Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
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Publications
Page MJ
(2019)
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation.
in Scientific reports
Page MJ
(2022)
The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation.
in Chronic stress (Thousand Oaks, Calif.)
Potgieter M
(2015)
The dormant blood microbiome in chronic, inflammatory diseases.
in FEMS microbiology reviews
Pretorius E
(2014)
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.
in Integrative biology : quantitative biosciences from nano to macro
Pretorius E
(2022)
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC).
in Cardiovascular diabetology
Pretorius E
(2018)
Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytrackerâ„¢ stains.
in Journal of the Royal Society, Interface
Pretorius E
(2014)
Eryptosis as a marker of Parkinson's disease.
in Aging
| Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
| Exploitation Route | Novel diagnostics. |
| Sectors | Digital/Communication/Information Technologies (including Software) Education Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Stellenbosch |
| Organisation | University of Stellenbosch |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
| Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
| Impact | See publications. |
| Start Year | 2017 |