Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Impact Summary
working in the field of bacterial flagella biogenesis.
Collaboration
Analysis of primary cilia in human cells
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Key Findings
epidemics and pandemics of the severe diarrhoeal disease cholera. V. cholerae swims through liquids...
Collaboration
Functional Conservation in Ciliary Trafficking
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Collaboration
PCD male fertility assessment
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
Collaboration with molecular basis of disease and therapeutics
Key Findings
cilia to be resorbed and identified the pathway responsible
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
UK Cilia Network
Collaboration
Developing calcium sensors in green algae
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Intellectual Property
Immunogenic compositions containing Escherichia coli O157:H7 flagella including fusion proteins and...
Collaboration
Role of primary cilia in cortical development
Collaboration
Engineering flagellar export pipes
Collaboration
Engineering flagellar export pipes
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Key Findings
been discovered that its motility apparatus (the bacterial flagella motor) has a novel architecture...
Key Findings
food-borne bacterial pathogen, Escherichia coli O157:H7, attach to plant hosts. Food-borne...
Key Findings
demonstrated that bovine TLR5 is active (there was published debate about this), and that bovine...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Collaboration
Scanning and three-dimensional electron microscopy methods for the study of Trypanosoma brucei and...
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Primary cilia in Joubert Syndrome
Collaboration
Nordic Centrosome and Cilia Network
Key Findings
understanding the substrate that YhaO transported (ie D serine) and correlating this with the...
Key Findings
range of cellular and developmental processes and defects in IFT underlie a range of pathological...
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Role of IFT-A in ciliary trafficking
Key Findings
how mechanical interactions with polymer networks in biological fluids influence the movement of...
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...
Key Findings
functions such as mucociliary clearance in our airways and for sperm to swim. The molecular motors...
Research Tools and Methods
We have developed and refined a procedure to attach superparamagnetic beads (1 micron in diameter)...
Key Findings
facility not a s[pecific project: Vaughan: 3-D organisation of the flagellar pocket in T....
Key Findings
mechanisms that underlie the workings of multicellular organisms, suggesting scenarios by which...
Key Findings
postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has...
Key Findings
in which the dynein-2 microtubule motor works in the formation and function of primary cilia. This...
Key Findings
years research works we now can confirm that planar cell polarity is important in the skin,...
Key Findings
interaction of human pathogen with edible plants. Using the model plant Arabidopsis thaliana have...
Collaboration
COST Action BEAT-PCD
Collaboration
Clamy - Michael Hippler
Collaboration
Clamy - Michael Hippler
Collaboration
Dr Dominic Norris, Polycystin-2 cilia mechnobiology
Key Findings
optical properties and macromolecule content, has been successfully employed to taxonomically...
Key Findings
microswimmer, the cause of leishmaniasis which affects millions worldwide, were investigated via...
Key Findings
of funding has been into the effects of complex fluids on the swimming algae (Dunaliella Salina)....
Key Findings
using grappling-hook like structures called pili.
- We have discovered that bacterial cells can...
Collaboration
Cécilia GEFFROY internship student from Polytech, MARSEILLE, France
Collaboration
structural biology of ciliary proteins
Collaboration
structural biology of ciliary proteins
Key Findings
cognitive functions unique to humans. In order to function properly, the cortex requires a large...
Research Databases and Models
Research Databases and Models
Impact Summary
2016 (part of European Researchers' Night), held at the Glasgow Science Center, in September 2016...
Key Findings
reproduction in trypanosomes, specifically how gametes are produced and how the gametes combine to...
Collaboration
molecular organization of the ciliary transition zone
Collaboration
molecular organization of the ciliary transition zone
Key Findings
chimeric synthetic flagellin proteins containing potential bioglue domains by the model bacterium...
Key Findings
from the award?
The most significant finding from the award was that C. jejuni flagella/motility is...
Collaboration
Investigating the role of primary cilia genes in human brain development using brain organoids
Collaboration
Structural biology and molecular genetics of IFT80
Collaboration
Structural biology and molecular genetics of IFT80
Key Findings
aims to explore and exploit the production of gas vesicles (GVs) in different Enterobacteria. Some...
Key Findings
enable Campylobacter jejuni, a causative agent of foodborne gastroenteritis, to adapt to and...
Key Findings
three-dimensional differentiated airway epithelial cell model at air-liquid interface (ALI) of the...
Key Findings
three products or processes:
Methodologies: The development of techniques to control microparticles...