Engagement Activities
the cilium in chondrocyte mechanotransduction
Key Findings
in TALPID3 lack primary cilia, a small organelle found on the surface of each cell.
As primary...
Research Databases and Models
Developed mathematical model for cilia-driven flow near a rigid substrate in a (linear)...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
PCD male fertility assessment
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Intellectual Property
A tactile sensor, consisting of a flexible main body with embedded magnets, soft magnetized cilia...
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Key Findings
first was to see IF we could see tiny organelles called primary cilia in the mouse growth plate and...
Engagement Activities
the University of Southampton
Key Findings
critical for cilia formation functions mechanistically, what lipid preferences it has, and at what...
Engagement Activities
Mucociliary Interactions
Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Engagement Activities
Hannah Mitchison
Engagement Activities
conference by Hannah Mitchison
Collaboration
Collaboration with molecular basis of disease and therapeutics
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Key Findings
cilia to be resorbed and identified the pathway responsible
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Collaboration
Role of primary cilia in cortical development
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Collaboration
UK Cilia Network
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Engagement Activities
Network Meeting
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Engagement Activities
Polycystins in Chondrocyte Mechanotransuction
Research Databases and Models
Computed flow from Stokes singularities in a two layer system
Key Findings
sensory cilia that sense flow stimuli, not only the type of flow (whether fast vibrations or flow...
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Engagement Activities
meeting Edinburgh 06/10/2024
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Engagement Activities
and Centrosomes Meeting, Awaji, Japan
Engagement Activities
years on - at EMBO Cilia 2022 in Cologne, Germany (4th October 2022)
Research Databases and Models
Paranasal sinuses are hollow spaces within the bones surrounding the nose. Of these, the largest...
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Collaboration
Primary cilia in Joubert Syndrome
Collaboration
Nordic Centrosome and Cilia Network
Collaboration
Nordic Centrosome and Cilia Network
Collaboration
Nordic Centrosome and Cilia Network
Products Interventions & Clinical Trials
CiliaScope automates the image collection of cilia for the diagnosis of Primary Cilia Dyskinesia...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...
Engagement Activities
Trinity Centre for Bioengineering
Key Findings
functions such as mucociliary clearance in our airways and for sperm to swim. The molecular motors...
Key Findings
facility not a s[pecific project: Vaughan: 3-D organisation of the flagellar pocket in T....
Further Funding
structure and function (PhD Studentship)
Impact Summary
understanding of the role of cilia related genes in male infertility and the unknown function of...
Key Findings
postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has...
Key Findings
in which the dynein-2 microtubule motor works in the formation and function of primary cilia. This...