EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers
Lead Research Organisation:
University of Cambridge
Department Name: Engineering
Abstract
While the survival rate for most cancers has doubled over the last 40 years, hard-to-treat cancers show survival rates below 14%. To combat these cancers, multiple pathways (immune/inflammatory, neoangiogenic, cell replication) need to be targeted and this necessitates a multimodal delivery approach that will increase not only the amount but also the range of therapeutic agents that reach the target site. This IRC will address this challenge by developing (i) delivery vehicles that are based on metal organic frameworks and organic cages and show substantially increased payload capacity, and (ii) implantable/injectable delivery platforms that are based on gels and electrophoretic pumps and enhance drug penetration through e.g. the blood-brain barrier. By combining these two approaches, we will achieve a step change in the amount and range of drugs that reach the tumour site. Two crosscutting translational activities, on material delivery & additive manufacturing and on validation, will consider the whole chain from the conception of the delivery system to its clinical application, leading to a holistic approach to the problem of targeted drug delivery. The proposed research program builds on an institutional-level initiative on therapeutic science and strong links with CRUK and with national labs and industry leaders in drug development. The interdisciplinary team involved in this IRC includes groups from five universities with expertise ranging from materials synthesis and characterisation, through device engineering and manufacturing, to pharmacology and cancer, and will deliver scientific breakthroughs that extend beyond the field of targeted drug delivery. Economic and societal impacts will be delivered and measured through a joined-up approach to market analysis, industry feedback and embedded anticipation of risks to translation. Engagement of end-users and stakeholders, which will begin as early as the preparation of the second-round proposal, will play a critical role in steering the IRC throughout its lifetime.
Planned Impact
The chief impact from this project will be the development of new treatments for hard-to-treat cancers. Over the long term, these treatments will improve patient outcomes and quality of life by increasing the amount and range of drugs that reach the tumour site. In the short term, stakeholders and end-users including clinicians, patient groups, regulatory agencies and members of the healthcare technology supply chain, will benefit from the creation of an ecosystem that engages them at the early stages of the generation of a novel therapeutic solution. Industry will benefit by participating in a project that brings together state-of-the-art materials and device solutions to the field of drug delivery in a way that de-risks their transition to the market. The general public will benefit from a wide range of outreach events that target increased awareness of the future of medical treatments. The academic community will benefit from new scientific knowledge and engineering solutions that will be created by this interdisciplinary project.
Organisations
- University of Cambridge (Lead Research Organisation)
- Friedrich-Alexander University Erlangen-Nuremberg (Collaboration)
- University of Leeds (Collaboration)
- University of Cambridge (Collaboration)
- University of Nottingham (Collaboration)
- University of Glasgow (Collaboration)
- Centre for Process Innovation (CPI) (Collaboration)
- British Lung Foundation (BLF) (Collaboration)
- Astrazeneca (Collaboration)
- Mesothelioma UK (Collaboration)
- Cancer Research UK Cambridge Institute (Collaboration)
- ARM Limited (Collaboration)
- Riptide Bioscience (Collaboration)
- Cardiff University (Collaboration)
- Great Ormond Street Hospital (GOSH) (Collaboration)
- Massachusetts Institute of Technology (Collaboration)
- Medicines Discovery Catapult (Collaboration, Project Partner)
- University of Strathclyde (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- National Physical Laboratory (Collaboration)
- ARM Limited (Project Partner)
- AstraZeneca (Project Partner)
- National Physical Laboratory (Project Partner)
- Centre for Process Innovation (Project Partner)
Publications
Foo CT
(2021)
Ambulatory Thoracoscopic Pleurodesis Combined With Indwelling Pleural Catheter in Malignant Pleural Effusion.
in Frontiers in surgery
Baker A
(2024)
An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
in Angewandte Chemie
Baker AG
(2024)
An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence.
in Angewandte Chemie (International ed. in English)
Chambers JE
(2018)
An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles.
in ACS nano
Elbadawi M
(2024)
Artificial intelligence generates novel 3D printing formulations
in Applied Materials Today
Barnett SE
(2023)
BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification.
in Molecular cancer research : MCR
Wang W
(2024)
Biointerface Fiber Technology from Electrospinning to Inflight Printing.
in ACS applied materials & interfaces
Obacz J
(2021)
Biological basis for novel mesothelioma therapies.
in British journal of cancer
Obacz J
(2021)
Biological basis for novel mesothelioma therapies.
| Description | One key achievement includes the development of a new electrical drug delivery concept, redox flow iontophoresis. This enables the continuous delivery of charged drug molecules into the brain using DC electric fields. Previously, this was not possible without significant production of electrochemical side products and potential degradation of the delivered drug molecules. Redox flow iontophoresis shows safe and continuous drug delivery at rates more than a thousand times greater than previously reported. The concept was patented, and we are now considering company creation. Other key achievements include the development and validation of injectable gels for localised drug delivery: We successfully scaled up the synthesis of peptide-functionalized polymer backbone, enabling future first-in-human clinical trials. We developed a facile route for synthesizing sterile gels, setting the foundation for both preclinical and clinical trials. Identified optimal sterilization conditions for the key drugs (Gemcitabine, Doxorubicin, and Irinotecan). We demonstrated injectability of the hydrogel system across various needle gauges without affecting the material's mechanical properties. We incorporated both empty and Doxorubicin-loaded metal-organic frameworks (MOFs) into the hydrogel at different concentrations, with no detrimental effects on mechanical properties. We demonstrated controlled release of Doxorubicin from MOF-loaded hydrogels. Stability studies revealed enhanced stability of MOFs within the hydrogel matrix compared to PBS solution, as confirmed by DLS and TEM analysis. We synthesized nanoparticles with different surface charges (neutral, cationic, and anionic) via RAFT polymerization, all of which remained stable in PBS for at least two months. We investigated the release of Doxorubicin from nanoparticles and nanoparticle-loaded gels, revealing different release profiles based on surface charge, with slower release observed within the hydrogel. Cytotoxicity studies confirmed that Doxorubicin-loaded nanoparticles within hydrogels were cytotoxic against HELA cells after 96 hours, with cationic nanoparticles demonstrating the highest cytotoxicity. We successfully synthesized PEG-PCL via ring-opening polymerization. In aqueous solutions, the polymer self-assembled into nanoparticles approximately 50nm in size. Covalently attached Doxorubicin to PEG-PCL using different linkers (imine and carbamate), resulting in varying release profiles-fast for the imine linker and slower for the carbamate linker. Both free and synergistic release of Gemcitabine and Doxorubicin from hydrogels was demonstrated without interference between the drugs. In vitro studies showed that the combination of Doxorubicin and Gemcitabine displayed synergistic effects when targeting patient-derived Glioblastoma cells. We successfully tagged the polymer backbone with a fluorescent dye (FITC) for tracking hydrogel behaviour in a GB rat model. We developed combination drug/pro-drug therapeutics designed to exploit the heterogeneous biology of GBM using patient-derived GBM invasive margin cells in in vitro and in vivo surgical resection models. Upon an initial drug screen incorporating primary glioblastoma 2D and 3D models, isolated from both the tumour proliferative core and infiltrative tumour margin, we identified Gemcitabine and Doxorubicin as the most potent compounds. Furthermore, both compounds in combination conferred a synergistic effect, as evidenced by DNA damage and markers of cell death. We incorporated lead drug compounds into supramolecular hydrogels amenable for post-surgical administration. Gemcitabine, Doxorubicin and Gemcitabine/Doxorubicin combinations were successfully formulated in a supramolecular hydrogel. This biomaterial is based on a peptide-functionalised hyaluronic acid backbone dynamically linked by cucurbit[8]uril-mediated host-guest interactions, and functions as an implantable drug-delivery system. These drug-loaded hydrogels demonstrated potency and maintenance of synergy, in an easy-to-administer in situ gelling formulation suitable for post-surgical delivery to the tumour cavity to potentially prevent or delay glioblastoma recurrence. As a complementary armament to this hydrogel delivery system, polymeric micelle nanoparticles have successfully been released from the hydrogel and demonstrated to internalise in glioblastoma cells via dynamin-dependent caveolin and clathrin pathways. Furthermore, increased doxorubicin uptake and localisation to the nucleus was observed when incorporated into nanoparticles, relative to free drug. Further achievements include the development and validation of novel nanoparticles for drug delivery. We demonstrated MOFs as an effective delivery system for treating mesothelioma and pancreatic cancer. This work led to the creation of Vector Bioscience, a spin-out from the University of Cambridge. The start-up has secured approximately £3 million in non-dilutive funding, reflecting strong commercial interest and potential for further development. Vector now employs 10 full-time staff. We have successfully designed and validated polydopamine-based nanocarriers and validated them for delivery of SN38 to pancreatic tumour. The system was validated in vitro and in vivo biodistribution studies were completed. Pluronic-polydopamine nanocarriers are tuneable in size, can be additionally modified and are immunocompatible. A patent has been filed and licencing conversations with companies were initiated. We carried out extensive work on biocompatibility of Zr MOFs, looking at the effect of metal choice and ligand choice on in vitro biocompatibility. We used state of the art in vitro assays to show that the Zr MOF UiO-66 is a prime candidate as a drug carrier due to its excellent biocompatibility and stability. We have extensively studied the uptake of pancreatic cancer standard of care gemcitabine by our Zr MOFs. Unfortunately, uptake is low due to the lack of interaction between gemcitabine and the MOFs, and we see rapid release. Our development of real-time cell analysis to probe drug delivery continued with doxorubicin as drug towards other cancer types, and we have successfully validated the technique to show how different drug localisations (particle outer surface vs particle inner pores) modifies release behaviour and the onset of cytotoxicity. We evaluated supramolecular vehicles in primary mesothelioma cancer cell lines obtained from the 'Mesobank' national mesothelioma bioresource: Zirconium-based metal-organic frameworks (MOFs) were modified with a bilayer coating strategy (NU-901). These remained well dispersed in biologically relevant fluids and the coating enhanced long-term stability in water. In mesothelioma 2D primary cell cultures, the bilayer coating slowed release of pemetrexed over 7 days. Super-resolution microscopy demonstrated bilayer-coated MOFs were targeted to lysosomes. Pemetrex-loaded NU-901 was cytotoxic to mesothelioma cells. We have shown that light-induced nitrile imine-mediated tetrazole-ene cycloaddition is a valid method for controllable, biocompatible surface modification. This has been validated by incorporation of galactose units to allow targeting of ASGPR receptors on cancer cells. The issues with loading of gemcitabine means that proof-of-concept was demonstrated against liver cancer rather than pancreatic cancer, but future work could focus on incorporation of stroma-disrupting compounds for pancreatic tumours. We have also shown that MOFs can be encapsulated in PEG-PLGA vesicles to enhance colloidal stability. We formulated polydopamine nanoparticles to enable gene delivery and successfully demonstrated uptake and desired protein expression. A recirculation device and 3D models of pancreatic cancer were established for advanced in vitro validation of polymeric nanocarriers. Novel polymeric (protein) nanocarriers were developed as second generation of biocompatible nanocarriers with higher drug loading for exploration in pancreatic cancer and lung mesothelioma. Key achievements include advancements in the validation of novel localised delivery technologies. We established protocols for testing toxicity of novel drug delivery systems (HET-CAM) and their uptake into (microscopy) and efficacy against (bioluminescent imaging, histology) mesothelioma, using the chorioallantoic membrane (CAM) of fertilised hens' eggs as an alternative xenograft model to rodents. We demonstrated that carboplatin/pemetrexed loaded MOFs penetrate cells, induce apoptosis and reduce mesothelioma tumour viability in CAM xenografts. |
| Exploitation Route | Work in IRC partner laboratories continues with >£5M additional funding along the following lines: Work on the redox flow iontophoresis technique is advancing towards validation in porcine models. Using funding secured from the NiHR Cambridge BRC, device manufacturing issues are being addressed to pave the way for human translation. The creation of a spinout is being considered. Work on gels continues towards the development of a single formulation which is capable of releasing a single or dual drug combinations at the desired timescales. This includes the development of nanoparticles with different degree of negative and positive charges and the assessment of their effect on rheology and release. Advances in hydrogel synthesis and functionalisation of vehicles are being explored in the field of tissue engineering and energy storage. Work on particles exploits established protocols for preparation and validation to newly developed moieties, such as antibody-targeted MOFs, and siRNA loaded MOFs, for mesothelioma or other cancers. Validation on mesothelioma organoids is ongoing through funding from Asthma+Lung UK. The spinout Vector, along with ongoing collaboration amongst IRC partners, will drive the commercial development and clinical translation of MOF-based therapies. Patenting of protein nanocarriers is ongoing together with Cambridge Enterprise, and the creation of a spinout is being considered. These biopolymer nanocarriers have attracted the attention of immunologists within Addenbrookes hospital interested in making use of these systems to target cancer promoting signalling proteins, and researchers working on targeting of senescent cells. A variety of "tangents" that were created by this IRC are now being explored. These include a project looking at modifying the tumour microenvironment with nanocarriers, which is being evaluated in CAM xenograft models of mesothelioma (we saw substantial stromal recruitment to the tumours). Protocols established for validation in mesothelioma patient derived xenografts (PDXs) are being used to evaluate the impact of different delivery technologies on tissue architecture, fibrosis and immune components, for example, through an EU Horizon MCSA DTP program. |
| Sectors | Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| URL | https://www.teddy.eng.cam.ac.uk/ |
| Description | The IRC has trained a cohort of >40 young scientists and engineers in interdisciplinary research and delivered them to industry and academia (see Next Destination). This includes researchers who are now Assistant/Associate Professors at Oxford, QMUL, Manchester, Nottingham Ningbo, and at Houston Methodist. The IRC promoted targeted delivery for cancer with a series of engagement activities (see Engagement Avtivities), including presentations to patients that demystified the scientific process and offered hope by introducing potential new therapies, and to the House of Lords. Cancer research and patient advocacy organizations have leveraged IRC findings to campaign for increased funding and support for innovative cancer treatments. These groups are using our research to highlight the urgent need for advancements in treating hard-to-treat cancers, creating a wider impact in advocacy and funding efforts. The IRC supported the creation of the Cambridge Bioelectronics Symposium, established in as a unique annual event aimed at young scientists in the field. Over 70% of the talks are presented by young scientists, and are selected by a program committee composed entirely of young scientists. The symposium combines comprehensive coverage of the state-of-the-art in the field and career furthering opportunities. Attendance has grown from 100 people for the 2023 edition, to 123 people for the 2024 edition. The creation of Vectra, with 10 employees, has already secured approximately £3 million in investment. This company is poised to commercialize the MOF-based drug delivery technologies developed during the project, with the potential to generate groundbreaking treatments for cancers like mesothelioma, pancreatic cancer, and glioblastoma. A collaboration with an industry partner has been established to explore the efficacy of drug-polymer conjugates for the delivery of hydrophobic drugs, which are particularly beneficial in the treatment of GB. This collaboration has opened up new avenues for improving drug loading capacity, controlling release rates, and incorporating hydrophobic drugs within a hydrophilic polymer matrix, addressing critical needs in cancer therapy. The IRC contributed to the initial establishment and recent expansion of the Egg Facility at the University of Liverpool. Dr Sarah Barnett (IRC post-doc and Egg Facility manager) joined the University's new Technical Research Professional career pathway and was recently promoted onto a grade equivalent to a lecturer. This pathway is sector-leading and Sarah is an exemplar for how it can support technical specialists; it is a model now being adopted in other Universities. |
| First Year Of Impact | 2022 |
| Sector | Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | A revolutionary, highly versatile drug delivery platform based on Metal-Organic Frameworks |
| Amount | € 2,500,000 (EUR) |
| Funding ID | 101113070 |
| Organisation | European Commission |
| Sector | Public |
| Country | Belgium |
| Start | 04/2023 |
| End | 04/2026 |
| Description | Development of Hydrogels for Localised Drug Delivery for the Treatment of Glioblastoma |
| Amount | £12,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 03/2023 |
| Description | Development of Hydrogels for Treatment of Glioblastoma |
| Amount | £800,000 (GBP) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Sector | Private |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 09/2024 |
| Description | EPSRC Impact Acceleration Account |
| Amount | £8,078 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 12/2019 |
| Description | ERC Proof of Concept |
| Amount | € 150,000 (EUR) |
| Funding ID | GAP_ERC-2020-PoC_957514-MOHEDD |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | |
| Description | Fast Start: Innovation |
| Amount | £50,000 (GBP) |
| Funding ID | 10046360 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 04/2023 |
| Description | GMP translated fabrication of dynamic cucurbit[8]uril based hydrogels for drug delivery in cancer treatment |
| Amount | £14,961 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 05/2021 |
| Description | Harnessing single cell sequencing technology to improve early diagnosis and prognostication |
| Amount | £92,596 (GBP) |
| Funding ID | MEDPG21F\4 |
| Organisation | British Lung Foundation (BLF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 08/2023 |
| Description | In-vitro sensing of aerosol delivery and efficacy of chemotherapy drugs targeting lung disease |
| Amount | £100,000 (GBP) |
| Funding ID | 2866482 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2023 |
| End | 09/2027 |
| Description | Medical implant to deliver precision cancer treatment through targeted chemotherapeutic delivery |
| Amount | £180,000 (GBP) |
| Funding ID | EF2020\100033 |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 12/2023 |
| Description | Metal-organic frameworks as a modular platform for advanced drug delivery |
| Amount | £449,693 (GBP) |
| Funding ID | 10037486 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2022 |
| End | 11/2024 |
| Description | NIHR Cambridge Biomedical Research Centre |
| Amount | £86,200,000 (GBP) |
| Funding ID | NIHR203312 |
| Organisation | National Institute for Health and Care Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2027 |
| Description | Senescence-detecting, urine-based nanobiosensor for early detection of lung cancer |
| Amount | £85,000 (GBP) |
| Funding ID | EDDPMA-May23/100051 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2023 |
| End | 12/2025 |
| Description | SonoBacter: Ultrasound-guided Activation and Imaging of Engineered Bacteria for Stroma Reprogramming |
| Amount | £52,344 (GBP) |
| Funding ID | MR/Y008227/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2023 |
| End | 02/2025 |
| Description | Supramolecular local drug delivery hydrogel depot for Glioblastoma (GB) |
| Amount | £49,999 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 03/2023 |
| Description | Targeted, Stimuli-Responsive Delivery of Senolytics from Metal-Organic Frameworks |
| Amount | £279,954 (GBP) |
| Funding ID | TCS-24-08 |
| Organisation | Chief Scientist Office |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2025 |
| End | 01/2027 |
| Description | WELLCOME TRUST - INSTITUTIONAL TRANSLATION PARTNERSHIP AWARD: UNIVERSITY OF CAMBRIDGE |
| Amount | £50,000 (GBP) |
| Funding ID | RG93172 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 05/2020 |
| Title | Mesothelioma organoids |
| Description | Mesobank is a repository of mesothelioma tissue and in vitro models. Recently, we generated new mesothelioma organoids (currently 19 models), which are 3D cell cultures that closely mimic the properties and behaviour of mesothelioma tumours found in patients. |
| Type Of Material | Cell line |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | With Mesobank organdies, researchers can test potential therapies and develop new treatments. This resource is critical for advancing our understanding of mesothelioma and improving the lives of those affected by the disease. The use of organoids in research has the potential to greatly accelerate the pace of discovery and lead to new treatments that can help patients with mesothelioma. |
| URL | https://www.mesobank.com |
| Title | Quantitative monitoring and modelling of retrodialysis drug delivery in a brain phantom |
| Description | AbstractA vast number of drug molecules are unable to cross the blood-brain barrier, which results in a loss of therapeutic opportunities when these molecules are administered by intravenous infusion. To circumvent the blood-brain barrier, local drug delivery devices have been developed over the past few decades such as reverse microdialysis. Reverse microdialysis (or retrodialysis) offers many advantages, such as a lack of net volume influx to the intracranial cavity and the ability to sample the tumour's micro-environment. However, the translation of this technique to efficient drug delivery has not been systematically studied. In this work, we present an experimental platform to evaluate the performance of microdialysis devices in reverse mode in a brain tissue phantom. The mass of model drug delivered is measured by computing absorbance fields from optical images. Concentration maps are reconstructed using a modern and open-source implementation of the inverse Abel transform. To illustrate our method, we assess the capability of a commercial probe in delivering methylene blue to a gel phantom. We find that the delivery rate can be described by classical microdialysis theory, except at low dialysate flow rates where it is impacted by gravity, and high flow rates where significant convection to the gel occurs. We also show that the flow rate has an important impact not only on the overall size of the drug plume, but also on its shape. The numerical tools developed for this study have been made freely available to ensure that the method presented can be used to rapidly and inexpensively optimise probe design and protocol parameters before proceeding to more in-depth studies. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | The brain tissue phantom and associated numerical tools are contributing to the development and validation of IRC drug delivery technologies. |
| URL | https://www.repository.cam.ac.uk/handle/1810/346048 |
| Title | CCDC 2005056: Experimental Crystal Structure Determination |
| Description | Related Article: Isabel N. Hegarty, Samuel J. Bradberry, June I. Lovitt, Jason M. Delente, Niamh Willis-Fox, Ronan Daly, Thorfinnur Gunnlaugsson|2023|Mater. Chem. Front.|7|906|doi:10.1039/D2QM00998F |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc259f75&sid=DataCite |
| Title | CCDC 2191861: Experimental Crystal Structure Determination |
| Description | Related Article: Xu Chen, Ba´rbara B. Mendes, Yunhui Zhuang, Joa~o Conniot, Sergio Mercado Argandona, Francesca Melle, Diana P. Sousa, David Perl, Alexandru Chivu, Hirak K. Patra, William Shepard, Joa~o Conde, David Fairen-Jimenez|2024|J.Am.Chem.Soc.|146|1644|doi:10.1021/jacs.3c12416 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2ckt6z&sid=DataCite |
| Title | CCDC 2296146: Experimental Crystal Structure Determination |
| Description | Related Article: Xu Chen, Ba´rbara B. Mendes, Yunhui Zhuang, Joa~o Conniot, Sergio Mercado Argandona, Francesca Melle, Diana P. Sousa, David Perl, Alexandru Chivu, Hirak K. Patra, William Shepard, Joa~o Conde, David Fairen-Jimenez|2024|J.Am.Chem.Soc.|146|1644|doi:10.1021/jacs.3c12416 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2h2b75&sid=DataCite |
| Title | Dataset: Peptide Stability in the Gastrointestinal Tract |
| Description | Article: https://doi.org/10.1016/j.ijpharm.2023.122643GitHub Repo: https://github.com/FrankWanger/ML_PeptideThis data was manually curated from published articles. The detailed information of references can be found in the article linked above.Abstract: The oral delivery of peptide therapeutics could facilitate precision treatment of numerous gastrointestinal (GI) and systemic diseases with simple administration for patients. However, the vast majority of licensed peptide drugs are currently administered parenterally due to prohibitive peptide instability in the GI tract. As such, the development of GI-stable peptides is receiving considerable investment. This study provides researchers with the first tool to predict the GI stability of peptide therapeutics based solely on the amino acid sequence. Both unsupervised and supervised machine learning techniques were trained on literature-extracted data describing peptide stability in simulated gastric and small intestinal fluid (SGF and SIF). Based on 109 peptide incubations, classification models for SGF and SIF were developed. The best models utilized k-Nearest Neighbor (for SGF) and XGBoost (for SIF) algorithms, with accuracies of 75.1% (SGF) and 69.3% (SIF), and f1 scores of 84.5% (SGF) and 73.4% (SIF) under 5-fold cross-validation. Feature importance analysis demonstrated that peptides' lipophilicity, rigidity, and size were key determinants of stability. These models are now available to those working on the development of oral peptide therapeutics. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| URL | https://figshare.com/articles/dataset/Dataset_Peptide_Stability_in_the_Gastrointestinal_Tract/259415... |
| Title | Dataset: Peptide Stability in the Gastrointestinal Tract |
| Description | Article: https://doi.org/10.1016/j.ijpharm.2023.122643GitHub Repo: https://github.com/FrankWanger/ML_PeptideThis data was manually curated from published articles. The detailed information of references can be found in the article linked above.Abstract: The oral delivery of peptide therapeutics could facilitate precision treatment of numerous gastrointestinal (GI) and systemic diseases with simple administration for patients. However, the vast majority of licensed peptide drugs are currently administered parenterally due to prohibitive peptide instability in the GI tract. As such, the development of GI-stable peptides is receiving considerable investment. This study provides researchers with the first tool to predict the GI stability of peptide therapeutics based solely on the amino acid sequence. Both unsupervised and supervised machine learning techniques were trained on literature-extracted data describing peptide stability in simulated gastric and small intestinal fluid (SGF and SIF). Based on 109 peptide incubations, classification models for SGF and SIF were developed. The best models utilized k-Nearest Neighbor (for SGF) and XGBoost (for SIF) algorithms, with accuracies of 75.1% (SGF) and 69.3% (SIF), and f1 scores of 84.5% (SGF) and 73.4% (SIF) under 5-fold cross-validation. Feature importance analysis demonstrated that peptides' lipophilicity, rigidity, and size were key determinants of stability. These models are now available to those working on the development of oral peptide therapeutics. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| URL | https://figshare.com/articles/dataset/Dataset_Peptide_Stability_in_the_Gastrointestinal_Tract/259415... |
| Title | Research data supporting "A Single-Component Photorheological Fluid with Light-Responsive Viscosity" |
| Description | Data files here contain the XY data reported in graphs in the main manuscript and ESI. The file "Linear Rheology" contains the raw rheology data reported as viscosity (X) vs shear rate (Y) for the native trans, cis PSS and blue PSS samples. The file "Oscillatory Rheology" contains raw rheology data reported as Storage and Loss Moduli (X) vs frequency (Y) for the native trans and blue recovered samples. "Cycling viscosity" reports viscosity at a fixed shear rate, for varying irradiation conditions (cis or trans PSS). The file "UV-Vis Absorption Spectroscopy" provides the absorbance (X) and wavelength (Y) for the AzoPS in the native trans, cis PSS and trans PSS. "UV Vis_Blue" reports the wavelength and absorbance for the trans PSS, as a function of blue light irradiation. "UV Vis_UV" reports the wavelength and absorbance for the cis PSS, as a function of UV light irradiation. The folders beginning with "SAXS" contain the relevant SAXS data referred to in the rest of the filename. Each file contains the q range (X), scattering intensity (Y) and error on scattering intensity (Y error). The model fits performed using SASview are also reported in each case as q (X) vs scattering intensity (Y). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/309628 |
| Title | Research data supporting "Quantitative monitoring and modelling of retrodialysis drug delivery in a brain phantom" |
| Description | The data was generated as part of the EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers . In this work we present a platform which can be used to investigate and optimise the performance of microdialysis probes in the context of drug delivery. Our detailed experimental rig and the software supplied with our work is aimed at facilitating the transition of this delivery technique to clinical trials. Above all, our work is a significant contribution to the field as we can rapidly image and measure drug concentration far from the probe and discuss the size and shape of the drug plume. The images are taken with the following setup: a collimated light source (CX0202-WHIIC, Edmund Optics) shines parallel beams through the brain phantom. A telecentric objective lens (TitanTL 0.184X, Edmund Optics) is mounted on a digital camera (Basler Ace acA1920-150um, 2/3" 10-bit monochromatic sensor). A pass-band filter (FB500-40, Thorlabs) centred around 500 nm, with a bandwidth of 40 nm is mounted at the back of the lens. Images are recorded at 1 frame per minute with a fixed exposure time for each series (in the range 9 ms to 11 ms). Images are processed using Python environment and open-source packages. The microdialysis probe used in this study is the 70 MD Bolt Catheter, from Mdialysis. The brain phantom is an agarose gel 0.6% in Dulbecco's phosphate-buffered saline. The model drug solution is methylene blue 0.2 mg/mL in DPBS. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/341600 |
| Title | Research data supporting "Theory of flow-induced covalent polymer mechanochemistry in dilute solutions" |
| Description | This is the dataset and software supporting the study *Theory of flow-induced covalent polymer mechanochemistry in dilute solutions* by Etienne Rognin, Niamh Willis-Fox, Ronan Daly, Institute for Manufacturing, Department of Engineering, University of Cambridge, 17 Charles Babbage Road, Cambridge CB3 0FS, United Kingdom. Contents -------- Main file ^^^^^^^^^ Use the Jupyter Notebook ``Supporting information.ipynb`` to run the data analysis and recreate the figures of the paper. Alternatively, open ``Supporting information.pdf`` to view the notebook outputs in a PDF reader without having to install and run the scripts. Raw data ^^^^^^^^ The folder ``bead-rod_dataset`` contains the results of bead-rod model simulations. For each simulation there is binary Python ``.npz`` file containing the data, and a text ``.json`` file containing metadata (such as date of the simulation, parameters...) The data is imported using ``np.load`` function which creates a Python dictionary for each simulation file. This dictionary contains the following labels: 1. ``t`` the time axis. 2. ``gradU`` the time series of velocity gradients used as forcing terms in the bead-rod simulation. 3. ``g_max`` the time series of the maximum tensile force, for each molecule of the simulation ensemble. 4. ``i_max`` the time series of the positions of the maximum force in the chain (not used in this study) 5. ``g_12`` the time series of the tensile force at the center of the chain, for each molecule. 6. ``A_average`` the time series of the average conformation tensor (second-order moment of the end-to-end vector). Used in section 4 for model validation. Note that the bead-rod algorithm and dimension normalization are described in a previous study (see Rognin et al. https://www.repository.cam.ac.uk/bitstream/1810/279443/1/multiscale_revision_clean.pdf) Other ^^^^^ The notebook ``JHTD_turbulence.ipynb`` has been used to extract data from the Johns Hopkins Turbulence Databases and is provided here for illustrative purposes only (it is not necessary to run this file). License ------- CC-BY-4.0 To view the full license, visit: https://creativecommons.org/licenses/by/4.0/legalcode Installation ------------ In the target directory, clone this repository:: git clone https://github.com/etiennerognin/flowmechanochem_dataset.git Usage ----- Run the notebook ``Supporting information.ipynb`` (you will need to have Jupyter installed, see https://jupyter.org/). The Python distribution will need to have packages listed in ``requirements.txt``. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/357787 |
| Description | Analysis of mesothelioma cell lines and tissues |
| Organisation | Mesothelioma UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Two-way sharing of data and reagents. |
| Collaborator Contribution | Supply of material and two-way sharing of data and reagents. |
| Impact | Ongoing awards of grant applications by the NC3Rs, North West Cancer Research, Cancer Research UK, and affiliation with EPSRC IRC (see further funding where applicable), as well as two papers published in 2022 and 2023 (see publications NC3Rs grant). |
| Start Year | 2016 |
| Description | Collaboration to adopt tools evolved within project |
| Organisation | Cardiff University |
| Department | Neuroscience and Mental Health Research Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Our research team supported the transfer of tools and methods developed within the grant to support the team in Cardiff for further implant development. |
| Collaborator Contribution | The partners supported our team through improving our understanding of the challenges in implant design. |
| Impact | Multi disciplinary bringing together engineering and neuroscience. No outputs available yet. |
| Start Year | 2024 |
| Description | Collaboration with Dr Richard Mair, University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My PhD student is employing the surface modification strategy developed within this project to develop next generation of DNA harvesting nanoparticles |
| Collaborator Contribution | Dr. Mair is providing clinical support and samples to test the DNA harvesting strategies and applied them to urine |
| Impact | Armstrong studentship awarded to PhD student, we are now working on patenting the technology |
| Start Year | 2022 |
| Description | Collaboration with Helen Mulvana, University of Glasgow |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have been working with Dr Mulvana on development of ultrasound sensitive poly dopamine nanoparticles for delivery to solid tumours. We have developed porous polydopamine nanoparticles and loaded them with SN38 drug. |
| Collaborator Contribution | Dr Mulvana has performed ultrasound experiments and PhD student working on the project spent 1 months doing measurements herself which we are just writing up. |
| Impact | We have secured MRC Primer award (18 months, £60k) for our work ( Grant Nr MR/Y008227/1) |
| Start Year | 2023 |
| Description | Collaboration with Nottingham (PDRA in Nottingham) |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are preparing a range of dynamic hydrogels with either a single API formulated within the gel or in combination with a polymeric nanoparticle that encapsulates a different drug. |
| Collaborator Contribution | Our partners in Nottingham are looking at a range of 3D spheroid models of GB patient cells, both invasive margin cells and core cells from the same patients and how APIs target these cells from solution as well as from our dynamic hydrogels. They are also looking at whether there are synergies with multimodal treatment. |
| Impact | chemistry, biology, materials, |
| Start Year | 2021 |
| Description | Collaboration with SN Bioscience, Korea |
| Organisation | Riptide Bioscience |
| Country | United States |
| Sector | Private |
| PI Contribution | Prepared the building blocks fro preparation of nano carriers and provided detailed protocols for preparation and loading of plutonic polydopamine with SN38 drug. SN Bioscience is a company based in Korea ( http://www.snbioscience.com) |
| Collaborator Contribution | Drug loading and in vivo testing of produced polydopaine-pluronic nano carrier |
| Impact | Complete protocols for drug loading established as well as scaled up reactions. In vivo experiments should be completed this year. |
| Start Year | 2023 |
| Description | Collaboration with University of Leeds |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Oren Scherman and Prof George Malliaras are supplying samples of hydrogels and implantable drug delivery devices for testing. |
| Collaborator Contribution | Leeds is testing hydrogels and implantable drug delivery devices in patient-derived brain tumour assembloids and resection-recurrence surgical mouse models. |
| Impact | Outputs and outcomes are still emergent. |
| Start Year | 2023 |
| Description | Collaboration with University of Liverpool |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Oren Scherman and Prof David Fairen Jimenez have provided samples of novel hydrogels and MOFs both unloaded and loaded with chemotherapeutic drugs. |
| Collaborator Contribution | Prof Judy Coulson has tested the samples provided using in ovo models to assess the toxicity of the materials and the action of drug-loaded materials on mesothelioma tumour cells. |
| Impact | Outputs and outcomes are still emergent. |
| Start Year | 2022 |
| Description | Collaboration with University of Strathclyde |
| Organisation | University of Strathclyde |
| Department | Department of Pure and Applied Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | IRC investigators Prof Duncan Jodrell, Prof Oren Scherman, Prof Ross Forgan and Prof David Fairen-Jimenez contributed to the development of the project plan, and provide advisory input to University of Strathclyde's role in the IRC. Researchers from Prof Oren Scherman, Prof Ross Forgan and Prof David Fairen Jimenez's groups synthesise and characterise materials for use in experiments at University of Strathclyde. |
| Collaborator Contribution | University of Strathclyde are contributing to the IRC through the validation of IRC technologies using in vivo mouse models for pancreatic cancer. |
| Impact | Outputs are still emergent. |
| Start Year | 2022 |
| Description | Engineered bacterial spores for pancreatic cancer treatement |
| Organisation | Cancer Research UK Cambridge Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 3D models of pancreatic cancer were provided to obtain preliminary data with delivery of bacteria to pancreatic cancer tissue. |
| Collaborator Contribution | Partners provided access to their cell lines (CRUK), expertise in engineered bacteria ( University of Cambridge and MIT). |
| Impact | UKRI Interdisciplinary Grant application ( still active) |
| Start Year | 2024 |
| Description | Engineered bacterial spores for pancreatic cancer treatement |
| Organisation | Massachusetts Institute of Technology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | 3D models of pancreatic cancer were provided to obtain preliminary data with delivery of bacteria to pancreatic cancer tissue. |
| Collaborator Contribution | Partners provided access to their cell lines (CRUK), expertise in engineered bacteria ( University of Cambridge and MIT). |
| Impact | UKRI Interdisciplinary Grant application ( still active) |
| Start Year | 2024 |
| Description | Engineered bacterial spores for pancreatic cancer treatement |
| Organisation | University of Cambridge |
| Department | Department of Chemical Engineering and Biotechnology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | 3D models of pancreatic cancer were provided to obtain preliminary data with delivery of bacteria to pancreatic cancer tissue. |
| Collaborator Contribution | Partners provided access to their cell lines (CRUK), expertise in engineered bacteria ( University of Cambridge and MIT). |
| Impact | UKRI Interdisciplinary Grant application ( still active) |
| Start Year | 2024 |
| Description | Establishment of CAM SciNet, a new international network to promote and standardise the 3Rs CAM model. |
| Organisation | Friedrich-Alexander University Erlangen-Nuremberg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Contributed to discussions on establishment and purpose of this new scientific network, as the UK representative in a group of founder members from across Europe and Asia. |
| Collaborator Contribution | Proposed the idea and lead discussions on establishment and purpose of this new international scientific network. |
| Impact | There are no outputs to date. However, there have been several outcomes in terms of collaborative activities that are underway, including submission of an application for an MSCA doctoral network to the European Commission, initiation of a collaborative systematic review of comparative use of mouse and CAM models, and invitation to host the 3rd international CAM conference in Liverpool in 2026. |
| Start Year | 2024 |
| Description | Fluorescent hypoxia detecting cells |
| Organisation | University of Cambridge |
| Department | Cambridge Stem Cell Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | developed nanoparticle based system to deliver oxygen to oxygen-low core of solid tumours. This system can enable improved treatment of solid tumours such as pancreatic cancer and deal with common resistance to widely used chemotherapies. |
| Collaborator Contribution | Collaborator provided fluorescent cells, which were incorporated within 3D models of pancreatic cancer and were able to signal the presence and absence of oxygen. |
| Impact | Multi-disciplinary collaboration resulted in development of new 3D model, first of its kind, which can be used by other researchers in development of more efficient therapies for solid tumours. |
| Start Year | 2024 |
| Description | GlioModel |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in chick embryo CAM models extrapolated from mesothelioma to glioblastoma, and currently developing orthotropic brain models to reduce/replace orthotropic mouse models for glioblastoma multiform (GBM). |
| Collaborator Contribution | Developing, characterising and standardising a suite of preclinical models to improve translation and reduce animal use in Glioblastoma research. This work is lead by Dr Lucy Stead, and links in with collaborators (e.g. Nottingham) from the EPSRC IRC in hard to treat cancers. |
| Impact | Grant application to be submitted to MRC/NC3Rs in vitro models hub call. |
| Start Year | 2025 |
| Description | Horizon Discovery |
| Organisation | Great Ormond Street Hospital (GOSH) |
| Department | Harris International Patient Centre |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Generated novel genome-editited cell lines |
| Collaborator Contribution | Horizon Discovery support the design or rAAV targeting constructs and protocols for genome editing |
| Impact | generated cell lines |
| Start Year | 2012 |
| Description | IRC-ARM |
| Organisation | Arm Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Hosting a meeting to discuss collaborative opportunities |
| Collaborator Contribution | None as yet |
| Impact | None as yet |
| Start Year | 2018 |
| Description | IRC-AZ |
| Organisation | AstraZeneca |
| Department | Research and Development AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in the devices and chemistries being deployed as part of the project. |
| Collaborator Contribution | AstraZeneca have provided expertise in drug delivery by providing a representative to sit on the steering committee for the project. They have also contributed by providing guidance in developing target product profiles and hosting a meeting to explore wider possibilities for collaboration. In addition to in-kind support AstraZeneca have also provided substantial additional funding for translation work on hydrogels for the treatment of glioblastoma |
| Impact | This is a multidisciplinary collaboration involving engineers, chemists and clinicians. The main outcome of the collaboration to-date has been to assist in shaping the strategic direction of the IRC. |
| Start Year | 2019 |
| Description | IRC-CPI |
| Organisation | Centre for Process Innovation (CPI) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in the technologies we are developing |
| Collaborator Contribution | Expertise in high value manufacturing |
| Impact | Assistance in shaping the approach we have taken to the manufacturing challenges associated with the project |
| Start Year | 2019 |
| Description | IRC-MDC |
| Organisation | Medicines Discovery Catapult |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in the drug delivery technologies being developed |
| Collaborator Contribution | Assistance in identifying possible additional project partners |
| Impact | Contacts made with potential industrial collaborators |
| Start Year | 2018 |
| Description | IRC-NPL |
| Organisation | National Physical Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in the drug delivery technologies being developed. |
| Collaborator Contribution | Expertise in medical instrumentation and mass spectrometry imaging |
| Impact | No outcomes as yet |
| Start Year | 2018 |
| Description | Internal collaboration using CAM model to study novel treatment of conjunctival melanoma. |
| Organisation | University of Liverpool |
| Department | Molecular and Clinical Cancer Medicine Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Training of masters student in CAM protocols with a view to generate preliminary data / proof of principle for grant application. |
| Collaborator Contribution | Drs Kalirai and Kearns provided an original research idea to test in the chick embryo model as an alternative to other animal models. |
| Impact | n/a |
| Start Year | 2023 |
| Description | Network |
| Organisation | British Lung Foundation (BLF) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We were active members of the MRN until it closed in 2022. We attended and presented our MPM-CAM models at several MRN events, and contributed to MRN newsletter to promote our model. |
| Collaborator Contribution | Helped to disseminate data and models |
| Impact | The MRN were project partners that supported this grant application that was awarded by NC3Rs. The MRN helped us promote our model to replace use of mice in mesothelioma research very successfully - especially through webinars comparing the different. models for mesothelioma research. The network has resulted in the establishment at 4 active collaborations, where research groups wish to use the CAM model as an alternative to mice (see further funding and collaborations section). |
| Start Year | 2017 |
| Description | PhD studentship Astra Zeneca |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | we will develop protein nano carriers for solid tumours to explore new formulation for drug delivery |
| Collaborator Contribution | partner will co-fund a studentship to explore delivery and provide targets, models and cargos to deliver into solid tumours. |
| Impact | Co-funding of the PhD student |
| Start Year | 2025 |
| Title | POLYDOPAMINE CO-POLYMER NANOPARTICLES |
| Description | The present invention relates to polydopamine co-polymer nanoparticles as defined in the application. The present invention also relates to processes for the preparation of these polydopamine co-polymer nanoparticles, to pharmaceutical compositions comprising them, and to their use in therapy. |
| IP Reference | WO2023194414 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2023 |
| Licensed | No |
| Impact | Collaboration with SN Bioscience interested in licensing the technology. We are currently working with them to establish clear protocols |
| Company Name | Vector Bioscience Cambridge |
| Description | Vector Bioscience Cambridge researches nanotechnology for use in drug delivery, including RNA-based cancer treatments, with the aim of commercialisation. |
| Year Established | 2021 |
| Impact | Vector Bioscience, a spin-out company of the Department of Chemical Engineering and Biotechnology at the University of Cambridge, has just received £2.2 million from the European Innovation Council (EIC) thanks to the "Transition Challenge" investment programme. This capital will allow Vector to develop its novel RNA delivery platform, increasing RNA therapies' safety, specificity, and effectiveness. Vector has already been awarded an additional £500k from Innovate UK |
| Website | https://www.vectorbiocam.com/home |
| Description | 'Made it my way', a set of kinetic sculptures that explore the concept of how different creative methods change the final product |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Creative Partnerships is a project that focuses on collaborations between researchers and local further education and higher education institutes with focus on creative arts. ''Made it my way' is a set of kinetic sculptures that explore the concept of how different creative methods change the final product. This piece is inspired by work of IRC researchers at the Institute for Manufacturing who are investigating how different manufacturing processes change the properties of new devices which deliver drugs for hard-to-treat cancers. Things that work perfectly, in a research lab, can fall down when they are made using real world processes which often have very different requirements. It is an interactive sculpture where people are invited to try for themselves and see if they can you make the same circle twice with both sculptures. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cam.ac.uk/public-engagement/creative-encounters-2023/partnerships#section-Made-it-my-way... |
| Description | 'Summer in the CDT' talk series held by University of Nottingham |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk as part of seminar series given over the summer for a number of research postgraduate students at doctoral training centre. |
| Year(s) Of Engagement Activity | 2020 |
| Description | 2023 Cambridge Bioelectronics Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Organised the Cambridge Bioelectronics Symposium, an event that combined comprehensive coverage of the state-of-the-art of the field with strong participation of young scientists (graduate students/postdocs), hands-on workshops, and career furthering opportunities. It offered: Coverage of fundamentals, materials, devices, applications, translation/commercialisation, ethical issues. Invited talks by world-class experts who convey their vision for the future of the field. Majority of contributed talks and posters presented by young scientists, selected by a committee of young scientists. Hands-on demonstrations: Interested in bioelectronics but do not know where to start? These demonstrations will give you some good ideas. Thematic panel discussion or road mapping exercise - more on this soon. "Meet the industry" session. Learn about startups in the field. Awards for best contributed talk and poster, selected by a committee of young scientists. Symposium dinner. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://bioelectronics.eng.cam.ac.uk/symposium-information |
| Description | A presentation at Industrial Print Integration 2024, an industrial conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Keynote talk at this industry-focused conference, leading to many subsequent discussions and follow-up meetings throughout the year regarding research collaborations. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://ipi-conference.com/programme |
| Description | BBC1 Naked scientist Question time guest |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Ljiljana Fruk joined a group of Panelist to answer the questions from the listeners concerning chemistry, nanotechnology and nano medicine in BB1 Naked scientist question time |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/extremely-curious-qna |
| Description | BNOS online research workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented 30 minute lecture virtually, then held a panel discussion with questions taken from audience located internationally. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Brain Tumour Charity's Research Involvement Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | We developed a questionnaire for patients/carers together with the Brain Tumour Charity's Research Involvement Network and establishing a panel to guide future work targeting brain cancer. Their feedback was very helpful in clarifying patient preferences for different treatment modalities. |
| Year(s) Of Engagement Activity | 2021 |
| Description | British Neuro-Oncology Society (BNOS) conference (Liverpool) oral presentation (prize for highest scoring abstract). Title: Pro-drug nanoparticle loaded supramolecular hydrogels for drug delivery to IDH1 wild-type glioblastoma. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at BNOS 2022 (Liverpool), delivered by Dr Rob Cavanagh, EPSRC IRC-funded post-doctoral fellow at University of Nottingham. Dr Cavanagh was selected as one of three top scoring abstracts, and invited to deliver a 15-minute presentation in a dedicated session for top abstracts. Approximately 300 delegates were in attendance, composed of diverse stakeholders within the UK brain cancer research community. The BNOS annual conference is the leading national symposia for neuro-oncology research, attended by academics, clinicians, patients, charities and industry. |
| Year(s) Of Engagement Activity | 2022 |
| Description | British Neuro-Oncology Society (BNOS) conference (Manchester) oral presentation (prize for highest scoring abstract). Title: Pro-drug nanoparticles as synergistic drug combination carriers for IDH-WT glioblastoma |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at BNOS 2023, delivered by Dr Rob Cavanagh, EPSRC IRC-funded post-doctoral fellow at University of Nottingham. Dr Cavanagh was selected as one of three top scoring abstracts, for the second year running, and invited to deliver a 15-minute presentation in a dedicated session for top abstracts. Approximately 300 delegates were in attendance, composed of diverse stakeholders within the UK brain cancer research community. The BNOS annual conference is the leading national symposia for neuro-oncology research, attended by academics, clinicians, patients, charities and industry. |
| Year(s) Of Engagement Activity | 2023 |
| Description | CRUK Cambridge PPI panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | We asked a PPI group to weigh in on various treatment scenarios. We received very helpful feedback on drug/imaging agent/placebo selection for hydrogels & on the design of the electrophoretic pumps |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Bioelectronics Symposium 2024 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Organised the Cambridge Bioelectronics Symposium, an event that combined comprehensive coverage of the state-of-the-art of the field with strong participation of young scientists (graduate students/postdocs), hands-on workshops, and career furthering opportunities. It offered: Coverage of fundamentals, materials, devices, applications, translation/commercialisation, ethical issues. Invited talks by world-class experts who convey their vision for the future of the field. Majority of contributed talks and posters presented by young scientists, selected by a committee of young scientists. Hands-on demonstrations: Interested in bioelectronics but do not know where to start? These demonstrations will give you some good ideas. Thematic panel discussion or road mapping exercise - more on this soon. Learn about startups in the field. Awards for best contributed talk and poster, selected by a committee of young scientists. Symposium dinner. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://bioelectronics.eng.cam.ac.uk/symposium-information |
| Description | Cambridge Creative Partnerships |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Niamh Fox and Dr Etienne Rognin participated in the production of kinetic sculptures called 'made it my way' in collaboration with artist Mahija Mandalika from Cambridge School of Visual and Performing Arts. This sculpture was exhibited for 10 days during the Cambridge Festival. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cam.ac.uk/public-engagement/creative-encounters-2023/partnerships |
| Description | Cambridge Experimental Cancer Medicine Centre PPI Panel |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presentation to Cambridge Experimental Cancer Medicine Centre Patient and Public Involvement Panel to inform them of our progress and to obtain their input on which drugs to use (tried and tested versus novel molecularly targeted therapies) and on design of implantable devices. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Festival - IfM open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | As part of the Cambridge Festival IFM open day, Dr Niamh Fox gave a demonstration using the "brain in a box" model to simulate the delivery of drugs into the brain by experimental devices being developed by Prof George Malliaras's group. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ifm.eng.cam.ac.uk/news/ifm-brain-in-a-box-to-feature-at-the-cambridge-festival/ |
| Description | Cambridge Festival - Youtube video on microscopy in research |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | As part of the Cambridge Festival, the University's annual public engagement festival, an IRC researcher from the Institute of Manufacturing created this short film explaining how microscopy is used in research. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=RDC9ZAf5xwI&ab_channel=InstituteforManufacturing%28IfM%29%2CUniversi... |
| Description | Cambridge Festival panel discussion, live activity, in-person and live-streamed event entitled 'What can we do about difficult cancers?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This event brought together a neurosurgeon (Mr Stephen Price), an engineer (Dr Ronan Daly) and chemists (Prof. Oren Scherman & Dr Ljiljana Fruk) to discuss the problems in delivering drugs to combat some of the most difficult to treat cancers, and how we can use new advances in engineering and chemistry to overcome them. There was also an opportunity to see simulated brain surgery to remove a tumour to help understand the challenges being addressed. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.eventbrite.co.uk/e/what-can-we-do-about-difficult-cancers-tickets-182059594147# |
| Description | Cambridge Philosophical Society invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Cambridge Philosophical Society talks are aimed at general public and the member of the University of Cambridge, and the lecturers are invited based on their expertise and ability to engage audiences with their chosen topic. The topic was Modern Molecular Science and how is it changing our life. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.cambridgephilosophicalsociety.org/lectures-visits/modern-molecular-science-and-how-it-ch... |
| Description | Cambridge Science Festival March 2019 hands-on microscopy activities for the general public (all ages) over two weekends. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The Cambridge Science Festival is a series of events held annually in March in Cambridge, and is the United Kingdom's largest free science festival.[1] The festival attracts more than 30,000 visitors to over 250 events.[2] University researches and students open their lecture halls and laboratories to the general public, and hold Talks, Exhibitions and Demonstrations, mostly free of charge.[1] The Marciniak lab plays a leading part in representing the Cambridge Institute for Medical Research (CIMR) in organising hands on cell biology activities. For young children these involve toys and games teaching about the structure of cells. For older children and adults, we use a variety of microscopes including fluorescence microscopy to illustrate how modern microscopy aids in the understanding of the molecular cell biology of disease. [1] "University of Cambridge Science Festival 2011". BBC News. Retrieved 21 March 2015. [2] "About - www.sciencefestival.cam.ac.uk". Retrieved 21 March 2015. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019 |
| URL | https://www.sciencefestival.cam.ac.uk/events/grander-view-how-modern-microscopy-illuminates-disease |
| Description | Conference presentation by Dr Niamh Willis-Fox at The Inkjet Conference 2019, Dusseldorf. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Conference presentation by Dr Niamh Willis-Fox at The Inkjet Conference 2019, Dusseldorf. This is the major industry-academic joint conference that looks at inkjet technologies. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference to celebrate the international day of Women and Girls in Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The online conference was organised by ICESCO (Islamic World Educational, Scientific and Cultural Organisation) and live-streamed from Marocco. The guests included high-ranking politicians, prominent scientists including Nobel price winners and policymakers. It was aimed at the celebration of the international day of Women and girls in science and it was streamed globally reaching audiences from all over the world, and it was organised in collaboration with Leibnitz Association (Germany) and Sp |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.icesco.org/en/wp-content/uploads/sites/2/2019/12/Celebration-of-the-International-Day-of... |
| Description | Connect Health Tech Live |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation on the IRC, reflecting on best practice in interdisciplinary collaboration, was given to an audience of knowledge exchange and commercialisation professionals. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ie.cam.ac.uk/event/connect-health-tech-live/ |
| Description | Connect HealthTech podcast interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Prof Colin Watts and Prof Ronan Daly appeared in the Connect HealthTech "Joining the Dots" podcast, interviewed by Paula Rogers-Brown. Connect HealthTech is an online academia-industry community for life sciences and health technology. In the podcast they explained the IRCs mission and gave insights into the challenges and benefits of our inter-disciplinary approach, raising awareness of the work of the IRC to a broader audience across academia and the heath tech industry. Prof Colin Watts and Claire McGlynn (IRC Programme Manager) have been invited to present at a future Connect Health Tech event. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.teddy.eng.cam.ac.uk/news/listen-irc-investigators-conversation-connect-health-tech-podca... |
| Description | Creation and distribution of the publication - The IfM colouring book "How Stuff Gets Made". |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Creation and distribution of the publication - The IfM colouring book "How Stuff Gets Made". This outreach activity was a highly popular contribution to the Cambridge Science Festival 2019 by the postdoctoral researcher on this grant Dr. Niamh Willis-Fox. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Distinguished USC Munushian Lecturer, University of Southern California |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Distinguished USC Munushian Lecturer: "Technology for Bioelectronic Medicine", Department of Electrical and Computer Engineering, University of Southern California, March 25, 2024, Los Angeles, CA. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://viterbi.usc.edu/news/events/calendar/?event=105744 |
| Description | EU Horizon Summit Zagreb |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | EU Horizon Summit was looking into ways how to consolidate innovation, start up companies and change the funding schemes to accommodate the needs of the researchers, innovators and investors. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://horizoneuropesummit.com |
| Description | Hosted annual visit by the Merseyside Asbestos Victims Support (MAVS) group |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | A group from MAVS visited our labs and egg facility to learn about how we use the CAM as a preclinical model to test new therapy ideas for mesothelioma. They had short presentations and hands on demos, from Judy Coulson, Sarah Barnett, Jan Schulze, Martina Tripari, Niall Kenneth, Adam Albanese and/or Liam Shaw. They filled out a questionnaire to feedback their thoughts on the model, and how informative they found the visit. |
| Year(s) Of Engagement Activity | 2023,2024 |
| URL | https://x.com/livuniLivSRF/status/1793564528103555519 |
| Description | IRC website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Website giving details of the work undertaken by the IRC, and contact details |
| Year(s) Of Engagement Activity | 2019 |
| Description | ISAC (Inspiring Scientists at CIMR): lab experience and mentoring event for less-advantaged Y12 pupils, 17th Feb 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | ISAC/M is a four-day, non-residential work experience programme which will take place during school half term in February 2024. The first three days will be held at two University of Cambridge research Institutes (The Cambridge Institute for Medical Research; CIMR and the MRC Mitochondrial Biology Unit; MBU) which share the same building on the Cambridge Biomedical (Addenbrookes) campus. The ISAC/M programme will start at 10:00 and end at 16:00 every day from Tuesday, 20th February - Friday 23rd February. Students will take part in biomedical research and learn more about how that research can lead to new treatments. The final day of the programme (Friday 23rd February) will take place at St Catharine's College in central Cambridge, where ISAC/M students will make short presentations on the research they took part in, and obtain advice and guidance on applying to Cambridge and other universities. Lunch will be provided each day, and travel costs reimbursed for all students taking part in the programme. What will students taking part in ISAC/M do? Spend time in a research lab at either CIMR or MBU, 'shadow' researchers, learn about how research is carried out, and run an experiment Prepare a scientific presentation about the experiment they ran Attend interactive seminars to help develop scientific knowledge and skills Attend guided tours and demonstrations of scientific core facilities and see some of the different technologies used such as cutting-edge microscopes Spend an interactive day run in partnership with St Catharine's College, Cambridge with workshops on how to apply to Cambridge and similar universities, and getting guidance on personal statements Network with other placement students, admissions staff, postgraduate students, and scientists as well as attend optional mentoring slots about studying and working in research Background to the Cambridge Institute for Medical Research (CIMR) and MRC Mitochondrial Biology Unit (MBU) CIMR is a biomedical research Institute that is part of the School of Clinical Medicine at the University of Cambridge. CIMR's mission is to determine the molecular mechanisms of disease to advance human health. We focus on translation between biological research and clinical applications. The Institute has 24 research teams studying how normal biological processes inside cells can go wrong during infections, or because of rare genetic changes. By understanding these processes and the molecules involved (particularly proteins) we aim to discover better treatments for diseases and enable better outcomes for patients. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cimr.cam.ac.uk/isacm-2024 |
| Description | IfM 'Brain in a Box' to feature at the Cambridge Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Two postdoctoral researchers from the IRC team explained and demonstrated what is glioblastoma using a full-scale model made from shop-bought dessert jelly. They demonstrated the approach that the project is taking to delivering drugs directly to the tumour and the challenges involved using this full-scale model. They also showed how we build tools within the project to help rapidly design implants for drug delivery. An imaging setup similar to the 'brain-in-a-box' developed and used within the IRC research was used. All images were projected onto the room's main screen to ensure everyone attending could see. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ifm.eng.cam.ac.uk/news/ifm-brain-in-a-box-to-feature-at-the-cambridge-festival/ |
| Description | Interview and summary on the role of design for manufacturing on the path from laboratory to clinic |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Manufacturing is a cross-cutting theme that runs through the IRC research programme. Dr Ronan Daly, Associate Professor in Science and Technology of Manufacturing, based at the Institute for Manufacturing at the University of Cambridge, leads this theme for the IRC, and in this interview and report describes why asking questions early in the research stage and looking ahead to manufacturing is key to getting products quickly to patients. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.teddy.eng.cam.ac.uk/cancer-sight-blog/november-2021-ahead-game-role-design-manufacturing... |
| Description | Invited Lecture at anniversary symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave an invited lecture as part of Prof. Bert Meijers' anniversary symposium. 250 members in the audience. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited lecture at RSC Chemical Nanoscience and Nanotechnology Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture at the annual symposium in London. More than 100 participants attended the symposium, which resulted in new collaboration related to quantum sensors in biomedicine. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.rsc.org/events/detail/76838/rsc-chemical-nanoscience-and-nanotechnology-network-annual-s... |
| Description | Invited talks at the MRS Spring Meeting, May 8-13, 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Delivered two invited talks and several contributed (by group members) to a large and interdisciplinary audience interested in applications of novel materials |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.mrs.org/meetings-events/spring-meetings-exhibits/past-spring-meetings/2022-mrs-spring-me... |
| Description | June Hancock Mesothelioma Research Fund 'Meet the researchers' event speaker, |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Meet the Researchers events are an opportunity for researchers and academics to engage with patients and practitioners. Non-researchers can gain insight into the aims, objectives, challenges, and opportunities of current research; researchers can hear patients' and practitioners' priorities for research. These events are designed to promote discussion and allow questions to be asked in a relaxed and informal way. The aim is to break down the barriers between researchers and patients and enable conversations that will lead to meaningful engagement and a better understanding of research. The two-hour event was opened by Dr Kate Hill, a founding Trustee and pro bono Manager of the research activity for the June Hancock Mesothelioma Research Fund (JHMRF), a campaigning charity that sponsors and promotes vital research into the causes and treatment of mesothelioma. The online format allowed the charity to open the Meet the Researchers event - previously held in-person - to a wider audience, and participants attended from across the UK and internationally. Everyone was encouraged to ask questions throughout the event and the emerging conversations between researchers, patients and practitioners were engaging and informative. |
| Year(s) Of Engagement Activity | 2022,2023 |
| URL | https://www.teddy.eng.cam.ac.uk/news/irc-team-meet-researchers-public-event |
| Description | Keynote Lecture Ruzicka Days |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote lecture at bi-annual meeting of Croatian chemists and chemical engineers. More than 100 people attended including heads of departments and industry representatives. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.ruzickadays.eu/programme.html |
| Description | Keynote presentation at 18th International Conference on Nanosciences and Nanotechnologies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation: "Technology for bioelectronic medicine", 18 International Conference on Nanosciences and Nanotechnologies (N&N), July 6-9, Thessaloniki, Greece (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.nanotexnology.com/index.php/nn |
| Description | Keynote presentation at 3rd International Conference on Flexible Electronics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation: "Technology for bioelectronic medicine", 3rd International Conference on Flexible Electronics (ICFE), Nov. 12-14, 2021, Hangzhou, China (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Keynote presentation at 72nd Annual Meeting of the International Society of Electrochemistry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation: "Electronics on the brain", 72nd Annual Meeting of the International Society of Electrochemistry, Aug. 29 - Sept. 3, 2021, Jeju Island, Korea (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Keynote presentation at British Society for Nanomedicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation: "Bioelectronic Medicine", British Society for Nanomedicine, Emmanuel College, Sept. 9-10, 2024, Cambridge, UK. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://md.catapult.org.uk/events/2024-british-society-for-nanomedicine-annual-meeting/ |
| Description | Keynote presentation at Hellenic Conference on Solid-State Physics and Materials Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave the keynote presentation at national conference |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://fsk36.materials.uoc.gr/ |
| Description | Keynote presentation at Nanotexnology Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Keynote presentation: "Technology for bioelectronic medicine", Nanotexnology, July 4-7, 2024, Thessaloniki, Greece. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.nanotexnology.com/ |
| Description | Keynote presentation- Nanotexnology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gve keynote talk at Nanotexnology meeting |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nanotexnology.com/2023/ |
| Description | Keynote talk at Nanotexnology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at nanotechnology conference, attended by physical scientist and engineers |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.nanotexnology.com/2019/ |
| Description | Keyonote presentation at International Conference on Intelligent Wearable Systems in Hong Kong |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave keynote presentation in Hong Kong at conference on werable electronics attended by academic and industrial scientists from around the world |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.polyu.edu.hk/en/riiwear/news-and-events/events/2022/jun/iciws-2022/ |
| Description | Lecture to Biomedical Sciences MRes students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Masters students from our Biomedical Sciences program attended my lecture, which focused on our research interests and recent data in mesothelioma, and highlighted the benefits of the chick embryo xenograft model in testing new cancer therapies. This sparked some discussions in the Q&A session that followed. A Polleverywhere survey showed low awareness of hens' egg models as alternative to mice at the start of the lecture, and almost 100% agreement that they are a viable replacement method by the end of the lecture. |
| Year(s) Of Engagement Activity | 2020,2021,2022,2023,2024,2025 |
| Description | Lecture to a Summer School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | A presentation to the CDT Summer School on pancreatic cancer and the activity in EPSRC IRC. |
| Year(s) Of Engagement Activity | 2020 |
| Description | MRS Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Large international conference; spoke at a symposium within the conference as invited speaker. 100-200 audience members attended talk, with healthy discussion afterwards. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Meet the Researcher June Hancock Mesothelioma Research Fund event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | An online public engagement event was held with the June Hancock Mesothelioma Research Fund to share the IRC research relating to mesothelioma with an audience of patients, their relatives and carers, and health care professionals. The event was publicised by the June Hancock Mesothelioma Research Fund and shared on social media which led to attendees not only from within the UK but also Europe and South America. The event was chaired by Dr Kate Hill of the June Hancock Mesothelioma Research Fund. Prof Stefan Marciniak, Claire McGlynn (IRC Programme Manager) and three IRC researchers gave short presentations, followed by a lively question and answer session and further discussion. Feedback from attendees indicated that the presentations were clear and understandable to a lay audience, they valued the work being done by the IRC towards improving treatments, and they were interested in learning about future progress at a later date. The IRC researchers benefited from learning about the views and concerns of stakeholders in their research, and in developing their skills in presenting research to a lay audience. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.teddy.eng.cam.ac.uk/news/irc-team-meet-researchers-public-event |
| Description | Mesothelioma Patient Group Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk to patients and carers on the fundamental research we are conducting into rare diseases |
| Year(s) Of Engagement Activity | 2024 |
| Description | National Symposium of Croatian Chemists and Chemical Engineers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at the annual conference in Rovinj, Croatia. It is an important national meeting with many participating companies and wider national reach. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.chemistryviews.org/28th-croatian-meeting-of-chemists-and-chemical-engineers-28hskiki/ |
| Description | Nature Creers Podcast: How ChatGPT and sounds from space brought a luminous jelly to life |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | nature podcast on the work of art inspired directly by hydrogels designed in Fruk lab |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nature.com/articles/d41586-023-03392-w |
| Description | Nature career podcast on The unexpected outcomes of artist-scientist collaborations |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | POdcast/interview with Julie Gould on working with artists and turning scientific research into art |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nature.com/articles/d41586-023-03390-y |
| Description | NeuroTechX talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk "Electronics on the Brain" at NeuroTechX, Jan. 25, 2021, held virtually (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://neurotechx.com/ |
| Description | Norwegian Biophysics Symposium Keynote lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote lecture of design of nanostructures at the Norwegian Biophysics Symposium. The lecture resulted in a collaboration and a paper which will be submitted this year. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://sites.google.com/view/stroehllab/learning/biophysics-symposium-2024 |
| Description | Outreach Talk at ASPIRE Research Showcase |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Outreach Talk: "Technology for bioelectronic medicine", ASPIRE Research Showcase, Medical School, Keele University, Nov. 17, 2021, Keele, UK (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Outreach Talk at Rosalind Franklin Conference 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Outreach Talk: "Electronics on the brain", Rosalind Franklin Conference 2021, Newnham College, April 9, 2021, Cambridge, UK (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Outreach Talk, IEEE Turkey Student Branches Engineering in Medicine and Biology Society Convention |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Outreach Talk: "Electronics on the brain", IEEE Turkey Student Branches Engineering in Medicine and Biology Society Convention, May 8, 2021, Istanbul, Turkey (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Outreach Talk: Digitalize in Stockholm |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Outreach Talk: "Technology for bioelectronic medicine", Digitalize in Stockholm, Stockholm, Sweden, Oct. 21, 2021 (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://digitalizeinsthlm21.se/ |
| Description | Participation in University of Birmingham Brain Cancer Patient Focus Group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Participation in University of Birmingham Brain Cancer Patient Focus Groups on 4th and 5th January 2023. Discussions with GB patients and carers around the use of dynamic hydrogels as a novel treatment option for patients with GB |
| Year(s) Of Engagement Activity | 2023 |
| Description | Participation in a documentary film Forever Young by Croatian National TV |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The documentary was shown at Croatian National TV, in a prime spot over 6 weeks ( 6 episodes). Follow up invitations to give talks to students and high school teachers in Croatia followed ( visits to universities and schools reaching additional 1000 people) |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://hrtprikazuje.hrt.hr/hrt1/zauvijek-mladi-10608110 |
| Description | Partners event - Advances in Targeted Delivery for Hard-to-Treat Cancers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | We organised this event to share progress in IRC research with stakeholders on 4th May 2023 at the Maxwell Centre in West Cambridge. The event featured presentations by IRC investigators and a poster session. The event stimulated further discussions about future opportunities for collaboration. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.teddy.eng.cam.ac.uk/event-advances-targeted-delivery-4th-may-2023 |
| Description | Pint of Science talk by Ljiljana Fruk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A presentation by Ljiljana Fruk (Co-PI on the award) as part of the Pint of Science series of talks. As well as the talk by an IRC Co- PI the event was sponsored by the IRC, publicising its activities to an audience who may not attend more formal presentations |
| Year(s) Of Engagement Activity | 2019 |
| Description | Plenary Talk at British Cochlear Implant Group 2021 Virtual Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary Talk: "Electronics on the Brain", British Cochlear Implant Group 2021 Virtual Meeting, May 11-12, 2021 (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Plenary presentation - Micro Nano 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave plennary presentation at Micro Nano meeting |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://2023.micro-nano.gr/plenary-speakers/ |
| Description | Plenary presentation - NanoBio 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave plenary talk at NanoBio |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nanobioconf.com/ |
| Description | Plenary presentation - RSC Chemical Nanoscience and Nanotechnology Interest Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave keynote talk at national meeting |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.rsc.org/events/detail/76838/rsc-chemical-nanoscience-and-nanotechnology-network-annual-s... |
| Description | Plenary presentation a XVII Meeting of the Spanish Polymer Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Plenary presentation: "Conducting Polymers for Bioelectronic Medicine", XVII Meeting of the Spanish Polymer Group, Sept. 16-19, 2024, Madrid, Spain |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.infinite-project.eu/event/gep-2024/ |
| Description | Plenary presentation at NanoBio 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Plenary presentation: "Thin film technology for bioelectronic medicine", NanoBio 2023, Sept. 11-15, 2023, Heraklion, Greece. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nffa.eu/news/events/nanobio2023/ |
| Description | Plenary presentation at RSC Chemical Nanoscience and Nanotechnology Interest Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary presentation: "Thin film technology for bioelectronic medicine", RSC Chemical Nanoscience and Nanotechnology Interest Group, Jan. 15-16, 2024, London, UK. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.rsc.org/events/member-network/interest-groups/chemical-nanoscience-and-nanotechnology-gr... |
| Description | Plenary presentationat Micro Nano 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Plenary presentation: "Thin film technology for bioelectronic medicine", Micro Nano 2023, Nov. 2-4, 2023, Athens, Greece. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://2023.micro-nano.gr/ |
| Description | Plenary talk at EANS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at the European Association of Neurosurgical Societies, attended mostly by clinicians |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://eans2019.com/ |
| Description | Plenary talk at Fpi14 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at the 14th International Symposium on Functional p-Electron Systems (Fp14) in Berlin |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.fpi14.de |
| Description | Plenary talk at International Conference for Flexible Electronics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at probably largest Flexible Electronics meeting in Asia |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://icfe.gfeit.com/ |
| Description | Plenary talk at MNE |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at key microfabrication conference attended by scientists and engineers |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.mne2019.org/ |
| Description | Plenary talk at ORBITALY |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at ORBITALY, attended by scientists interested in applications of organic electronic materials in biology |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.orbitaly2019.eu/ |
| Description | Plenary talk at Virtual FLEX 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary Talk: "Electronics on the brain", Virtual FLEX 2021, Feb. 22-26, 2021 (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://flex.semi.org/ |
| Description | Podcast on art/science interface |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Nature careers podcast on interface of science and art: Art and science: close cousins or polar opposites? by Julie Gould |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nature.com/articles/d41586-023-03389-5 |
| Description | Poster given by Dr Kasapidou at RSC Macrocyclic and Supramolecular Chemistry meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | This annual meeting strives to be on the frontier of science in the field of supramolecular chemistry. The short presentation time allocated during the poster sessions offered Dr Kasapidou an excellent opportunity to highlight and showcase her research to all conference attendees, and network with fellow delegates. Dr Kasapidou was able to add to her knowledge about current state-of-the-art topics and make valuable contacts with many researchers across the UK. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster presentation by Dr Kasapidou at OxCD3 Oncological Drug Delivery Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | This conference seeks to transform both clinical and industry practice in drug delivery by demonstrating the value and feasibility of engineering approaches, involving a combination of stimulus-responsive nanocarriers and medical devices, for improved tumour uptake and therapeutic outcome. The purpose of this conference in oncological drug delivery is to share the findings with the expert community, but also to identify and re-focus efforts on those therapeutic strategies. All invited key-note speakers were presenting exciting data which helped to understand the current challenges and opportunities in the field. The presentations defined and analysed the most important state-of-the-art ideas in the area of drug delivery systems. After each session the speakers listed a list of bullet points to encourage the discussion from audience. Dr Kasapidou participated in this meeting with a poster presentation, a great opportunity for her to meet and discuss with experts from this field. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentaton at the House of Lords |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presented our IRC to the House of Lords during day organised by EPSRC |
| Year(s) Of Engagement Activity | 2020 |
| Description | Project Partners Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | A meeting to engage with potential partners with expertise in drug delivery technologies.These included small biotech companies, contract research organisations, pharma and engineering companies as well as charity representatives |
| Year(s) Of Engagement Activity | 2019 |
| Description | Prometej- science show on Croatian National TV |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | PI was invited to be the main guest within the prominent science TV show on Channel 1 of Croaitan National TV. Early detection of cancer, including design of the biosensor was discussed. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Public Seminar on Bioelectronic Medicine, University of Linkoping, Sweden. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Public seminar on the occasion of award of honorary doctorate, reaching current members, alumni and steakholders of Linkoping University. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Public presentation at Cambridge Alumni Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave talk on brain implants to Cambridge Alumni Festival |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.alumni.cam.ac.uk/festival/events/electronics-on-the-brain |
| Description | Public presentation at Cambridge Society for Application of Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave talk to Cambridge Society for Application of Research - https://www.csar.org.uk/ - on implantable devices for the brain |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.csar.org.uk/lectures/2020-2021/tbc_20201012/ |
| Description | Rapidly developing area of Bionanotechnology |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | An hour long interview with the podcaster Shaun in Science on the importance of bionanotechnology, posted on You tube and live video streamed from Cambridge |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=kObqkoqG3XI |
| Description | RareFest 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rarefest 22 was a public engagement event focused on raising awareness and promoting understanding of rare diseases. The event was held in Cambridge and aimed to bring together individuals, families, and communities affected by rare diseases, as well as healthcare professionals and researchers. The goal of Rarefest 22 was to increase public knowledge and understanding of rare diseases, and to provide support and resources to those affected. The event featured informative talks, interactive workshops, and opportunities for attendees to connect with others who have similar experiences. Several hundred members of the public attended the even held in the Guild Hall, Cambridge. |
| Year(s) Of Engagement Activity | 2017,2022 |
| URL | https://www.camraredisease.org/rarefest22/ |
| Description | Royal Society of Chemistry Chemical Nanoscience and Nanotechnology Network Annual Symposium 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the annual meeting to talk about Bionano tools for hard to treat cancers |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.rsc.org/events/detail/76838/rsc-chemical-nanoscience-and-nanotechnology-network-annual-s... |
| Description | Seminar - Constantin C. Coussios |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar by Professor Constantin C. Coussios addressing attendees from various departments, including discussions on future collaborations |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar - Uli Weisner |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar by Professor Uli Weisner (Cornell University) to research community at University of Cambridge |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar -Snow Stolnik & Cameron Alexander |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A seminar attended by academics/researchers from various departments within University of Cambridge, followed by disucssions of how to collaborate more closely in future, |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar by Chris McConville |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar on "ChemoSeed: a solid biodegradable implant for the localised treatment of glioblastoma". Pprompted discussion on regulatory pathway to the clinic. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Seminar by Claudia Fischbach |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Seminar entitled "Engineering models to analyze tumorstroma interactions and their relevance to cancer progression and therapy" prompted discussions on role of matrix in timour progression |
| Year(s) Of Engagement Activity | 2021 |
| Description | Seminar by Hayley Francies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Seminar entitled "Towards the next generation of cancer". Pormpted discussion on pre-clinical pathway |
| Year(s) Of Engagement Activity | 2020 |
| Description | Seminar by Marco Siccardi |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | An on-line seminar by Marco Siccardi on "Mechanistic Modelling for the Prediction of Nanobiomaterial Biodistribution" |
| Year(s) Of Engagement Activity | 2020 |
| Description | Seminar by Ruman Rahman |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | An online seminar titled "Targeting glioblastoma residual disease using neurosurgically-applied drug delivery systems" which lead to a new research collaboration. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Soothe: Dance Theatre and Brain Chemistry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Soothe is a dance performance that looks into brain chemistry and represents the changes in brain related to our emotional state and disease. It was mean to highlight the intricate chemistry of brain in a fun and approachable way. The performances ( 3 of them in various Cambridge venues) were followed by question and answer section with PI's participation. PI has taken an active part in development of the show. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.westroad.org/whats-on/soothe-dance-theatre-and-brain-chemistry |
| Description | Symposium of Spanish Researchers in UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the annual symposium of Spanish Researchers in Uk on bio nano tools for drug delivery |
| Year(s) Of Engagement Activity | 2023 |
| Description | TEDx talk Dusseldorf |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk by Ljiljana Fruk at TEDxKoenigsallee in Düsseldorf within the theme "Outside the Bubble" |
| Year(s) Of Engagement Activity | 2019 |
| Description | TEDx talk on Nanocarriers (Duesseldorf, Germany) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | TED platform is one of the most popular platform to highlight the ideas and personalities. I was invited to give a talk in front of 1000 audience in Duessledorf concert hall, which was distributed further on a TEDx you tube channel generating wider interest. The talk was on the topic on design of nano carriers. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=3QgJIuT33w0 |
| Description | Talk at EuroMOF 2019, Paris. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | European MOF conference |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk at public outreach event organised by Fundación Ramón Areces |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk on symposium organised by Fundación Ramón Areces, attended by the general public |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.fundacionareces.es/fundacionareces/en/events/biomimetic-sensors-their-use-and-potential-... |
| Description | Twitter account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Twitter account established to dissemenate news relevant to the work of the IRC |
| Year(s) Of Engagement Activity | 2019 |
| Description | Virtual booth at Festival of Tomorrow |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Held virtual booth at Festival of Tomorrow 2021 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.scienceswindon.com/festival-of-tomorrow |
| Description | YouTube video - Brain in the Box |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A short video was created explaining the "Brain in a box" phantom developed by IRC researchers in the Institute of Manufacturing, and shared on social media to raise awareness and generate interest in the IFM Open Day as part of the Cambridge Festival. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=aqYqj253UjQ&ab_channel=IRConTargetedDeliveryforHard-to-TreatCancers |
| Description | iSmart Distinguished Lecture of the International Journal of Smart and Nano Materials |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 17,000 people joined online for this lecture |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://mp.weixin.qq.com/s/qIJrRlQhwiP0SdAiu9vxWQ |
| Description | • Talk at a Mesothelioma UK patients' conference in Brighton on 5th October 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | One day meeting primarily for patients and carers relating to malignant mesothelioma. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.mesothelioma.uk.com/patient-carer-day-awards-night/ |