Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
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Publications
Kell DB
(2015)
The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).
in Integrative biology : quantitative biosciences from nano to macro
Kell DB
(2022)
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications.
in The Biochemical journal
Kell DB
(2017)
Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting.
in Progress in biophysics and molecular biology
Kell DB
(2014)
Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells.
in Metallomics : integrated biometal science
Kell DB
(2018)
No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.
in Biological reviews of the Cambridge Philosophical Society
Kell DB
(2015)
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death.
in Integrative biology : quantitative biosciences from nano to macro
| Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
| Exploitation Route | Novel diagnostics. |
| Sectors | Digital/Communication/Information Technologies (including Software) Education Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Stellenbosch |
| Organisation | University of Stellenbosch |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
| Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
| Impact | See publications. |
| Start Year | 2017 |