Cycling (FFC) MRI

over conventional MRI is its ability to make measurements and collect images over a wide range of...

Policy Influence

Arthrosamid advisor Health Canada

Contribution to new or improved professional practice

Impact Summary

The imaging and testing framework established in

this project has been applied to investigate the effects of mRNA therapies and nano-protein cages...

Key Findings

This project funding was for research equipment.

The grant funded the purchase of a new Field Emission Gun Scanning Electron Microscope (FEGSEM], to...

Key Findings

We have identified two types of collaboration

models for the delivery of orthopaedic surgery services in the East Anglia local heath economy: the...

Collaboration

CARDIFF UNIVERSITY in collaboration with Cardiff University

Next Generation Early Career Researcher Scientific Exchange

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Leuven

Next Generation Early Career Researcher Scientific Exchange

Key Findings

We discovered that 5-days of bed rest resulted in

significant thigh muscle loss in older males. A short-term strength training programme in the week...

Key Findings

We have verified the feasibility of automating

the process of customised instrumentation. having verified this, we have used it clinically over...

Products Interventions & Clinical Trials

Eastell - prevention of GIO using 11-beta HSD inhibitor

Prevention of glucocorticoid-induced osteoarthritis

Collaboration

CRANFIELD UNIVERSITY in collaboration with The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust

Cranfield University, Keele University and Robert Jones and Agnes Hunt Orthopedic Hospital

Collaboration

CARDIFF UNIVERSITY in collaboration with Royal Veterinary College (RVC)

Next Generation Early Career Researcher Work Placement

Collaboration

CARDIFF UNIVERSITY in collaboration with Royal Veterinary College (RVC)

Next Generation Early Career Researcher Work Placement

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with Seikagaku Corporation

Collaborationn with Seikagaku

Collaboration

UNIVERSITY OF READING in collaboration with Royal Berkshire Hospital

Geniculate Artery Embolisation in Patients with Osteoarthritis of the Knee (GENESIS)

Collaboration

University of Leeds in collaboration with University Medical Center Utrecht (UMC)

Understanding repair activity in knee joint distraction

Collaboration

QUEEN MARY UNIVERSITY OF LONDON in collaboration with Radboud University Nijmegen

Peter van de Kraan

Collaboration

UNIVERSITY OF BATH in collaboration with University of Birmingham

Long non-coding RNAs in osteoarthritis

Collaboration

Keele University in collaboration with Royal Orthopaedic Hospital

Martyn Snow- Clinician/Professor Follow-up Grant Proposals

Collaboration

ROYAL VETERINARY COLLEGE in collaboration with Royal Veterinary College (RVC)

TSPO role in Osteoarthritis (OA) and Bone Remodelling

Research Tools and Methods

New physical and computational tests

I developed new Finite Element Analysis (FEA) models to simulate knee joint motion and loading for...

Impact Summary

Our research findings have been widely

publicised. The research publication (Davidson et al 2013) led to reports in the press and on...

Collaboration

University of Bristol in collaboration with University of Bristol

Adult imaging

Key Findings

New device for testing tribology of our implants

against cartilage. PCL/Silica hybrids can be 3D printed into scaffolds suitable for knee cartilage...

Policy Influence

NICE Technology Assessment TA477 ACI for treating symptomatic articular cartilage defects of the knee

Contribution to a national consultation/review

Policy Influence

NICE Technology Assessment TA477 ACI for treating symptomatic articular cartilage defects of the knee

Contribution to a national consultation/review

Policy Influence

ESCEO position paper on osteoporosis and osteoarthritis in the oldest old

Participation in a guidance/advisory committee

Policy Influence

ESCEO position paper on osteoporosis and osteoarthritis in the oldest old

Participation in a guidance/advisory committee

Products Interventions & Clinical Trials

POC052- Perry

Osteoarthritis is a painful condition that affects joints, where the surfaces within the joints...

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Sheffield

INSIGNEO Institute for in silico Medicine

Key Findings

Ageing predisposes to an inevitable loss of

cartilage that results in osteoarthritis; one of the most common ageing-related disorders. This...

Intellectual Property

NOVEL ANTIBODY AND USE IN DIAGNOSIS AND THERAPY OF ARTHROPATHIES

We have developed an antibody that binds specifically to collagen type II post-transnationally...

Collaboration

University of Bristol in collaboration with University College London

Synthetic botulinum molecules for lasting relief from chronic pain in animals

Collaboration

University of Bristol in collaboration with University of Sheffield

Synthetic botulinum molecules for lasting relief from chronic pain in animals

Key Findings

I have developed a novel mechanical loading

instrument used to mimic the compressive strains experienced by cartilage tissue present in the...

Policy Influence

Targeting nociceptors in osteoarthritis in the post-NGF (nerve growth factor) era

Influenced training of practitioners or researchers

Policy Influence

Targeting nociceptors in osteoarthritis in the post-NGF (nerve growth factor) era

Influenced training of practitioners or researchers

Policy Influence

Targeting nociceptors in osteoarthritis in the post-NGF (nerve growth factor) era

Influenced training of practitioners or researchers

Impact Summary

Cell signalling is a fundamental process that is

central to the understanding of embryonic development, cell cycle progression, lineage...

Impact Summary

We have successfully obtained funding from Versus

Arthritis (£1.2m) to analyse the patient data from the App and combine it with the clinical...

Research Tools and Methods

A smart knee exoskeleton for assessment and rehabilitation treatment

The research tool includes two new systems: 1) A smart sensing system for assessing the functions...

Research Tools and Methods

Use of TSG-6 for osteoarthritis

A patent has been filed that includes the use of TSG-6 (Link_TSG6) for the treatment of...

Collaboration

Wellcome Sanger Institute in collaboration with Broad Institute

Overlap analysis of obesity and osteoarthritis

Collaboration

Wellcome Sanger Institute in collaboration with Wellcome Sanger Institute

Overlap analysis of obesity and osteoarthritis

Key Findings

MIIND is a software package for simulating

interacting populations of neurons. Up to the inception of this project, MIIND provided the ability...

Impact Summary

There has been some coverage of my work in

academic and media platforms. The academic ones have been reported in other sections of the report....

Collaboration

UNIVERSITY OF OXFORD in collaboration with University of Oxford

STEp UP OA Consortium

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

STEp UP OA Consortium

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

STEp UP OA Consortium

Research Tools and Methods

Molecular imaging for early detection of osteoarthritis

We developed an antibody that binds selectively to damaged cartilage at very early stages and...

Impact Summary

The EPSRC Centre for Innovative Manufacturing in

Medical Devices, is developing new methodologies for stratified and personalised design and...

Collaboration

QUEEN MARY UNIVERSITY OF LONDON in collaboration with Grifols

Grifols

Key Findings

1) Identification of the importance of Type 2

fusion defects (due to incomplete diffusion at interface) to the structural integrity of Ultra-High...

Key Findings

This project funded period is now complete, and

we have made extensive progress on foundation research into the needs and use-cases for data...

Intellectual Property

Bonefinder system

An automatic system for locating the outlines of various bones in medical images such as...

Policy Influence

Clinical commissioning policy: Fresh osteochondral allograft for osteochondral lesions of the knee in adults and post-pubescent children

Contribution to a national consultation/review

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Imperial College London

Imperial College Bioeng

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Imperial College London

Imperial College Bioeng

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Imperial College London

Imperial College Bioeng

Impact Summary

The FREEHAB project has developed a new soft

robotic exosuit device for knee rehabiliation. This has been co-developed with clinical partners in...

Products Interventions & Clinical Trials

lIfestyle iNterventionS for PaIn ReliEf (INSPIRE)

We are deploying physical therapy through an app (physical therapy is part of the treatment...

Collaboration

CARDIFF UNIVERSITY in collaboration with Cardiff University

Programmed necrosis markers in arthritis

Impact Summary

Osteoarthritis (OA) is common cause of gait

impairment as well as physical disability. Aging and obesity are the most common contributions as...

Collaboration

UNIVERSITY OF NOTTINGHAM in collaboration with Nottingham University Hospitals NHS Trust

ARUK Centre for Sport Exercise and Osteoarthritis

Collaboration

UNIVERSITY OF NOTTINGHAM in collaboration with Nottingham University Hospitals NHS Trust

ARUK Centre for Sport Exercise and Osteoarthritis

Policy Influence

Invited speaker at national meeting on the topic of the role of sex hormones in hand osteoarthritis

Influenced training of practitioners or researchers

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Lancashire

Markerless MOCAP - ECR Training Workshop - November 2022

Key Findings

The principal objective relating to funding for

animal usage was to enable the post-doctoral reasearcher on the grant (see 'RCUK secondments') to...

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Projects (513)

Publications (1165)

People (670)

Organisations (2)

Outcomes (320)

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