Engagement Activities
the cilium in chondrocyte mechanotransduction
Collaboration
Analysis of primary cilia in human cells
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Collaboration
Functional Conservation in Ciliary Trafficking
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Engagement Activities
the University of Southampton
Collaboration
PCD male fertility assessment
Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Engagement Activities
Mucociliary Interactions
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
Collaboration with molecular basis of disease and therapeutics
Engagement Activities
conference by Hannah Mitchison
Engagement Activities
Hannah Mitchison
Key Findings
cilia to be resorbed and identified the pathway responsible
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
UK Cilia Network
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Engagement Activities
Takeover 3 - Fraser McPhie, PhD Student
Engagement Activities
Polycystins in Chondrocyte Mechanotransuction
Collaboration
Role of primary cilia in cortical development
Engagement Activities
Takeover 2 - Dr Daniel Dodd,
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Engagement Activities
years on - at EMBO Cilia 2022 in Cologne, Germany (4th October 2022)
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Primary cilia in Joubert Syndrome
Collaboration
Nordic Centrosome and Cilia Network
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Role of IFT-A in ciliary trafficking
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...
Key Findings
functions such as mucociliary clearance in our airways and for sperm to swim. The molecular motors...
Engagement Activities
Trinity Centre for Bioengineering
Key Findings
facility not a s[pecific project: Vaughan: 3-D organisation of the flagellar pocket in T....
Further Funding
Quidwai, Title: WDR35/ IFT121 functions like COPI vesicles to transport cilia specific cargo to...
Key Findings
postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has...
Key Findings
in which the dynein-2 microtubule motor works in the formation and function of primary cilia. This...
Key Findings
years research works we now can confirm that planar cell polarity is important in the skin,...
Collaboration
COST Action BEAT-PCD
Engagement Activities
UCL
Further Funding
structure and function (PhD Studentship)
Collaboration
Dr Dominic Norris, Polycystin-2 cilia mechnobiology
Further Funding
regulates chondrocyte response to inflammatory cytokines
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Engagement Activities
effects of lithium on cilia and hedgehog signalling
Collaboration
Cécilia GEFFROY internship student from Polytech, MARSEILLE, France
Collaboration
structural biology of ciliary proteins
Collaboration
structural biology of ciliary proteins
Key Findings
cognitive functions unique to humans. In order to function properly, the cortex requires a large...
Research Databases and Models
Research Databases and Models
Impact Summary
2016 (part of European Researchers' Night), held at the Glasgow Science Center, in September 2016...
Collaboration
molecular organization of the ciliary transition zone
Collaboration
molecular organization of the ciliary transition zone
Engagement Activities
in Human Disease Symposium 'The Role of Cilia in Biology and Medicine'
Further Funding
CEP41 in autism spectrum disorder using human cortical organoids
Engagement Activities
Prof. Metin Sitti - Soft-bodied small-scale mobile robots
Engagement Activities
Prof. Metin Sitti - Soft-bodied small-scale mobile robots
Collaboration
Investigating the role of primary cilia genes in human brain development using brain organoids
Engagement Activities
2018