Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Impact Summary
working in the field of bacterial flagella biogenesis.
Key Findings
epidemics and pandemics of the severe diarrhoeal disease cholera. V. cholerae swims through liquids...
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Collaboration
Analysis of primary cilia in human cells
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Collaboration
Functional Conservation in Ciliary Trafficking
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
PCD male fertility assessment
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
cilia to be resorbed and identified the pathway responsible
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Collaboration
Developing calcium sensors in green algae
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
Collaboration with molecular basis of disease and therapeutics
Research Databases and Models
This is a collection of Matlab programming functions, that between them, can track the two flagella...
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
UK Cilia Network
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Research Tools and Methods
We have used techniques like protein structure prediction with mutation, cloning, and bacterial...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
Engineering flagellar export pipes
Collaboration
Engineering flagellar export pipes
Collaboration
Role of primary cilia in cortical development
Key Findings
been discovered that its motility apparatus (the bacterial flagella motor) has a novel architecture...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Key Findings
food-borne bacterial pathogen, Escherichia coli O157:H7, attach to plant hosts. Food-borne...
Key Findings
demonstrated that bovine TLR5 is active (there was published debate about this), and that bovine...
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Collaboration
Scanning and three-dimensional electron microscopy methods for the study of Trypanosoma brucei and...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Research Databases and Models
Draft genome sequence of Blastocladiella emersonii genome complete with 17x coverage and additional...
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Key Findings
understanding the substrate that YhaO transported (ie D serine) and correlating this with the...
Key Findings
range of cellular and developmental processes and defects in IFT underlie a range of pathological...
Collaboration
Primary cilia in Joubert Syndrome
Collaboration
Nordic Centrosome and Cilia Network
Key Findings
how mechanical interactions with polymer networks in biological fluids influence the movement of...
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...
Research Databases and Models
Paranasal sinuses are hollow spaces within the bones surrounding the nose. Of these, the largest...
Key Findings
functions such as mucociliary clearance in our airways and for sperm to swim. The molecular motors...
Further Funding
Quidwai, Title: WDR35/ IFT121 functions like COPI vesicles to transport cilia specific cargo to...
Key Findings
facility not a s[pecific project: Vaughan: 3-D organisation of the flagellar pocket in T....
Key Findings
mechanisms that underlie the workings of multicellular organisms, suggesting scenarios by which...
Research Tools and Methods
We have developed and refined a procedure to attach superparamagnetic beads (1 micron in diameter)...
Collaboration
Clamy - Michael Hippler
Collaboration
Clamy - Michael Hippler
Key Findings
in which the dynein-2 microtubule motor works in the formation and function of primary cilia. This...
Key Findings
years research works we now can confirm that planar cell polarity is important in the skin,...
Key Findings
postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has...
Research Tools and Methods
We have successfully designed and cloned the Mot A/Mot B replace the amino acids with Cysteine to...
Key Findings
interaction of human pathogen with edible plants. Using the model plant Arabidopsis thaliana have...
Further Funding
structure and function (PhD Studentship)
Collaboration
COST Action BEAT-PCD
Impact Summary
understanding of the role of cilia related genes in male infertility and the unknown function of...
Research Databases and Models
Proteomics data for the paper 'Genetic dissection of a Leishmania flagellar proteome demonstrates...
Collaboration
Dr Dominic Norris, Polycystin-2 cilia mechnobiology
Further Funding
regulates chondrocyte response to inflammatory cytokines
Key Findings
optical properties and macromolecule content, has been successfully employed to taxonomically...
Artistic and Creative Products
A rotating magnetic field can be used to control the speed of superparamagnetic beads attached to...
Artistic and Creative Products
A rotating magnetic field can be used to control the speed of superparamagnetic beads attached to...
Key Findings
microswimmer, the cause of leishmaniasis which affects millions worldwide, were investigated via...
Research Databases and Models
Research Databases and Models
Key Findings
of funding has been into the effects of complex fluids on the swimming algae (Dunaliella Salina)....
Key Findings
using grappling-hook like structures called pili.
- We have discovered that bacterial cells can...