Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Vuuren MJV
(2020)
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease.
in Biomolecules
Visser MJE
(2019)
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
in Frontiers in cellular and infection microbiology
Pretorius L
(2018)
Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia
in Frontiers in Neuroscience
Pretorius E.
(2017)
A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease
in Advances in Alzheimer's Disease
Pretorius E
(2014)
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.
in Integrative biology : quantitative biosciences from nano to macro
Pretorius E
(2022)
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC).
in Cardiovascular diabetology
Pretorius E
(2014)
Eryptosis as a marker of Parkinson's disease.
in Aging
| Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
| Exploitation Route | Novel diagnostics. |
| Sectors | Digital/Communication/Information Technologies (including Software) Education Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Stellenbosch |
| Organisation | University of Stellenbosch |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
| Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
| Impact | See publications. |
| Start Year | 2017 |