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Key Findings

The chicken talpid3 mutant, which have a mutation

in TALPID3 lack primary cilia, a small organelle found on the surface of each cell. As primary...

Research Databases and Models

Cilia-driven flow

Developed mathematical model for cilia-driven flow near a rigid substrate in a (linear)...

Research Databases and Models

effectors of ciliogenesis

list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...

Research Databases and Models

effectors of ciliogenesis

list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Royal Brompton Hospital

PCD male fertility assessment

Key Findings

We have identified a motile cilia defect in Fat4

and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....

Intellectual Property

FORCE SENSOR

A tactile sensor, consisting of a flexible main body with embedded magnets, soft magnetized cilia...

Key Findings

Cilia are antenna-like organelles found on the

surface of almost every cell type in the body. They are critical for human physiology, as they they...

Impact Summary

We have defined the subunit composition of the

cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...

Key Findings

The early stages of this project had 2 aims. The

first was to see IF we could see tiny organelles called primary cilia in the mouse growth plate and...

Key Findings

We have determined how a protein complex that is

critical for cilia formation functions mechanistically, what lipid preferences it has, and at what...

Key Findings

The work used the green alga, Chlamydomonas, as a

model organism to examine signalling processes in flagella. We identified how the movement of...

Artistic and Creative Products

Visualisation3.avi

Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...

Artistic and Creative Products

Visualisation3.avi

Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...

Artistic and Creative Products

Visualisation3.avi

Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...

Collaboration

University of Sheffield in collaboration with University of Leeds

Analysis of rho kinase inhibitors of ciliary function

Collaboration

UNIVERSITY OF OXFORD in collaboration with Harvard University

Cryo-EM structure of cilia

Collaboration

University of Glasgow in collaboration with Harvard University

Cryo-EM structure of cilia

Collaboration

NEWCASTLE UNIVERSITY in collaboration with University of Leeds

Collaboration with molecular basis of disease and therapeutics

Key Findings

Ciliopathies are a group of diseases to a wide

spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...

Collaboration

University of Southampton in collaboration with University Hospital Southampton NHS Foundation Trust

From Astronomy to detecting Respiratory Cilia cells

Collaboration

University of Southampton in collaboration with Royal Brompton Hospital

From Astronomy to detecting Respiratory Cilia cells

Collaboration

University of Leeds in collaboration with University of California, San Diego (UCSD)

functional characterization of ciliopathy proteins

Collaboration

University of Leeds in collaboration with Johannes Gutenberg University of Mainz

functional characterization of ciliopathy proteins

Collaboration

University of Leeds in collaboration with Radboud University Nijmegen Medical Center

functional characterization of ciliopathy proteins

Collaboration

University of Leeds in collaboration with Eberhard Karls University of Tübingen

functional characterization of ciliopathy proteins

Key Findings

We identified that cell stress causes primary

cilia to be resorbed and identified the pathway responsible

Research Tools and Methods

transgenic lines

We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.

Key Findings

The most significant achievements from the

award: 1. We have produced single cell sequencing data to generate a single cell atlas of the...

Collaboration

UNIVERSITY OF EDINBURGH in collaboration with Sorbonne University

Role of primary cilia in cortical development

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Tampere University Hospital

Finnish PCD genetics

Collaboration

KING'S COLLEGE LONDON in collaboration with Max Planck Society

Analysis of cilia development and patterning

Collaboration

University of Bristol in collaboration with Queen Mary University of London

UK Cilia Network

Research Databases and Models

Reverse genetics siRNA-based visual phenotype screen datasets identifying genes involved in supernumerary primary cilium formation

High content siRNA screen carried out to identify genes which when knocked-down, cause the...

Research Databases and Models

Reverse genetics siRNA-based visual phenotype screen datasets identifying genes involved in supernumerary primary cilium formation

High content siRNA screen carried out to identify genes which when knocked-down, cause the...

Collaboration

OXFORD BROOKES UNIVERSITY in collaboration with University of Oxford

Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.

Key Findings

- We achieved the first fully three-dimensional

reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...

Key Findings

Marine invertebrate larvae have specialised

sensory cilia that sense flow stimuli, not only the type of flow (whether fast vibrations or flow...

Research Tools and Methods

Confocal microscopy of katydid hearing organ

We have used traditional paraformaldehyde fixation and histological staining combined with confocal...

Research Tools and Methods

genetic & small molecule effectors of ciliogenesis

1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...

Research Tools and Methods

genetic & small molecule effectors of ciliogenesis

1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...

Research Tools and Methods

genetic & small molecule effectors of ciliogenesis

1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...

Research Databases and Models

Modelling active mucus flow theoretically

Paranasal sinuses are hollow spaces within the bones surrounding the nose. Of these, the largest...

Collaboration

University of Bristol in collaboration with Goethe University Frankfurt