Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
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Publications
Kell DB
(2015)
The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).
in Integrative biology : quantitative biosciences from nano to macro
Kell DB
(2018)
No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.
in Biological reviews of the Cambridge Philosophical Society
Kell DB
(2016)
A Dormant Microbial Component in the Development of Preeclampsia.
in Frontiers in medicine
Kell D
(2020)
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria
in Frontiers in Immunology
Grobbelaar LM
(2021)
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19.
in Bioscience reports
Grobbelaar LM
(2022)
Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness.
in Seminars in thrombosis and hemostasis
Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
Exploitation Route | Novel diagnostics. |
Sectors | Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Stellenbosch |
Organisation | University of Stellenbosch |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
Impact | See publications. |
Start Year | 2017 |