Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Collaboration
Analysis of primary cilia in human cells
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Collaboration
Functional Conservation in Ciliary Trafficking
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
PCD male fertility assessment
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
cilia to be resorbed and identified the pathway responsible
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
Collaboration with molecular basis of disease and therapeutics
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
UK Cilia Network
Collaboration
Role of primary cilia in cortical development
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...