Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Further Funding
transport within cilia and flagella
Further Funding
transport within cilia and flagella
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Impact Summary
working in the field of bacterial flagella biogenesis.
Key Findings
epidemics and pandemics of the severe diarrhoeal disease cholera. V. cholerae swims through liquids...
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Collaboration
Analysis of primary cilia in human cells
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Research Tools and Methods
We have succeeded in generating transgenic Chlamydomonas cell lines that express fluorescent...
Collaboration
Functional Conservation in Ciliary Trafficking
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Key Findings
computer algorithm, that should be able to diagnose mutations that affect flagella. The alga...
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
PCD male fertility assessment
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Key Findings
cilia to be resorbed and identified the pathway responsible
Impact Summary
the impact of phase variation on adaptation of Campylobacter jejuni to different selective...
Collaboration
Developing calcium sensors in green algae
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Collaboration
Collaboration with molecular basis of disease and therapeutics
Research Databases and Models
This is a collection of Matlab programming functions, that between them, can track the two flagella...
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
UK Cilia Network
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Research Tools and Methods
We have used techniques like protein structure prediction with mutation, cloning, and bacterial...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
Engineering flagellar export pipes
Collaboration
Engineering flagellar export pipes
Collaboration
Role of primary cilia in cortical development
Key Findings
been discovered that its motility apparatus (the bacterial flagella motor) has a novel architecture...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Key Findings
food-borne bacterial pathogen, Escherichia coli O157:H7, attach to plant hosts. Food-borne...
Key Findings
demonstrated that bovine TLR5 is active (there was published debate about this), and that bovine...