Engagement Activities
the cilium in chondrocyte mechanotransduction
Key Findings
in TALPID3 lack primary cilia, a small organelle found on the surface of each cell.
As primary...
Research Databases and Models
Developed mathematical model for cilia-driven flow near a rigid substrate in a (linear)...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
PCD male fertility assessment
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....
Intellectual Property
A tactile sensor, consisting of a flexible main body with embedded magnets, soft magnetized cilia...
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Key Findings
first was to see IF we could see tiny organelles called primary cilia in the mouse growth plate and...
Engagement Activities
the University of Southampton
Key Findings
critical for cilia formation functions mechanistically, what lipid preferences it has, and at what...
Engagement Activities
Mucociliary Interactions
Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Artistic and Creative Products
Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Engagement Activities
Hannah Mitchison
Engagement Activities
conference by Hannah Mitchison
Collaboration
Collaboration with molecular basis of disease and therapeutics
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Key Findings
cilia to be resorbed and identified the pathway responsible
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...