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Key Findings

We have found that the presence of blood and

extra fluid in the joint are the greatest risk factors identifiable at the time of the knee injury...

Key Findings

New methodologies have been developed that enable

whole cadaveric knees to be tested in a laboratory. The methods allow the performance of...

Key Findings

We have found that the presence of blood and

extra fluid in the joint are the greatest risk factors identifiable at the time of the knee injury...

Key Findings

Osteoarthritis is a degenerative disease of the

joints, where cartilage is destroyed. Around 8.5 million people in the UK having moderate to severe...

Key Findings

High Tibial Osteotomy (HTO) surgery is performed

as a treatment for people who have osteoarthritis (OA) affecting one side of their knee. It...

Key Findings

The project developed computer algorithms for

automatically matching (corresponding) and delineating (segmenting) anatomical structures in 3D...

Key Findings

We have developed substantial research capacity

and capability, in experimental and computational simulation systems, and fundamental knowledge of...

Artistic and Creative Products

Anatomy of Pain Sculpture

The 2.5-meter-tall, 200 kg sculpture is built on a sturdy wooden structure, wrapped in chicken...

Key Findings

With respect to important new research questions,

several new research networks, collaborations and partnerships have worked towards establishing new...

Collaboration

LANCASTER UNIVERSITY in collaboration with Lancaster University

Acoustic emissions in biomechanics & sports science

Collaboration

University of Warwick in collaboration with Royal Institute of Technology

KTH University - Bio-imaging

Key Findings

Please explain for a non-specialist audience what

has been discovered or achieved as a result of the work funded through this award. * A clinical...

Key Findings

Initially, dose-response curves across 2.5 -

20µM were conducted for 11 compounds (luteolin, isoliquiritigenin, curcumin, genistin,...

Intellectual Property

SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a...

Key Findings

The main achievement of this project was that the

knee device prototypes were successfully tested and evaluated with human participants in the...

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

AUGMENT study (Universities of Bristol, Southampton, Aberdeen, Cardiff and Queensland)

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

AUGMENT study (Universities of Bristol, Southampton, Aberdeen, Cardiff and Queensland)

Collaboration

University of Bristol in collaboration with Erasmus MC

Genetics of Osteoarthritis Endophenotypes Working Group

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

Collaboration with Ben Faber

Key Findings

Defintion of a new wear law for polyethylene in

knee replacements Defintion of a novel computational model to predict wear of polyethylene in the...

Key Findings

A functional smart knee implant prototype was

made, giving additional evidence that smart knee implants could be introduced in future healthcare.

Key Findings

We have been developing a proof-of-concept

bio-inspired prosthetic knee joint based on the human bones dimensions. This novel bio-inspired...

Key Findings

This award facilitated the development of a new

method for investigating human knee and leg biomechanics. This method uses a robotic joint which...

Key Findings

A initial electronic sleeve (E-sleeve) prototype

has been developed for knee joint pain relief which includes a knee sleeve with dry fabric...

Key Findings

We have demonstrated that for bow-legged knees (a

common deformity in active people), the joint alignment can change, but there are specific...

Key Findings

Dogs with osteoarthritis have unregulated spinal

responses to tissue damaging stimuli indicative of central sensitisation - this provides additional...

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

University of Leeds in collaboration with Invibio

Invibio

Collaboration

UNIVERSITY OF SUSSEX in collaboration with University of Oxford

Professor Tonia Vincent

Collaboration

UNIVERSITY OF OXFORD in collaboration with Wellcome Sanger Institute

Genetics of Osteoarthritis Consortium member

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with Wellcome Sanger Institute

Genetics of Osteoarthritis Consortium member

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with Wellcome Sanger Institute

Genetics of Osteoarthritis Consortium member

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with University of Brighton

UCL and Andrew Pitsillides, Royal Veterinary College, Katherine Staines, University of Brighton....

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Royal Veterinary College (RVC)

UCL and Andrew Pitsillides, Royal Veterinary College, Katherine Staines, University of Brighton....

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Tonia Vincent

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Tonia Vincent

Collaboration

ROYAL VETERINARY COLLEGE in collaboration with Reference Hospital The Equine

Arthrostem

Key Findings

New findings from using measurements taken on

patients at Denver have identified ways in which the hip joint moves in some patients that may...

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Sydney

Glucocorticoid rhythm, osteoarthritis and bone loss

Key Findings

Key findings: -Significant new knowledge derived

directly from patient and healthcare providers that have driven the technical development of this...

Intellectual Property

A PROSTHETIC JOINT AND PROSTHETIC LIMB COMPRISING THE SAME

A design for a through knee prosthesis

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with National Institute for Health and Care Research

Imperial Patient Experience Research Centre (PERC)

Key Findings

MeDe Innovation was created to lead the UK in the

innovative manufacture of implants, biomaterials and new regenerative devices for the treatment of...

Collaboration

QUEEN MARY UNIVERSITY OF LONDON in collaboration with University Hospital Magdeburg

jessica bertrand

Collaboration

QUEEN MARY UNIVERSITY OF LONDON in collaboration with University Hospital Magdeburg

jessica bertrand

Collaboration

CARDIFF UNIVERSITY in collaboration with InHealth Group

Pump Priming Project Governance Process Collaboration

Collaboration

CARDIFF UNIVERSITY in collaboration with Leeds Teaching Hospitals NHS Trust

Pump Priming Project Governance Process Collaboration

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Leeds

Pump Priming Project Governance Process Collaboration

Collaboration

UNIVERSITY OF EXETER in collaboration with Cardiff University

From Ultrastructure to Functionality: a New Paradigm on Cartilage Repair and Regeneration

Collaboration

CARDIFF UNIVERSITY in collaboration with Arthritis UK

PhD Studentship

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Warwick

PhD Studentship

Key Findings

Critical factors in the surgeon's operative

technique that are most likely to determine the success of unicompartmental knee replacement have...

Collaboration

University of Leeds in collaboration with University of Leeds

Collaboration with researchers in osteoarthritis

Collaboration

University of Liverpool in collaboration with Florida Atlantic University

Poulet - Florida Atlantic University New MMP13 inhibitor against osteoarthritis

Collaboration

CARDIFF UNIVERSITY in collaboration with Ampersand Health

Osteoarthritis Application Technology

Collaboration

CARDIFF UNIVERSITY in collaboration with City St George's, University of London

Osteoarthritis Application Technology

Artistic and Creative Products

Supplementary material for 'The uncontrolled manifold theory can explain only part of the inter-trial variability of knee contact force during level walking'

This repository contains the supplementary material for the paper 'The uncontrolled manifold theory...

Key Findings

New methods have been developed to predict user

intent during activities of daily living. Powered knee for transfemoral prosthetic devices has been...

Collaboration

University of Leeds in collaboration with European University of Madrid

Acquisition of Meniscus Geometries

Collaboration

University of Leeds in collaboration with University of Connecticut

Acquisition of Meniscus Geometries

Key Findings

With the aim of enhancing understanding of the

biomechanics of elite sprint running we discovered that in contrast to previous research related to...

Key Findings

During this multidisciplinary research project,

we developed two portable fibre-optic probe-based instruments for in situ single point measurements...

Intellectual Property

miR-544a as therapeutic target for the treatment of osteoarthritis

We characterise the role of this new micro-RNA in the context of cartilage homeostasis and...

Key Findings

We have generated and characterised two zebrafish

mutant models of lmx1b - a gene associated both with Nail patella syndrome and more recently with...

Collaboration

University of Sheffield in collaboration with Flinders University

Application of validated finite element models to assess the effect of osteoarthritis on the...

Key Findings

Some of the key principal achievements from this

award have been: First, it has generated preliminary new knowledge concerning the in vivo...

Collaboration

UNIVERSITY OF EXETER in collaboration with Tokyo Medical and Dental University

Early Diagnosis of Osteoarthritis

Key Findings

We have developed a novel soft robotic knee

rehabilitation device for people who have had stroke. This medical device has received approval...

Collaboration

UNIVERSITY OF OXFORD in collaboration with University of Oxford

Centre for Osteoarthritis Pathogenesis Versus Arthritis

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

UK Biobank analysis of shift workers and osteoarthritis risk

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Centre for Osteoarthritis Pathogenesis Versus Arthritis

Collaboration

IMPERIAL COLLEGE LONDON in collaboration with University of Oxford

Centre for Osteoarthritis Pathogenesis Versus Arthritis

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

UK Biobank analysis of shift workers and osteoarthritis risk

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with University of Bristol

UK Biobank analysis of shift workers and osteoarthritis risk

Artistic and Creative Products

Mechanics of Life

With support from "Enhanced surgical treatments for hip osteoarthritis" and Royal Academy...

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with Erasmus MC

The World COACH Consortium (a Worldwide Collaboration in OsteoArthritis prediCtion of the Hip)

Key Findings

The advantage of Fast Field-Cycling (FFC) MRI

over conventional MRI is its ability to make measurements and collect images over a wide range of...

Key Findings

This project funding was for research equipment.

The grant funded the purchase of a new Field Emission Gun Scanning Electron Microscope (FEGSEM], to...

Key Findings

We have identified two types of collaboration

models for the delivery of orthopaedic surgery services in the East Anglia local heath economy: the...

Collaboration

CARDIFF UNIVERSITY in collaboration with Cardiff University

Next Generation Early Career Researcher Scientific Exchange

Collaboration

CARDIFF UNIVERSITY in collaboration with University of Leuven

Next Generation Early Career Researcher Scientific Exchange

Key Findings

We discovered that 5-days of bed rest resulted in

significant thigh muscle loss in older males. A short-term strength training programme in the week...

Key Findings

We have verified the feasibility of automating

the process of customised instrumentation. having verified this, we have used it clinically over...

Collaboration

CRANFIELD UNIVERSITY in collaboration with The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust

Cranfield University, Keele University and Robert Jones and Agnes Hunt Orthopedic Hospital

Collaboration

CARDIFF UNIVERSITY in collaboration with Royal Veterinary College (RVC)

Next Generation Early Career Researcher Work Placement

Collaboration

CARDIFF UNIVERSITY in collaboration with Royal Veterinary College (RVC)

Next Generation Early Career Researcher Work Placement

Collaboration

UNIVERSITY OF MANCHESTER in collaboration with Seikagaku Corporation

Collaborationn with Seikagaku

Collaboration

UNIVERSITY OF READING in collaboration with Royal Berkshire Hospital

Geniculate Artery Embolisation in Patients with Osteoarthritis of the Knee (GENESIS)

Collaboration

University of Leeds in collaboration with University Medical Center Utrecht (UMC)

Understanding repair activity in knee joint distraction

Collaboration

QUEEN MARY UNIVERSITY OF LONDON in collaboration with Radboud University Nijmegen

Peter van de Kraan

Collaboration

UNIVERSITY OF BATH in collaboration with University of Birmingham

Long non-coding RNAs in osteoarthritis

Collaboration

Keele University in collaboration with Royal Orthopaedic Hospital

Martyn Snow- Clinician/Professor Follow-up Grant Proposals

Collaboration

ROYAL VETERINARY COLLEGE in collaboration with Royal Veterinary College (RVC)

TSPO role in Osteoarthritis (OA) and Bone Remodelling

Collaboration

University of Bristol in collaboration with University of Bristol

Adult imaging

Key Findings

New device for testing tribology of our implants

against cartilage. PCL/Silica hybrids can be 3D printed into scaffolds suitable for knee cartilage...

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Projects (513)

Publications (1165)

People (670)

Organisations (2)

Outcomes (221)

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