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Engagement Activities

Keynote at Cell under Pressure conference

Engagement Activities

CILIA 2018 poster presentation: Polycystins and

the cilium in chondrocyte mechanotransduction

Key Findings

The chicken talpid3 mutant, which have a mutation

in TALPID3 lack primary cilia, a small organelle found on the surface of each cell. As primary...

Engagement Activities

Cilia 2016

Engagement Activities

Cilia Network

Research Databases and Models

Cilia-driven flow

Developed mathematical model for cilia-driven flow near a rigid substrate in a (linear)...

Collaboration

University of Glasgow in collaboration with Imagine Institute

Medetia

Collaboration

University of Dundee in collaboration with German Cancer Research Center

Analysis of primary cilia in human cells

Key Findings

We have identified a motile cilia defect in Fat4

and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....

Key Findings

Cilia are antenna-like organelles found on the

surface of almost every cell type in the body. They are critical for human physiology, as they they...

Research Databases and Models

effectors of ciliogenesis

list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...

Research Databases and Models

effectors of ciliogenesis

list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...

Collaboration

University of Edinburgh in collaboration with University of Edinburgh

Functional Conservation in Ciliary Trafficking

Engagement Activities

Pint of Science - From Hip Cells to Implants

Engagement Activities

UK Cilia Club

Engagement Activities

Cilia 2022 conference

Engagement Activities

UK Cilia Club

Engagement Activities

UK Cilia Club

Impact Summary

We have defined the subunit composition of the

cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...

Engagement Activities

Presentation in European testis workshop

Engagement Activities

Cilia Flashmob at Science & Engineering Day at

the University of Southampton

Key Findings

The work used the green alga, Chlamydomonas, as a

model organism to examine signalling processes in flagella. We identified how the movement of...

Engagement Activities

Presentation in UK Cilia Network Fall meeting 2023

Collaboration

UNIVERSITY COLLEGE LONDON in collaboration with Royal Brompton Hospital

PCD male fertility assessment

Engagement Activities

Gordon Research Conference on Cilia, Mucus and

Mucociliary Interactions

Key Findings

Ciliopathies are a group of diseases to a wide

spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...

Artistic and Creative Products

Visualisation3.avi

Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...

Artistic and Creative Products

Visualisation3.avi

Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...

Artistic and Creative Products

Visualisation3.avi

Multichannel images of fixed Platynereis dumerilii larvae after 3 days post-fertilisation. Labels:...

Key Findings

We identified that cell stress causes primary

cilia to be resorbed and identified the pathway responsible

Research Tools and Methods

transgenic lines

We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.

Engagement Activities

Ciliopathy Alliance UK Strategy Planning Day

Engagement Activities

Oral presentation at 2nd Crick Rare Disease

conference by Hannah Mitchison

Engagement Activities

Oral presentation at BEAT-PCD conference by

Hannah Mitchison

Collaboration

Newcastle University in collaboration with University of Leeds

Collaboration with molecular basis of disease and therapeutics

Key Findings

The most significant achievements from the

award: 1. We have produced single cell sequencing data to generate a single cell atlas of the...

Engagement Activities

Poster presentation in CiIia conference

Collaboration

University of Leeds in collaboration with Radboud University Nijmegen Medical Center

functional characterization of ciliopathy proteins

Collaboration

University of Leeds in collaboration with Eberhard Karls University of Tübingen

functional characterization of ciliopathy proteins

Collaboration

University of Leeds in collaboration with Johannes Gutenberg University of Mainz

functional characterization of ciliopathy proteins

Collaboration

University of Leeds in collaboration with University of California, San Diego (UCSD)

functional characterization of ciliopathy proteins

Engagement Activities

UK Cilia meeting October 2023

Engagement Activities

Cilia in Development and Disease

Engagement Activities

Keynote - Primary cilia and mechanobiology

Engagement Activities

CIP visit of PCD families

Collaboration

University of Glasgow in collaboration with Harvard University

Cryo-EM structure of cilia

Collaboration

University of Oxford in collaboration with Harvard University

Cryo-EM structure of cilia

Collaboration

University of Sheffield in collaboration with University of Leeds

Analysis of rho kinase inhibitors of ciliary function

Collaboration

University of Bristol in collaboration with Queen Mary University of London

UK Cilia Network

Engagement Activities

Ciliopathy Alliance UK

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Projects (103)

Publications (180)

People (141)

Organisations (1)

Outcomes (160)

Classifications (0)