Enabling industrial deployment of deep eutectic solvents through manufacturing tools
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
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People |
ORCID iD |
| Laura Torrente Murciano (Principal Investigator) |
Publications
Exposito A
(2020)
Fast Synthesis of CeO 2 Nanoparticles in a Continuous Microreactor Using Deep Eutectic Reline As Solvent
in ACS Sustainable Chemistry & Engineering
Datta S
(2020)
Morphological Control of Nanostructured V2O5 by Deep Eutectic Solvents.
in ACS applied materials & interfaces
Datta S
(2023)
Role of the Deep Eutectic Solvent Reline in the Synthesis of Gold Nanoparticles.
in ACS sustainable chemistry & engineering
Manasi I
(2021)
Self-assembly of ionic and non-ionic surfactants in type IV cerium nitrate and urea based deep eutectic solvent.
in The Journal of chemical physics
Manasi I
(2022)
Surfactant effects on the synthesis of porous cerium oxide from a type IV deep eutectic solvent
in Journal of Materials Chemistry A
| Description | In this project, we explored the role of a new type of green, no-toxic and biodegradable type of solvents, deep eutectic solvents, in a range of applications, namely as solvents in organic transformations and also for the synthesis of metal nanoparticles and nanostructured materials. This project is part of a small consortium where our role is the development of flow reactors to enable the deployment of the abovementioned systems. One of the main challenges is the high viscosity associated to these green solvents, which we have overcome by their mixing with water in particular ratios so the structure of the solvent is not modified. As part of the project, we have demonstrated: - The synthesis of nanostructured ceria in deep eutectic solvents using a flow reactor, able to cope with the high viscosities of the medium and also able to achieve long residence times (~ 20 min) - The deployment of flow reactors for organometallic reactions using air sensitive organo-lithium catalysts. By combining the different expertise brought by the consortium, we have demonstrated for the first time these reactions in flow, opening the door to a range of opportunities, specially in the pharmaceutical industry. |
| Exploitation Route | Prof Eva Hevia (co-I) in the grant has had conversations with a number of pharmaceutical and chemical companies (such as Johnson&Johnson) for their adaptation of the research findings. At the moment, organo-metallic reactions can only be carried out safely at very low temperatures but we have demonstrated the safe and stable performance in this new type of solvents. |
| Sectors | Chemicals Energy Environment Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | Policy briefing - Green Carbon for the Chemical Industry by Royal Society |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Title | Data set for "Surfactant Effects on the Synthesis of Porous Cerium Oxide from a Type IV Deep Eutectic Solvent" |
| Description | This dataset relates to a novel, low temperature and green method for atom-efficient solvothermal synthesis of crystalline, micelle templated cerium IV oxide (ceria) from a type IV deep eutectic solvent (DES) comprising a hydrated cerium containing metal salt, cerium(iii) nitrate hexahydrate (Ce(NO3)3·6H2O), and a hydrogen bond donor, urea, in a molar ratio of 1:3.5. We have used high concentration (20% w/w) solutions of C-12 and C-16 alkyl chain length cationic surfactants (C?TAB and C?TANO3) and C-16 alkyl chain length non-ionic surfactant BrijC10 in the DES to alter the porosity of the cerium oxide produced. The characterisation of the cerium oxide has been carried out using scanning and transmission electron microscopy (SEM/TEM), N2 sorption, Small Angle X-ray Scattering (SAXS) and temperature programmed reduction (TPR) to understand and quantify the nature of the crystallinity, morphology and porosity along with CO oxidation for the catalytic activity of the material. Included in the dataset are the X-ray diffraction (XRD), SAXS, N2 sorption, SEM Energy Dispersive X-Ray Analysis (EDX), X-ray photoelectron (XPS) and CO oxidation characterization data for these materials. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://researchdata.bath.ac.uk/id/eprint/1190 |
| Title | Research data supporting: Continuous, stable and safe organometallic reactions inflow at room temperature assisted by deep eutectic solvents |
| Description | The video data is related to the publication entitled "Continuous, stable and safe organometallic reactions in flow at room temperature assisted by deep eutectic solvents". The supporting media contains: * Hydrodynamic studies using segmented flow between the DES or DES/aqueous phase and the organic phase containing the substrate. For further information please refer to the publication and the video. * NMR data |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | The video data is related to the publication entitled "Continuous, stable and safe organometallic reactions in flow at room temperature assisted by deep eutectic solvents". The supporting media contains: * Hydrodynamic studies using segmented flow between the DES or DES/aqueous phase and the organic phase containing the substrate. For further information please refer to the publication and the video. * NMR data |
| URL | https://www.repository.cam.ac.uk/handle/1810/334274 |
| Description | Eva Hevia |
| Organisation | University of Bern |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | This is a collaboration project together. They are developing new chemistries using deep eutectic solvents which we are translating into continuous flow systems for their adaptation in industry. |
| Collaborator Contribution | They are exploring the use of deep eutectic solvents in organic reactions using air-sensitive catalysts. Two members of Prof Hevia's group have been visiting Cambridge for different periods of time including Florian Mulks and Andrew Platten |
| Impact | We have demonstrated for the first time the synthesis of organometallic reactions in flow at room temperature assisted by deep eutectic solvents in a stable and safe manner (Chem 8 (2022) 3382-3394, DOI: 10.1016/j.chempr.2022.11.004) |
| Start Year | 2019 |
| Description | Karen Edler |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developing flow systems for the synthesis of nanostructured materials using deep eutectic solvents |
| Collaborator Contribution | Understanding the interaction and role of deep eutectic solvents with a range of inorganic materials |
| Impact | This is a multidisciplinary collaboration and we are publishing joint papers |
| Start Year | 2013 |
| Description | Arkwright Scholars Visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Presentation on the catalysis and nanoparticles research of our lab group to Year 12 students on scholarships to study Engineering |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Cambridge Festival - Art using Nanoparticles |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Demonstration of art designs using nanoparticles |
| Year(s) Of Engagement Activity | 2021,2024 |