Japan Partnering Award: The Generation of Eye Tissues from Human Induced Pluripotent Stem (iPS) Cells.
Lead Research Organisation:
CARDIFF UNIVERSITY
Department Name: Optometry and Vision Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Huang W
(2025)
Transient ocular hypertension remodels astrocytes through S100B.
in PloS one
Baba K
(2021)
The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes
in International Journal of Pharmaceutics
Howard L
(2024)
Single-cell transcriptomics reveals the molecular basis of human iPS cell differentiation into ectodermal ocular lineages.
in Communications biology
Shibata S
(2018)
Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages.
in Cell reports
Shiraki N
(2022)
PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids
in Stem Cell Reports
Kobayashi Y
(2020)
Ocular surface ectoderm instigated by WNT inhibition and BMP4.
in Stem cell research
Hashida N
(2022)
Mitochondrial DNA as a Biomarker for Acute Central Serous Chorioretinopathy: A Case-Control Study.
in Frontiers in medicine
Fujimoto S
(2019)
KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-ß2 suppression.
in Regenerative therapy
Soma T
(2024)
Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan.
in Lancet (London, England)
Maeno S
(2024)
Imaging pathology in archived cornea with Fuchs' endothelial corneal dystrophy including tissue reprocessing for volume electron microscopy.
in Scientific reports
| Description | Numerous inward and outward researcher exchanges between Cardiff and Osaka leading to training given and received and numerous papers being published. |
| Exploitation Route | UK-Japan collaborations in the vision sciences will be established. |
| Sectors | Healthcare |
| Description | Dr Yixin Wang research in Osaka University |
| Organisation | Osaka University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | My PhD student, Dr Yixin Wang, conducted experiments in Osaka University on human induced pluripotent stem cells and extracellular matrix molecules that is advancing our knowledge and will lead to publications in the next year or so |
| Collaborator Contribution | Professor Ryuhei Hayashi hosted Dr Wang and provided training and mentorship |
| Impact | None yet |
| Start Year | 2014 |
| Description | JPA collaboration |
| Organisation | Newcastle University |
| Country | United Kingdom |
| PI Contribution | Research collaboration between Cardiff Newcastle and Osaka |
| Collaborator Contribution | Research collaboration between Cardiff Newcastle and Osaka |
| Impact | None yet |
| Start Year | 2018 |
| Description | JPA link Nottingham Trent |
| Organisation | Nottingham Trent University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | New research in lens development and beamtime at the Japan synchrotron |
| Collaborator Contribution | New research in lens development and beamtime at the Japan synchrotron |
| Impact | Data being written up |
| Start Year | 2018 |
| Description | Nishida SEAM collaboration |
| Organisation | Osaka University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | The joint ongoing study of iPS cell derived eye-like cells |
| Collaborator Contribution | The joint ongoing study of iPS cell derived eye-like cells |
| Impact | Preliminary, unpublished data as part of this new collaborative project with long-standing partners |