High Containment
Lead Research Organisation:
THE PIRBRIGHT INSTITUTE
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Pirbright Institute is a front-line national capability in the response to incursions of exotic viral pathogens in the UK and is a key player in worldwide research of methods to predict, detect and control outbreaks of disease. To achieve this vital role there is a requirement to provide infrastructure and highly specialised expertise across a variety of disciplines, underpinning the science outlined in the institute’s new BBSRC Institute Strategic Programme Grants (ISPG). The primary high containment facilities at The Pirbright Institute are the Animal Isolation units, which enable studies of viral infection in natural ruminant hosts (cattle, sheep, pigs, goats) and the Plowright building, a state of the art laboratory facility housing opened in 2015. These facilities enable studies to be carried out on the most infectious viral diseases of animals known, including foot and mouth disease virus and African swine fever virus. In addition, the Plowright Laboratory is also increasingly used in the study of zoonotic viruses and those that are transmitted between humans by insect vectors. This broadening of research scope is a key aspect to strategic planning and reflects an increasing integration between medical and veterinary research at the site.
The High Containment National Capability has been used to address COVID-19 related challenges from 1 April 2020.
The High Containment National Capability has been used to address COVID-19 related challenges from 1 April 2020.
Planned Impact
unavailable
Organisations
- THE PIRBRIGHT INSTITUTE (Lead Research Organisation)
- Atomic Weapons Establishment (Collaboration)
- UNIVERSITY OF BRISTOL (Collaboration)
- University of Surrey (Collaboration)
- State Central Veterinary Laboratory (Collaboration)
- Department of National Defence (Collaboration)
- Friedrich Loeffler Institute (Collaboration)
- University of Saskatchewan (Collaboration)
- DIAMOND LIGHT SOURCE (Collaboration)
- Aerogen (Collaboration)
- UNIVERSITY OF ST ANDREWS (Collaboration)
- Hebrew University of Jerusalem (Collaboration)
- Public Health Agency of Canada (Collaboration)
- MSD Animal Health (Collaboration)
- Royal Veterinary College (RVC) (Collaboration)
- University of Minnesota (Collaboration)
- NHS ENGLAND (Collaboration)
- FERA SCIENCE LIMITED (Collaboration)
- United States Department of Homeland Security (DHS) (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- National Centre for Foreign Animal Diseases (NCFAD) (Collaboration)
- University of Guelph (Collaboration)
- Francis Crick Institute (Collaboration)
- National Nuclear Laboratory (Collaboration)
- University of Copenhagen (Collaboration)
- University of Wisconsin-Madison (Collaboration)
- UK HEALTH SECURITY AGENCY (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Royal Society of Biology (RSB) (Collaboration)
- Bharat Biotech International (Collaboration)
- University of California, Davis (Collaboration)
- SISAF LTD (Collaboration)
- Defence Science & Technology Laboratory (DSTL) (Collaboration)
- Commonwealth Scientific and Industrial Research Organisation (Collaboration)
- LIVERPOOL SCHOOL OF TROPICAL MEDICINE (Collaboration)
- Meteorological Office UK (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- AIMM Therapeutics (Collaboration)
- Institute of Molecular Biology, Academia Sinica (Collaboration)
- Cardiff University (Collaboration)
- University of Edinburgh (Collaboration)
- Centre for Environment, Fisheries and Aquaculture Science (Collaboration)
- University of Glasgow (Collaboration)
- Government of Thailand (Collaboration)
- Thermo Fisher Scientific (Collaboration)
- John Innes Centre (Collaboration)
- Animal and Plant Health Agency (Collaboration)
- University of York (Collaboration)
- National Physical Laboratory (Collaboration)
- Zoetis (Collaboration)
- Global Affairs Canada (Collaboration)
- St George's University of London (Collaboration)
- KASETSART UNIVERSITY (Collaboration)
- UNIVERSITY OF PLYMOUTH (Collaboration)
- La Trobe University (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
- Robert Koch-Institut (Collaboration)
- Technical University of Denmark (Collaboration)
- UNIVERSITY OF BATH (Collaboration)
- SPYBIOTECH LIMITED (Collaboration)
- University of Oxford (Collaboration)
- Bauchi State University (Collaboration)
- UNIVERSITY OF WARWICK (Collaboration)
- Health and Safety Executive (HSE) (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- University of Leeds (Collaboration)
- UK ATOMIC ENERGY AUTHORITY (Collaboration)
- Sanofi (Collaboration)
- Metrica (Collaboration)
- University of Veterinary Medicine Vienna (Collaboration)
- Centers for Disease Control and Prevention (CDC) (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- National Institute for Biological Standards and Control (NIBSC) (Collaboration)
- National Center for Genetic Engineering and Biotechnology (BIOTEC) (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- Scotland's Rural College (Collaboration)
- Polytechnic University of Valencia (Collaboration)
- Food and Agricultural Organisation (FAO) (Collaboration)
- University of Dundee (Collaboration)
- BABRAHAM INSTITUTE (Collaboration)
- University Hospital Erlangen (Collaboration)
- Kansas State University (Collaboration)
- Boehringer Ingelheim (Collaboration)
- The Pirbright Institute (Collaboration)
Publications
Chang P
(2019)
The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines
in Access Microbiology
Netherton CL
(2019)
The Genetics of Life and Death: Virus-Host Interactions Underpinning Resistance to African Swine Fever, a Viral Hemorrhagic Disease.
in Frontiers in genetics
Flannery J
(2019)
Improved PCR diagnostics using up-to-date in silico validation: An F-gene RT-qPCR assay for the detection of all four lineages of peste des petits ruminants virus.
in Journal of virological methods
James J
(2019)
The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NF?B-dependent promoter antagonism in chicken cells.
in The Journal of general virology
Rajko-Nenow P
(2019)
A rapid RT-LAMP assay for the detection of all four lineages of Peste des Petits Ruminants Virus.
in Journal of virological methods
Dorey-Robinson DLW
(2019)
Complete Genome Sequence of a Bovine Ephemeral Fever Virus Isolate from Israel.
in Microbiology resource announcements
Huang KA
(2019)
Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.
in Nature microbiology
VanWormer E
(2019)
Viral emergence in marine mammals in the North Pacific may be linked to Arctic sea ice reduction.
in Scientific reports
Stevens L
(2019)
A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host
in Journal of General Virology
| Title | Additional file 2 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 2: Figure S1. Air and soil temperature data for 2016-2018 for each farm site: daily mean and maximum air temperature (°C) (top and middle rows, respectively) and daily mean soil temperature at a depth of 3.5 cm (bottom row) for ON (left-hand column) and PW (right-hand column). Line colour indicates the year: 2016 (red); 2017 (blue); or 2018 (cyan). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_2_of_Emergence_dynamics_of_adult... |
| Title | Additional file 2 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 2: Figure S1. Air and soil temperature data for 2016-2018 for each farm site: daily mean and maximum air temperature (°C) (top and middle rows, respectively) and daily mean soil temperature at a depth of 3.5 cm (bottom row) for ON (left-hand column) and PW (right-hand column). Line colour indicates the year: 2016 (red); 2017 (blue); or 2018 (cyan). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_2_of_Emergence_dynamics_of_adult... |
| Title | Additional file 3 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 3: Figure S2. Observed and expected daily number of Culicoides biting midges caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_3_of_Emergence_dynamics_of_adult... |
| Title | Additional file 3 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 3: Figure S2. Observed and expected daily number of Culicoides biting midges caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_3_of_Emergence_dynamics_of_adult... |
| Title | Additional file 4 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 4: Figure S3. Observed and expected daily number of Culicoides obsoletus/scoticus females caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_4_of_Emergence_dynamics_of_adult... |
| Title | Additional file 4 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 4: Figure S3. Observed and expected daily number of Culicoides obsoletus/scoticus females caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_4_of_Emergence_dynamics_of_adult... |
| Title | Additional file 5 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 5: Figure S4. Observed and expected daily number of Culicoides obsoletus males caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_5_of_Emergence_dynamics_of_adult... |
| Title | Additional file 5 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 5: Figure S4. Observed and expected daily number of Culicoides obsoletus males caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_5_of_Emergence_dynamics_of_adult... |
| Title | Canvas print of IBV infected TOC |
| Description | A printed canvas of a confocal microscopy image showing an ex vivo tracheal organ culture infected with IBV and labelled with anti-dsRNA, anti-tubulin and DAPI. |
| Type Of Art | Artwork |
| Year Produced | 2020 |
| Impact | The canvas was awarded as a prize following entry into a image competition. |
| Title | E17 Art Trail - STEAM theme (Jennifer Simpson) |
| Description | Laboratory of Tiny Things installation which ran in London for three weeks. Open to the general public. |
| Type Of Art | Image |
| Year Produced | 2017 |
| Impact | No known impact |
| Title | The Pathologist - Through the Looking Glass (Jennifer Simpson) |
| Description | Article showcasing a gallery of beautiful images from all walks of laboratory medicine |
| Type Of Art | Image |
| Year Produced | 2017 |
| Impact | No impacts known |
| Description | The key development within High Containment Science at The Pirbright Institute is the provision and maintenance of cutting edge biological containment facilities enabling study of high consequence viruses. The continuous operation of these facilities is dependent on a wide range of supporting expertise in biocontainment risk, quality assurance and security. Within the five years since the project was initiated, no releases of viruses into the wider environment have occurred and we have worked closely with HSE to remain in full compliance with our SAPO license and other health and safety law. We have additionally maintained our excellent reputation for the highest standards of animal welfare through our interactions with the Home Office and frequent meetings of our Animal Welfare and Ethical Review Body. Together, this has enabled our scientists to deliver almost 250 peer-reviewed publications working with external researchers accessing high containment through collaboration and also carry out over 450 engagement activities to raise awareness of how these studies translate to disease control. Within the BBSRC National Virology Centre (Plowright Building), downtime for science has been limited almost entirely to planned preventative maintenance programmes in the period 2017-2022. In 2021 the first 'black building test' of this facility was conducted where energy supply is turned off, enabling major upgrading of electronic monitoring and regulation systems. This process was completed successfully and led to a minimum of research downtime. In 2019 and 2020-1 there have been major interruptions to use of the contained animal facilities, which have impacted on users. By maintaining a close and open relationship with funding bodies and prioritising areas of high strategic importance, however, we have minimised this impact. We have also implemented a new approach to scheduling of animal studies within these facilities that has led to improved efficiency in parallel running of experiments. Within the current reporting period we have also initiated studies at Containment Level 3 (CL3) on insect vectors and avian hosts, building entirely new capacity in this area and expanding the portfolio of viruses we study. This was vital as part of Pirbright's response to the SARS-CoV-2 incursion from 2020 and the more recent monkey pox response in enabling high containment studies of this virus where dedicated CL3 space was at a premium nationally. This provision will be complemented in the next reporting period by the Brooksby facility, a new animal isolation unit that will enable CL3 studies in the natural hosts and is due to open in 2023. In the first year of the High Containment grant, more than 50 workers received biosecurity training alongside a range of international activities that included membership of BSL4Znet, a network of high containment laboratories and specific partnerships with Ethiopia, Tanzania and Argentina. In addition, our Risk and Assurance and quality assurance departments lead on several high profile committees on biological containment approaches within the UK and contribute to both policy and best practice documents with governmental organisations and other laboratories (e.g. PHE and APHA). This advice ranged from infrastructure planning and development through to formal processes put in place to maintain a high level of health and safety and biosecurity. Broad, strategic discussions have also been held on access and collaboration within high containment facilities with a range of UK partners including initiatives with the University of Surrey, Royal Veterinary College, The University of Oxford, University of Liverpool, Glasgow University and the Roslin Institute. Within the reporting period we have responded to ongoing outbreaks of African swine fever virus and bluetongue virus, both of which currently threaten the UK, and provided horizon scanning for foot and mouth disease and lumpy skin disease virus enabled by retention of UK reference laboratories that operate at ISO/EC 17025 quality requirements. The Institute website has also been revised to improve the public understanding of how containment facilities work, and a range of outreach exercises have taken place that describe both our science and the role of infrastructure in enabling research. Dedicated videos have also been produced by our communications department with interviews from all the senior members of the CCG group. Infrastructure projects aimed at increasing flexibility in the use of contained animal facilities and in poultry research are continuing including the completion of a poultry SPF facility in CCG reporting year four. |
| Exploitation Route | The provision of safe and reliable high containment facilities provides a National Capability for the UK and enables both fundamental science and applied outcomes in disease control. At an infrastructure level, we continue to learn and improve on methods to minimise interruptions to science through advance planning of maintenance and to operate to the highest levels of health and safety and biosecurity. This experience is shared with other high containment sites through a variety of means and is additionally visible to regulators defining best practise for these operations. At a fundamental science level, the High Containment facilities that we maintain enable collaborative relationships to be formed with external workers wishing to carry out studies in this environment. This was particularly visible in the case of the response to the SARS-CoV-2 incursion where CL3 facilities and specialist workers in this area were able to support a wide range of external projects from academic science to industrial companies involved in vaccines and diagnostics. Finally, our capacity to respond to incursions of exotic veterinary viruses into the UK is translated through providing high quality disease information to underpin policy decision making by Defra and central government in the UK, EFSA and the EU in Europe and the OIE and FAO at a global level. |
| Sectors | Agriculture Food and Drink |
| URL | https://www.pirbright.ac.uk/campus-redevelopment/bbsrc-national-virology-centre-plowright-building |
| Description | Use of expertise in High Containment has been visible through relationships with Public Health England, where we have advised on an ad hoc basis on the design and maintenance of laboratories and also supported the design of new facilities, including the major redevelopment at the Animal and Plant Heath Agency. Within the fundamental science sector, a significant proportion of our studies are translated to real world disease control scenarios including developing, validating and using diagnostic assays for a vast array of viruses and devising new vaccines that are tested in the natural host (e.g. African swine fever virus in pigs). In addition, much of the data generated within animal experiments is provided as evidence for policy decision making and outbreak response scenario exercises. Recent examples include the response to import of cattle that showed evidence of infection with bluetongue virus where assessment of infectious viraemia generated in containment at Pirbright was used to resolve decision making in the field. Through maintenance of expertise in virus outbreaks, we are currently primary sources of information in national policy making for internationally important viruses of livestock including foot-and-mouth disease, lumpy skin disease, bluetongue, African swine fever and Rift Valley fever virus. |
| First Year Of Impact | 2017 |
| Sector | Agriculture, Food and Drink |
| Impact Types | Societal Economic Policy & public services |
| Description | ALERT20 Co-Chair |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Provision of equipment to enhance and enable fundamental research within BBSRC remit |
| Description | Advice on Bluetongue virus and Epizootic Heamorrhagic disease virus |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Impact on disease control and surveillance implemented in GB following incursion of BTV-3 in summer 2024 |
| Description | Advice on bluetongue virus |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Impact on disease control and surveillance implemented in GB following incursion of BTV-3 late 2023 |
| Description | Advice to AgResults FMD vaccine challenge project |
| Geographic Reach | Africa |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | The AgResults FMD vaccine project aims to encourage the development of high quality vaccines tailored to strains of FMD circulating in East Africa. I provided analysis and advice in the development of criteria used to assess whether vaccines submitted to the competition are successful. |
| URL | https://agresults.org/projects/fmd-vaccine |
| Description | BBSRC 18ALERT panel member |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Provision of multi-user equipment to core facilities to enable BBSRC remit science. Part of the remit for this call was to allow shared access from other institutions, widening the impact of BBSRC investment. |
| Description | BBSRC ALERT19 panel member (invited) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Panel for ALERT18 multi-user equipment award by BBSRC |
| Description | BBSRC Bioimaging Review |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | BBSRC Transformative Technologies Strategic Advisory Panel - invited expert |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Criteria for the ALERT call have changed, there is an increased focus on RTPs, plus the amount available in the call has increased, and the maximum individual grant possible has increased. |
| Description | Bioimaging Steering Group |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Improving access and efficient organization of Bioimaging for researchers at Pirbright |
| Description | Bioimaging Steering Group |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Better management of workload and facility internally |
| Description | Biorisk advisor training |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.pirbright.ac.uk/engage-with-us/training-pirbright/biosafety-courses/biorisk-advisor-trai... |
| Description | Chair of ALERT21/22 panel |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Enabled UKRI funded research, supporting cutting edge research across different disciplines. |
| Description | Defra/NERC SysRisk case study on biosecurity (zoonotic disease risk) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Development of a framework for assessing systemic environmental risks |
| URL | https://www.sysrisk.org.uk/ |
| Description | Development and Evaluation of PPR DIVA vaccines |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | Peste des petits ruminants (PPR) is a highly contagious disease, severely affects small ruminants in almost 70 countries in Africa, the Middle East and parts of Asia. It causes USD 1.5 to 2 billion in losses each year in regions that are home to over 80% of the world's sheep and goats and to more than 330 million of the world's poorest people, many of whom depend on them for their livelihoods. The estimated current expenditure on PPR vaccination ranges between USD 270 and 380 million. The annual impact of PPR alone may be valued at between USD 1.45 and 2.1 billion per year. Approximately a third of the global financial burden of PPR is borne by Africa, with a further quarter borne by South Asia. This burden will be removed with the successful eradication of PPR. The undiscounted costs for a fifteen-year Global control Strategy of FAO and OIE are between USD 7.6 and 9.1 billion, with the first five years costing between USD 2.5 and 3.1 billion. (http://www.fao.org/3/a-i4460e.pdf). PPR is currently controlled by vaccination using mainly two live attenuated PPRV vaccines (Nigeria 75/1 and Sungri 96). However, the current vaccines and serological tests are unable to enable Differentiation between naturally Infected and Vaccinated Animals (DIVA). This factor precludes meaningful assessment of vaccine coverage and epidemiological surveillance based on serology, in turn reducing the efficiency of control programmes. Therefore, it is almost impossible to assess the quality and efficacy of existing PPR vaccines without knowing whether positive animals are vaccinated or naturally infected. Unlike rinderpest, where cattle and buffalo were primary hosts, in PPR, new crops (about 30-40%) of lambs and kids are produced every year and are the most susceptible population to bring back new PPR outbreaks6&7. Therefore, it is likely that the cycle of vaccinations and PPR outbreaks will continue until and unless we reach the stage of 80-90% herd immunity. Therefore, development of a marker vaccine and associated DIVA diagnostics will enable the assessment of vaccine efficacy which is essential for any successful vaccination campaign. https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-peste-des-petits-ruminant The availability of a recombinant PPRV vaccine with a proven functionality is a prerequisite for the development of novel vaccines that may enable the development of DIVA tools for PPRV diagnostics. In the DBT-BBSRC FADH BB/L004801/1 grant we have rescued Sungri 96 and Nigeria 75/1 vaccine strains. Both the vaccine strains were rescued from respective synthetic c-DNA clones with mutations in the variable part of C terminus of the nucleocapsid (N) gene similar to Dolphin Morbillivirus (DMV) to enable negative marker DIVA vaccines. These two DIVA vaccines along with parental vaccines have been recently tested in a pilot studies in goats. Both the DIVA and parent vaccines provided safety, stability and protection for vaccinated goats whereas the control animals were clinically infected. Patent applications have been made to protect these DIVA vaccines. Agreements are being done with vaccine industries for the licensing and commercialisation. |
| URL | https://www.pirbright.ac.uk/press-releases/2018/09/pirbright-collaboration-provides-tools-peste-des-... |
| Description | Drafted resolution that was endorsed by the World Assembly of Delegates (for the World Oganisation of Animal Health - OIE) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | This policy document relates to one of the FMDV serotypes (called serotype C) which has disappeared for >10 years from the surveillance activities of the global OIE/FAO FMD Reference Laboratories (led by the Pirbright Institute). These laboratories now consider that the production of FMDV serotype C vaccines and their use in vaccine challenge experiments represent a risk of virus escape. Based on this evidence and concerns, this resolution urges that OIE Member Countries and vaccine manufacturers to stop the use of FMDV serotype C in vaccine challenge experiments and to consider halting the production of FMDV serotype C vaccines and inclusion in multivalent FMD vaccines except for holding in vaccine banks. |
| URL | http://www.oie.int/fileadmin/Home/eng/About_us/docs/pdf/Session/2017/A_RESO_2017_Public.pdf |
| Description | EFSA working group on Rift Valley fever |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Analysis of data on Rift Valley fever; assessment of risk of introduction to European Union; advice to European Commission on control measures |
| URL | https://www.efsa.europa.eu/en/news/rift-valley-fever-risk-low-eu-must-remain-vigilant |
| Description | EFSA working group on Rift Valley fever |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | The outputs from the working group were used to inform the European Commission about surveillance and disease control policy for Rift Valley fever in Europe (and Mayotte) |
| URL | https://www.efsa.europa.eu/en/news/rift-valley-fever-surveillance-measures-assessed |
| Description | EFSA working group on category A diseases of the Animal Health Law |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Assessment of the surveillance measures to implemented following outbreaks of each of the 14 diseases* in category A of the European Animal Health Law. The outputs from the assessment will be used by EU member states to design their surveillance efforts in the event of an outbreak of any of these diseases. * The diseases covered in 2020 were FMD, HPAI, ASF, LSD and AHS DOIs for the assessment for each disease: Methodology: 10.2903/sp.efsa.2020.EN-1988) Highly pathogenic avian influenza: 10.2903/j.efsa.2021.6372 African swine fever: 10.2903/j.efsa.2021.6402 African horse sickness 10.2903/j.efsa.2021.6403 Foot-and-mouth disease: 10.2903/j.efsa.2021.6632 Lumpy skin disease: 10.2903/j.efsa.2022.7121 |
| URL | https://www.efsa.europa.eu/en/topics/topic/animal-health |
| Description | EFSA working group on category A diseases of the Animal Health Law |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Assessment of the surveillance measures to implemented following outbreaks of each of the 14 diseases* in category A of the European Animal Health Law. The outputs from the assessment will be used by EU member states to design their surveillance efforts in the event of an outbreak of any of these diseases. * Diseases covered in 2021 are CSF, PPR, sheep and goat pox, RVF, Newcastle disease, rinderpest, CBPP, CCPP and glanders DOIs for the assessment for each disease: Classical swine fever: 10.2903/j.efsa.2021.6707 Peste des petits ruminants: 10.2903/j.efsa.2021.6708 Sheep and goat pox: 10.2903/j.efsa.2021.6933 Newcastle disease: 10.2903/j.efsa.2021.6946 Contagious bovine pleuropneumonia: 10.2903/j.efsa.2022.7067 Contagious caprine pleuropneumonia: 10.2903/j.efsa.2022.7068 Burkholderia mallei (Glanders): 10.2903/j.efsa.2022.7069 Rift Valley fever: 10.2903/j.efsa.2022.7070 Rinderpest: 10.2903/j.efsa.2022.7071 |
| URL | https://www.efsa.europa.eu/en/topics/topic/animal-health |
| Description | EFSA working group on lumpy skin disease |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Report to the European Commission on the spread and control of lumpy skin disease in the Balkans |
| URL | http://www.efsa.europa.eu/en/efsajournal/pub/5176 |
| Description | EFSA working group on lumpy skin disease |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Collation of data on lumpy skin disease outbreaks in Europe and neighbouring regions; provision of advice to European Commission and to affected countries on control and surveillance |
| URL | https://www.efsa.europa.eu/en/efsajournal/pub/6010 |
| Description | EFSA working group on lumpy skin disease |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | The models developed to describe the spread of lumpy skin disease virus (LSDV) within and between farms have been used to inform disease control policy following incursion of LSDV to south-eastern Europe. Specifically, the models were used to assess the impact of vaccination on disease spread. They were also used to investigate the duration of a vaccination campaign to prevent re-emergence of LSDV and to help design surveillance programmes to detect the re-emergence of the virus or its re-introduction from neighbouring countries. The results have been communicated to the European Commission and to affected countries via the European Food Safety Authority. |
| URL | https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2018.5452 |
| Description | Enhancing the duration of Immunity by adding the TLR III adjuvant to the current FMDV vaccine formulation |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | We have demonstrated that addition of TLR III agonist to the existing FMD vaccine formulation, the duration of immunity could be enhanced from 3 to 6 months. There the biannual vaccination practised in endemic country will have no window for the infection. |
| Description | Facilitated the transfer of molecular technology for the capacity building of the Sokoine University of Agriculture (SUA) Southern African Centre for Infectious Disease Surveillance (SACIDS) peste des petits ruminants (PPR) laboratory.19-25.01.2020 |
| Geographic Reach | Africa |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Facilitated the transfer of molecular technology for the capacity building of the Sokoine University of Agriculture (SUA) Southern African Centre for Infectious Disease Surveillance (SACIDS) peste des petits ruminants (PPR) laboratory.19-25.01.2020. The PPR virus infected samples can be diagnosed now at SUA, Tanzania without sending to Pirbright or CIRAD reference laboratories. This will enhance the capacity building of SUA and help immensely in the ongoing PPR eradication. |
| Description | Grants Review Team |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Impact | More effective inclusion of microscopy technology in grants submitted from the Institute |
| Description | HEPA Filtration: Validation, Testing and Changing |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.pirbright.ac.uk/engage-with-us/training-pirbright/engineering-courses/hepa-filtration-va... |
| Description | I provided images of the gross pathology of lumpy skin disease (LSD) to Defra and to the Swiss veterinary authorities for the purpose of educating veterinarians and promoting rapid diagnosis of LSD should it emerge in Switzerland or the UK |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Imperial College London (Masters-level training) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The students will be better prepared for how to prepare and respond to outbreaks of tropical vector-borne diseases, which is highly relevant as many students on the course were from disease-endemic countries. |
| URL | https://www.imperial.ac.uk |
| Description | Imperial Masters student training |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Improvement on FMD and PPR vaccines. Through this partnering award we were able to achive further DBT-BBSRC FADH grant and BBSRC follow on grants whicvh helped us to improve the existing FMD and PPR vaccine. We have now demonstrated that adding TLR adjuvants to the existing vaccine the duration of immunity can be increased upto 6 months. Similarly we have develped PPR DIVA vaccine which can differentiate between infection and vaccination. The Indian Natioanl Goverment and industries are aware of this development so as other through recent FAO/OIE PPR meetings. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Inter-institute imaging network |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | International Society for Neglected Tropical Diseases Dengue Advisory Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://www.isntd.org/dengue-advisory-group |
| Description | Invited expert at OIE Regional Consultation webinars on lumpy skin disease for Asia and the Pacific |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://rr-asia.oie.int/en/events/lumpy-skin-disease-webinar-series/ |
| Description | Invited member of RCaH Science Advisory Board |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | The Research Complex at Harwell is a UKRI funded building with the remit of enabling researchers across many disciplines to take advantage of the national facilities on the Harwell campus. RCaH is going through significant change at the moment and the advisory board has been asked to contribute to defining its future direction. |
| Description | Invited participant, UK SAGE exercise on a zoonotic outbreak |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | Participation in a simulated outbreak of Rift Valley fever to UK to identify gaps in response, including detection, implementation of control measures (for livestock and humans) and communication. |
| Description | Livestock Viral Diseases Pathology Slide Set. A set of histology slides of tissues from livestock affected by notifiable viral diseases, provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland. |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Longer duration immunity for FMD vaccine with TLR adjuvant-Conducted screening of 8 adjuvants with FMD vaccine in cattle and analyse the samples originated from the experiments. 4 selected adjuvants were tested in cattle at the Pirbright Institute and TLR III adjuvant was found as the best one. Under Follow on grant 12 cattle were vaccinated with existing vaccine with oil adjuvant and 12 cattle were vaccinated with oil and TLR III adjuvants. The protective immununity was assessed from the virus neutralizing antibody status. By 6 months post-vaccination only 17% of cattle were having protective antibodies (1:45 dilution) in conventional vaccine group whereas 80% cattle were having protective neutralizing titer (1:45) in TLR adjuvanted group. Therefore it is clear that adding TLR adjuvant one can increase the duration of immunity up to 6 months. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Member of Defra Science Advisory Council Exotic and Emerging Diseases (SAC-ED) subcommittee |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | More effective anticipation of and response to disease outbreaks reducing their impact on the farming and wider community |
| Description | Member of RMS EM Section committee |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | This committee informs the RMS on which areas to invest funds in regarding training, conferences, outreach events. RMS members are international. |
| Description | Microbiology Society Members Panel |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | A number of initiatives have been implemented that have made activities within the Microbiology Society more accessible to historically marginalised groups, for example the promotion of pronouns, changes to alcohol provision to make conference sessions more accessible to people who cannot be around alcohol, introduction of a knowledge-exchange forum as a new session at the Society's annual conference, improved equality, diversity and inclusion training, introduction of quiet rooms for neurodiverse scientists. |
| URL | https://microbiologysociety.org/why-microbiology-matters/council-governance/standing-panels/members-... |
| Description | Oxford Brookes Bioimaging Steering Group |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Oxford Medical Students training |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | PPR DIVA Vaccine development . FAO/OIE in the meeting proceedings in December, 2018 recorded the future use of DIVA vaccine in the ongoing PPR eradication programme. This will be useful at least at the end phase of eradication to differentiate between vaccination and infection.As such few industries have contacted us to have the DIVA vaccine strains for commercialisation. Also some of the endemic countries are keen to have the strain for testing the DIVA vaccines in endemic settings. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Description | PhD research training |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The concrete outcomes of this PhD training was the skills learnt by the respective students while under my guidance. Their immediate destinations after graduating were: Postdoctoral academic research (US): one student Postdoctoral academic research (UK): one student |
| Description | Press release on threat of PPR to Europe |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Impact | We have press released in May 2018 and the PPR out break, first in Europe main land, Happened in June-July 2018 |
| URL | https://www.pirbright.ac.uk/press-releases/2017/05/peste-des-petits-ruminants-neglected-disease-whic... |
| Description | Publication policy document for core facilities - EM-UK |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | I am a founder member of the network created for electron microscopists within UK, EM-UK. The annual meeting is highly productive, and training and managing core facilities is regularly discussed. Recognition of these facilities is essential for their continued existence so we produced a generic document hosted on the RMS website which can be adopted by any core facility in any institution, and describes the publication policy which users had to adhere to. This has already raised the profile of core facilities around the country and is a successful outcome from the EM-UK meetings. |
| Description | Quantifying Levels of Peste Des Petits Ruminants (PPR) Virus in Excretions from Experimentally Infected Goats and Its Importance for Nascent PPR Eradication Programme |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | This publication highlight the sample types to be used in the PPR eradication programme to detect the viral genome. Therefore without invasive sampling nasal swabs can be taken from the body of the infected animal for the detection of viral nucleotides. Also this publication highlight the pick period of virus excretion which shows the most probale period of virus transmission to the in contact animals. The manuscript has been sent to FAP and PPR secretariat and received well appreciation that the work will be helpful for eradication programme. |
| Description | Royal Microscopical Society Microscopy Training Focussed Interest Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Royal Microscopical Society Training Focussed Interest Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | A review of the microscopy training courses available globally has been undertaken. We are in the process of collating and preparing a gap analysis. This will be used to guide RMS policy on training provided in the UK, both UK and international delegates. |
| Description | Training of Masters students (Imperial College London) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The students gained specialist knowledge in vector-borne diseases - their transmission and emergence potential. Students came from multiple countries across the world and will take this knowledge back with them in the future. |
| Description | Training of medical students (University of Oxford) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The students on this medical degree programme were trained in tropical medicine. |
| Description | University of Copenhagen PhD course |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | We train approx 20 students per year to use the microscopes which allows them to complete their PhDs |
| Description | University of Oxford (Medical students training) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Medical students in the UK may encounter tropical diseases in patients returning from overseas travel. In this lecture they gained an insight into the disease caused by dengue virus and how people can protect themselves when they travel overseas, allowing them to better care for patients when they enter the clinic. |
| URL | https://www.ox.ac.uk |
| Description | University of Oxford (medical students training) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The students gained an understanding for important tropical diseases that they may encounter in patients when they begin work in the clinic. Since these diseases are not endemic to the UK they would otherwise not have gained this information. |
| URL | https://www.ox.ac.uk |
| Description | University of Surrey MSc Vet microbiology - teaching (Jennifer Simpson) |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Two days of teaching practical microscopy, a useful cross disciplinary skill for many researchers |
| Description | Update to OIE Scientific Committee on Animal Diseases (SCAD) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | WOAH Global Network of African swine fever diagnostic labs |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Participated in discussions to establish an WOAH Global Network of African swine fever virus diagnostic laboratories and became a member of the organizing committee |
| Description | Zika pandemic preparedness ten-year plan consultation (Wellcome Trust/WHO) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | A One Health Approach to Alkhumra Haemorrhagic Fever Virus Species Tropism, Pathogenesis and Epidemiology |
| Amount | £99,082 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 04/2026 |
| Description | A One Health approach to pan-valent morbillivirus vaccines |
| Amount | £773,237 (GBP) |
| Funding ID | BB/R019843/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2021 |
| Description | A live attenuated pseudorabies virus vectored Nipah vaccine for enhanced protection in pigs |
| Amount | £332,404 (GBP) |
| Funding ID | 10024897 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2023 |
| Description | Active and passive Immunity induced by aerosols |
| Amount | £100,000 (GBP) |
| Funding ID | BB/R506448/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 08/2021 |
| Description | African swine fever control tools |
| Amount | £1,077,663 (GBP) |
| Funding ID | SE1520 |
| Organisation | Department For Environment, Food And Rural Affairs (DEFRA) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2026 |
| Description | Application of AI to profile the nasal and faecal microbiota of pigs following respiratory virus challenge |
| Amount | £16,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 07/2024 |
| Description | Application of field-deployable surveillance tool to enhance molecular xenomonitoring of multiple vector borne diseases |
| Amount | £4,675,662 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 09/2023 |
| Description | Application of molecular xenomonitoring in a lateral flow test format for multiplexed monitoring of vector-borne viruses and their animal reservoirs and insect vectors in low-income settings |
| Amount | £49,015 (GBP) |
| Funding ID | IAA2149 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 03/2025 |
| Description | BBSRC IAA |
| Amount | £12,061 (GBP) |
| Funding ID | BB/S506680/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 03/2019 |
| Description | BBSRC IAA |
| Amount | £13,989 (GBP) |
| Funding ID | BB/S506680/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 03/2022 |
| Description | BBSRC IAA' |
| Amount | £30,000 (GBP) |
| Funding ID | BB/S506680/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 04/2020 |
| Description | BBSRC Industrial CASE (iCASE) studentship programme Oxford Interdisciplinary Bioscience Doctoral Training Partnership |
| Amount | £80,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2023 |
| Description | BBSRC Newton Fund Swine and Poultry Research Initiative |
| Amount | £865,623 (GBP) |
| Funding ID | BB/R01275X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 06/2021 |
| Description | BBSRC responsive mode funding |
| Amount | £356,484 (GBP) |
| Funding ID | BB/T005173/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2021 |
| Description | BBSRC responsive mode grant |
| Amount | £367,000 (GBP) |
| Funding ID | BB/P006841/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 03/2019 |
| Description | BBSRC-funded Oxford Doctoral Training Partnership in vivo skills award |
| Amount | £15,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 06/2021 |
| Description | Biotechnology and Biological Sciences Research Council (BBSRC) and University of Oxford joint Doctoral Training Project |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 08/2022 |
| Description | Blood Markers for prediction of respiratory virus infection |
| Amount | £21,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 07/2024 |
| Description | Bluetongue virus changes the emission of volatile organic chemicals in the body odour of sheep and cattle during infection |
| Amount | £471,421 (GBP) |
| Funding ID | BB/T014601/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 01/2022 |
| Description | Bovine herpesvirus 4 as a vaccine platform for African swine fever virus antigens in pigs |
| Amount | £199,890 (GBP) |
| Funding ID | BB/Y006224/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2024 |
| End | 12/2025 |
| Description | Broad and effective protection against influenza achieved by viral vectored vaccines |
| Amount | £1,668,741 (GBP) |
| Funding ID | MR/S037160/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 04/2023 |
| Description | China UK One Health research for epidemic preparedness and AMR initiative |
| Amount | £900,000 (GBP) |
| Funding ID | MR/Y015061/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2025 |
| End | 02/2028 |
| Description | Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence |
| Amount | £200,000 (GBP) |
| Funding ID | LKCS-2019- 665 |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 10/2022 |
| Description | Components of the Medea gene drive system in a mosquito Aedes aegypti |
| Amount | £758,098 (GBP) |
| Funding ID | BB/S001964/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 10/2022 |
| Description | Conserved molecular mechanisms of replication for mosquito-borne flaviviruses |
| Amount | $199,350 (USD) |
| Funding ID | 1R21AI168716-01 |
| Organisation | National Institutes of Health (NIH) |
| Department | National Institute of Allergy and Infectious Diseases (NIAID) |
| Sector | Public |
| Country | United States |
| Start | 02/2022 |
| End | 01/2024 |
| Description | DARPA PREEMPT |
| Amount | $2,700,000 (USD) |
| Organisation | Defense Advanced Research Projects Agency (DARPA) |
| Sector | Public |
| Country | United States |
| Start | 09/2018 |
| End | 03/2022 |
| Description | Defining the molecular signature of pericyte dysfunction in severe dengue patients |
| Amount | $20,000 (USD) |
| Organisation | UGPN |
| Sector | Academic/University |
| Start | 09/2020 |
| End | 07/2021 |
| Description | Dengue haemorrhage: a novel role for perivascular cells |
| Amount | £74,137 (GBP) |
| Organisation | University of Surrey |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2024 |
| Description | Development of multispecies validated serology protocols for complex ecosystems, focused on East Africa, in support of Global PPR eradication |
| Amount | £697,673 (GBP) |
| Funding ID | EP/T015381/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2021 |
| Description | Development of next generation vaccine technology inducing rapid and strong immunity through targeted delivery of antigens to chicken immune cells |
| Amount | £473,080 (GBP) |
| Funding ID | BB/T013087/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2021 |
| End | 05/2024 |
| Description | ERA-NET Cofund on International Coordination of Research on Infectious Animal Diseases (ICRAD) |
| Amount | £1,526,000 (GBP) |
| Funding ID | SE1518 |
| Organisation | Department For Environment, Food And Rural Affairs (DEFRA) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 03/2024 |
| Description | EU VetBioNet Transnational Access Fund: Evaluation of the immunogenicity of a bivalent PRRS-Nipah virus vaccine |
| Amount | £61,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | Belgium |
| Start | 04/2021 |
| End | 07/2021 |
| Description | Efficacy of mRNA expressed antibodies against influenza |
| Amount | £2,000,000 (GBP) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 07/2021 |
| End | 08/2022 |
| Description | Emerging porcine influenza and coronaviruses" (EPICVIR) |
| Amount | £596,027 (GBP) |
| Funding ID | BB/X019780/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 10/2026 |
| Description | Evaluation of CD4+ T-cell responses to vaccination with next generation FMD vaccines using Tetramer-guided epitope mapping of foot-and-mouth disease virus capsid |
| Amount | £18,000 (GBP) |
| Funding ID | BB/S506680/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 08/2021 |
| Description | Evaluation of transmission blockers in the pig influenza challenge model |
| Amount | $2,371,127 (USD) |
| Funding ID | INV-058747 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 06/2023 |
| End | 07/2025 |
| Description | Evalution of a stable liquid formulation of the PPR vaccine in sheep and goats |
| Amount | £225,638 (GBP) |
| Funding ID | IAH-R67A1151A1 |
| Organisation | GALVmed |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 07/2021 |
| Description | Exploiting novel African swine fever virus virulence factors and a porcine macrophage cell line to develop a live attenuated vaccine |
| Amount | £372,805 (GBP) |
| Funding ID | BB/V007947/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2021 |
| End | 06/2024 |
| Description | Exploring transcription of a large DNA virus of importance for global food security |
| Amount | £227,037 (GBP) |
| Funding ID | BB/X015424/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 10/2026 |
| Description | FLI- TPI joint PhD studentships African swine fever virus host-pathogen interactions. |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 04/2023 |
| Description | FLI- TPI joint PhD studentships Avian influenza immunology markers. |
| Amount | £100,000 (GBP) |
| Organisation | Friedrich Loeffler Institute |
| Sector | Academic/University |
| Country | Germany |
| Start | 06/2018 |
| End | 06/2022 |
| Description | Floid Cell imager (X2) |
| Amount | £24,459 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2021 |
| End | 03/2022 |
| Description | G2P-UK; A National Virology Consortium to address phenotypic consequences of SARSCoV-2 genomic variation |
| Amount | £4,021,993 (GBP) |
| Funding ID | MR/W005611/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 07/2023 |
| Description | GALVmed DFID Funding |
| Amount | £1,000,000 (GBP) |
| Organisation | GALVmed |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 03/2022 |
| Description | Genomia Project Grant |
| Amount | £174,052 (GBP) |
| Organisation | Genomia fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2020 |
| Description | Global characterisation of interlinked mosquito immune networks |
| Amount | £38,936 (GBP) |
| Funding ID | BB/W510725/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 07/2021 |
| End | 03/2022 |
| Description | H2020 work programme topic 9 Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy, work topic SFS-10-2017 Research and approaches for emerging diseases in plants and terrestrial livestock |
| Amount | € 5,986,250 (EUR) |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 04/2018 |
| End | 04/2023 |
| Description | How does the lung protect itself against influenza? |
| Amount | £120,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 07/2026 |
| Description | Identification of innate immune genes in Aedes aegypti |
| Amount | £10,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 03/2023 |
| Description | International Workshops |
| Amount | £10,000 (GBP) |
| Funding ID | BB/R021198/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 05/2019 |
| Description | Investigating the feasibility of adapting a direct PCR diagnostics approach to in-field animal testing |
| Amount | £864,356 (GBP) |
| Funding ID | 104623 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 04/2020 |
| Description | Investigation of Canonical and Noncanonical Transcription during Coronavirus Replication |
| Amount | £122,000 (GBP) |
| Funding ID | STUD312000 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2025 |
| Description | Market research and technical feasibility of a bivalent porcine reproductive and respiratory syndrome / Nipah virus vaccine |
| Amount | £10,880 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 03/2020 |
| Description | Multilateral UK-USA-France Partnership in Genetic Engineering of Disease Vectors |
| Amount | £17,500 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 06/2024 |
| Description | Newton Fund: UK-China-Philippines-Thailand Swine and Poultry Research Initiative |
| Amount | £841,995 (GBP) |
| Funding ID | BB/R012679/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2020 |
| Description | Next generation peste-des-petits ruminats (PPR) vaccines that differentiate between infected and vaccinated animals (DIVA) - proof of concept in sheep |
| Amount | £158,845 (GBP) |
| Funding ID | BB/T004096/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2021 |
| Description | OIE Twinning: Development of capacity for independent assessment of FMDV vaccines in Africa |
| Amount | $1,466,186 (USD) |
| Organisation | World Organisation for Animal Health, France |
| Sector | Public |
| Country | France |
| Start | 03/2019 |
| End | 03/2021 |
| Description | Oxford DTP - Diamond Light Source/Harwell |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2022 |
| Description | PRCV model to better understand immunity to SARS-CoV2 |
| Amount | £50,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 03/2022 |
| Description | Pathogenesis, immunity, and control of coronaviruses in a large natural host animal, the pig |
| Amount | £893,800 (GBP) |
| Funding ID | BB/X014266/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2026 |
| Description | Pericyte dysfunction contribution to severe dengue haemorrhage in Brazilian patients |
| Amount | £44,934 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Department | Global Challenges Research Fund |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 08/2021 |
| Description | Pirbright Institute Flexible Talent Mobility Account |
| Amount | £255,000 (GBP) |
| Funding ID | BB/S507945/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 03/2022 |
| Description | Pirbright Institute PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 08/2022 |
| Description | Pirbright Institute PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2022 |
| Description | Pirbright Institute PhD studentship |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2023 |
| Description | Protecting poultry from avian influenza, Newcastle disease, infectious bronchitis, and Gumboro disease with a single dose of a multivalent vaccine |
| Amount | £448,937 (GBP) |
| Funding ID | BB/W003325/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 12/2024 |
| Description | Quadrivalent foot-and-mouth disease virus vaccine technology |
| Amount | $1,474,103 (USD) |
| Funding ID | INV-003628 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 07/2019 |
| End | 02/2022 |
| Description | Reducing the Economic and Zoonotic Impact of Avian Influenza (REZIAI): delivering novel vaccines and diagnostics from laboratory to the field. |
| Amount | £400,000 (GBP) |
| Funding ID | BB/S013792/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2021 |
| Description | SFS-10-2017 - Research and approaches for emerging diseases and pests in plants and terrestrial livestock: Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND) |
| Amount | € 5,986,250 (EUR) |
| Funding ID | 773701 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 05/2018 |
| End | 05/2023 |
| Description | SOMAmer technology to diagnose coronavirus infection: veterinary and zoonotic implications |
| Amount | £1 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Description | Society Conference Grant |
| Amount | £380 (GBP) |
| Organisation | Microbiology Society |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 04/2022 |
| Description | The Global Challenges Research Fund |
| Amount | £640,473 (GBP) |
| Organisation | Research Councils UK (RCUK) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2024 |
| Description | The Pirbright Institute - University of Surrey collaborative studentship: Not all viruses come alone - the impact of orbivirus co-infections on bluetongue virus reassortment and diversity |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 03/2025 |
| Description | The Pirbright Institute Flexible Talent Mobility Account Innovation Fellowship |
| Amount | £19,636 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 10/2020 |
| Description | The Pirbright Livestock Antibody Hub |
| Amount | $5,500,000 (USD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2019 |
| End | 11/2024 |
| Description | The genetic and functional analysis of variation in innate immune genes associated with restriction of influenza virus for chicken lines |
| Amount | £422,383 (GBP) |
| Organisation | Aviagen Group |
| Sector | Private |
| Country | United States |
| Start | 01/2020 |
| End | 03/2021 |
| Description | The role of perivascular cell dysfunction in hepatic complications of dengue haemorrhagic fever |
| Amount | £589,017 (GBP) |
| Funding ID | MR/X009203/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2024 |
| End | 01/2027 |
| Description | UK International coronavirus network (UK-ICN) |
| Amount | £510,207 (GBP) |
| Funding ID | BB/W003287/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Description | US-UK-China Collab-Understanding the Impact of Poultry Vaccination on H5Nx Avian Influenza Virus Evolution and Ecosystem Dynamics |
| Amount | £3,000,000 (GBP) |
| Funding ID | APP18977: 3291 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2024 |
| End | 10/2029 |
| Description | Use of FMDV sequence data to trace outbreaks and monitor disease incursion risks to the UK |
| Amount | £1,326,558 (GBP) |
| Funding ID | SE2944 |
| Organisation | Department For Environment, Food And Rural Affairs (DEFRA) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2022 |
| Description | Using machine learning to identify the molecular determinants of vector-borne transmission in viruses |
| Amount | £110,327 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 04/2028 |
| Description | Viral entry at the human-animal interface; dissecting the pan-tropic nature of zoonotic viruses. |
| Amount | £393,707 (GBP) |
| Funding ID | BB/W006162/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2025 |
| Description | Workpackage within a Horzion 20:20 grant |
| Amount | € 6,000,000 (EUR) |
| Funding ID | EU project 727393 Horizon 20:20 PALE-Blue |
| Organisation | European Union |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2017 |
| End | 11/2021 |
| Description | [YY-EEID US-UK XXXX] Evaluating how immunosuppression influences influenza A virus transmission and evolution in wild and domestic birds |
| Amount | £606,360 (GBP) |
| Funding ID | BB/T008806/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 06/2023 |
| Description | iCASE studentship: Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2023 |
| Title | A ligation and restriction enzyme independent cloning technique: an alternative to conventional methods for cloning hard-to-clone gene segments in the influenza reverse genetics system |
| Description | we developed an easy and efficient ligation and restriction enzyme independent (LREI) cloning method for cloning influenza gene segments into pHW2000 vector. The method involves amplification of megaprimers followed by PCR amplification of megaprimers using a bait plasmid, DpnI digestion and transformation. ligation and restriction enzyme independent (LREI) cloning method represents an alternative strategy for cloning influenza gene segments that have internal restriction sites for the enzymes used in reverse genetics. Further, the problem of genetic instability in bacteria can be alleviated by growing recombinant bacterial cultures at a lower temperature. This technique can be applied to clone any influenza gene segment using universal primers, which would help in the rapid generation of influenza viruses and facilitate influenza research and vaccine development. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | The method will help in the rapid generation of reverse genetic base influenza viruses and facilitate influenza research and vaccine development. |
| URL | https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01358-2 |
| Title | A male-specific cell line from a mosquito Anopheles gambiae |
| Description | A new male-specific cell line from a mosquito Anopheles gambiae has been isolated from sexed neonate larvae. To our knowledge this is the only cell line derived exclusively from male mosquitoes. |
| Type Of Material | Cell line |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The cell line will greatly facilitate studies on components of the sex determination pathway and of dosage compensation machinery in mosquitoes. There are only several cell lines derived from Anopheles gambiae available and these are female-like. Over-expression of genes involved in male sex determination or dosage compensation is detrimental to female cells, hence use of male-derived cells is necessary for such studies. The cell line will become available upon acceptance of a manuscript describing characterization of that cell line. |
| Title | A novel optimized pre-embedding antibody-labelling correlative light electron microscopy technique |
| Description | This method provides a protocol and tips for further optimisation to allow fusing of standard immunofluorescence with electron microscopy of the same cells. This is an accessible correlative light electron microscopy protocol that does not require specialised equipment or availability of biological resources expressing fluorescent proteins. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | This method has been used by others at TPI to study bRSV inclusion bodies. |
| Title | Correlative Light and Electron Microscopy (CLEM) on IBDV-infected cells |
| Description | Jenny Simpson and Pippa Hawes have developed the technique of Correlative Light and Electron Microscopy (CLEM). This technique has been used to visualise Virus Factories of IBDV. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The Virus Factories (VFs) of IBDV were thought to be paracrystalline arrays of virions in the cytoplasm. However, combining our GFP11-tagged IBDV with CLEM technology revealed that the VFs are actually proteinaceous accumulations in the cytoplasm. This has opened up a new avenue of research in terms of the ultrastructure, formation and function of the VFs. |
| Title | Detection of HA antigens of avian influenza viruses |
| Description | Assay for detection of recombinant HVT expressing HA antigens of avian influenza viruses |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This new method will help to detect recombinant HVT vaccine expressing HA antigen in infected cell. |
| Title | Developed assays for evaluation of antigen specific memory chicken T cells |
| Description | An in vitro model for generation of effector cells from memory T cells for chicken T cells were developed |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | This method will enable scientists working on poultry vaccines and immune response to pathogens to assess memory T cell responses in chickens. |
| Title | Development of CLEM techniques for RSV |
| Description | We have developed the technical expertise to perform correlative light electron microscopy on respiratory syncytial virus infected cells. This allows us to directly compare immunofluorescent images with transmission EM of the same cell. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | We have recently submitted a paper and grant building on this expertise, as well as forging new collaborations with Diamond light source. |
| Title | Development of assay for assessing antigen-specific T cell responses in chickens |
| Description | An in vitro assay were developed to generate effector memory T cells from memory T cells (cultured ELISPOT assay for chicken T cells) |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | Enables scientists to assess memory T cell responses induced by poultry vaccines |
| Title | Development of chicken NKT cell tetramer |
| Description | Tetramer for detection and quantification of chicken NKT cells are developed and tested. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | This will lead to identification of a novel chicken lymphocytes which has major role in the control of infectious diseases and tumour in chickens. |
| Title | Development of tetramers to study immune responses in pigs |
| Description | The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume. It is also an important vector in the birds to human infection cycle. A major drawback of the current pig model is the inability to analyze antigen-specific CD8+ T-cell responses, which are critical to respiratory immunity. We addressed this knowledge gap using an established in-bred pig model with a high degree of genetic identity between individuals, including the MHC (Swine Leukocyte Antigen (SLA)) locus. We developed a toolset that included long-term in vitro pig T-cell culture and cloning and identification of novel immunodominant influenza-derived T-cell epitopes. We also generated structures of the two SLA class I molecules found in these animals presenting the immunodominant epitopes. These structures allowed definition of the primary anchor points for epitopes in the SLA binding groove and established SLA binding motifs that were used to successfully predict other influenza-derived peptide sequences capable of stimulating T-cells. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Peptide-SLA tetramers were constructed and used to track influenza-specific T-cells ex vivo in blood, the lungs and draining lymph nodes. Aerosol immunization with attenuated single cycle influenza viruses (S-FLU) induced large numbers of CD8+ T-cells specific for conserved NP peptides in the respiratory tract. Collectively, these data substantially increase the utility of pigs as an effective model for studying protective local cellular immunity against respiratory pathogens. |
| Title | Ex vivo skin model |
| Description | An in vitro model of bovine skin has been developed, designed to allow feeding of dipteran species. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | This has already reduced the number of procedures carried out on cattle in our studies by providing an alternative to insects feeding on cattle. |
| Title | Fluorescence Recovery after Photobleaching (FRAP) of infectious bursal disease virus (IBDV) replication factories |
| Description | Fluorescence Recovery after Photobleaching (FRAP) of infectious bursal disease virus (IBDV) replication factories. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | We have used this technology to determine that IBDV replication factories display qualities of liquid-liquid phase separation |
| Title | Fluorescence activated single cell sorting to isolate gene-deleted/modified African swine fever virus |
| Description | A method was developed to use fluoresecence activated single cell sorting to isolate recombinant gene-deleted ASFV using insertion of fluorescence protein genes under control of African swine fever virus promoters as reporter to isolate cells infected with recombinant viruses. This method was used to generate 15 different single and multiple gene-deleted ASFV and study the impact of the gene deletions on virus replication and host responses and develop candidate live attenuated vaccines. This method has been further refined by splitting the fluorescent protein gene such that two genes can be deleted at the same time. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Development of candidate gene-deleted live attenuated African swine fever virus vaccines |
| URL | https://doi.org/10.3390/v12060615 |
| Title | Generation of cell-free virus using feather follicle stem cells |
| Description | An in vitro model for generation and purification of cell-free virus using feather follicule stem cells |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | Cell lines could be used to generate cell free vaccines against Marek's disease virus |
| Title | Generation of monocyte-derived dendritic cells and analyses of their infection by foot-and-mouth disease virus |
| Description | CD14+ cells were selected. Day 4 monocyte-derived dendritic cells (moDC) were generated by positive selection using CD14 magnetic beads and LS columns, followed by differentiation by culturing in the presence of IL-4 and GM-CSF. Both non-cell culture adapted and cell culture adapted FMDV were used in this study. Immuno-fluorescence microscopy (IFM) was used to investigate internalisation of FMDV and immune complexed (IC) FMDV at 1-6 hours post infection (hpi) and also to investigate the uptake pathways utilised by non-cell culture and cell culture adapted FMDV in the presence of different pharmacological inhibitors. Western blot, IFM and quantitative RT-PCR was used to analyse viral replication at 0-6, 8, 16 and 24 hpi. Plaque assays were used to investigate the yields of live virus produced in moDC at 0, 4, 8 and 24 hpi. Flow cytometry was used to investigate the changes in IL-12 and IL-10 secretion following FMDV infection at 2, 4 and 6 hpi. MxCAT ELISA was used to investigate the secretion of IFN at different times post infection. |
| Type Of Material | Cell line |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | These methods were used to generate MODC and characterise their interaction with FMDV. They are currently being incorporated into a manuscript for peer review and provide a workflow to analyse FMDV infections of other dendritic cell types. |
| Title | Method to evenly load flowcells with multiple samples |
| Description | Pirbright has an Illumina NextSeq sequencing machine installed in containment. Given the large amount of sequencing reads produced by each run, multiple samples are usually multiplexed on the same flowcell. However, determining the correct concentrations needed to obtain the same amount of reads for each sample is a hard problem, and usually requires a number of expensive and material-consuming kits to be run prior to sequencing. We have developed a method that allows samples to be evenly multiplexed based only on Bioanalyzer data (we routinely run Bioanalyser on the samples anyway as a form of quality control). The method works well, and reliably across a wide range of sample concentrations and sequenced organisms. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The method greatly increased the quality of our output, and drastically simplified our workflow by eliminating the external quantification steps that were previously required. |
| Title | Microbiopsy method |
| Description | We have optimised a technique for cutaneous skin biopsy of cattle. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The microbiopsy technique is less invasive and less painful than the traditional biopsy technique |
| Title | NGS for PPR virus whole genome sequencing |
| Description | We have finalised a protocol to sequence the whole genome of PPR virus |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The method has been described and shard with project partners and a draft has been written for publishing the methods |
| Title | Recombinant antibody generation pipeline - WM |
| Description | Validated a sequencing protocol at Pirbright for mouse hybridomas, cattle heterohybridomas, and porcine B cells. Vector constructed for humans, mouse, cattle, pigs and chicken to allow ligation of commercially generated antibody gene blocks or PCR products generated by degenerate or 5' RACE PCR. These methods allow the following: • Sequencing mAbs • Making Fab fragments from mAbs • Class switching mAbs • Species switching mAbs |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The methods developed have enabled a standardised pipeline that allows cloning of PCR products or synthetic gene constructs for recombinant antibody generation from various species. This uniform approach avoids development of bespoke protocols for each species thus saving time and resources. |
| URL | http://www.immunologicaltoolbox.co.uk |
| Title | method for identification of lung Tissue resident memory cells in pigs |
| Description | Recent overwhelming evidence indicates the importance of local tissue-resident memory T cells (TRM) in protective immunity. Most work on TRM has been performed in mice and the TRM defined as inaccessible to intravenously administered anti-T cell antibody. However there are very few data on TRM in large animals. For the first time we have defined TRM in the pig influenza model. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The identification of TRM and their robust protective capacity in site-specific infection has provided a new paradigm by which to assess T cell-mediated responses and an important new target for vaccine design. Since swine are an economically important species, are used as a large animal model for human infection and play a key role in the emergence of novel and potentially zoonotic influenza viruses, the identification of TRM in pigs will allow us to study their role in immunity to swine influenza.and how best to induce them by immunisation. |
| Title | porcine TOCs |
| Description | We have developed the method of preparing and infecting tracheal organ cultures (TOCs) from pigs with porcine coronaviruses. |
| Type Of Material | Cell line |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | The development of the porcine TOCs will allow us to study the replication, tropism and evolution of porcine coronaviruses in biologically relevant tissues, without the requirement for an in vivo study. Porcine coronaviruses can be used as a model for SARS-CoV-2 infection of humans. |
| Title | scRNA seq analysis of porcine BAL |
| Description | We describe for the first time scRNA-seq analysis of porcine bronchoalveolar lavage (BAL), a cell source increasingly used to analyse respiratory immune responses, and which has been shown to be major correlate for protection against respiratory infections such as influenza, respiratory syncytial virus, and SARS-CoV-2. Our work reveals both similar and unique cell subsets and divergent transcriptome profiles of BAL immune cells compared to publicly available data from blood cells. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | The data we have generated will provide an atlas for future pig BAL scRNA-seq studies. |
| Title | AI-Powered Tool for Automatically Identifying Environmental Risk Factors of African Swine Fever |
| Description | Provides a method for users to interrogate the scientific literature using large language models with African swine fever and the environment as the subject |
| Type Of Material | Data analysis technique |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | None as yet. Ongoing discussions with stakeholders to see if this could be developed further |
| Title | Additional file 7 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 7: Data S1. Full data set of collected Culicoides including site, trap location, collection date and morphological identification |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Emergence_dynamics_of_adul... |
| Title | Additional file 7 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 7: Data S1. Full data set of collected Culicoides including site, trap location, collection date and morphological identification |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Emergence_dynamics_of_adul... |
| Title | Capsid-Specific Antibody Responses of Domestic Pigs Immunized with Low-Virulent African swine fever virus |
| Description | Excel file contains the raw data (P/N ratios) and results of statistical analyses that were used to plot the figures outlined in the publication Tng et al. Capsid-Specific Antibody Responses of Domestic Pigs Immunized with Low-Virulent African swine fever virus.Graphs were produced with GraphPad Prism v.9 and statistical analysis was performed with GraphPad Prism v.9. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://figshare.com/articles/dataset/Capsid-Specific_Antibody_Responses_of_Domestic_Pigs_Immunized_... |
| Title | Capsid-Specific Antibody Responses of Domestic Pigs Immunized with Low-Virulent African swine fever virus |
| Description | Excel file contains the raw data (P/N ratios) and results of statistical analyses that were used to plot the figures outlined in the publication Tng et al. Capsid-Specific Antibody Responses of Domestic Pigs Immunized with Low-Virulent African swine fever virus.Graphs were produced with GraphPad Prism v.9 and statistical analysis was performed with GraphPad Prism v.9. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://figshare.com/articles/dataset/Capsid-Specific_Antibody_Responses_of_Domestic_Pigs_Immunized_... |
| Title | Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
| Description | Raw data for manuscript. Contains temperature, clinical scores, qPCR, blood cell numbers and immune responses over time for two groups of pigs immunised with low virulent African swine fever virus and challenged with highly virulent virus. Data for each panel or figure is displayed on a separate worksheet in the file. The readme worksheet contains a brief description of each figure. The majority of data is displayed in an XY table format, with the number of days post immunisation with low virulent virus indicated. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://zenodo.org/record/6794941 |
| Title | Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
| Description | Raw data for manuscript. Contains temperature, clinical scores, qPCR, blood cell numbers and immune responses over time for two groups of pigs immunised with low virulent African swine fever virus and challenged with highly virulent virus. Data for each panel or figure is displayed on a separate worksheet in the file. The readme worksheet contains a brief description of each figure. The majority of data is displayed in an XY table format, with the number of days post immunisation with low virulent virus indicated. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | None as yet |
| URL | https://zenodo.org/record/6794942 |
| Title | Data S1 from Quantifying the relationship between within-host dynamics and transmission for viral diseases of livestock |
| Description | Data on virus isolation and challenge outcome from a series of one-to-one transmission experiments for foot-and-mouth disease virus in cattle |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| URL | https://rs.figshare.com/articles/dataset/Data_S1_from_Quantifying_the_relationship_between_within-ho... |
| Title | Data S2 from Quantifying the relationship between within-host dynamics and transmission for viral diseases of livestock |
| Description | Data on virus isolation and challenge outcome from a series of one-to-one transmission experiments for swine influenza virus in pigs |
| Type Of Material | Database/Collection of data |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| URL | https://rs.figshare.com/articles/dataset/Data_S2_from_Quantifying_the_relationship_between_within-ho... |
| Title | Data from: The history of foot-and-mouth disease virus serotype C: the first known extinct serotype? |
| Description | Foot-and-mouth disease (FMD) is a highly contagious animal disease caused by an RNA virus subdivided into seven serotypes that are unevenly distributed in Asia, Africa and South America. Despite the challenges of controlling FMD, since 1996 there have been only two outbreaks attributed to serotype C, in Brazil and in Kenya, in 2004. This review describes the historical distribution and origins of serotype C and its disappearance. The serotype was first described in Europe in the 1920s, where it mainly affected pigs and cattle but as a less common cause of outbreaks than serotypes O and A. No serotype C outbreaks have been reported in Europe since vaccination stopped in 1990. FMD virus is presumed to have been introduced into South America from Europe in the 19th century, although whether serotype C evolved there or in Europe is not known. As in Europe, this serotype was less widely distributed and caused fewer outbreaks than serotypes O and A. Since 1994, serotype C had not been reported from South America until four small outbreaks were detected in the Amazon region in 2004. Elsewhere, serotype C was introduced to Asia, in the 1950s to the 1970s, persisting and evolving for several decades in the Indian subcontinent and for eighteen years in the Philippines. Serotype C virus also circulated in East Africa between 1957 and 2004. Many serotype C viruses from European and Kenyan outbreaks were closely related to vaccine strains, including the most recently recovered Kenyan isolate from 2004. International surveillance has not confirmed any serotype C cases, worldwide, for over 15 years, despite more than 2000 clinical submissions per year to reference laboratories. Serology provides limited evidence for absence of this serotype, as unequivocal interpretation is hampered by incomplete intra-serotype specificity of immunoassays and the continued use of this serotype in vaccines. It is recommended to continue strengthening surveillance in regions of FMD endemicity, to stop vaccination against serotype C and to reduce working with the virus in laboratories, since inadvertent escape of virus during such activities is now the biggest risk for its reappearance in the field. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | N/A |
| URL | http://datadryad.org/stash/dataset/doi:10.5061/dryad.v6wwpzgv6 |
| Title | FDA drug screening of RSV and SARS-CoV-2 cell-cell fusion |
| Description | Using inducible cell-cell fusion assays for SARS-CoV-2 and RSV we have screened the FDA approved use drug library for inhibitors of these viral-induced processes |
| Type Of Material | Data analysis technique |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | No impact as yet, data still being validated in live virus assays |
| Title | FMDV sequence database (FMDbase) |
| Description | Pirbright has recently developed a database (FMDbase) for FMDV sequences that is open-access and available to FMD researchers. The database uses MySQL (using a MariaDB relational database) and currently includes >15,000 records which have been annotated by an FMDV expert. The database current adopts a Drupal platform front-end to allow users to filter, search and retrieve FMDV sequences (in FASTA or .csv format). We anticipate that the database will provide a foundation for the further development of phylogenetic and epidemiological modules |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Pirbright is working in partnership with EuFMD to develop dynamic dashboards to display FMD data. Current tools on the OIE/FAO FMD Laboratory Network website (https://foot-and-mouth.org/) are static in nature and the aim is to provide tools that will allow our international partners (such as researchers, disease control and risk assessment managers) to use the available data to tailor outputs to more closely meet their requirements. In order to better understand the priorities for these tools, we have circulated a survey to request feedback from the likely users of such a system. We have recently established a collaboration with Epi-interactive in New Zealand (https://www.epi-interactive.com/) to develop an FMDV genotyping model that will allow external users to prepare customised phylogenetic trees and reports. It is planned that the new system will be ready for demonstration in March 2022. |
| URL | https://www.fmdbase.org/ |
| Description | AI-Powered Tool for Automatically Identifying Environmental Risk Factors of African Swine Fever |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided expertise on African swine fever and helped test final product |
| Collaborator Contribution | Developed tool |
| Impact | Details available here https://doi.org/10.17605/OSF.IO/M7JPW I provided virology expertise. Expertise in AI and large language models provided by Surrey. |
| Start Year | 2023 |
| Description | ASFV Structure |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have prepared samples for analysis |
| Collaborator Contribution | Electron tomographic analysis of the samples we provided. |
| Impact | None as yet. |
| Start Year | 2019 |
| Description | Aerosol delivery of vaccines and therapeutics |
| Organisation | Aerogen |
| Country | Ireland |
| Sector | Private |
| PI Contribution | Developed the pig influenza model which is a natural host pathogen system |
| Collaborator Contribution | Provided expertise and equipment for aerosol delivery |
| Impact | Successfully delivered vaccines by aerosol |
| Start Year | 2015 |
| Description | Anihwa Call 1 |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | 1. Conducted challenge experiments in goats to study pathogenicity. 2. Developed NGS technology to sequence PPR whole genome. |
| Collaborator Contribution | FLI has conducted transmission study between different species ( Goats, pig, camel). For the first time they showed that pigs are clinically infected by PPR virus. |
| Impact | Joint Publications |
| Start Year | 2013 |
| Description | Assembly of DNA virus (tegumentation of HSV) |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Use of advanced microscopes to investigate tegumentation of HSV |
| Collaborator Contribution | Molecular biology skills and reagents for investigating tegumentation of HSV |
| Impact | Joint Pirbright-Surrey PhD studentship Joint MRC grant applications |
| Start Year | 2018 |
| Description | Assessment of the effect of IL-1beta on the induction of protective mucosal immunity to influenza |
| Organisation | University Hospital Erlangen |
| Country | Germany |
| Sector | Hospitals |
| PI Contribution | We have provided the pig influenza model and the tools we have developed to test local mucosal immunity and protection against heterologous viruses. |
| Collaborator Contribution | The team of Professor Tenbusch provided the Adeno viral vectored constructs expressing Il-1beta and the influenza hemagglutinin and nucleoprotein. |
| Impact | We have shown that IL-1B increased the mucosal antibody responses. |
| Start Year | 2021 |
| Description | BBSRC - Oxford University iCASE Studentship (October 2019- September 2023). Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration between The Pirbright Institute (UK), Oxford University (UK) and industrial partners in Italy. This project will conceived and developed bu MI. The PhD student (Holly Everest) in my group is investigating the antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production. |
| Collaborator Contribution | The partners in Italy will produce and purify natural antiviral molecules effective against avian influenza and other poultry viruses. |
| Impact | This project started in January 2020. |
| Start Year | 2020 |
| Description | BBSRC LINK Project |
| Organisation | University of Plymouth |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Confirm susceptibility of porcine macrophage cell line to African swine fever virus |
| Collaborator Contribution | Provide a conditionally transformed porcine macrophage cell line for research and diagnosis of African swine fever virus |
| Impact | None yet |
| Start Year | 2019 |
| Description | BBSRC-UC Davis workshop, 16-18 October |
| Organisation | University of California, Davis |
| Department | UC Davis College of Biological Sciences |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities. |
| Collaborator Contribution | Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities. |
| Impact | Discussion of potential joint publications and grant applications; no tangible impacts yet. |
| Start Year | 2017 |
| Description | BBSRC-UC Davis workshop, 16-18 October |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities. |
| Collaborator Contribution | Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities. |
| Impact | Discussion of potential joint publications and grant applications; no tangible impacts yet. |
| Start Year | 2017 |
| Description | BSL4ZNet |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Centers for Disease Control and Prevention (CDC) |
| Country | United States |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Commonwealth Scientific and Industrial Research Organisation |
| Country | Australia |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Department of National Defence |
| Country | Canada |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Global Affairs Canada |
| Country | Canada |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | National Centre for Foreign Animal Diseases (NCFAD) |
| Country | Canada |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Public Health Agency of Canada |
| Department | National Microbiology Laboratory (NML) |
| Country | Canada |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | Robert Koch-Institut |
| Country | Germany |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Agricultural Research Service |
| Country | United States |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Animal and Plant Health Inspection Service |
| Country | United States |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | UK Health Security Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | BSL4ZNet |
| Organisation | United States Department of Homeland Security (DHS) |
| Country | United States |
| Sector | Public |
| PI Contribution | BSL4ZNet is a consortium of high containment organisations in UK, Canada, Germany, Australia and USA, subsidised by the Government of Canada. It seeks to establish cooperation, joint action and communities of practice across science (eg emerging pathogens), training, international response (to disease incursion), institutional cooperation (eg, biorisk community of practice) and working groups (eg, on inactivation). Pirbright is actively engaged in all areas. BSL4ZNet organise a 5-day international online conference every 2 years. At the September 2024 conference, Andrew White (Director of Risk & Assurance) chaired a 1-day session, and Pirbright provided 3 presentations across the conference. AW is on the BSL4ZNet Steering Committee. |
| Collaborator Contribution | CFIA provide basic funding, governance and administration of BSL4ZNet. All partners contribute to varying extents across the range of activities and workstreams. For example, AW coordinates a biorisk community of practice in conjunction with the Director of the USDA National Bio and Agro-Defense Facility, which holds regular online workshops and seminars. |
| Impact | International conferences every 2 years - where Pirbright chairs sessions and provides presentations. Range of cooperation, joint action and communities of practice which Pirbright contributes to and gains from across science, training, international response, institutional cooperation and various working groups. BSL4ZNet has five working groups: Institutional Cooperation (AW is Pirbright rep), International Response (Carrie Batten, Head of NVRL, is Pirbright rep), Scientific Excellence (Prof John Hammond is Pirbright rep), Science Communication (Heath Jefferies, Head of Comms & Engagement, is Pirbright rep), and Education & Training (Sarah Gold, Deputy BSO, is Pirbright rep). The Institutional Cooperation Working Group includes a 'Lab Directors Circle' for High Containment Lab Directors, an 'MTA Task Force' to develop MTAs (Material Transfer Agreements) to enable rapid exchange of materials in outbreak emergencies (Lizelle Gouverneur, Head of Business Development is Pirbright rep), and 'Communities of Practice' (COP) for sharing of best practice and new developments. The COPs are biosafety & biosecurity (which AW is leading, with Graeme Harkess as Pirbright rep), biocontainment facilities & engineering (Andrian Harsono and Jason Tearle, Biorisk Technical Lead are Pirbright reps), inactivation (GH is Pirbright rep) and 'Risk Group 4 Pathogens' (JH is Pirbright rep). |
| Start Year | 2022 |
| Description | Belsham |
| Organisation | Technical University of Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Collaborator Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Impact | Joint PhD studentship Further funding |
| Start Year | 2016 |
| Description | Belsham |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Collaborator Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Impact | Joint PhD studentship Further funding |
| Start Year | 2016 |
| Description | Bioimaging collaboration with Dr. Daniel Clare, Dr. James Gilchrist, Dr. Pippa Hawes - cryo-electron tomography Diamond Light Source |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of preliminary data on inclusion body structure to support higher resolution approaches. |
| Collaborator Contribution | Discussion of project and experimental design, technological approaches and limitations. |
| Impact | No outputs to date. Multi-disciplinary team of virologists and structural biologists |
| Start Year | 2020 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | Boehringer Ingelheim |
| Department | Animal Health |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | National Institute for Biological Standards and Control (NIBSC) |
| Country | United Kingdom |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | Royal Society of Biology (RSB) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Professional Registration Scheme (BPRS) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | These members of the Biorisk Strategic Leadership Group (BSLG) [see separate entry] have collaborated to develop and launch a new professional accreditation framework for biorisk practitioners ('BSO's), to enhance the professional status, credibiity and standards of BSOs, to provide a career pathway for BSOs to attract scientists into this role, to provide a benchmark for duty holders when recruiting, and to ensure BSOs have the required blend of technical knowhow and wider skills so they can effectively empower safe science. |
| Collaborator Contribution | Royal Society of Biology are key, as they host / administer several other such schemes and provide not only the required governance, but also as an incorporated body with a royal charter, the professional credibility. The other partner organisations provide the expertise to develop and to govern the scheme, and also contributions to a startup fund. |
| Impact | Development of the scheme was finalised 2022-23, and the scheme launched 2024. Partners are working to implement the scheme, and to promote and communicate the scheme across the sector. |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | Boehringer Ingelheim |
| Department | Animal Health |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | Health and Safety Executive (HSE) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | NHS England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | National Institute for Biological Standards and Control (NIBSC) |
| Country | United Kingdom |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | Royal Society of Biology (RSB) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | UK Health Security Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | Biorisk Strategic Leadership Group (BSLG) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | HSE asked Pirbright to set up and to coordinate a consortium of leading bio containment labs, holding regular establish meetings to exchange best practice, benchmarking data and learning from experience, and developing substantive workstreams. I chair BSLG, and in that role organise the meetings and also specialist workshops, drive forward the workstreams, and represent the group across a variety of settings. Group has become well established and productive, and includes APHA, UKHSA, Dstl, MHRA, Crick Institute, CVR, Unis of Cambs, Oxon, L'pool and Imperial, Boehringer, Biobest, Labcorp, NHS England, RSB, HSE, and has achieved significant tangible outputs such as the Biorisk Professional Registration Scheme (BPRS), and has established specialist subgroups in areas such as CL4 users, containment engineering and human factors. |
| Collaborator Contribution | All BSLG members actively contribute by attending meetings, giving presentations, engaging in debates, input to preparation of best practice briefs, supporting specialist technical workshops, involvement in specialist subgroups, and contribution to the workstreams such as the BPRS. |
| Impact | 2-3 meetings + technical workshops annually The Biorisk Professional Registration Scheme (BRPS) CL4 User Group, Containment Engineering Group, Human Factors Group Various briefing notes from technical workshops / benchmarking data reports Links established with other Major Hazard Groups such as Process Safety Forum, COMAH Strategic Forum |
| Start Year | 2022 |
| Description | CUI at King's College London |
| Organisation | King's College London |
| Department | Centre for Ultrastructural Imaging |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint PhD student based at King's |
| Collaborator Contribution | Primary supervisor is at King's |
| Impact | Student has attended Imaging meetings in Ireland and UK and has given a talk and submitted two posters. |
| Start Year | 2022 |
| Description | CVR |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Pirbright has several groups investigating various aspects of vector-borne diseases. My group provides mosquito expertise, including gene editing, genetics and transgenesis. CVR have expert arbovirologists with complementary interests. We have developed and exchanged research materials and reagents, shared expertise, and have shared grant funding. |
| Collaborator Contribution | Pirbright has several groups investigating various aspects of vector-borne diseases. My group provides mosquito expertise, including gene editing, genetics and transgenesis. CVR have expert arbovirologists with complementary interests. We have developed and exchanged research materials and reagents, shared expertise, and have shared grant funding. |
| Impact | Joint grant. Several ongoing research strands within this. |
| Start Year | 2021 |
| Description | Characterisation of ASFV isolates |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Full genome sequencing of uncharacterised ASFV isolates |
| Collaborator Contribution | Biological characterisation of ASFV isolates |
| Impact | Non as yet. |
| Start Year | 2020 |
| Description | Chicken Microbiome - Robert La Ragione - University of Surrey |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing sequencing data of gut microbiome from chickens infected with avian influenza viruses. |
| Collaborator Contribution | Sharing expertise in the analysis of microbiome data |
| Impact | Joint manuscripts and funding opportunities are being explored |
| Start Year | 2019 |
| Description | Close collaboratiron has been initiated with Bharat Biotech, Hyderabad and Biovet, Bangalore |
| Organisation | Bharat Biotech International |
| Country | India |
| Sector | Private |
| PI Contribution | Bharat Biotech through Biovet has recently negociating with the Institute to have the DIVA vaccines for commercialisation |
| Collaborator Contribution | Bharat Biotech through Biovet has recently negociating with the Institute to have the DIVA vaccines for commercialisation |
| Impact | Multidisciplinary |
| Start Year | 2019 |
| Description | Collaboration in epidemiology with Royal Veterinary College |
| Organisation | Royal Veterinary College (RVC) |
| Department | Veterinary Epidemiology and Public Health Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data and expertise on diseases worked on at The Pirbright Institute; complementary expertise in epidemiology (e.g. modelling, molecular epidemiology) |
| Collaborator Contribution | Complementary expertise in epidemiology (e.g. field studies, economics, social sciences); access to students |
| Impact | 2020: Four MSc projects were carried out in summer 2020, all students passed their vivas. Two projects were written up for conference proceedings (EuFMD, SVEPM). Three joint RVC-Pirbright PhD projects were submitted for funding. |
| Start Year | 2019 |
| Description | Collaboration on replication of mumps virus in cells |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input so far, training research assistant to prepare samples, imaging samples in transmission electron microscopes |
| Collaborator Contribution | Preliminary confocal microscopy to optimize sample conditions. Preparation of samples for EM. |
| Impact | No outcomes yet |
| Start Year | 2018 |
| Description | Collaboration on replication of mumps virus in cells |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input so far, training research assistant to prepare samples, imaging samples in transmission electron microscopes |
| Collaborator Contribution | Preliminary confocal microscopy to optimize sample conditions. Preparation of samples for EM. |
| Impact | No outcomes yet |
| Start Year | 2018 |
| Description | Collaboration with Bauchi State Veterinary Services, Nigeria |
| Organisation | Bauchi State University |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | We have provided expertise on sheeppox, goatpox and lumpy skin disease virus diagnosis and epidemiology |
| Collaborator Contribution | Our collaborators in Bauchi State have provided virus samples and epidemiological data |
| Impact | Preliminary data was used to support successful funding via a BBSRC Impact Accelerator Award, and a Pathways to Impact project in BBSRC project BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines" |
| Start Year | 2016 |
| Description | Collaboration with John Innes Center (UK) on BTV VLP production |
| Organisation | John Innes Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | None yet. |
| Collaborator Contribution | Collaborators at the JIC (GL group) are producing Bluetongue virus-like particles (in-king contribution) for us to analyse the B cell response post BTV vaccination in cattle. |
| Impact | None yet. |
| Start Year | 2024 |
| Description | Collaboration with SpyBiotech |
| Organisation | SpyBiotech Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have established a powerful pig model to assess efficacy of vaccines against coronavirus infections. |
| Collaborator Contribution | We have tested vaccines provided by SpyBiotech inducing either a strong antibody or T cell immune responses |
| Impact | not yet |
| Start Year | 2023 |
| Description | Collaboration with St George's Hospital, University of London |
| Organisation | St George's University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Molecular virology expertise, funding and high containment facilities |
| Collaborator Contribution | Molecular biology expertise, particularly in the interferon response, and provision of some reagents |
| Impact | Paper: J Virol. 2020 Dec 16:JVI.01136-20. |
| Start Year | 2015 |
| Description | Collaboration with State Central Veterinary Laboratory, Mongolia |
| Organisation | State Central Veterinary Laboratory |
| Country | Mongolia |
| Sector | Public |
| PI Contribution | We provided tools, techniques and expertise on sheeppox and goatpox |
| Collaborator Contribution | Our colleagues provided data and field samples |
| Impact | A workshop was held in Pirbright in March 2017, and a return workshop in Ulaanbaatar in July 2017. Preliminary data supported successful grant applications for an Impact Accelerator Award, and a Pathways to Impact project in BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines". |
| Start Year | 2016 |
| Description | Collaboration with University of Cambridge |
| Organisation | University of Cambridge |
| Department | Virology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments with SARS-CoV-2 to investigate the host response to infection in vitro. |
| Collaborator Contribution | Our partners have led the research and we have published a paper detailing the results. |
| Impact | Information on the host responses to SARS-CoV-2 infection in vitro. Echavarría-Consuegra L, Cook GM, Busnadiego I, Lefèvre C, Keep S, Brown K, Doyle N, Dowgier G, Franaszek K, Moore NA, Siddell SG, Bickerton E, Hale BG, Firth AE, Brierley I, Irigoyen N. Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection. PLoS Pathog. 2021 Jun 17;17(6):e1009644. doi: 10.1371/journal.ppat.1009644. PMID: 34138976; PMCID: PMC8211288. |
| Start Year | 2020 |
| Description | Collaboration with University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed in vitro experiments with infectious bronchitis virus, contributed to data analysis, preparation of manuscripts and discussed further funding opportunities. |
| Collaborator Contribution | Our partners have analysed viral transcription and translation, and host gene expression after infection of host cells with infectious bronchitis virus, prepared manuscripts and discussed further funding opportunities. |
| Impact | Dinan, A., Keep, S., Bickerton, E., Britton, P., Firth, A. and Brierley, I. (2019) Comparative analysis of gene expression in virulent and attenuated strains of infectious bronchitis virus at sub-codon resolution. J. Virol. 93(18) e00714-19. PhD studentship funding from The Pirbright Institute "Investigation of Canonical and Noncanonical Transcription during Coronavirus Replication" which commenced in 2021. |
| Start Year | 2012 |
| Description | Collaboration with University of Copenhagen CFIM on cell biology of virus-host interactions |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input into virus projects which come in to the microscopy core facility at the University. Limited practical work and training given to researchers there. Includes lecturing/organisation of MSc and PhD courses at Copenhagen. PH awarded Visiting Professorship. |
| Collaborator Contribution | Research projects are presented to the core facility, I advise on the best route for achieving the data required and those researchers complete preliminary data following my advice. Collaborators are then able to produce the best possible samples for further advanced microscopy as necessary. |
| Impact | No tangible outcomes yet as we are in early stages. This is multi-disciplinary as projects can come from several University departments (medical, pathology, cell biology, veterinary, food), and other Universities in Denmark (DTU). University awarded Visiting Professorship |
| Start Year | 2018 |
| Description | Collaborative PhD studentship on the mechanisms and importance of BTV co-infections on viral reassortment and diversity |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise on BTV infections of relevant host and vector cells, carrying out synchronous and asynchronous BTV co-infection between multiple strains, identification of superinfection exclusion, assay development for BTV strain specific detection, NGS sequencing |
| Collaborator Contribution | Expertise on analysis of large data sets especially bioinformatic analysis of NGS sequence data and identification of reassortment, application of advanced mathematical analysis |
| Impact | Shared supervision of a PhD candidate, regular team meetings, training and development of a PhD candidate across both organizations, inter-disciplinary exchange between virology, genetics, molecular diagnostics, NGS sequencing and bioinformatics, mathematical modelling |
| Start Year | 2021 |
| Description | Collaborative doctoral project on viral and insect factors influencing BTV replication in Culicoides vector insects |
| Organisation | Friedrich Loeffler Institute |
| Department | Institute of Infectology |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | This is a shared doctoral project funded by the German partner where the student has spend significant time in our lab from August 2019- November 2020. The student has carried out her first initial part of the project (16 months) at FLI in Germany and during this time came for a 2 weeks visit in 2018 to our lab where we provided training on Culicoides biting midge biology, virus titration and handling, virus infection of insects and molecular diagnostics. During her time in our lab she managed to complete all planned insect vector BTV infection studies and generated some interesting results which will be published in the near future. The student returned to FLI for 01.12.2020 and will now complete writing her thesis for a DVM while we jointly work towards publishing of obtained results. |
| Collaborator Contribution | The main project (student salary, some consumables, travel) is funded by the German partner while we contribute costs to the consumable budget for the work carried out in our lab. We will share data obtained at either side and publish results together accordingly |
| Impact | This partnership is still ongoing. Each partner contributes their unique expertise (Virology, insect biology, next-generation sequencing and bioinformatics), the student carried out her placement at The Pirbright Institute from August 2019 to November 2020 |
| Start Year | 2017 |
| Description | Collaborative project between The Pirbright Institute, UK and Kasetsart University, Thailand |
| Organisation | Kasetsart University |
| Country | Thailand |
| Sector | Academic/University |
| PI Contribution | Hosting student from Kasetsart university for 6 months and providing expertise in recombinant FMDV technology and high containment SAPO4 facilities |
| Collaborator Contribution | Financial support for student and co-authorship on future publication. |
| Impact | The project involves the use of reverse genetics to generate recombinant foot-and-mouth disease viruses with improved cell culture adaptation properties. |
| Start Year | 2019 |
| Description | Collaborative project on identification of volatile organic chemicals in the body odour of sheep and cattle following bluetongue virus infection |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in bluetongue virus infection of cattle and sheep and in-vivo animal infection studies plus Virology, Immunology and Entomology expertise especially for Culicoides -borne viruses, exploration of diagnostic methodologies to detect viral infections |
| Collaborator Contribution | Expertise in chemical ecology, identification of volatile organic chemicals released in the body odour of mammals, exploration of diagnostic application of VOC changes in response to infections |
| Impact | Successful application for external funding, project has now started as a collaborative BBSRC grant in 2021. This collaboration combines key disciplines of virology, veterinary medicine with chemical ecology and engineering. |
| Start Year | 2020 |
| Description | Collaborative studentship PPRV |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Practical laboratory work and in vivo animal studies carried out |
| Collaborator Contribution | Intellectual input in scientific remit of studentship, training of student, use of facilities and lab |
| Impact | DOI: 10.1128/JVI.01471-18 Thesis: The immune response to live, attenuated peste des petits ruminants virus vaccines |
| Start Year | 2014 |
| Description | Collaborative studentship between The Pirbright Institute and Friedrich Loeffler Institute |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | The 3.5 year studentship is based at The Pirbright Institute with a 6-12 month period of research at FLI. |
| Collaborator Contribution | FLI will provide access to their extensive collection of mammalian cell lines. |
| Impact | Title: Functional characterisation of foot-and-mouth virus replication in mammalian cell lines. The project will investigate FMDV infection in different wild type and gene-edited mammalian cell lines, and will determine the effects that host proteins such as type1 IFN have on virus replication. |
| Start Year | 2018 |
| Description | Consultancy support for decommissioning and decontamination of US DHS Plum Island Animal Disease Center |
| Organisation | Metrica |
| Country | United States |
| Sector | Private |
| PI Contribution | Dr Jason Tearle, Pirbright Biosafety Technical Lead, led the decommissioning and decontamination of the previous Institute high containment facilities when the new BBSRC National Virology Centre (Plowright Building) became operational in 2015. Dr Tearle has been contracted to provide advice and support to DHS on the decommissioning and decontamination of the aged and obsolete Plum Island Animal Disease Center, Long Island New York, once the replacement USDA National Bio and Agro-Defense Facility (NBAF) Kansas is fully operational and PIADC closes in 2025. |
| Collaborator Contribution | This is primarily Pirbright assisting DHS, but it serves to reinforce collaborative bonds between high containment facilities in UK and US developed through other channels such as BSL4ZNet. |
| Impact | Collaboration is just starting, but should cement Pirbright / BBSRC as a technical centre of technical excellence in biorisk high containment. |
| Start Year | 2025 |
| Description | Consultancy support for decommissioning and decontamination of US DHS Plum Island Animal Disease Center |
| Organisation | United States Department of Homeland Security (DHS) |
| Country | United States |
| Sector | Public |
| PI Contribution | Dr Jason Tearle, Pirbright Biosafety Technical Lead, led the decommissioning and decontamination of the previous Institute high containment facilities when the new BBSRC National Virology Centre (Plowright Building) became operational in 2015. Dr Tearle has been contracted to provide advice and support to DHS on the decommissioning and decontamination of the aged and obsolete Plum Island Animal Disease Center, Long Island New York, once the replacement USDA National Bio and Agro-Defense Facility (NBAF) Kansas is fully operational and PIADC closes in 2025. |
| Collaborator Contribution | This is primarily Pirbright assisting DHS, but it serves to reinforce collaborative bonds between high containment facilities in UK and US developed through other channels such as BSL4ZNet. |
| Impact | Collaboration is just starting, but should cement Pirbright / BBSRC as a technical centre of technical excellence in biorisk high containment. |
| Start Year | 2025 |
| Description | DSTL collaboration with Steve Lever and Diane Williamson |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Discussion of experimental design for Nipah virus animal model establishment at DSTL |
| Collaborator Contribution | Discussion of experimental design for Nipah virus animal model establishment at DSTL |
| Impact | No outputs to date |
| Start Year | 2019 |
| Description | Developing biosafety training for Human Containment Level 3 with VIDO |
| Organisation | University of Saskatchewan |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | VIDO (Vaccine and Infectious Disease Organization) at the University of Saskatchewan Canada is a centre for infectious disease research and vaccine development for humans and animals. Pirbright biorisk experts are working with VIDO colleagues to develop training for workers at human containment level 3. |
| Collaborator Contribution | This is a joint effort between VIDO and Pirbright. |
| Impact | Ongoing development of training. Mutual exchange visits to share best practice and identify and foster wider collaborative links. |
| Start Year | 2022 |
| Description | Development of a bivalent PRRS/Nipah virus vaccine |
| Organisation | National Center for Genetic Engineering and Biotechnology (BIOTEC) |
| Country | Thailand |
| Sector | Public |
| PI Contribution | Expertise in PRRSV and Nipah virus vaccine research |
| Collaborator Contribution | Expertise in genetically engineering PRRSV |
| Impact | Too early. |
| Start Year | 2020 |
| Description | Development of tetramers in the Babraham pig model |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developed the aerosol delivery method of vaccine and provided material (spleen, BAL and blood) from inbred animals (Babraham pigs) following immunisation with the candidate universal vaccine, S-FLU. |
| Collaborator Contribution | Developed porcine influenza specific class I tetramers and provided the epitope map of Babrahams S-Flu responses to NP, M1, M2, PB1 and PB2 that could be presented by SLA-1 or SLA-2 Grew pig T cell clones for the first time in 30 years. |
| Impact | Multidisciplinary - immunology, virology, protein chemistry. Paper not yet published |
| Start Year | 2014 |
| Description | Dr Carol Cardona, University of Minnesota- avian influenza virus challenge of IBDV or mock-infected chickens |
| Organisation | University of Minnesota |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We will challenge birds that have been exposed to IBDV, or mock exposed, with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens. |
| Collaborator Contribution | Dr Cardona's group will challenge birds that have been exposed to IBDV, or mock exposed, with low pathogenic avian influenza (LPAI) strains to determine how IBDV-mediated immunosuppression impacts upon LPAI infection in chickens. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/T008806/1) |
| Start Year | 2019 |
| Description | Dr Caroline Denesvere |
| Organisation | French National Institute of Agricultural Research |
| Department | INRA Loire Valley Centre |
| Country | France |
| Sector | Public |
| PI Contribution | Worked together to establish a collaboration on development of feather follicular stem cell lines as a platform for the generation of cell-free vaccine against Marek's disease virus. |
| Collaborator Contribution | Provided expertise on cell free Marek's disease and microscopic evaluation of cells generating the virus. |
| Impact | Generation of data leading to a successful BBSRC IPA grant application |
| Start Year | 2020 |
| Description | Dr Holly Shelton, The Pirbright Institute- avian influenza virus challenge of IBDV or mock-infected chickens |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We will expose birds to IBDV, compared to mock controls |
| Collaborator Contribution | Holly will train my group in conducting studies with avian influenza viruses and, together, we will challenge birds with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/T008806/1) |
| Start Year | 2019 |
| Description | Dundee |
| Organisation | University of Dundee |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-INvestigator on BBSRC sLoLa award |
| Collaborator Contribution | Co-INvestigator on BBSRC sLoLa award |
| Impact | BBSRC sLoLa award ongoing |
| Start Year | 2012 |
| Description | Edinburgh - Haas |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-Investigator on BBSRC sLoLa award Co-Investigator on BBSRC project grant Collaboration in virus-host interactions |
| Collaborator Contribution | Co-Investigator on BBSRC sLoLa award Co-Investigator on BBSRC project grant Collaboration in virus-host interactions |
| Impact | BBSRC sLoLa award BBSRC project grant |
| Start Year | 2012 |
| Description | Efficacy of a candidate universal influenza vaccine, S-FLU. |
| Organisation | University of Oxford |
| Department | Radcliffe Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Tested the immunogenicity and efficacy of a candidate universal influenza vaccine, S-FLU, in pigs. For the first time we demonstrated that S-FLU when administered by aerosol can reduce viral load in nasal swabs and lung in pigs after influenza virus challenge. We have shown that the most efficient way to administer this vaccine is by aerosol. |
| Collaborator Contribution | Professor Alain Townsend has developed the S-FLU vaccine. |
| Impact | The most efficient way to induce immune response in the lung is after aerosol delivery of LAIV vaccines in pigs. The most efficient way to induce cross-protective immunity is by aerosol delivery of S-FLU to the lungs of pigs |
| Start Year | 2014 |
| Description | Establishment of a novel poultry vaccine platform inducing rapid and strong immunity through targeted delivery of antigens to chicken immune cells |
| Organisation | MSD Animal Health |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research focus is to develop next-generation of poultry vaccines that induce rapid and strong immune responses in chickens. The candidate vaccine constricts will be developed at the Pirbright Institute |
| Collaborator Contribution | The collaborating partner "MSD Animal Health" will evaluate the potency and efficacy for registration and feasibility for commercial production. |
| Impact | Based on the project preliminary data a new project was developed entitled Protecting poultry from avian influenza, Newcastle disease, infectious bronchitis, and Gumboro disease with a single dose of a multivalent vaccine". This project further strengthened the collaborative research work with MSD Animal Health. |
| Start Year | 2021 |
| Description | EuFMD Special Committee on Biorisk Management (SCBRM) |
| Organisation | Food and Agricultural Organisation (FAO) |
| Country | Italy |
| Sector | Charity/Non Profit |
| PI Contribution | Graeme Harkess, Pirbright Head of Biorisk, is UK rep on the FAO EuFMD (The European Commission for the Control of Foot-and-Mouth Disease) Special Committee on Biorisk Management (SCBRM), currently updating the EuFMD FMDV Minimum Standards. GH attends regular SCBRM meetings and workshops (eg 2-day face-to-face meeting Istanbul Turkey November 2024) to work on the Minimum Standards update. GH chairs the EuFMD SCBRM Disinfection Working Group, looking to rationalise how disinfection methods are approved and established within the Minimum Standards. EuFMD is a pan-European body under UN FAO to maintain the FMDV-free status of Europe. The Minimum Standards set out detailed requirements for any site working with FMDV in Europe. |
| Collaborator Contribution | SCRBM are organising a programme of mutual cross-institutional site inspection visits, and GH and Sarah Gold (Deputy Biological Safety Officer) carried out an inspection at AGES Vienna Austria January 2025. These inspection visits both enable sharing of best practice and also cement the position of Pirbright / BBSRC as a centre of excellent in biorisk containment management. |
| Impact | Influence for the UK on international regulatory policy. The mutual cross-institutional site inspection visits (eg, AGES Vienna 2025) enabling sharing of best practice and cementing the position of Pirbright / BBSRC as a centre of excellent in biorisk containment management. |
| Start Year | 2022 |
| Description | Evaluate the potential of AstraZeneca's sialic acid tag technology for treating influenza viruses with Fc molecules |
| Organisation | Liverpool School of Tropical Medicine |
| Department | Parasite Immunology Liverpool |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Established partnership to investigate the antiviral properties of novel antiviral ( fragment-crystallisable (Fc) molecules) compounds that potentially block influenza virus infection. These compounds will be used to test their antiviral activity against avian influenza and Newcastle Disease virus that are causing sever economic looses to the poultry industry. |
| Collaborator Contribution | The Partners have developed these antiviral compounds and showed that these compounds bids to specific cell surface receptors that are required by the virus to bind to and enter into the cell to cause infection. |
| Impact | Project is just started |
| Start Year | 2022 |
| Description | Evaluation of COVID-19 vaccine candidate immunogenicity in pigs |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in evaluating vaccine immunogenicity in pigs |
| Collaborator Contribution | Provided COVID-19 vaccine candidates |
| Impact | Joint publication on the evaluation of ChAdOx1 nCoV-19 (AZD1222) (https://doi.org/10.1038/s41541-020-00221-3). Data included in in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application. |
| Start Year | 2020 |
| Description | Evaluation of COVID-19 vaccine candidate immunogenicity in pigs |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in evaluating vaccine immunogenicity in pigs |
| Collaborator Contribution | Provided COVID-19 vaccine candidates |
| Impact | Joint publication on the evaluation of ChAdOx1 nCoV-19 (AZD1222) (https://doi.org/10.1038/s41541-020-00221-3). Data included in in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application. |
| Start Year | 2020 |
| Description | Evaluation of COVID-19 vaccine candidate immunogenicity in pigs |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise of using the pig as a model to evaluate vaccine immunogenicity. |
| Collaborator Contribution | Provision of COVID-19 vaccine candidates |
| Impact | The immunogenicity data of ChAdOx1 nCoV-19 in pigs was included in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application. The immunogenicity data of RBD-SpyVLP in pigs helped support secure funding to further develop with vaccine candidate and to enter clinical trials. Published papers to date: https://www.nature.com/articles/s41541-020-00221-3 and https://www.nature.com/articles/s41467-020-20654-7 |
| Start Year | 2019 |
| Description | Evaluation of a PRRSV-vectored Nipah virus vaccine |
| Organisation | National Center for Genetic Engineering and Biotechnology (BIOTEC) |
| Country | Thailand |
| Sector | Public |
| PI Contribution | Expertise in porcine immunology/vaccinology, inc. PRRSV and Nipah |
| Collaborator Contribution | Expertise in PRRSV reverse genetics |
| Impact | None as yet |
| Start Year | 2019 |
| Description | Exploiting mosquito immunity for generating refractory mosquitoes |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I brought my expertise in mosquito immunology and viral evasion of innate immune responses in vertebrates and invertebrates. I provided intellectual input into the project and provided training for three research assistants and one undergraduate placement student. |
| Collaborator Contribution | The partner (Luke Alphey, The Pirbright Institute) brought their expertise in mosquito transgenesis and molecular approaches to developing refractory mosquitoes that cannot transmit viruses. The partner also provided intellectual input into the project. |
| Impact | The following publications are associated with this collaboration: DOI: 10.3390/v13112116 |
| Start Year | 2020 |
| Description | Exploiting novel porcine macrophage cell lines and ASFV virulence factors |
| Organisation | University of Plymouth |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My team has developed gene-deleted African swine fever viruses in order to study the role of these virus genes in virus replication and modulation of host responses. These gene-deleted viruses are also being evaluated as candidate live attenuated vaccines. |
| Collaborator Contribution | University of Plymouth provided novel porcine macrophage cell lines to evaluate their susceptibility to African swine fever virus (ASFV) replication and as tools for ASFV research, vaccine development and diagnosis. These cell lines are being further characterized and developed by our partners at University of Plymouth. |
| Impact | Multi-disciplinary: Virology, Immunology, Cell biology, Vaccinology |
| Start Year | 2019 |
| Description | Exploiting novel porcine macrophage cell lines and ASFV virulence factors |
| Organisation | Zoetis |
| Country | United States |
| Sector | Private |
| PI Contribution | The Pirbright Research Team is constructing gene deleted African swine fever viruses and is testing these in pig macrophage primary cell cultures and using novel pig macrophage cell lines from University of Plymouth. These are also being tested in pigs in immunization and challenge vaccination experiments. |
| Collaborator Contribution | Zoetis will establish conditions for scaling up of the novel pig macrophage cell lines in a commercial setting. |
| Impact | Multi-disciplinary: Virology, cell biology, pathogenesis, immunology, vaccinology |
| Start Year | 2015 |
| Description | FLU-Trailmap: Transmission and risk of avian influenza: learning more to advance preparedness |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | This project brought together eight leading scientific organizations in the UK to develop strategies for mitigating bird flu. Its main objective is to devise tools that bridge significant knowledge gaps concerning the virus's prevalence in wild birds and the factors leading to its emergence in poultry. We are exploring molecular determinants potentially related to changes in virus virulence, antigenicity, cross-species transmission, and the capacity to infect humans. |
| Collaborator Contribution | The partners provided field samples and sequence data of viruses isolated from disease outbreaks. This data was used to identify molecular determinants linked to virus phenotype changes. |
| Impact | At the frontline, ethnographic surveys were designed and implemented to understand farmers perceptions of farm biosecurity. Studies highlighted the need for an improved understanding of key biosecurity risk points and the implementation of effective biosecurity practices. Outputs showed that high quality facilities and management systems can be undermined by weaknesses in procedural compliance. As such, targeted farm worker education could help mitigate against future incursions which will be addressed in the follow-on research programme, FLUTRAILMAP. Recent work indicates that farm-to-farm spread is rare and that the virus is not spread long distances as an aerosol. Linked to biosecurity, virulence for poultry and the potential role of airborne spread of the virus was evaluated. Active sampling on infected premises across different hosts supported the experimental evaluation of pathogenesis and transmission (FLUMAP: Pathogenesis) by demonstrating that this virus is not spread long distances by the aerosol route (FLUMAP: Aerosol). Further, studies demonstrated that different bird species represent different risk levels for excretion of infectious material and potential transmission routes (FLUMAP: Gannets; FLUMAP: Environment; Pheasants). Ultimately, experimental, field and genetic data supported a lack of aerosol spread between premises. In support of this, genetic analysis of over 800 full bird flu virus genomes demonstrated that farm-to-farm spread was very rare with independent incursions from wild birds driving infection in poultry (FLUMAP: Genetics; Phylodynamics). Several genetic characteristics were identified that expanded our knowledge, explaining the explosive success of the current H5N1 bird flu viruses to spread fast and infect a greater range of bird species including a shift of infection dynamics to affect seabirds (FLUMAP: Infection dynamics) and via long distance and transatlantic spread (Transatlantic). These traits have contributed to the current H5N1 viruses having increased fitness across multiple species. Contemporary H5N1 viruses have enhanced fitness to infect, transmit and persist in birds, but remain of low risk to humans (FLUMAP: Characterization; Human Case). This project has defined a role for multiple virus genes which have switched and evolved over time to act together in a highly efficient manner. To better understand key species that may tolerate infection with this virus in the absence of clinical disease, sampling of hunter harvested wild birds was undertaken. Virus positive birds were detected in a small subset of Teal, Wigeon, and Pink-Footed Geese although carcasses were not available to evaluate the distribution of virus in these birds (Healthy birds). Further assessment of different avian species using this approach are planned. Gannet populations around the UK have been severely impacted by High Pathogenicity Avian Influenza (HPAI), at Bass Rock the number of occupied nest sites decreased by over 70%. Linked to the detection of the virus in apparently healthy birds, interrogating survival from infection, and in particular the role of antibodies in birds that may have been infected, but survived infection was a key interest (FLUMAP: Gannets). FLUMAP has enabled the development of a suite of laboratory tools that will enable us to dissect the immune response in birds that may have been exposed to multiple and different influenza viruses in their lifetime. Tools are now available to dissect antibody responses to each of the two different viral surface proteins (both individually and in tandem). How these two different viral coat proteins interact with each other and what optimal protein combinations mean with respect to stability of interaction has also been assessed. These tools will enable a better understanding of how different key surface proteins drive immune responses and what that means where viruses emerge containing different coat proteins. The periodic switching of the neuraminidase (NA) protein (i.e., N8 to N1) is an important factor in influencing the emergence of new strains and the tools developed in FLUMAP will enable the impact of these genetic reassortment events to be assessed. Whilst further outputs are realised from the FLUMAP project, the follow-on project, FLUTRAILMAP, will enable the application of these data to this continually emerging global situation and will enable better prevention and mitigation approaches to be defined. |
| Start Year | 2023 |
| Description | Flavivirus microvascular pathogenesis |
| Organisation | University of Surrey |
| Department | Faculty of Health and Medical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I brought my expertise in dengue and virology, and had significant intellectual input into shaping the research question and methodological approach. I also directly contributed to the training of one shared MSc student, two shared PhD students and three undergraduate students who have contributed to this project so far. |
| Collaborator Contribution | The partner (Dr. Paola Campagnolo, University of Surrey) brought their expertise in cardiovascular biology and had significant intellectual input into shaping the research question and methodological approach. They also directly contributed to the training of one shared MSc student, one shared PhD student and three undergraduate students who have contributed to this project so far. |
| Impact | The collaboration has resulted in the following publications: DOI: 10.1128/mSphere.00258-20 DOI: 10.1099/jgv.0.001634 This is an interdisciplinary collaboration. The disciplines are microbiology/virology (me) and cardiovascular biology (Dr. Paola Campagnolo, University of Surrey). |
| Start Year | 2018 |
| Description | Genetic analysis orbiviruses |
| Organisation | University of Surrey |
| Department | Faculty of Health and Medical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Virus sequences provided for analysis. Meeting and discussion for analysis by virologist employed on this project and biomathematican at the University of Surrey |
| Collaborator Contribution | Analysis of data, training of the virologist and computational and mathematical methodology, discussion about analysis strategies |
| Impact | The collaboration is multi-disciplinary - between mathematical modelling and virology. Data analysis is still ongoing but is envisaged as preliminary data for future funding applications |
| Start Year | 2017 |
| Description | High containment microscopy with Thermo Fisher |
| Organisation | Thermo Fisher Scientific |
| Country | United States |
| Sector | Private |
| PI Contribution | Provide advice on decontamination protocols |
| Collaborator Contribution | Development/optimisation of microscope decontamination procedures |
| Impact | No outputs, other than knowledge exchange. Thermo Fisher later developed heat inactivation for the microscope at STRUBI. |
| Start Year | 2019 |
| Description | Imperial |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint supervision of PhD student |
| Collaborator Contribution | Joint supervision of PhD student |
| Impact | One successful completed PhD student. Papers published or in preparation. Another PhD student in progress. |
| Start Year | 2010 |
| Description | Interferon stimulated genes |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosted meetings and carried out preliminary experiments |
| Collaborator Contribution | Contributed reagents and expertise |
| Impact | Preliminary data was used to support an MSc project. This has since led to a publication and a PhD project. |
| Start Year | 2016 |
| Description | Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses |
| Organisation | Royal Veterinary College (RVC) |
| Department | Veterinary Basic Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The overarching aims of the proposed research are to improve controls against H5 subtype of avian influenza viruses infecting poultry by investigating underlying mechanisms that define how vaccines renders effectiveness and develop novel approaches enhancing the effectiveness of H5 avian influenza vaccines. We recently generated a panel of monoclonal antibodies (mAbs) that recognise a variety of different clades of H5 viruses. Propagation of AIV in eggs or cultured cells together with mAbs drives virus to escape from mAbs neutralisation activity. These classical virus neutralization assays (VN) followed by HA gene sequence analysis allowed us to defined the role of amino acid substitutions that are associated with evasion of antibody neutralization through emergence of antigenic variants and failure of vaccine efficacy. |
| Collaborator Contribution | provided intellectual input for achieving prescribed objectives of this work. |
| Impact | Talk entitled "Molecular determinants for antigenicity and vaccine efficacy of avian influenza viruses" was presented at Newton Agham Researcher Links Workshop " Novel Vaccines and Diagnostic Technologies against Emerging and re-emerging Veterinary Pathogens" at Rizal Park Hotel, Manila, Philippines, 4-7 February 2019. |
| Start Year | 2019 |
| Description | JN - Preparation of capped mesoporpus silica nanoparticles |
| Organisation | Polytechnic University of Valencia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | We were involved with testing the nanoparticles once they had been made. We also contributed purified antibody and shipped it to our collaborators for the generation of one type of nanoparticle, which we subsequently tested. We were involved with the intellectual design of experiments |
| Collaborator Contribution | Our partners generated the nanoparticles and shipped them to us for testing. Our partners were also involved with the intellectual design of experiments. |
| Impact | Experimental work performed to investigate the use of mesoporous silica nanoparticles to detect FMDV proteases in clinical samples |
| Start Year | 2016 |
| Description | LMB |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration |
| Collaborator Contribution | Collaboration |
| Impact | Collaborative research |
| Start Year | 2016 |
| Description | Lactate dehydrogenase elevating virus infection in mice as a model to study arterivirus induced immune dysregulation |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration to establish lactate dehydrogenase elevating virus infection in mice as a model to study arterivirus induced immune dysregulation. |
| Collaborator Contribution | Expertise in arterivirus immunology. |
| Impact | Ongoing work. |
| Start Year | 2022 |
| Description | Leeds FBS |
| Organisation | University of Leeds |
| Department | Faculty of Biological Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research |
| Collaborator Contribution | Research and student supervision |
| Impact | Research |
| Start Year | 2009 |
| Description | Livestock Viral Diseases Pathology Slide Set |
| Organisation | Scotland's Rural College |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Pip Beard (The Pirbright Institute) and Dr Sandra Scholes (Scotland's Rural College) designed a set of histology slides of tissues from livestock affected by notifiable viral diseases. The Livestock Viral Diseases Pathology Slide Set contains examples of lumpy skin disease, African swine fever, bluetongue, rift valley fever, and peste des petits ruminant. The slide set has been provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland. This activity was included in the Pathways to Impact of BB/R002606. |
| Collaborator Contribution | Dr Pip Beard (The Pirbright Institute) and Dr Sandra Scholes (Scotland's Rural College) designed a set of histology slides of tissues from livestock affected by notifiable viral diseases. The Livestock Viral Diseases Pathology Slide Set contains examples of lumpy skin disease, African swine fever, bluetongue, rift valley fever, and peste des petits ruminant. The slide set has been provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland. |
| Impact | None yet |
| Start Year | 2018 |
| Description | Mapping ligand binding domain on African swine fever virus CD2v protein |
| Organisation | University of Oxford |
| Department | Weatherall Institute of Molecular Medicine (WIMM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Testing of mutant versions of CD2v extracellular domain for ability to bind to red blood cells |
| Collaborator Contribution | Produced predicted model of CD2v extracellular domain and selected mutations to be made |
| Impact | Preliminary results for publication and future funding application |
| Start Year | 2018 |
| Description | Maria Harkiolaki - soft xray tomography |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The project aims to characterise coronavirus replication organelles in whole infected cells. My team provides significant experience in coronavirus replication organelles. The project is funded by a joint studentship and the student is, predominantly based in my laboratory. |
| Collaborator Contribution | Maria's team provide extensive expertise in soft Xray tomography and are advising on experimental design and dat aanalysis. |
| Impact | Preliminary experiments have been performed to visualise replication organelle membranes. Optimisation of experimental set up is underway. |
| Start Year | 2020 |
| Description | Merial/BI |
| Organisation | Sanofi |
| Department | Merial Plc |
| Country | Global |
| Sector | Private |
| PI Contribution | Collaborative BBSRC Link award |
| Collaborator Contribution | Collaborative BBSRC Link award |
| Impact | BBSRC Link award helped develop/validate FMDV reverse genetics for commercial vaccine production. Relationship with Merial (now Boehringer Ingelheim) is still active. |
| Start Year | 2016 |
| Description | Miles Carroll PHE collaboration on pseudotyping |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Provision of reagents to perform pseudotyping of Ebola G protein Hosting of visiting students to attempt sarbecovirus pseudotyping |
| Collaborator Contribution | Discussion of preliminary data Provision of sarbecovirus constructs |
| Impact | None to date, publications in preparation. |
| Start Year | 2019 |
| Description | Mosquito Interest Group |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques. |
| Collaborator Contribution | Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques. |
| Impact | Exchange of practical techniques, for instance in tracking oviposition of individual mosquitoes. Brainstorming for projects and papers, resulting in a GCRF VBD network proposal (which passed the first review but was not funded in the second) and an informal collaboration (which was intended for submission to UK-Thai call in 2017 but Thai partner was not eligible). Exchanges of colony strains of insects planned this month. |
| Start Year | 2016 |
| Description | Mucosally Associated Invariant T cells (MAIT) in pig influenza model |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identified MAIT cells in pig Influenza model. Provide samples from infected and immunised protected animals |
| Collaborator Contribution | Provide expertise in characterising MAIT: development of tetramer; Zell scanner technology allowing high resolution studies of cell phenotype and functions |
| Impact | Joint PhD studentship with Paul Klenerman, University of Oxford |
| Start Year | 2016 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | Atomic Weapons Establishment |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | Centre For Environment, Fisheries And Aquaculture Science |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | Fera Science Limited |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | Health and Safety Executive (HSE) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | Meteorological Office UK |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | National Nuclear Laboratory |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | National Physical Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | UK Atomic Energy Authority |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | National Laboratories Alliance (NLA) |
| Organisation | UK Health Security Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | NLA is a well-established consortium of Public Sector Research Establishments (PSREs) which are National Capabilities, which have come together to work on key issues of concern and to develop subgroups and workstreams of shared practice. Pirbright successfully lobbied to join as a national capability, despite not being a government agency like the other members. Pirbright is supporting a range of the NLA subgroups and workstreams. The Institute Director is working with key NLA reps supporting government to develop a coherent science research strategy that encompasses PSREs and UKRI Research Institutes in response to the Nurse Report 2. Prof Charleston is able to utilise the advantage that Pirbright is both a PSRE and a UKRI RI and can speak from both perspectives. |
| Collaborator Contribution | NLA members work together on a range of issues, including via its subgroups and workstreams, most particularly supporting development of government follow-up to the Nurse Report 2 and seeking cooperation with UKRI Research Institutes (and others). |
| Impact | Sharing best practice approaches in diverse areas from Big Data and AI to health & safety benchmarking. Ongoing development of cooperative dialogue between PSREs and Research Institutes and HMG. |
| Start Year | 2023 |
| Description | Novel PRRS and swine influenza vaccines |
| Organisation | National Center for Genetic Engineering and Biotechnology (BIOTEC) |
| Country | Thailand |
| Sector | Public |
| PI Contribution | Expertise in PRRS immunology and vaccine evaluation. |
| Collaborator Contribution | Novel vaccine strains and SE Asian field strains |
| Impact | Collaborative grant proposal funded under the BBSRC Newton Fund UK-China-Philippines-Thailand Swine and Poultry Research Initiative |
| Start Year | 2017 |
| Description | Oxford - Strubi |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Collaborator Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Impact | Collaboration on virus structural biology has produced a number of novel virus structures and new understanding of virus entry and packaging |
| Start Year | 2008 |
| Description | PARTNERSHIP: Nanoparticle Vaccines Against Emerging Poultry Infections |
| Organisation | University of Wisconsin-Madison |
| Department | Department of Pathobiological Sciences |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We established a joint project with School of Veterinary Medicine, University of Wisconsin, Madison, USA. My team will contribute in the development of Novel Target antigen delivery vaccines that selectively delivers antigens to the chicken immune cells and induces faster and stronger immune responses in vaccinated chickens. |
| Collaborator Contribution | The partner developed a novel DNA nano-vaccine platform. This partnership will merge both technologies to enhance both the potency and delivery systems for poultry vaccines. |
| Impact | The partnership submitted a joint research grant proposal to USDA-NIFA-AFRI (Program A1181 Agricultural Biosecurity) entitled "Partnership: Nanoparticle Vaccines Against Emerging Poultry Infections". This grant proposal has been approved by the funders. |
| Start Year | 2022 |
| Description | PRRS and Influenza co-nfection studies |
| Organisation | Government of Thailand |
| Department | National Science and Technology Development Agency (NSTDA) |
| Country | Thailand |
| Sector | Public |
| PI Contribution | The Pirbright team of 4 scientists with expertise in immunology and animal care visited Thailand in July 2018 to train Thai colleagues to perform animal experiments (Chiang Mai) and analyse immune responses by ELISPOT and Flow cytometry (Bangkok). This provided Thailand with trained personnel and expertise in testing vaccines in pigs. As a result of the joint work, the Chiang Mai animal facility is currently being renovated. Development of such an animal facility will promote the production and testing of more vaccines by Thai scientists. |
| Collaborator Contribution | Our Thai colleagues provided us with local Thai PRRS and Influenza virus strains which we use in our co-infection studies. |
| Impact | None yet |
| Start Year | 2018 |
| Description | Pathology of BTV in T cell depleted sheep |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Carrying out animal studies, taking samples for histopathology and sending material |
| Collaborator Contribution | Certified pathologist will attend selected necropsies, sample processing and pathological analysis |
| Impact | Protocols and sample sending established - first clinical trial to start in March 2018 |
| Start Year | 2017 |
| Description | Pathology of bovine skin post Culicoides midge blood-feeding |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collection of skin samples from cattle responding with local inflammation to Culicoides biting midges blood feeding, sending of materials |
| Collaborator Contribution | Processing of samples, histopathological analysis, sharing of results |
| Impact | Further identification of cellular and histological local changes in ruminant skin to Culicoides blood-feeing which will inform pathogenesis of co-transmitted arboviruses such as BTV |
| Start Year | 2017 |
| Description | Paul Digard & Reidun Twarock - Packaging signals |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets". |
| Collaborator Contribution | University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student. |
| Impact | Studentship commenced in October 2019 |
| Start Year | 2019 |
| Description | Paul Digard & Reidun Twarock - Packaging signals |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets". |
| Collaborator Contribution | University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student. |
| Impact | Studentship commenced in October 2019 |
| Start Year | 2019 |
| Description | Paul Verkade - Electron tomography and CLEM |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Nicole Doyle has performed electron tomography to analyse the three dimensional structure of membrane rearrangements induced by the expression of IBV non-structural proteins 4 or 3 and 4 in the absence of other viral components. Sample set up was performed at Pirbright and analysis was subsequently performed at University of Bristol followed by additional analysis at Pirbright. |
| Collaborator Contribution | Paul has assisted with electron tomography data generation providing access to electron microscopes in Bristol as well as training for Nicole Doyle in performing experiments and analysing and modelling data. He is also advising Nicole while establishing correlative light electron microscopy at Pirbright. |
| Impact | doi: 10.3390/v10090477 |
| Start Year | 2018 |
| Description | Peer support for Dstl 'Safety Reset' Programme |
| Organisation | Defence Science & Technology Laboratory (DSTL) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Pirbright's in-house expertise is being used to provide advice and support, share best practice and carry out peer review of the extensive restructure programme of major hazard safety at Dstl Porton Down. |
| Collaborator Contribution | A series of exchange visits has enabled Pribright subject matter experts to liaise with Dstl SMEs, and whilst the objective is to assist the 'safety reset' at Dstl, there is significant mutual benefit as Pirbright reflects on its own practice and considers novel proposals from Dstl in areas such as Bowties as a management tool and facility management planning. |
| Impact | Fruitful exchanges of best practice to mutual benefit of both parties, leading to several separate workstreams on specific topics. |
| Start Year | 2023 |
| Description | Pirbright-Diamond collaboration |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | 50% of my time is now based at Diamond, I am considered in-house staff and can apply to use the instrumentation. I feed projects to eBIC for collaboration using advanced electron microscopy, centered around cell biology of host-pathogen interactions using advanced electron microscopy, plus potential use of Xray microscopy (on application). |
| Collaborator Contribution | Instrument time on cryo-FIB-SEM and screening TEM (two days per month). Diamond have loaned us a plunge freezing device. |
| Impact | No outputs yet |
| Start Year | 2019 |
| Description | Placement Studentship: Production and characterisation of nanobodies recognising avian influenza and Newcastle disease virus surface glycoproteins using phage display technology |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Studentship allocated to Roddy Brookes producing and characterising llama nanobodies which recognise avian influenza and Newcastle disease virus surface glycoproteins, using our established methods of phage display technology. |
| Collaborator Contribution | Supervisory contributions, expertise and research guidance for undergraduate placement, attributed to the Bachelor of Science award. |
| Impact | On-going. |
| Start Year | 2023 |
| Description | Pre-exposure influenza model and effect of routes of immunization on vaccine efficacy |
| Organisation | University of Oxford |
| Department | Nuffield Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed the pre-exposure swine influenza model, the expertise to target different parts of the respiratory tract and the tools to assess the local and systemic immune responses. |
| Collaborator Contribution | The team of Professor Sarah Gilbert provided the viral vectored vaccines expressing influenza nucleoprotein, matrix protein and neuraminidase. |
| Impact | We have established a pre-exposure influenza pig challenge model, which closely mimics the situation in humans, who are commonly exposed to different influenza viruses. We showed that ChAdOx NP-M1-NA induces immune response in the face of pre-existing immunity , which is highly relevant to the situation in pigs and human where many vaccinees are pre-exposed to respiratory infections. |
| Start Year | 2019 |
| Description | Professor Jim Kaufman |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided information on CD4 T cell epitopes derived from Marek's disease virus |
| Collaborator Contribution | Provided knowledge and information on assessing peptide binding to chicken MHC molecules |
| Impact | Generation of data leading to understanding correlate of protection against Marek's disease virus. |
| Start Year | 2019 |
| Description | Professor Shayan Sharif, University of Guelph, Canada |
| Organisation | University of Guelph |
| Department | Department of Pathobiology |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Collaboration between my team and Professor Sharif lead to new finding in Avian immunology, specifically in understanding the effects of nutrients on antigen presenting cells and T cells of chicken. We took the lead in studying the effects of some nutrients (Vitamin D) on the function of chicken T cells, performed most of the experiments in our laboratory. Meanwhile, we participated in studying the effects of Vitamin D on antigen presenting cells of chicken by performing some key experiments because we had access to some specific reagents (monoclonal antibodies) recognizing molecules expressed on chicken antigen presenting cells. |
| Collaborator Contribution | Professor Sharif team took the lead in studying the effects of Vitamin D on antigen presenting cells of chicken, and contributed to experimental plan for studying the effects on chicken T cells. |
| Impact | Two publications in 2015 and 2016: 1. Nitish Boodhoo, Shayan Sharif, Shahriar Behboudi. 1a,25(OH)2 Vitamin D3 Modulates Avian T Lymphocyte Functions without Inducing CTL Unresponsiveness. PLoS One. 2016 Feb 24;11(2):e0150134 2. Bahram Shojadoost, Shahriar Behboudi, Villanueva AI, Jennifer Brisbin, Ali Ashkar, Shayan Sharif. Vitamin D3 modulates the function of chicken macrophages. Res. Vet. Sci. 2015 June, 100: 45-51 |
| Start Year | 2019 |
| Description | Provision of PRRSV field strains |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Experimental heterologous PRRSV challenge model to assess the induction of broadly neutralizing antibodies. Model to assess dendritic cell tropism of PRRS viruses |
| Collaborator Contribution | Provision of PRRSV-1 and -2 field strains |
| Impact | Not yet |
| Start Year | 2016 |
| Description | Provision of PRRSV field strains |
| Organisation | Kansas State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Experimental heterologous PRRSV challenge model to assess the induction of broadly neutralizing antibodies. Model to assess dendritic cell tropism of PRRS viruses |
| Collaborator Contribution | Provision of PRRSV-1 and -2 field strains |
| Impact | Not yet |
| Start Year | 2016 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | Reporter PRRS viruses |
| Organisation | Kansas State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | A new application for recombinant reporter PRRS viruses i.e. to use them as a high throughput screen for neutralizing (monoclonal) antibodies. Use as tools to assess the tropism of PRRSV for dendritic cell subsets and the functional consequences. |
| Collaborator Contribution | Provision of plasmids encoding GFP-expressing PRRSV-1 and -2. |
| Impact | Not yet |
| Start Year | 2016 |
| Description | Retroviral-mediated genetic programming of porcine memory B cells |
| Organisation | AIMM Therapeutics |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | Provided a novel 'model' system to test their technology to isolate novel monoclonal antibodies |
| Collaborator Contribution | To provide their patented platform technology to genetically program porcine memory B cells to enable the isolation of memory B cells |
| Impact | Not yet |
| Start Year | 2016 |
| Description | Risk management best practice development and sharing with AWE |
| Organisation | Atomic Weapons Establishment |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Collaborative links established with risk management colleagues at AWE to identify and develop touch points for best practice sharing and development. |
| Collaborator Contribution | Mutual exchange visits took place 2023-2024, involving a range of colleagues on both sides, with areas explored including bowties, use of VR in training and functional safety management systems. |
| Impact | Specific areas of follow-up collaborative working, such as a dozen colleagues from AWE to visit Pirbright in 2025 for a workshop on Learning from Experience, organised and hosted by Ana Corral, Pirbright Head of Quality & Organisation. |
| Start Year | 2023 |
| Description | Roslin - Grey |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-investigator in BBSRC project grant Collaboration in genetic screens to understand virus host interactions |
| Collaborator Contribution | Co-investigator in BBSRC project grant Collaboration in genetic screens to understand virus host interactions |
| Impact | Co-investigator in BBSRC project grant Collaboration in genetic screens to understand virus host interactions |
| Start Year | 2019 |
| Description | Semiochemical-based detection of arboviral infection |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Preliminary data collection on the influence of arboviral infection on semiochemical output from sheep. These studies are being conducted as part of an unrelated animal experiment within the isolation units at Pirbright. We are carrying out the animal-based studies and collecting air entrainments from animals both pre- and post-infection. These are then decontaminated for movement to LSHTM. |
| Collaborator Contribution | LSHTM are carrying out analysis of air entrainments using GC-MS. They will assess differences in profiles of infected vs uninfected animals and report their findings to us. |
| Impact | Still ongoing. |
| Start Year | 2018 |
| Description | SiSaf Ltd, FMDV + carriers |
| Organisation | SiSaf Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Advice on experimental design, provision of FMDV empty capsids (Alison Burman). Will do practical work in the future. |
| Collaborator Contribution | Preparation of carrier formulations |
| Impact | No outputs. Company did not respond to proposed experimental plan. |
| Start Year | 2019 |
| Description | St Andrews |
| Organisation | University of St Andrews |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-investigator on BBSRC sLoLa |
| Collaborator Contribution | Lead-investigator on BBSRC sLoLa |
| Impact | BBSRC sLoLa ongoing |
| Start Year | 2012 |
| Description | Stephen Graham collaboration on structural biology with University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data and sharing of experimental ideas regarding viral host range and techniques for simulating virus evolution |
| Collaborator Contribution | Structural analysis of mutants to viral glycoproteins |
| Impact | Journal of Virology paper on potential PPRV emergence in human populations (Abdullah et al, 2018) Application of error-prone PCR to functionally probe the morbillivirus Haemagglutinin protein. Gallo G, Conceicao C, Tsirigoti C, Willett B, Graham S and Bailey D. Journal of General Virology. J Gen Virol 2021 Apr;102(4). doi: 10.1099/jgv.0.001580. https://pubmed.ncbi.nlm.nih.gov/33739251/ The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins. Conceicao C, Thakur N, Human S, Kelly JT, Logan L, Bialy D, Bhat S, Stevenson-Leggett P, Zagrajek AK, Hollinghurst P, Varga M, Tsirigoti C, Tully M, Chiu C, Moffat K, Silesian AP, Hammond JA, Maier HJ, Bickerton E, Shelton H, Dietrich I, Graham SC, Bailey D. PLoS Biology. 2020 Dec 21;18(12):e3001016. doi: 10.1371/journal.pbio.3001016. eCollection 2020 Dec. https://pubmed.ncbi.nlm.nih.gov/33347434/ |
| Start Year | 2018 |
| Description | Structural analysis of ASFV-host protein interactions |
| Organisation | La Trobe University |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Mutations were introduced into ASFV autophagy modulators and the effects of these were tested in cell based microscopy assays. |
| Collaborator Contribution | Structural analysis of virus-host interactions identified residues important for binding between virus and host proteins. These residues were the residues that chosen for mutation and subsequent analysis at Pirbright |
| Impact | One peer-reviewed paper (https://www.ncbi.nlm.nih.gov/pubmed/31461953) This is multi-disciplinary. Pirbright has expertise in virology and cell based assays. La Trobe have expertise in structural biology. |
| Start Year | 2017 |
| Description | Taiwan Partnering |
| Organisation | Institute of Molecular Biology, Academia Sinica |
| Country | Taiwan, Province of China |
| Sector | Public |
| PI Contribution | My Team provide expertise and licensed facility in High Containment to study African swine fever virus biology, diagnosis and vaccines |
| Collaborator Contribution | The Taiwan Team bring expertise in virus entry mechanisms, Vaccinia virus, protein expression |
| Impact | Multi-disciplinary: Virology, cell biology, immunology |
| Start Year | 2019 |
| Description | The GCRF One Health Poultry Hub |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The focus of the research is to achieve sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. We are undertaking research to investigate the diversity of avian influenza viruses prevalent in poultry and wild birds in south east Asia. |
| Collaborator Contribution | Royal Veterinary College, London is leading this GCRF One Health Poultry Hub. The project will address the need to meet rising demand for poultry meat and eggs in developing countries, while minimising risk to international public health. Population growth is driving global demand for poultry, meat and egg production; this unfortunately creates conditions in which animal diseases can spread to humans ('zoonoses'). These include bacterial food poisoning and strains with avian influenza with epidemic or pandemic potential. The GCRF One Health Poultry Hub will adopt a 'One Health' approach to the issue of combatting animal-to-human diseases by bringing together a team of laboratory, clinical, veterinary and social scientists. This team will test and evaluate novel interventions. The need for safe poultry production is most urgent in South and South East Asia, so the RVC and its partners will then use their local networks in these regions to put its positive research to immediate use. |
| Impact | Development of international interdisciplinary partnership of 55 investigators from 13 countries to address the emerging global challenges of food security and public health associated with intensification of poultry production. |
| Start Year | 2018 |
| Description | The Pirbright "Livestock Antibody Hub" funded by Bill & Melinda Gates Foundation |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Me and my team established collaboration in the "Livestock Antibody Hub" funded ($5.5 million) by the from Bill & Melinda Gates Foundation. Focus of our partnership is to develop techniques and capacity to analyse immune cells (B cells) of cattle, poultry and pigs that produce virus neutralizing antibodies. This research will support rational development of next generation of vaccines and to explore antibody-based passive immunization approaches for treatment and prophylaxis of infectious viral diseases affecting livestock and humans. Our initial focus is to target major animal viral pathogens that cause severe losses within Low and Middle-Income Countries (LMIC) animal production systems including avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV) and foot-and-mouth disease virus (FMDV). |
| Collaborator Contribution | This is a collaborative project and partners are providing help in provision of reagents and techniques for analysis of diversity of B cells repertoire that produce infleunza virus-specific antibodies, single cell sequencing and bioinformatic analysis. This project will further strengthen our on-going research collaborations with many research groups in academia as well as with animal health industry (Zoetis, Boehringer Ingelheim Animal Health, Merck, CEVA, Jovac, YeBio, ILRI, Galvmed, The Roslin Institute, HuMabs, AbCellera and Distributed Bio) to take the research outputs from laboratory to the field. The outputs of research will be improved vaccines and diagnostics enabling to reduce the impact of infectious diseases on farm animals, which offer substantial direct and indirect economic, public health, environmental and social benefits to the UK and rest of the world. |
| Impact | Development of passive immunization approaches against avian influenza viruses affecting poultry (project incited in January 2020). |
| Start Year | 2020 |
| Description | The effect of the microbiota on immunity to swine infleunza |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We wish to establish the gut and nasal microbiome in normal healthy pigs and how this is affected by influenza infection. We have collected gut samples from pigs at different stages of infection, as well as nasal swabs which we will provide to our collaborators in Surrey. |
| Collaborator Contribution | Our collaborators in Surrey will perform the sequencing and bioinformatics analysis to determine the microbial communities present in the samples. |
| Impact | No outcomes yet - we are in the process of analysing the samples. |
| Start Year | 2017 |
| Description | Thomas Bowden - STRUBI - University of Oxford - Glycoprotein structure collaboration |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data and advice about the biological properties of viral glycoproteins, e.g. their fusion capacity with various receptors, their role in determining host-range |
| Collaborator Contribution | Advice and technical support at the structural level supporting future project development and design |
| Impact | No outcomes as yet |
| Start Year | 2018 |
| Description | TrailMap-One Health |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b is panzootic in birds. Its widespread geographical distribution, sheer numbers of infections and frequent incursions in mammals indicate it to be a virus with pandemic potential. We are working as a consortium to achieve a coordinated in-depth risk assessment of clade 2.3.4.4b viruses particularly zoonotic potential of the current clade 2.3.4.4b H5N1 viruses. |
| Collaborator Contribution | The collaborating partners are jointly providing data and samples necessary for evaluating the threat posed by H5N1 Clade 2.3.4.4b highly pathogenic avian influenza viruses (HPAIV) to human health. This effort aims to understand the risks, potential spillover routes into humans, the virus's capacity to adapt for human transmission, and the probable severity of human infections should they occur. We will meet these objectives through three interconnected work packages: (1) assessing the infection likelihood in non-human mammals that could serve as bridging species, (2) evaluating the risk of direct or adapted virus spillover infections in humans, and (3) examining the potential for Clade 2.3.4.4b H5N1 viruses to become transmissible among humans. |
| Impact | The work is currently in its initial stages, with anticipated outcomes expected by the end of this current year, 2024/2025. |
| Start Year | 2024 |
| Description | Understanding animal health threats from emerging H5 high pathogenicity avian influenza viruses |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | This is a collaborative research project funded by the UKRI-BBSRC to understand how the high pathogenicity Avian Influenza virus (H5N1) persisting in different species of wild birds and transmits from wild birds to farmed poultry, the gaps in biosecurity that allow the virus to penetrate premises, and how this could be addressed. My team contributing by by generating research reagents (such as viruses generated using reverse genetic technique) that allows the identification of molecular markers in the virus genes responsible for virus virulence, transmission and/or antigenic change. The data generated helped the partners to utilise the viruses and reagents for testing their biological behaviors ( such as infectivity and transmission parameters) via animal infection studies. The outcome of this collaborative work will provide insights for assessing threats from new and emerging strains, enabling national and international agencies to design and execute contingencies as part of risk mitigation and disease control. This will provide vital information when considering how to invest scarce resources for surveillance design aimed at early warning of the threat. |
| Collaborator Contribution | The collaboration enhance both the capacity of my team by providing field data ( such as sequences of viruses isolated from the field) and reagents such as post-infection antiserum containing antibodies specific to the field virus. This allowed the investigation of field virus antigenic profiles that can be used for selection of candidate vaccine seeds for the production of effective vaccines. |
| Impact | The data generated provided a risk assessment of contemporary H5Nx HPAIVs that are acquiring adaptive changes to increase fitness within domestic and wild avian populations. This partnership identified viral and host factors that potentially contribute to increased transmissibility, persistence, and pathogenicity in wild birds and those that enhance their potential to disseminate and manifest disease in poultry. We identified genetic changes that drive the virological, immunological, and zoonotic infection potential of these H5N1 viruses. The data generated allowed us an establishment of current and future risks from these viruses to both animals and humans if they continue to remain prevalent in wild bird populations. |
| Start Year | 2022 |
| Description | Use of fluorescent virions to isolate PRRSV-specific porcine B cells |
| Organisation | University of Minnesota |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Deployment of a novel technology to facilitate isolation of PRRSV neutralizing monoclonal antibodies |
| Collaborator Contribution | Provision of a method to fluorescently tag purified virions to label PRRSV-specific B cells |
| Impact | None to report to date |
| Start Year | 2016 |
| Description | Volatile organic compounds emitted by sheep and cattle before and after BTV infection analyzed by thermal desorption - gas chromatography |
| Organisation | University of Warwick |
| Department | School of Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Viral infection of livestock, disease pathogenesis, VOC collection of skin, breath and body odor in sheep and cattle prior and after, bluetongue virus infection conducted in high containment, implementation of biosafety procedures of sample processing from high containment facilities |
| Collaborator Contribution | Engineering and collection of volatile organic chemicals in body odor and breath, analysis and identification of compounds by thermal desorption gas chromatography time of flight coupled mass spectrometry (ATD-GC-TOF-MS), advanced statistical analysis and modelling of results |
| Impact | The collaboration is highly inter-disciplinary between virology, veterinary medicine, engineering, chemical ecology and mathematical modelling . Outputs so far include improved methodologies, additional analytical approaches of existing samples collected in an animal infection study, improved quantity and quality of results. |
| Start Year | 2021 |
| Description | Wilhelm Gerner |
| Organisation | University of Veterinary Medicine Vienna |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Our lab hosted Dr Gerner who brought samples for RNA-seq. My lab planned and executed the sequencing and is contributing to the analysis. |
| Collaborator Contribution | Dr Gerner did all the animal work and cell sorting to produce the samples reading for RNA-seq |
| Impact | None as yet, analysis is ongoing |
| Start Year | 2019 |
| Description | Y chromosome-linked X-shredding gene drives |
| Organisation | Hebrew University of Jerusalem |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | We shared with the partner Y chromosome-linked docking lines generated in our lab. |
| Collaborator Contribution | Provided some plasmid constructs. |
| Impact | No outputs yet. |
| Start Year | 2021 |
| Description | York |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration |
| Collaborator Contribution | Collaboration |
| Impact | Collaboration |
| Start Year | 2015 |
| Title | ??????? |
| Description | The present invention provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes: multigene-family 360 genes 9L, 10L, 11L, 12L, 13L and 14L; and multigene-family 505 genes 1R, 2R, 3R and 4R. The invention further provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the DP148R gene. The present invention also provides a vaccine comprising such an attenuated virus and its use to prevent ASF. Further, the invention relates to intranasal administration of an attenuated ASF virus. |
| IP Reference | UA121217 |
| Protection | Patent application published |
| Year Protection Granted | 2020 |
| Licensed | No |
| Impact | The gene-deleted African swine fever virus strains are being evaluated as live attenuated vaccines |
| Title | METHODS FOR GROWING AFRICAN SWINE FEVER VIRUS IN FETAL PORCINE LUNG ALVEOLAR MACROPHAGE CELLS |
| Description | A method for generating progeny of an African swine fever (ASF) virus includes providing an isolated or purified fetal porcine lung alveolar macrophage cell capable of replicating the ASF virus, wherein the cell is cultured for at least 5 passages; exposing the cell to the ASF virus; and allowing the ASF virus to replicate in the cell; thereby generating progeny of the ASF virus. |
| IP Reference | CA3146409 |
| Protection | Patent application published |
| Year Protection Granted | 2021 |
| Licensed | Commercial In Confidence |
| Impact | The cell line can be used for growing modified live attenuated African swine fever virus vaccine strains |
| Title | PPR DIVA vaccine |
| Description | We ahve developed two PPR live attenuated DIVA vaccines that can differentiate between vaccinated and infected animals. |
| IP Reference | PCT/GB2019/053641,WO2020128496 |
| Protection | Patent application published |
| Year Protection Granted | 2020 |
| Licensed | Commercial In Confidence |
| Impact | Till date there is no PPR vaccine avalable that can differentiate between vaccination and infection. This causes a huge issue on eradication of the didease and declare freedom from the disease. Therefore our newly develped chimeric live attenauted PPR vaccine and DIVA tests can differentiate between vaccination and infection which is a great achievement for ongoing PPR eradication. Please see detail from the below web. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020128496 |
| Title | VACCINE AGAINST AFRICAN SWINE FEVER VIRUS INFECTION |
| Description | The present invention relates to attenuated African Swine Fever viruses. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent African Swine Fever. The invention also relates to EP402R proteins of African Swine Fever virus comprising particular amino acid substitutions, as well as polynucleotides encoding such proteins and African Swine Fever viruses comprising such proteins. |
| IP Reference | WO2021176236 |
| Protection | Patent application published |
| Year Protection Granted | 2021 |
| Licensed | No |
| Impact | The gene-deleted African swine fever viruses are being taken forward as candidate live attenuated vaccines and included in a BBSRC LINK award |
| Title | Vaccine |
| Description | The present invention provides an African swine fever virus (ASFV) subunit vaccine which comprises: (i) one or more recombinant polynucleotides which encode polypeptides shown as SEQ ID NO: 1, 2 and 3 or an immunogenic fragment thereof; or a variant with at least 70% sequence identity to one of SEQ ID NO: 1, 2 or 3; wherein the total number of different ASFV polypeptides encoded by the one or more recombinant polynucleotides is 10 or fewer; or (ii) recombinant polypeptides shown as SEQ ID NO: 1, 2 and 3 or an immunogenic fragment thereof; or a variant with at least 70% sequence identity to one of SEQ ID NO: 1, 2 and 3; wherein vaccine comprises 10 or fewer different ASFV polypeptides. |
| IP Reference | TW202118771 |
| Protection | Patent application published |
| Year Protection Granted | 2021 |
| Licensed | Commercial In Confidence |
| Impact | The polypeptides are being taken forward to develop subunit vaccines for African swine fever virus |
| Title | Approximate Bayesian computation to infer transmission parameters from mortality data |
| Description | Fortran code to implement ABC methods for inferring transmission parameters from mortality data |
| Type Of Technology | Webtool/Application |
| Year Produced | 2021 |
| Impact | Making methods available for other researchers. The code has been used by researchers working on ASF and HPAI. |
| URL | https://github.com/SimonGubbins/ABC-SMC_MortalityData |
| Title | SimonGubbins/WithinHostDynamicsAndTransmission: Release for publication |
| Description | No description provided. |
| Type Of Technology | Software |
| Year Produced | 2022 |
| Impact | Improves reliability and future use of methods in article. |
| URL | https://zenodo.org/record/7347010 |
| Description | "Challenges for Poultry Industry". Organised by Fakieh Poultry at the Ritz-Carlton Hotel in Jeddah, Saudi Arabia, 2nd -3rd December 2018, |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed prevention and control of infectious diseases affecting poultry production. |
| Year(s) Of Engagement Activity | 2018 |
| Description | "Interactive session with poultry stakeholders". Title: Overview of Avian Influenza group Research at The Pirbright Institute. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The workshop discussed the economic impacts and prevention strategies against avian influenza viruses affecting poultry production and zoonotic infections. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 1st Research Coordination Meeting (RCM) of the Coordinated Research Project (CRP) on "Generic approach for the development of genetic sexing strains for SIT applications" Vienna, 7-11 October 2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FAO/IAEA Coordinated Research Project on exploring genetic and molecular methods of sex separation in insect pests; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2. Overview of Avian Influenza group Research at The Pirbright Institute. Presented at "Interactive session with poultry stakeholders" at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research Project outcomes These include presenting research data for vaccine seed strains with emergent field avian influenza variants; The zoonotic risk posed by emerging avian influenza viruses circulating in the wild birds and poultry. Impact of virus evolution on vaccine efficacy and persistence in poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 2019 Culture of Care Meeting Pirbright |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The fourth annual Culture of Care and 3Rs meeting was hosted at The Pirbright Institute on 16 October 2019. Dr Beatriz Sanz-Bernardo presented the advancements made in applying the 3Rs to lumpy skin disease research. These include refining biopsy procedures to minimise animal suffering and replacing laboratory experiments with simulations modelling host-vector interactions. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.pirbright.ac.uk/news/2019/10/pirbright%E2%80%99s-2019-culture-care-meeting-focuses-anima... |
| Description | 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.labanimaltour.org/pirbright |
| Description | AHSV talk on transmission for OIE (Thailand online) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on transmission of AHSV to interested parties following outbreak in 2020. Talk given on 9/6/20 to approx 150. |
| Year(s) Of Engagement Activity | 2020 |
| Description | AN INTERVIEW WITH PROFESSOR VENUGOPAL NAIR |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Professor Venugopal Nair is a Research Group Leader at The Pirbright Institute, a visiting Professor of Avian Virology at the Department of Zoology, and a Jenner Investigator at the Jenner Institute, University of Oxford. He is also a member of the Microbiology Society, and in this interview, he tells us more about his research into viral diseases of livestock. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/membership/meet-our-members/focus-area-viruses/an-interview-with-pro... |
| Description | ASF Genotypes Study Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Interview to discuss recent publication on a hybrid virus discovered in China |
| Year(s) Of Engagement Activity | 2023 |
| Description | Animal Technician talk at Woking College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | External talk at Woking Sixth Form College |
| Year(s) Of Engagement Activity | 2017 |
| Description | Article and Video in AP press on African swine fever risk to pygmy hogs |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview and video recording for AP press on risks of African swine fever virus to critically endangered pygmy hogs in Assam India |
| Year(s) Of Engagement Activity | 2020 |
| Description | Article in Microscopy & Analysis - ELMI, Joanna Wells |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Joanna wrote a summary of the ELMI meeting as an article for the publication. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Article in The Scientist Magazine following interview with Katya Zimmer (June 2019) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Journalist with The Scientist Magazine for a News Article concerning Race to Build ASFV vaccine in response to outbreaks in China/Asia |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.the-scientist.com/news-opinion/scientists-race-to-build-vaccine-for-african-swine-fever-... |
| Description | Ash Manor GCSE Mentoring 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Ash Manor school challenge week science workshops |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Provide information on research activity at The Pirbright Institute and informing on pathogens infecting farmed animals. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Ash Manor school challenge week science workshops |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Discussion of research activities with school children and the school reported increased interests in the related subject. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Attend SEMT |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attend in person conference, Society for Electron Microscopy Technology |
| Year(s) Of Engagement Activity | 2021 |
| Description | Attend SEMT - Joanna Wells |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engaged with microscopy community |
| Year(s) Of Engagement Activity | 2021 |
| Description | Avian Influenza Evolution: Impact on Virulence, Vaccines and Diagnostics. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented a keynote talk at the International Seminar 2024 "Poultry Health Challenges in Pakistan on 21 November 2024 at the University of Agriculture, Faisalabad, Pakistan. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Avian Influenza Research at Pirbright |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker to the Animal Diseases Surveillance and Control Team at The Department for Environment, Food, and Rural Affairs (DEFRA), London, UK sharing the research goals and achievements performed at the Pirbright Institute. The topics focused on (i) understanding the genetic and antigenic evolution of avian influenza viruses, (ii) drivers of zoonotic potential, (iii) improvement of poultry vaccine potency, (iv) investigating molecular markers of antigenic variants, (v) improving avian influenza detection and diagnostic approaches, e.g. lateral flow devices and (vi) development of novel vaccine candidates to improve protective efficacy including vector- and multivalent-based vaccines and targeted delivery of antigens. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Avian Influenza Vaccines Research at Pirbright |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Delivered a presentation to key research grant funders and stakeholders in the UK, including BBSRC and DEFRA, associated with animal welfare, disease control, and the research goals and achievements performed at the Pirbright Institute. The topics focused on (i) understanding the genetic and antigenic evolution of avian influenza viruses, (ii) drivers of zoonotic potential, (iii) improvement of poultry vaccine potency, (iv) investigating molecular markers of antigenic variants, (v) improving avian influenza detection and diagnostic approaches, e.g. lateral flow devices and (vi) development of novel vaccine candidates to improve protective efficacy including vector- and multivalent-based vaccines and targeted delivery of antigens. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Avian Influenza Viruses: Potential Threats and Disease Mitigation Strategies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented a talk (as an invited keynote speaker) at the 8th Scientific Conference on Transboundary Animal Diseases on 10 October 2024, Tunis, Tunesia |
| Year(s) Of Engagement Activity | 2024 |
| Description | Avian Influenza and One Health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented Talk at the Infectious Diseases seminar for senior medical practitioners on 25 September 2024, at the Gordon Museum of Pathology, Hodgkin Building, Guy's Campus, London. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Avian Influenza: Global Situation & Control Strategies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the International Symposium on Poultry Health Challenges in Pakistan. Organized by the World Veterinary Poultry Association (WVPA-Pakistan Branch) at Serena Hotel Faisalabad, Pakistan. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Avian flu: our food chain is in crisis. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The New paper "Telegraph" correspondent Sarah Newey (GLOBAL HEALTH SECURITY CORRESPONDENT) Interviewed Professor munir Iqbal regarding the impacts and threats of current wave if high pathogenicity avian influenza virus causing disease widespread losses to poultry production, mortality of wild birds and mammalian species (otters, foxes, minks sealions), The discussion focus on the impacts of avian influenza infections on the livelihood of farming comunities and threat of zoonotic infection to wider public. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.telegraph.co.uk/global-health/science-and-disease/what-bird-flu-pandemic-killedmillions-... |
| Description | Avian influenza virus evolution impacts on virulence and antigenicity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk was presented at Royal Veterinary College, London, by Thusitha Karunarathna (a PhD student in the Avian Influenza group at The Pirbright Institute). The Talk described the mechanisms used by the avian influenza viruses to evade host immunity to cause disease outbreaks and persists in poultry. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Avian influenza viruses can combine two techniques to evade vaccine immunity |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A study by researchers at The Pirbright Institute reveals more clues about how avian influenza viruses can evade vaccine immunity, aiding their spread in the field. The findings are published in Emerging Microbes and Infections. Influenza viruses are able to mutate, which can enable them to evade immunity generated by natural infection or vaccination. Influenza viruses have four main ways of duping the immune system so that they can continue to infect and spread between birds. Pirbright scientists investigated two of these to further understand how the H9N2 avian influenza virus can change its genetic makeup to overcome poultry vaccines. One of the methods the virus can use is to alter one of its surface proteins, haemagglutinin (HA), which enables the virus to enter the cell and replicate. HA is also a common target for the immune system's antibodies, which block the virus from binding to cell receptors. By changing just one or two protein components, HA can latch on far more tightly to the cell, preventing antibodies from stopping the virus. However, this can come at a cost, as particularly strong binding can prevent effective replication. The other method scientists investigated is how H9N2 viruses disguise themselves by adding sugar chains to the surface of their HA proteins. This can block antibodies from binding, but also has varying fitness outcomes for the influenza virus. The researchers found that the location of the sugar chain on HA could determine how effectively the virus replicated. They also demonstrated that the two evasive techniques could either compliment or act against each other - if an influenza virus had gained mutations that enable it to bind more strongly to cells, a sugar chain in the right position could restore its ability to replicate effectively. In contrast, weakly binding influenza viruses do not benefit from HA sugar additions, which instead reduce the virus's ability to replicate. Professor Munir Iqbal, head of the Avian Influenza Group at Pirbright said, "We can use this knowledge to develop new vaccines that will help antibodies to recognise how the flu virus can change. This will provide protection to birds even as the virus evolves. We can also use this information to understand how viruses survive in poultry despite vaccination and monitor new adaptions that may appear in the field." This research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI) and the British Council with support from the Newton Fund. Article: Sealy, J. E., Peacock, T. P., Sadeyen, J. R., Chang, P., Everest, H. J., Bhat, S., Iqbal, M. (2020). Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness. Emerging Microbes & Infections, advance online publication, 12 November 2020, doi: 10.1080/22221751.2020.1850180 [SOURCE: The Pirbright Institute] |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.star-idaz.net/2020/12/avian-influenza-viruses-can-combine-two-techniques-to-evade-vaccin... |
| Description | Avian influenza: tackling large numbers of outbreaks this winter in the UK |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Nearly two years on, the COVID-19 pandemic is still dominating the news and continues to cause concern for populations across the globe. However, UK poultry and wild bird populations are currently facing their own health threat. We are not the only ones that have faced lockdowns because of spreading viruses, UK poultry and captive birds have also faced a similar situation to protect them from avian influenza. Scientists at The Pirbright Institute are working to increase understanding of how genetic changes in influenza A viruses can impact disease spread, host responses to infection and the pathology associated with the disease. What is the avian influenza virus? Avian influenza viruses are Influenza A viruses that circulate and transmit amongst birds. The disease is what we commonly know as 'bird flu'. Influenza A viruses can infect a range of hosts, including humans and two subtypes H1N1 and H3N2 circulate as seasonal flu each winter in the UK. Avian influenza viruses are different to those that can infect humans in that they cannot easily infect humans and must change and adapt to do so. Aquatic birds are a natural reservoir for avian influenza viruses, these birds typically experience fewer clinical symptoms but can spread disease to domestic birds, particularly in the migratory season, between October and March. Avian influenza viruses are categorised as either highly pathogenic (HPAI) or low pathogenic (LPAI) and this categorisation is linked to the severity of disease in chickens. HPAI has a high mortality rate which can be up to 100%, other symptoms can include swelling of the head, death of cells in the comb and wattle, red discolouration of legs and feet and diarrhoea. HPAI causes disease in more organs than just those in the respiratory or gastrointestinal tracts like LPAI, which mostly presents as respiratory symptoms such as a snick (like a sneeze), a rattle in the chest (known as rales) and discharge from the eyes and nose. What is causing bird flu outbreaks in domestic birds now? We are currently in the normal migratory season of wild birds. In the spring and summer months, these birds spend their time breeding and raising their young in North-eastern Asia where they mix with other bird species which enables virus transmission and mutation. Then, when they migrate for the autumn and winter months, they shed virus in their faeces along the way. One of the migratory paths is across Northern Europe and this includes the UK. This year, in the UK, the first avian influenza outbreak was on 15 October and was discovered in captive aquatic birds. To date (17 December 2021) there have been 50 outbreaks in England, 1 in Wales and 2 in Scotland, this has resulted in over half a million birds being destroyed to control the spread of disease. Are there more outbreaks this year compared to other years? The number of outbreaks this year has been the most extensive ever. There have been over 50 outbreaks in the UK, compared to 26 outbreaks last year. Although it is hard to pin down the reason for this high number, we know it is not linked to the COVID-19 pandemic. The UK's response to the spread of avian influenza has been rapid, and from 29 November birds were required to be housed inside with additional biosecurity measures put in place such as foot dips and disinfecting clothing. Testing and surveillance of wild birds have shown that there is a high prevalence of the virus in these birds currently, and this is contributing to the spread of disease to farm and domestic bird populations. A more detailed look at the genetic make-up of these viruses shows that they are different to those from previous years. This is predicted to be as a result of the virus infecting multiple birds across a range of species, and this provides the perfect opportunity for the virus to evolve. Analysis of these genetic changes does not raise any alarm bells for increased transmission to humans, but they are likely impacting the spread and severity of disease in birds. What should we do if we find a dead bird or are concerned about bird health? If the public finds dead waterfowl birds they are encouraged not to touch them but to report them to Defra using the appropriate phone number that can be found on the website, also any other wild birds found dead in numbers of five or greater should be reported. What is Pirbright doing to tackle this virus? Researchers at Pirbright are attempting to enhance the control and detection of avian influenza in poultry populations as well as extend our basic knowledge about the virus in avian and mammalian hosts. The research groups led by Professor Munir Iqbal and Dr Holy Shelton are investigating how avian influenza virus strains originated from wild birds can rapidly adapt to cause disease outbreaks in poultry and gain the potential to infect humans. In addition, Professor Munir Iqbal is developing improved poultry vaccines that prevent virus replication and spread. These vaccines are particularly useful in countries where avian influenza is regularly found in the domestic poultry and the control and prevention of spread isn't easy, such as in the UK. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/12/avian-influenza-tackling-large-numbers-outbreaks-winter-uk |
| Description | BBC News story - Rinderpest virus destruction |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The Pirbright Institute as one of five Rinderpest virus (RPV) holding facilities destroyed its final stocks of rinderpest virus and in doing so is leading the way for other countries to follow suit. RPV is one of only two viruses that has been eradicated and therefore is of interest to a very wide audience. The story was broadcasted on the BBC 6 O' clock news after a days filming within the high containment facility at Pirbright. |
| Year(s) Of Engagement Activity | 2019 |
| Description | BBC World Service Science Programme "Science in Action" Broadcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This was an broadcast with BBC World Service Science in Action Programme to inform the public about the current African swine fever situation and provide information on pathogenesis mechanisms of transmission and our research on vaccine development |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.bbc.co.uk/programmes/p002vsn |
| Description | BBC4 Big and Small series of programmes filmed 2021 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Filming for section on electron microscopy of viruses. Programme not due to be scheduled until Spring 2022 |
| Year(s) Of Engagement Activity | 2021 |
| Description | BBSRC Impact Showcase 2022 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was asked to record an interview answering questions relating to the impact of BBSRC funding on our research. This has been included as an impact case study on the BBSRC research outcomes and impact pages. |
| Year(s) Of Engagement Activity | 2022 |
| Description | BBSRC Partnering Seminar, University of Liverpool, Tamilnadu Veterinary and Animal Science University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk presented entitled " Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses". The research data shared with the colleagues working to reduce the impact of avian infectious diseases on poultry production. The discussion led to more collaboration and work together, acquiring reagents and protocols for further research and development activities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | BSI report on the future of veterinary immunology and vaccinology |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Organised and published a joint IVVN/BSI report to raise awareness of the UK's research status in veterinary vaccinology and immunology and the importance of maintaining this for the R&D landscape 'Securing Our Future: the value of veterinary vaccines'. This was aimed at influencing policymakers to support and commit to maintaining the UK's leading position. |
| Year(s) Of Engagement Activity | 2021 |
| Description | BSI webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I presented a webinar hosted by the British Society for Immunology entitled "BSI Coronavirus webinar: What can we learn from the animal coronaviruses?", which sparked questions and discussions afterwards. I have since been contacted to establish new collaborations with people in the audience. |
| Year(s) Of Engagement Activity | 2020 |
| Description | BTV3 Symposium: Navigating the outbreak in Europe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Symposium to share experiences of BTV-3 across affected countries in Europe |
| Year(s) Of Engagement Activity | 2024 |
| Description | Big Band Science Event- AH, ER, LVC, MdP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Big Bang Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This is a South of England Showground in which students from schools and their parents participated which lead to discussion and interest in both school children and their parents. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://nearme.thebigbangfair.co.uk/view/?eve_id=1956 |
| Description | Big Bang Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The Big Bang Near Me is a programme of regional and local Big Bang Fairs that take place all across the UK. Together with The Big Bang UK Young Scientists & Engineers Fair and The Big Bang Competition, it forms part of the wider Big Bang programme, bringing science, technology, engineering and maths (STEM) to life for young people |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://nearme.thebigbangfair.co.uk/about/ |
| Description | Big Bang SE |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation (HB and MA) in Big Bang SE |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.thebigbangfair.co.uk/ |
| Description | Big Bang SE |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Big Bang UK- Jennifer Simpson |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Big Bang UK is a science competition. JS acted as moderator for final projects submitted by students from across the UK. |
| Year(s) Of Engagement Activity | Pre-2006,2019 |
| Description | BioimagingUK meeting 2022 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | UK bioimaging community meet to discuss future directions of technology and what UK facilities are required in the future |
| Year(s) Of Engagement Activity | 2022 |
| Description | Bird flu: What is it and what's behind the outbreak? ( BBC New) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussion with BBC News Editors (Helen Briggs & Jeremy Howell). As the The world is going through its worst-ever outbreak of bird flu which led the deaths of hundreds of thousands of wild birds and millions of domestic ones. It is also being found in mammals, so what are the threats from this virus to economy, food security, animal welfare and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bbc.co.uk/news/science-environment-63464065 |
| Description | Blenheim High School Fair - DB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Team members attended sessions at a local high school with secondary school children and those in the 6th form to talk about paths into scientific careers, sharing their experiences of working at The Pirbright Institute. Approximately 300 students attended and it stimulated increased interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Bluetongue and Wildlife (15 minute presentation on Epizootic Haemorhagic Disease Virus), (July/Pirbright, UK) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Policymakers reported greater interest in deer-associated diseases including EHDV and BTV |
| Year(s) Of Engagement Activity | 2018 |
| Description | Broadcast on African swine fever on BBC wolrd service "The Food Chain" |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with BBC World Service "The Food Chain" on African swine fever virus. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bbc.co.uk/programmes/p05xhflj |
| Description | CABI_Research activity of Avian Immunology Group at The Pirbright Institute |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Release of research activity within Avian Immunology group at The Pirbright Institute |
| Year(s) Of Engagement Activity | 2018 |
| Description | CC Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | MA participated in a careers fair at Collingwood College |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cafe Scientifique, Bradfield School, West Berkshire: "How insects spread viruses" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cafe Scientifique, Reading: "How insects spread viruses" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions. |
| Year(s) Of Engagement Activity | 2007,2017 |
| Description | Career Development and Training Focused Interest Group 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Royal Microscopical Society (international membership) FIG, training and career development for microscopists |
| Year(s) Of Engagement Activity | 2021 |
| Description | Chair - Royal Entomological Society Session on Insect Vectors |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session on Insect Vectors including selecting speakers and managing session. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.royensoc.co.uk/sites/default/files/RES%20Ento%20'19%20Reg.%20Leaflet_web.pdf |
| Description | Chair BioimagingUK meeting 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion on funding issues influencing equipment acquisition in UK |
| Year(s) Of Engagement Activity | 2021 |
| Description | Chair and Co-Organiser for UK Vector-borne Diseases Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | UK Vector-borne Diseases meeting held bi-Annually. Half day sessions on 2nd, 9th, 16th, 23rd November 2020. Chaired session on 9th November 2020. Meeting was held online with invited and selected presentations and a poster session. Also included funders from Defra and BBSRC. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Chairing Biosafety Strategic Leadership Group (BSLG) Biocontainment Engineering Working Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Bringing together engineering professionals from biocontainment facilities in the UK, to share best practice and discuss processes. Improved communication channels between engineering teams in UK biocontainment facilities |
| Year(s) Of Engagement Activity | 2024,2025 |
| Description | Challenges and Innovations in Avian Influenza Vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented Avian Pathology Lecture at the 6th WVPA Asia Meeting, 17-18 October 2024, Manila, Philippines. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at the festival covering the Institute science in general, and transmission and gene editing to control disease, in particular. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Panel discussion at the Cheltenham Science Festival in 2018 One of the biggest threats to our food security is disease of our livestock and crops. Disease affects our economy and the availability of food in our shops. Don King, Head of the World Reference Lab for Foot-and-Mouth Disease, chemical ecologist John Pickett and food systems researcher John Ingram join climate scientist Tamsin Edwards to explore the risks to the UK's food supply and how preventing and controlling these diseases keeps our store cupboards well-stocked. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.cheltenhamfestivals.com/science/whats-on/2018/how-safe-is-our-food-supply/ |
| Description | Cheltenham Science Festival 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Attended the Cheltenham Science Festival and presented "Pandemic Live" an interactive debate on the spread of viruses in livestock. The audience were guided through the decision making processes that accompany an outbreak of an exotic livestock disease outbreak. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival- AH, ER, JC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Present at the Pirbright stand to discuss science with the public |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenham Science festival - LB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | National science festival which Team members attended to demonstrate to the public how scientists at The Pirbright Institute can work to contain and control viral outbreaks. Over 500 people accessed the information and this stimulated increased interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenhan Science Festival - Dana Perry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | DP helped to run a stand at the festival, questions from the general public stimulated increased interest in science and research and increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Commentary on AHSV outbreak in Thailand in Science Magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | 'Thailand scrambles to contain major outbreak of horse-killing virus' - Article in Science Mag April 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.sciencemag.org/news/2020/04/thailand-scrambles-contain-major-outbreak-horse-killing-viru... |
| Description | Conference presentations at Negative Strand Virus meeting 2022 in Braga, Portugal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Four members of the research group (Drs Bailey, Jobe and Newman as well as Miss Thakur) travelled to Portugal to present our work on SARS-CoV-2 host range, immunity and also RSV inclusion bodies. We had 2 talks and a poster. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Conference session organiser at MMC2017 - Host Pathogen Interactions |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chair for the Imaging Host-Pathogen Interactions session run at MMC2017 (and in previous years). Session usually attracts approx. 30 delegates from national/international backgrounds, mostly academic. Talks sparked discussions and networking opportunities. |
| Year(s) Of Engagement Activity | 2012,2014,2015,2017 |
| Description | Controlling and monitoring Avian Influenza in poultry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Engagement with veterinarian and farmers involved in poultry production. The discussion focused was new strategies (vaccines and diagnostics) for reducing the the impacts of high pathogenicity of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Copenhagen PhD course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Scientific organiser and lecturer on PhD course in EM at University of Copenhagen |
| Year(s) Of Engagement Activity | 2021 |
| Description | Coronavirus lecture MSc students (Surrey) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A lecture was presented on the replication, cellular interactions and pathogenesis of coronaviruses to 15-20 MSc students from University of Surrey. The students were engaged and interested, answering and asking questions during the session. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | Could Bird Flu become a pandemic? (Aljazeera TV) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The discussion ( Inside Story) has been impacts of high pathogenicity avian influenza on poultry and whether bird flu become a pandemic?. The inside story was presented by Al Jazeera English corresponded "Mohammed Jamjoom" the discussion focus remains as the world is experiencing its largest recorded outbreak of bird flu, populations of poultry and wild birds are becoming infected. So what are threats of these viruses on food supplies, economy and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.youtube.com/watch?v=spp2Cg-jqoc |
| Description | Cross-scale dynamics of foot-and-mouth disease virus: from within hosts to between farms |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited mini-symposium presentation on "Cross-scale dynamics of foot-and-mouth disease virus: from within hosts to between farms" at Society for Mathematical Biology 2023, Columbus, Ohio, USA, 17-21 July 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | DB Winston Churchill School Careers event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | School careers event for a Secondary School - 1500 children ages 11 to 16 years |
| Year(s) Of Engagement Activity | 2021 |
| Description | Defence Science and Technology Laboratory (DSTL) - Peer review carried out at Porton Down |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Knowledge sharing, open discussions regarding processes and procedures - knowledge gain. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Defence Science and Technology Laboratory (Dstl) - Knowledge sharing visit to Pirbright from Dstl Engineering team |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Knowledge sharing, open discussions regarding processes and procedures |
| Year(s) Of Engagement Activity | 2025 |
| Description | Defence Science and Technology Laboratory (Dstl) - Visit to Porton Down to give presentation on Process Safety |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Provide overview on Process Safety at Pirbright - Knowledge gain. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Deimante Lukosaityte: Microbiology Society conference 2019. Poster presentation: Chicken protection against H9N2 virus by passive immunization |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques for development of next generation of vaccines against viral diseases affecting animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Delivered a lead talk and chaired a session at VIROCON international conference, New Delhi on Early events on PPRV pathogenesis- February 18-20, 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered a lead talk at VIROCON international conference, New Delhi on Early events on PPRV pathogenesis- February 18-20, 2020. This parks questions and discussions after the talk. The scientists working on other morbilliviruses, example on Measles were keen to know the new fact I delivered that PPRV primarily infect immune cells in pharyngeal tonsil, but not in the epithelium of respiratory tract as believed. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Delivered a lead talk at Indian Association of Vetrinary Microbiology and Immunology ( IAVMI) at IVRI, Bareilly on PPR and FMD control by vaccination- February 6-7th, 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered a lead talk at Indian Association of Vetrinary Microbiology and Immunology ( IAVMI) at IVRI, Bareilly on PPR and FMD control by vaccination- February 6-7th, 2020. Further attended the panel meeting with FMD vaccine producers and FMD scientists at PDFMD and IVRI Bangalore to recommend Govt of India for the future control of FMD. Suggested boosting of the first dose FMDV vaccinated animals which will stimulate the immunity up to the second biannual vaccination to avoid any window for infection. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Delivered a talk on PPR DIVA vaccine at EU Epizone meeting in Berlin-25.8.19-28-08.19 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered a talk on PPR DIVA vaccine at EU Epizone meeting in Berlin-25.8.19-28-08.19 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Delivered an invited talk on Epidemiology of PPR at wildlife Arusha, Tanzania - 22.10.10-26.10.19 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Delivered an invited talk on PPR epidemiology at wildlife Arusha, Tanzania - 22.10.10-26.10.19 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Demonstrating Mathematics (Angita Shrestha) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Angita Shrestha (PhD student within Avian Influenza group) provided help in a Maths session to the new Oxford Doctoral Training Porgramme (DTP) cohort. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Determinants of antigenicity of H9 Avian Influenza Viruses. UK-China Swine and Poultry Workshop.17-18 June 2019, The Pirbright Institute, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Developing Novel Multivalent Vaccines for Poultry Viral Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal present talk Presented at the Oxford University Human and Veterinary Vaccinology Course on 30th October 2024, Pirbright, UK. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Developing novel multivalent vaccines for poultry viral diseases |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk entitled "Developing novel multivalent vaccines for poultry viral diseases" was presented to post-graduate students from Univerity of Oxford. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Development programme public consultation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Public consultation on the Pirbright development programme hosted at the Pirbright Village Hall. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Diamond (TT) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Diamond Light Source Open Day - explaining to general public the importance of structural biology and microscopy for understanding viruses and designing improved vaccines. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diamond Light Source Open day - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A public open day for Diamond Light Source, which Pirbright attended as a user of the facility to showcase research being performed at Pirbgith in collaboration with Diamond. There was a lot of interest in the fundamental research and sicussion about future plans and how it fit with the facility at Diamond. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diamond open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Over 300 people visited our stand at the open day, in which we described the importance of our work for food security and public health. Children from all ages were involved and learned about viruses and played with the huge virus particle that we had produced. One of the major impact was that we described to several people why we work on some viruses that we do not have them in the UK, and the importance of the work for the UK and UK economy and public health was explained. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.diamond.ac.uk/Public/VisitUs.html |
| Description | EM-UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Co-organiser and speaker for UKRI supported network for electron microscopists in the UK. I was one (or two) of the founder members. Meeting has been running for 5 years. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | EM-UK 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientific organiser, meeting for EM community in UK |
| Year(s) Of Engagement Activity | 2021 |
| Description | EM-UK 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientific organiser of EM-UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | EM-UK 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM-UK is a network for electron microscopists to discuss policy, practice and science relating to the use of the microscopes. Industry representatives and funder representatives (including BBSRC) also contribute to the programme every year. |
| Year(s) Of Engagement Activity | 2022 |
| Description | EMBO Workshop: Molecular and population biology of mosquitoes and other disease vectors: vector and disease control |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Sex determination pathway in Anopheles gambiae as a target for mosquito control" given during the meeting held on 22 - 26 July 2019 in Kolymbari, Greece. Following a presentation a request was made to give an informal seminar at the Department of Life Sciences, Imperial College, London. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://meetings.embo.org/event/19-mosquitoes |
| Description | Elle Campbell Presented her data at the 2019 Microbiology Society Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Elle Campbell gave an oral presentation at the 2019 Microbiology Society Annual Meeting on the work we were doing with fluorescently tagged IBDVs and virus factory movement. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Emergence and Fitness of H5N1 Clade 2.3.4.4b Viruses Currently Infecting Poultry, Wild Birds, Mammals, and Humans |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented a talk at the International Pandemic Sciences Conference, 1-2 July 2024, Oxford, UK. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Emerging Animal Infectious Disease Conference, Co-hosted by Penn State's College of Agricultural Sciences, the Pennsylvania Department of Agriculture and Penn State's Center for Security Research and Education |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker - provided a presentation on FMD |
| Year(s) Of Engagement Activity | 2021 |
| Description | Emerging Threats: The Evolution and Persistence of Avian Influenza Viruses in Poultry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an Invited speaker at the 2023 International Symposium on Important Animal Diseases and Zoonoses of Yangzhou University, China. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Encouraging women into science and engineering STEM. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | MH Visited Warwick School, Redhill to talk to secondary students about careers in STEM. A very positive outcome and well received. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Engagement with poultry stakeholders (farmers and veterinarians at "Morocco Poultry Day"). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk was presented to poultry stakeholders including farmers describing the new emerging technologies that increase the efficacy of poultry vaccines, in particular vaccines against Avian influenzas and Newcastel disease virus,.The meetings was attended over 80 participates. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Environmental transmission of foot-and-mouth disease virus and implications for disease surveillance |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar on "Environmental transmission of foot-and-mouth disease virus and implications for disease surveillance" at Wageningen University, Wageningen, The Netherlands on 3 April 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | EpiRisk Workshop, IZS Teramo, Italy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on work done as part of EFSA lumpy skin disease working groups to inform risk modellers/epidemiologists about possible approaches |
| Year(s) Of Engagement Activity | 2019 |
| Description | Epizone participation by team member |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Postdocteral scientist attended poster session at EPIZONE, "Breaking walls" Berlin 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | European Society Vector Ecology (Invited Chair for two sessions and speaker for 15min talk); (October/Palermo, Sicily) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired two sessions, one on vector-borne diseases, one on scientific networks. Latter included a discussion with early career researchers. Main outcome was coordination between active networks including The Gnatwork. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.sove.org/European%20SOVE%20folder/greecescientificprogram/palermo_Scientific_program_revi... |
| Description | Evolution of H9N2 avian influenza virus under immune pressure. Presented at 10th International Symposium on Avian Influenza, 15th - 18th April 2018, The Grand Hotel, Brighton, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of the workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. In addition, the activity hopes provide information about the emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Evolutionary Dynamics of Avian Influenza (H5/H7/H9) in Asia and Its Risks |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented a talk at the 6th WVPA Asia Meeting, 17-18 October 2024, Manila, Philippines. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://wvpa-asia2024.com/ |
| Description | Expert commentary on New Scientist article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I provided expert commentary on an article published in New Scientist, which summarised research performed by researchers at the University of Leeds on how mosquito bites enhance the transmission of vector-borne diseases. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://institutions.newscientist.com/article/2231141-skin-cream-applied-to-mosquito-bites-stops-vir... |
| Description | FAO and Nanjing Agricultural University One Health Global Experts Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited key note presentation - entitled "Global and regional risks of foot-and-mouth disease" |
| Year(s) Of Engagement Activity | 2021 |
| Description | FLI - presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of current research to the FLI - Germany to build collaborations 19/20 November 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Facebook Live: Infectious Disease Portrayals in Pop Culture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Infectious diseases are a frequent topic in movies. The CDC has used zombies to talk about infectious disease and disaster preparedness, and infotainment has flamed fears of Ebola. I took part in a Facebook Live chat organised by the AAAS Public Engagement team about why infectious diseases are so often the topic of pop culture discussions; what movies, books, and other pop culture gets right and wrong about infectious disease; and how scientists can use pop culture as a jumping-off point for public engagement. The chat was broadcast live on the AAAS Facebook page. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.aaas.org/event/facebook-live-infectious-disease-portrayals-pop-culture |
| Description | Farnborough Sixth Form College Careers Fair - Chris Chiu |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | CC engaged at a careers day, and answered questions presented by sixth form students about working in science. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Farnborough futures careers event - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The careers event aimed to introduce the range of careers available at Pirbright. In addition I discussed my own career progression and highlighted the range of possible careers that I could have entered. Finally, I discussed some details of the research with interested students. The students had a wide range of backgrounds and career aims but were interested to hear about the Institute and the sort of work opportunities available. Several of them planned to follow up by investigating future job opportunities at Pirbright. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Food security and the control of infectious disease in livestock |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A workshop was organized by myself at St Catherine's College Oxford for the duration of three days. Representative from industry, funding agencies and media (publishers) attended this workshop. Over 20 delegates from Egypt and 20 delegates from the UK attended this meeting. The purpose of this workshop/ meeting was to promote international collaborations, provide training for undergraduate students, promote the importance of managing and controlling infectious disease in livestock and public health. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Fox Corner Community Wildlife Committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Pirbright Institute representative on the Fox Corner Community Wildlife Committee - locally held meetings, every 2 months. |
| Year(s) Of Engagement Activity | 2017 |
| Description | GFRA (TT) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Global Foot-and-mouth disease Research Alliance (GFRA) meeting, presentation on virus packaging and implications for vaccine production, initiated collaboration discussions between international academic and industry partners. |
| Year(s) Of Engagement Activity | 2019 |
| Description | GFRA scientific meeting, Thailand 29-31/10/2019 Poster presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster title: EVALUATION OF CD4+ T-CELL RESPONSES TO VACCINATION WITH NEXT GENERATION FMD VACCINES USING TETRAMER-GUIDED EPITOPE MAPPING OF FOOT-AND-MOUTH DISEASE VIRUS CAPSID |
| Year(s) Of Engagement Activity | 2019 |
| Description | Global epidemic trend of avian influenza virus and its harm to public health |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk as an invited speaker at The 2023 China-ASEAN Seminar on Prevention and Control of Cross-border Animal Diseases, Guangxi Veterinary Research Institute, Nanning, Guangxi, China. The persistence of avian influenza viruses in bird populations increases zoonotic and pandemic risks. Research focuses on reducing prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). To address this, topics discussed included research focuses in: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Guest lecturer MSc Imaging course at University of Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Guest lecturer for PhD course in EM, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. Increase visibility of The Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | H5Nx Clade 2.3.4.4b Avian Influenza Viruses: An Increasing Risk for Global Poultry, Livestock, and Humans |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented a talk at the WVPA Regional Conference for Africa and the Middle East 3-6 September 2024, Cairo, Egypt. |
| Year(s) Of Engagement Activity | 2024 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research outcomes to prevent and control of infectious diseases of animals and humans. - Avian influenza virus evolution and efficacy. - |
| Year(s) Of Engagement Activity | 2018 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Focus of the conference was to improve control against infectious diseases affecting poultry and livestock. |
| Year(s) Of Engagement Activity | 2018 |
| Description | HPAI Update: Global and Asian Situation and Control. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Munir Iqbal Presented talk et "Let's Speak Poultry" (ASKAN), on 16 October 2024 in Manila, Philippines. |
| Year(s) Of Engagement Activity | 2024 |
| Description | High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. Presented via Webinar, organized by Boehringer Ingelheim, 3rd July 2020. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled; High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. talk was organized by Boehringer Ingelheim, 3rd July 2020 and presented via Webinar. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Holt School Surrey. Bee meadow & A-level outreach Talk. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I discussed the importance of pollinators for biodiversity and food security with the younger students. I also discussed careers in science with A-Level students. There was good interaction and many questions surrounding both topics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Host training day for APHA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | 4 users from APHA visited for training on our confocal, which is the same make and model as theirs. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Identification of antigenic epitopes to broaden and enhance the efficacy of avian influenza vaccines. Presented at 6th Animal Vaccines and immune Adjuvant Technologies Salon & Advanced seminar, Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 18-20 October 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Illumina EMIDA seminar series - Graham Freimanis |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Applying High-Throughput Sequencing to Animal Health Research. Illumina internal staff seminar series. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Imagineering Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talked to the general public about Pirbright science and Beekeeping |
| Year(s) Of Engagement Activity | 2019 |
| Description | Immuno-pathobiology of H9N2 avian influenza viruses: looking at how the viruses evolve and persist in poultry. Presented at "Techniques for Healthy Farming and Diseases Prevention & Control of Livestock and Poultry. Beijing, August 13th-15th, 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dissemination of research outputs. Improvement of vaccines and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Imperial College London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | KM gave an invited seminar to a department of microbiology researchers at Imperial College London, including postgraduate students. The audience engaged with questions during the talk and a conference organiser grant was submitted due to this engagement. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Improving Breadth and Duration of Immunity of Poultry Vaccines: Targeted Delivery of Antigens to Chicken Antigen Presenting Cells. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled "Improving Breadth and Duration of Immunity of Poultry Vaccines: Targeted Delivery of Antigens to Chicken Antigen Presenting Cells" presented by Professor Iqbal at 2022 Yangzhou International Conference on Agriculture and Agri-Product Safety - Germplasm Innovation and Agri-Product Safety on 30th November 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Detection Sensitivity of Lateral Flow-Based Rapid Diagnosis of Emerging Avian Influenza H5Nx Clade 2.3.4.4b Viruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Munir Iqbal presented a talk at the International Pandemic Sciences Conference, 1-2 July 2024, Oxford, UK. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Improving Potency of Poultry Vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Research outcomes were presented by Munir iqbal at the 2022 International Animal Husbandry: High quality development of animal health and animal husbandry- Virtual Scientific Conference, on 19-Nov-2022, hosted by Shandong Vocational Animal Science and Veterinary College. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Potency of Poultry Vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk entitled "Improving Potency of Poultry Vaccines" presented by Munir Iqbal to post graduate students at meeting "The 2022 International Animal Husbandry High-Quality Development Conference" on On 19th November 2022 hosted by Shandong Vocational Animal Science and Veterinary College. More than 300 post graduate and university staff from Shandong Vocational Animal Science and Veterinary College attended the meeting and discussed the advanced in the strategies to reduce the impacts of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Vaccines against Avian Influenza and Newcastle Disease Viruses |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the Sino-European Modern Livestock and Poultry Industry Technical Innovation seminar and the launch of the Joint Laboratory of China and European Countries. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Improving vaccines and diagnostics for Avian influenza viruses affecting poultry. Presented at the International Poultry Expo "Poultry Science Conference", Lahore, Pakistan, 13-15 September 2019. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Inception meeting for a Global Challenges Research Fund (GCRF) Global Research Translation Awards, 12.11.2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Inception meeting for a Global Challenges Research Fund (GCRF) Global Research Translation Awards, 12.11.2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Influenza update 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Approx. 70 scientists attended a Influenza update meeting at which our group presented an oral presentation and poster presentation on our work. These actions resulted in establishment of new collaborations for ongoing work and the initiation of a joint grant writing exercise. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Influenza update meeting (Pengxiang Chang) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | presented work entitled: Antigenic characterization of avian influenza H7N9 virus by in vitro immune escape mutant selection method. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Initiation of a mass vaccination campain ( 2018) in TamilNadu, India |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Scientists from The Pirbright Institute's Vaccine Differentiation group have recently returned from Chennai in India, where they conducted a mass peste des petits ruminants (PPR) vaccination campaign and awareness programme. They joined scientists from four specialist organisations; Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Indian Veterinary Research Institute (IVRI), National Institute of Animal Biotechnology (NIAB) and National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI). Peste des petits ruminants (PPR), also known as goat plague, is highly contagious and infects small ruminants such as sheep and goats, causing up to 90% mortality. The disease is prevalent across large parts of Africa, the Middle East, India and China and is estimated to cost between US$1.4 billion and US$2.1 billion globally each year. In 2017, the Food and Agricultural Organization (FAO) and the World Organisation for Animal Health (OIE) introduced a global eradication programme to reduce the devastating impact PPR has on the economy and food security of affected countries. "Over 40 vets joined our vaccination campaign in the Tanir Kulum village of Tiruvallur District, TaminNadu (close to Chennai), where we administered vaccines to over 400 sheep and goats in a single day. We also ran an awareness camp where we provided farmers and vets alike with expert guidance on diagnosing clinical signs of PPR and what measures they could take to reduce its spread", said Professor Satya Parida from Pirbright, who led the collaborative effort with Dr Dhinakar Raj from TANUVAS. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes... |
| Description | InnovSur : Conference in IRD Montpellier on Insect Vector Surveillance |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Working group on standardisation of techniques for surveillance of insect vectors. Included break out group brainstorming and subsequent commentaries. Total audience approximately 110 people for main lectures. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.alphavisa.com/isessah-innovsur/2018/ |
| Description | Innovate Guildford (Angita Shrestha): |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | GENERAL SCIENCE |
| Year(s) Of Engagement Activity | 2019 |
| Description | Innovate Guildford - DB & KC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Public science event where team members participated on a Pirbright Institute stand which contained activities to help the public understand how scientists can help to contain and control viral outbreaks. Over 500 members of the general public attended which stimulated increased interest in science and research and led to requests for more information. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Innovate Guildford 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at the Innovate Guildford event, covering the work of the Institute in general and genetic modification through gene editing specifically. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.guildford.gov.uk/IG18 |
| Description | Innovate Guildford, ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented at the Pirbright Institute stand discussing science performed by the Institute with the general public. The stand focussed on an exhibit on avian influenza virus but more general virology topics were also discussed including our research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guilford-AH, AA, ER, EL |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | General science festival engaging the public in the research undertaken at Pirbright |
| Year(s) Of Engagement Activity | 2019 |
| Description | Inreview with Daily Telegraph about African swine fever |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with reporter from Daily Telegraph about African swine fever virus and risks to UK farmers |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.telegraph.co.uk/news/2018/12/12/uk-farmers-warned-alert-african-swine-fever-virus-hits-e... |
| Description | Insect Festival 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Ran a stand on blood-sucking arthropods and their role in the transmission of disease at the Royal Entomological Society's Insect Festival. Talked to public, answered questions. Lots of enquiries about ticks, midges, mosquitoes and large biting flies (particularly horseflies). |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.yorkmuseumstrust.org.uk/whats-on/events/insect-festival-2017/ |
| Description | Institute stand "Disease Detectives" at Royal Society Summer Science Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Institute stand "Disease Detectives" at Royal Society Summer Science Exhibition, 6-10 July 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://royalsociety.org/science-events-and-lectures/2022/summer-science-exhibition/ |
| Description | Institute stand at Surrey Vet School open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Discussion with pupils interested in veterinary medicine (and their parents) about the Institute, its role and livestock disease in general. |
| Year(s) Of Engagement Activity | 2013,2015,2016 |
| Description | Institute stand at Surrey Vet School open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | International Avian Respiratory Disease Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michael presented his research at the 2018 International Avian Respiratory Disease Conference in the US to an audience of avian researchers and representatives form the poultry veterinary vaccine industry. This sparked discussion and potential future collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | International Congress of Entomology (Florida) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session and gave presentation on progress in Culicoides research. Largest ever meeting involving the Culicoides community with 100+ attendees. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://ice2016orlando.org/ |
| Description | International Day of Women and Girls in Science |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a quote as a STEM ambassador about why I think it is important to make sure women and girls have the same opportunities in STEM. This was shared on social media to celebrate International Day of Women and Girls in Science, a UN-led initiative. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Interview on "Disease Detectives" |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview about "Disease Detectives" for BBC World Service Health Check programme, broadcast 7 July 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bbc.co.uk/sounds/play/w3ct32wl |
| Description | Interview on lumpy skin disease |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Interview on lumpy skin disease with Simon Quilty of Global AgriTrends |
| Year(s) Of Engagement Activity | 2023 |
| Description | Interview with Anne Gulland - Telegraph article Nov 2020 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Anne Gulland of the Telegraph about HPAI outbreaks in wild birds, article published https://www.telegraph.co.uk/global-health/climate-and-people/farmers-urged-alert-highly-pathogenic-form-bird-flu/ quoted in the article. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.telegraph.co.uk/global-health/climate-and-people/farmers-urged-alert-highly-pathogenic-f... |
| Description | Interview with Associated Press |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with a journalist from Associated Press about coronavirus research at The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with Associated Press on ASFV vaccines |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Associated Press |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://apnews.com/32f84f66ce77415b96c4e90915cce6ee |
| Description | Interview with Australian Broadcasting Corporation on African swine fever virus impact and vaccine development |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Australian Broadcasting Corporation about ASFV impact and vaccines |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.abc.net.au/news/rural/2019-11-01/african-swine-fever-vaccine-development/11645366 |
| Description | Interview with BBC Radio 4 Inside Science |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | An interview with BBC Radio 4 Inside Science producers to inform them about African swine fever virus and our research on vaccine development |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.bbc.co.uk/programmes/p05v91jq |
| Description | Interview with BBC Radio Surrey |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with journalists from BBC Radio Surrey on the breakfast show about coronavirus research at The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with BBC journalist for article on viral emergence in new species |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interviewed by Jonathon Ball who was writing an article for the BBC on the emergence of morbilliviruses in new hosts and the importance of vaccination. I helped him to contextualise the story and put him in touch with my collaborators. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bbc.co.uk/news/science-environment-50839868 |
| Description | Interview with BuzzFeed News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with a journalist from BuzzFeed News about coronavirus research at The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with CNN on African swine fever virus |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Nina Avramova from CNN International about African swine fever virus generally including transmission mechanisms and control strategies |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://edition.cnn.com/2018/10/02/health/african-swine-fever-europe-china-spread-intl/index.html |
| Description | Interview with Dominique Patton, Beijing, Reuters article Jan 2021 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Dominique Patton (Reuters - Beijing) about outbreaks of HPAI in wild birds. Quoted in https://www.reuters.com/article/us-health-birdflu-asia/reeling-from-coronavirus-asias-poultry-farmers-battle-bird-flu-outbreak-idUSKBN29J00D?edition-redirect=uk which was picked up by multiple media outlets. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.reuters.com/article/us-health-birdflu-asia/reeling-from-coronavirus-asias-poultry-farmer... |
| Description | Interview with Farmers Weekly |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Interview with journalist from Farmers Weekly on African swine fever virus vaccine development |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with German Radio on African swine fever virus risks and vaccine development |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio broadcast on German Radio |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with Health for Animals about African swine fever vrius vaccine development and current situation |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Interview with journalists from Health for Animals about African swine fever vaccine research published in a newsletter sent to 200 people. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://healthforanimals.org/resources-and-events/newsletter-repository/17-disease-outbreaks.html?q=... |
| Description | Interview with IEG Policay about ASFV vaccines |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Interview with Peter Rixon of IEG policy about the prospects for development of vaccines for African swine fever vrius |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://iegvu.agribusinessintelligence.informa.com/CO221819/ASF-outbreak-in-Belgium-highlights-lack-... |
| Description | Interview with Journalist with The Scientist Magazine concerning ASFV vaccines and our research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Katya Zimmer Science Journalist with The Scientist Magazine published in July. This lead to follow up interviews for an in depth article on ASFV vaccines for the Scientist Magazine. In addition The Scientist published 4 Infographics images associated with the article |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.the-scientist.com/features/can-a-vaccine-save-the-worlds-pigs-from-african-swine-fever |
| Description | Interview with New Scientist Magazine about African swine fever virus spread and vaccines |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview for an article in New Scientist about impact of African swine fever in Asia |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.newscientist.com/article/2222501-a-quarter-of-all-pigs-have-died-this-year-due-to-africa... |
| Description | Interview with United Press about ASFV vaccine development |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with United Press International on Development of ASFV vaccines |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.upi.com/Top_News/US/2019/07/12/World-races-to-develop-African-swine-fever-vaccine/671156... |
| Description | Interviews to discuss COVID vaccine results |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio interviews (BBC Radio Surrey and Oxford), television interview (BBC South Today) and interviews with press to discuss results from our studies evaluating COVID-19 vaccine candidates in pigs. |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | Investigating avian influenza antigenic evolution and improving potency of poultry vaccines (Internal seminar) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk presented describing how the genetic evolution of avian influenza viruses can result in vaccine failure and how we developed approaches that improve the effectiveness of poultry vaccines to reduce the economic loss in poultry. We describe our research data H5 subtype of avian influenza viruses are evolving rapidly and being classified into different clades. These viruses carry significant antigenic heterogeneity and a single candidate vaccine may not be able to protect against the virus variants infecting poultry in different countries around the globe. Our data will allow for the generation of vaccines that are better strain-matched, thus reducing the impact of AIVs in the poultry industry. We also present our work on the development of next-generation poultry vaccines termed "Targeted Antigen Delivery Vaccine (TADV)" that selectively deliver vaccine antigens to the chicken immune cells known as Antigen-presenting cells and potentiates immunogenicity of the vaccine. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited Chair at European Congress of Entomology (Naples,July) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session on vector-borne diseases at meeting and subsequent question sessions with 15 minute presentation on Culicoides biting midges. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ece2018.com/scientific-programme/day-1-monday-2-july/ |
| Description | Invited Keynote Presentation on African swine fever and vaccine development |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Keynote presentation at China Animal Breeding and Genetics conference December Guangzhou, attended by more than 2000 delegate. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Lecture - Antivec Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation give on 'The Gnatwork'. 21/06/19. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.gla.ac.uk/research/az/antivec/ |
| Description | Invited Lecture - Public Health Interest Group (London School Hygiene and Tropical Medicine) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk presented and discussion session particiation (09/04/19) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Lecture - Wageningen University and Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title: Culicoides-borne arboviruses in Europe - Invited lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Panelist - Canada Animal Health Forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I joined a panel to discuss the selection, use and quality control of FMD vaccines |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://animalhealthcanada.ca/forum-2023 |
| Description | Invited Presentation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presentations at the European PRRS Research Award ceremonies |
| Year(s) Of Engagement Activity | 2016,2017 |
| Description | Invited Presentation to Pig Veterinary Society Birmingham UK October 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited Seminar China Agricultural University Beijing September 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar at China Agricultural University Veterinary Faculty on "African swine fever virus evasion of host defences and vaccine development". Discussion with faculty and postgraduate students. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited Speaker - GFRA/EuFMD Webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker: Importance of independent vaccine quality control: the role of regional reference FMDV antigens to assess heterologous vaccination responses. Joint EuFMD/GFRA meeting on Public-private Partnerships for Progressive control of foot-and-mouth disease in endemic settings, February 2022. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=U-onxVpZRug&t=1699s |
| Description | Invited Speaker - Pig veterinary Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation to the Pig Veterinary Society to provide an overview of vesicular disease cases in England |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.pigvetsoc.org.uk/meetings |
| Description | Invited Speaker: 33rd World Veterinary Congress, South Korea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Provided two invited keynote presentations at the 33rd World Veterinary Congress, Incheon, South Korea, August 2017: [1] Foot-and-mouth disease: recent outbreaks and patterns of virus spread [2] New tools for the detection and characterisation of transboundary diseases |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.worldvet.org/congress.php?year=2017 |
| Description | Invited Talk: 8th International Veterinary Congress, Moscow, Russia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DK was invited to give a talk entitled "Global surveillance for foot-and-mouth disease: new tools and approaches to predict risks and help control outbreaks" at the 8th International Veterinary Congress, in Moscow, Russia, April 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited Talk: Indian Veterinary Institute, Bareilly, India |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | SP delivered a talk at faculty on FMD vaccine strain selection in South East Asia including India |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited as PPR vaccine expert to vaccine producers meeting at Jordan, Amman-organised by OIE and FAO PPR secretariat-13.04.19-17.4.19, |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited as PPR vaccine expert to vaccine producers meeting at Jordan, Amman-organised by OIE and FAO PPR secretariat-13.04.19-17.4.19, |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited lecturer for MSc Biological Electron Microscopy, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited oral presentation at 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited oral presentation: 'Trying to hit a moving target: Novel approaches to porcine reproductive and respiratory syndrome virus vaccine development', 18th National Conference for Pig Disease Prevention and Eradication, Wuhan, China |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited presentation at the Friedrich Loeffler Institute (January; Riems) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Formal presentation on biting midges and bluetongue to professional audience with question session and collaborative meetings |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited presentation: 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited by the British Society for Immunology to give a presentation on vaccine research at the 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens, Berkeley, UK. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited seminar at INRAE, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar to present our recent and ongoing PRRSV research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited speaker - Moredun |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on Bioimaging capabilities at Pirbright to Moredun Institute. Attended by Head of Bioimaging at Roslin too, increased links between these institutes. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | Invited speaker - PHE Colindale |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on high containment microscopy, asking for my advice prior to the design of a new high containment microscopy facility at PHE. This sparked a discussion at the end of the meeting, and several key points of advice that I put forward for them to consider during this process. I made it clear that I am available for other discussions at a later date if needed. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker - RMS EM School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to lecture on certain aspects of electron microscopy. I provided advice on individuals difficulties they had with sample preparation. Delegates had the opportunity to ask me any questions then had relating to any sample type. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker - Tunis |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker: Épidémiologie de la Fièvre Aphteuse en Afrique du Nord 7ème Journée Scientifique sur les Maladies Animales Transfrontalières, Tunis, Tunisia, September 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited speaker - WOAH Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The presentation highlighted the wide-scale problems relating to the quality of FMD vaccines that are used in endemic countries. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.wavld.org/content/past-and-upcoming-meetings |
| Description | Invited speaker British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker on "Bluetongue virus and Schmallenberg virus - recognising the continued threat of Culicoides-borne viruses of ruminants" British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology School of Veterinary Medicine, University of Surrey, 29th of September 2018, |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bsvp.org/event/applied-ruminant-pathology-disease-investigation-diagnosis-and-surveillan... |
| Description | Invited speaker VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker on "The Host-vector-pathogen Interface of Culicoides-borne Bluetongue Virus" at the VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 4th-5th December 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at APHA surveillance meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker on insect surveillance at Animal and Plant Health Agency meeting with discussion around current studies. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at Imperial College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on our recent research in swine influenza. Discussions with PIs at Imperial after the talk. Established collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker, . Jenner Symposium, Royal Society, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on One Health vaccines |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited speaker, Merseyside BSI Affinity group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | I described the methods we used to identifyTissue resident memory cells in pigs, which sparked a lively discussion and interest in the technique. As a result I have established two collaborations with colleagues from Liverpool. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker, Surrey University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Under- and postgraduate students attended a talk I gave at the Department of Biological Sciences in Surrey. There was a lively discussion afterwards and as a result I have established a new collaboration. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker, VIRCON (Indian Society for Virology) International Satellite Symposium. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited speaker: Developing a 'One Health' Nipah virus vaccine to protect animal and public health. VIRCON (Indian Society for Virology) International Satellite Symposium. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited speaker, Vienna Veterinary School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave a guest lecture at the Veterinary school in Vienna. There were a lot of questions and discussion after the talk. As a result established collaboration with Gerner Wilhelm's group. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.vetmeduni.ac.at/de/graduate-school-pig-and-poultry-medicine/ |
| Description | Invited talk at Agricultural Science congress at New Delhi, India, February-2019- Use of reverse genetics to study the early pathogenesis and to develop marker vaccines for PPR |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 1. In a DBT-BBSRC FADH grant, The Pirbright Institute in collaboration with four Indian partners (TANUVAS, IVRI, NIAB and NIVEDI) has developed a PPR vaccine, which will be the first to differentiate between infected and vaccinated animals (DIVA), for which a patent application has been filed. Scientists have manipulated in the genome of PPR full length cDNA and rescued the DIVA vaccine virus using reverse genetic technique. Further this vaccine has been tested in goats providing full safety and potency upon virulent virus challenge. In contrast to current vaccine, this new DIVA vaccine can differentiate between naturally infected and vaccinated animals, therefore will help in meaningful assessment of vaccine coverage and epidemiological surveillance based on serology, in turn increasing the efficiency of control programmes. 2. Little is known about the early events in the development of peste des petits ruminants (PPR) virus (PPRV) infection. The current dogma is that similar to RPV, PPRV replicates primarily in the epithelium of the respiratory tract before disseminating throughout the host. However, our investigations, using intranasal inoculation of PPRV containing GFP (Green Fluorescent Protein) to mimic natural infection, indicate this is not the case and that immune cells in the pharyngeal tonsil is the primary target. This is a ground breaking discovery which changes the PPR pathogenesis. This infectious GFP virus is made from a synthetic cDNA of field virus (PPRV/Mor-08) using reverse genetics technique under FADH grant. The presentation sparked questions and discussions after the talk. Two PPR DIVA vaccines developed and the mechanism of PPR virus pathogenesis explained. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk at International High-End Conference on the Challenges in Veterinary Vaccine Development |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at International High-End Conference on the Challenges in Veterinary Vaccine Development on ASFV subunit vaccines. Chinese Academy of Engineering and Henan Agricultural University from December 4th to 6th, 2021 in Zhengzhou City, China |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited talk at World Vaccine Congress, Washington DC, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed the potential for structural vaccinology to advance livestock vaccine development including examples of FMDV, bRSV and PRRSV |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited to attend and present at the RSPCA Lay members Forum, Royal Society London 10th of December 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Invited to attend to the RSPCA Lay members Forum, Royal Society London 10th of December 2018 and present on the ethical review process of animal research |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://science.rspca.org.uk/sciencegroup/researchanimals/ethicalreview/differentsystems/uk/events |
| Description | Invited to give a seminar at the Clinical and Molecular Virology Institute, Erlangen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was invited by Professor Tenbusch to give a talk on our work on porcine tissue resident memory cells. We have established a very productive collaboration, applied for and were awarded joint funding and his PhD student has come to a working visit to our Institute. |
| Year(s) Of Engagement Activity | 2021 |
| Description | JN - Woking school 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Careers Fair at a local school encouraging children to consider science as a career and representing the institute in the local community. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Jennifer Simpson - Big Bang Competition judge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | The Big Bang Competition recognises and rewards young people's achievements in all areas of science, technology, engineering and maths (STEM), whilst providing them with the opportunity to build their skills and confidence in project-based work. The Competition is open to all UK residents in full-time education or training. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Jennifer Simpson - Careers Fair at Woking High School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Pirbright Institute stand at the careers fair. Speak to students interested in a career in science. Sparked questions and discussions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - Girls into STEM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach activity for girls in local schools to demonstrated the variety of careers available within the STEM sector. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - InFocus article on Bioimaging in high containment |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Magazine article describing the facilities for imaging in high containment at Pirbright. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - Surrey MSc students visit to Pirbright |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Jenny organized a practical session where the students prepared their own samples for the confocal microscope, then they were able to image these samples using our instrument. The activities provoked questions and discussion. This session is always very warmly received by the students. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | Joined as a FAO expert at Chiang Mai, Thailand for PPR and FMD control in SAARC region and delivered two invited talks- 16.06.19-23.06.19 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Joined as a FAO expert at Chiang Mai, Thailand for PPR and FMD control in SAARC region and delivered two invited talks on FMD and PPR Global situations- 16.06.19-23.06.19 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Katy Moffat - Surrey MSc student visit to Pirbright |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Katy ran a small workshop for the students which enabled them to see the whole flow cytometry workflow. These activities provoke questions and discussions, and are always very warmly received. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | Keynote - GFRA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote Speaker: Can new technologies bridge surveillance gaps for foot-and-mouth disease? Scientific meeting of the Global Foot-and-mouth Disease Research Alliance, Kampala, Uganda, November 2023 |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ars.usda.gov/GFRA/reports/2023%20GFRA%20Meeting%20Program.pdf |
| Description | Keynote Presentation China Swine Society Conference 2019 Qingdao China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Keynote presentation at China Swine Society Conference 2019 Qingdao attended by ~1300 scientist and practitioners |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote Presentation European Society for Veterinary Virology Ghent Belgium Sep 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | More than 500 people attended an International Conference on Veterinary Virology |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://esvv2022.ugent.be/ |
| Description | Keynote Presentation: 6ème Journée Scientifique sur les Maladies Animales Transfrontalières, Tunisia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Provided invited keynote presentation entitled "Épidémiologie de la Fièvre Aphteuse en Afrique du Nord" at the 6ème Journée Scientifique sur les Maladies Animales Transfrontalières, Gammarth, Tunisia, November 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keynote Presentation: EuFMD Open session |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote Presentation entitled "Global status report for foot-and-mouth disease: tracking the emergence and spread of new viral lineages" at the Open Session of the Standing Technical and Research Committee of the European Commission for the control of Foot-and-Mouth Disease, Borgo Egnazia, Puglia, Italy, October 2018. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://intvetvaccnet.wordpress.com/2018/12/18/eufmd-open-session-2018-global-vaccine-security-borgo... |
| Description | Keynote Presentations at International Workshop on African swine fever virus Beijing September 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The International Workshop on African swine fever virus was organised by the US/China Animal health Network and attended by ~50 people comprising leading International experts, policy makers, postgraduate students and experts from industry. The aim was to review current knowledge on ASFV and identify areas for future research. A report on the meeting and outcomes was published in Viruses. It is expected that future meetings will be organised. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Keynote presentation at the Swedish Virology Society Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | About 100 people from Swedish Society of Virology attended my keynote talk at their annual meeting |
| Year(s) Of Engagement Activity | 2021 |
| Description | Keynote speaker - 89th IUVSTA Workshop, Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote seminar to 'high vacuum' community, including life scientists and physical scientists, with experience in microscopy or other high end analystical techniques. increased visibility of the Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker - Danish Virology Society Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was personally invited to be keynote speaker at the annual meeting of the Danish Virology Society, to talk about high containment microscopy of cell biology of host-virus interactions. The meeting was held at the State Serum Institute in Copenhagen, followed by a social evening which enabled me to add new contacts into my network. This invitation came direct from the Danish Virology Society, independent of the work I already do with the University of Copenhagen. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keynote speaker - Society for Electron Microscopy annual meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a seminar about working with microscopes in high containment. This sparked questions and discussion. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker: EuFMD - OS22 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Keynote speaker: Innovation in molecular diagnosis, next generation sequencing and molecular epidemiology for FMD and FAST diseases. Open Session of the Standing Technical and Research Committee of the European Commission for the control of Foot-and-Mouth Disease, Marseille, France, October 2022. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=mKMZh4mt2Bg&t=24032s |
| Description | Keynote speaker: EuFMD - OS22 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote speaker: Headline events from global FMD surveillance activities (2020-2022). Open Session of the Standing Technical and Research Committee of the European Commission for the control of Foot-and-Mouth Disease, Marseille, France, October 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Kingdown School Warminster Wiltshire talk to 6th form students about career in science. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I presented my career path to the students to engage them on STEM careers. I had a good level of discussion and many questions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Krantz visit with American HEPA company WSP, prior to project at APHA |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Tour of Plowright facility to look at HEPA engineering systems in-situ which led to some knowledge gain. |
| Year(s) Of Engagement Activity | 2023 |
| Description | LEAF open farm Sunday- JH, GM, WM, AH, KR, JS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual open farm day attended by businesses in the working in the farming industry in the Guilford area |
| Year(s) Of Engagement Activity | 2019 |
| Description | LSD Epizone 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Oral presentation at 13th annual epizone meeting, Berlin 2019. "Risk of transmission of LSDV from experimentally infected cattle to insect vectors". Beatriz Sanz Bernardo. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Laboratory Science Animal association (LASA) meeting in Birmingham, Invited speaker |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a presentation on the tools we have developed to study swine influenza |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.lasa.co.uk/meetings/ |
| Description | Latest Pirbright collaboration uncovers genetic markers that could guide avian influenza surveillance |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Research outputs were mass comminated for the general public via a news story. This was published online at the Pirbright Institute webpage and One Health Poultry Health webpage and distributed wildly on social media including Facebook, Twitter, In Share. Researchers at The Pirbright Institute have identified the genetic markers on avian influenza ('bird flu') viruses that could help the viruses to jump the species barrier and cause disease in people, in collaboration with other members of the One Health Poultry Hub. Co-investigators Professor Munir Iqbal and Dr Joshua Sealy worked with scientists at Imperial College London, the University of Glasgow and The Francis Crick Institute, to show how the genetic traits of avian influenza H9N2 viruses influence their preference for infecting bird or human cells. The paper detailing their findings, 'Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza viruses' is published in the Journal of Virology. The research identifies genetic traits that alter a key H9N2 viral protein, called haemagglutinin, that makes it easier for the virus to recognise and bind to different cell receptors. This is the first step of viral infection, and the general inability of avian influenza viruses to effectively bind to human receptors is a major reason why they do not, in general, jump the species barrier to people. However, given that human infections with H9N2 have been detected on an almost monthly basis since 2015, there may be a capacity for these viruses to evolve and gain the ability to efficiently target cellular receptors in people. This latest discovery reveals which haemagglutinin properties of existing H9N2 strains allow them to bind to human receptors more effectively. These included small genetic differences as well as the overall structure and charge of the haemagglutinin protein. These findings will help guide future avian influenza surveillance by providing the genetic markers that signify the emergence of viruses with the potential to transmit to people. There have been more than 60 cases recorded of people infected with H9N2 influenza viruses to date in 2020, all in countries where the virus is endemic. However, these viruses have not adapted to spread efficiently from person to person, a key element of a virus that has the potential to cause a pandemic. Professor Iqbal and his team at Pirbright have previously described H9N2 viruses which showed a preference for human-like receptors. Professor Iqbal said: "Understanding more about which traits increase the likelihood of H9N2 viruses jumping into humans help to identify viruses that could pose a future threat. Keeping an eye on viruses with these traits can help us to be prepared in the event that one of them evolves to pass between people rather than only from birds to humans." This research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) the Medical Research Council (MRC) both part of UK Research and Innovation (UKRI). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/01/latest-pirbright-collaboration-uncovers-genetic-markers-cou... |
| Description | Launch of first industry guidance on safe working with arthropods and GM insects |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Around 50 biosafety professionals and regulators including representatives from HSE attended the formal launch of the first industry guidance on working safely with arthropods and genetically modified insects on 21st April at Pirbright. This initiative originated with Sharon Webster, Chair of ISTR's Biosafety Steering Group, and was developed based on consultation with myself and members of my group with practical experience of working with arthropods in containment. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.pirbright.ac.uk/news/2017/04/first-industry-guidance-safe-working-arthropods-and-gm-inse... |
| Description | Laura Dunn - Female role models |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Careers day for secondary school students, with the focus on careers for women in science |
| Year(s) Of Engagement Activity | 2018 |
| Description | Laura Dunn - Surrey Vet School Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Providing information about a career in research to prospective veterinary students |
| Year(s) Of Engagement Activity | 2018 |
| Description | Lecture given to University of Surrey MSc Veterinary Microbiology students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A 2-hour teaching lecture given to 10 MSc Veterinary Microbiology students at the University of Surrey on 8th December (Lara Harrup) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Lecture of dynamics of vector-borne diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Two-hour lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at University of Cambridge |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021,2022,2023,2024 |
| Description | Lecture on dynamics of infectious diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture as part of MSc in Veterinary Microbiology at University of Surrey |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017 |
| Description | Lecture on entereic coronaviruses to MSc Students (Surrey) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A lecture was presented on the pathology, diagnosis and detection of enteric coronaviruses, including virus replication and interaction with the host. The students were engaged and asked/answered question throughout the session. We were invited to repeat the lecture for the subsequent student intakes. |
| Year(s) Of Engagement Activity | 2015,2016,2018 |
| Description | Lectures for MSc course in Copenhagen 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Taught on a masters microscopy course (approx 20 delegates) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Linking within-host dynamics and between-host transmission for viral diseases of livestock |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation on "Linking within-host dynamics and between-host transmission for viral diseases of livestock" for a workshop on "The scales of epidemic modelling" held Institut des Systèmes Complexes, Paris, France on 26 September 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | Livestock Viral Diseases Pathology Slide Set |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Pip Beard (The Pirbright Institute) and Dr Sandra Scholes (Scotland's Rural College) designed a set of histology slides of tissues from livestock affected by notifiable viral diseases. The Livestock Viral Diseases Pathology Slide Set contains examples of lumpy skin disease, African swine fever, bluetongue, rift valley fever, and peste des petits ruminant. The slide set has been provided free of charge to eleven veterinary training schools and institutes in the UK and Ireland. The aim of the s |
| Year(s) Of Engagement Activity | 2019 |
| Description | Lorin Adams (Gordon's School Careers Fair) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Lumpy Skin Disease D2R2 profile |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Provided expert opinion to the assessment (D2R2) of the risk of lumpy skin disease virus (LSDV) to the UK. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | MBPAV -presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Molecular Biology and Pathogenesis of avian viruses conference - Oxford 3-4th September 2018. Oral presentation given on drug resistant influenza viruses to approximately 50 scientist. Increased collaborative approaches following presentation. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://microbiologysociety.org/event/society-events-and-meetings/focused-meeting-2018-molecular-bio... |
| Description | MMC 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attend biannual microscopy congress, engage with colleagues and manufacturers |
| Year(s) Of Engagement Activity | 2021 |
| Description | MMC 2021 - Joanna Wells |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engage with peers, start to build network, represent the Institute |
| Year(s) Of Engagement Activity | 2021 |
| Description | MMC Learning Zone - invited speaker |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Microscience Microscopy Conference, speaker at the Learning Zone - specimen preparation for life sciences. Increase the visibility of Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC PhD Student DTP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | I gave a career development seminar to the MRC PhD student DTP to discuss opportunities and realities of an academic research career in universities and research institutions. |
| Year(s) Of Engagement Activity | 2021 |
| Description | MW gave a tour of Pirbright site for the B-Cell meeting attendees (2 batches ) this was organised by Selma Schmidt and Jane Edwards |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Highlighting the unique facilities of Pirbright |
| Year(s) Of Engagement Activity | 2023 |
| Description | Mapping antigenic determinants of H9N2 avian influenza viruses and improving vaccines and diagnostics" presented at Foreign Talent Lecture: New strategies and new techniques for the prevention and control of major avian diseases. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. 6th August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The focus of the meeting was to improve the control systems against poultry diseases including development of improved vaccines and diagnostics |
| Year(s) Of Engagement Activity | 2018 |
| Description | Media engagement on COVID-19 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Comments on epidemiology and modelling of COVID-19 in the early stages of the pandemic via the Science Media Centre, specifically on: - herd immunity - modelling by Oxford University on the potential seroprevalence in the UK (comments taken up and reported widely via Agence Presse France) - modelling by IMHE to predict the potential number of deaths due to COVID-19 in the UK (comments picked up by CNN and affiliates) |
| Year(s) Of Engagement Activity | 2020 |
| Description | Member of BBSRC sLoLa grants committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Member of sLoLa Committee to shortlist outline applications and review/assess application at the full stage of submission. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Member of a BBSRC expert group on the use of animal models in research |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Reviewed the key findings of the survey and identify key trends and emerging opportunities. Reviewed the proposed recommendations, discuss the challenges and barriers surrounding the use of models, and suggest how UKRI-BBSRC can help overcome these. Identified key stakeholders that UKRI-BBSRC could partner with to act on recommendations and how the report should be disseminated. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Microbiology Society Annual Meeting, Belfast, 8-11 April 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk describing research to date - the molecular mechanism by which the Npro protein of classical swine fever virus inhibits dsRNA-induced apoptosis in infected host cells. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Microbiology Society Annual Meeting, Belfast, 8-11 April 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to present project results to date - describing the interaction of foot-and-mouth disease virus (FMDV) with monocyte-derived dendritic cells (moDC). Stimulating increased interest in science and research at The Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | Microbiology Society Annual conferences- invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Scientific talk on successful cross-species transmission of vector-borne viruses |
| Year(s) Of Engagement Activity | 2019 |
| Description | Microbiology Society talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Oral presentation at Microbiology Society Annual Conference 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Microbiology Today article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited article titled 'How to Image an Exotic Virus' in special Imaging issue (February 2018). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Microbiology society- 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation of research at annual microbiology society conference. Increased interest in collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Microscopy Society of Ireland annual meeting 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at annual meeting |
| Year(s) Of Engagement Activity | 2021 |
| Description | Miyazaki University Symposium - Oral presentation 03/12/2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation title: The N-terminal autoprotease of classical swine fever virus. Stimulating increased interest in science and research at The Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | Mock Interview Programme Cove School- Ai, AA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular Determinants for Antigenicity and Vaccine Efficacy of H9 and H7 Avian Influenza Viruses. Newton Agham Researcher Links Workshop: Novel vaccines and diagnostics technologies against Emerging and re-emerging veterinary Pathogens. 4-7 February 2019 at Rizal Pak Hotel, Manila, Philippines. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular Risk Assessment of Clade 2.3.4.4b H5Nx Avian Influenza Viruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | UK-China Avian Flu Control Workshop and Flu-Trail Map Workshop on 11 and 12 November 2024 at The Pirbright Institute, UK. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Molecular determinants modulating avian influenza H7N9 virus antigenicity. Presented at The Microbiology Society Annual Conference 2019, 8-11 April ICC Belfast, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses. Presented as invited speaker at BBSRC UK-India Partnering Award seminar: University of Liverpool. 2 May 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Multiple talks at XXIInd World Veterinary Poultry Association Congress - WVPAC 2023, Verona, Italy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | three independent talks titled: (1) Selectively targeting antigens to chicken immune cells induces faster and very strong immunity in chicks with high levels of maternally derived antibodies, (2) The impact of avian influenza vaccination on zoonotic infections: lessons learned from the H7N9 avian influenza control, (3) Investigating molecular markers influences the haemagglutination activity of the H9N2 avian influenza viruses. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effective: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Munir Iqbal: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | NA PRRS Symposium & Conference of Research Workers in Animal Disease - Oral and poster presentations |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation title: Identification of host proteins that interact with non-structural proteins-1a and -1ĂŸ of PRRSV-1 |
| Year(s) Of Engagement Activity | 2019 |
| Description | New rapid protection bird flu vaccine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article published in the magazine "Poultry World) by Freelance journalist Natalie Berkhout describing the development of a new methods have been developed to enhance the immune response that vaccines produce and reduce the amount of virus that birds shed into the environment. One technique involves tagging flu virus proteins with a marker that makes them easier for antigen-presenting cells (APCs) to capture. These immune cells can efficiently process the tagged proteins, resulting in a robust and long-lasting antiviral response in chickens. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.poultryworld.net/health-nutrition/health/new-rapid-protection-bird-flu-vaccine/ |
| Description | Newton Agham Researcher Links Workshop on "Novel Vaccines and Diagnostic Technologies Against Emerging and Re-emerging Veterinary Pathogens, Rizal Park Hotel, Manila, Philippines 4-7 February 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of this workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. The workshop provided information on emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Nido2021 - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a poster at the Nidovirus symposium entitled "Identification of sites of infectious bronchitis virus RNA synthesis". She discussed our data with the audience. |
| Year(s) Of Engagement Activity | 2021 |
| Description | OIE expert lecture AHSV transmission in Thailand |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Online lecture on AHSV transmission following unprecedented outbreak in Thailand - part of OIE arranged seminar series. 20th April 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://rr-asia.oie.int/en/events/oie-webinar-on-the-african-horse-sickness/ |
| Description | One Health Science event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Dr Carrie Batten, Dr Don King and Dr Simon Graham, attended this event hosted by the UK CVO at the ambassadors residence in Paris, representing the Pirbright Institute. The event was to showcase the UKs capabilities in the One Health space. CVOs and other relevant stakeholders were in attendance. |
| Year(s) Of Engagement Activity | 2019 |
| Description | One Health: Zoonosis and Their Control Through the Use of Vaccines |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the conference entitled "National Dialogue on Agricultural Research" at the National Agricultural Research Centre (NARC), Islamabad, Pakistan. The persistence of avian influenza viruses in bird populations increases zoonotic and pandemic risks. Research focuses on reducing prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). To address this, topics discussed included research focuses in: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Opening of The Biggs Avian Research Facility |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | We presented our research and spoke to guests attending the opening of the Biggs Avian Research Facility at Pirbright. Guests who attended included politicians and members of the public from the local area, eminent researchers from other institutions, and members of BBSRC. Guests reported that they felt much more informed about the work going on at Pirbright and were impressed by our facilities. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral and poster presentation at European Society of veterinary Virology and EPIZONE (ESVV/EPIZONE) at Vienna, Austria 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation has been made on early events of PPR virus pathogenesis. The presentation reveled that PPR virus first taken up by the immune cells to the Pharyngeal tonsil and then to other lymph nodes before generalisation of the disease. Secondary replication happens in epithelial cells. This alters the existing believe that virus primarily replicate in the epithelial cells. Similarly a poster presentation has been done to show the detection of nucleic acid of PPR virus during PPR eradication programme, nasal sample has been shown as the best sample for viral genome detection. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at International Pig Veterinary Symposium and International PRRS Symposium, Chongqing, China. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation on our PRRS research at the International Pig Veterinary Symposium and International PRRS Symposium, Chongqing, China. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Organisation of "Imaging viruses in cells" meeting, 2024 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | A scientific meeting was organised for invited researchers to present and discuss ongoing projects relating to advanced bioimaging of viruses in cells and virus induced changes to infected cells. This included a range of light and electron microscopy techniques and image processing and analysis. The event provided a networking opportunity for researchers working with these complex techniques. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Organised IVVN/BSI meting on T cell biology |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Organised virtual T cell meeting: invited 8 speakers, opened the meeting, chaired session and closed the meeting. Highly successful meeting with 170 delegates from 28 countries and excellent feedback on scientific content, engagement and organisation. Brought together immunologists from the mouse, human and veterinary filed, facilitate exchange of ideas and new collaborations. |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.immunology.org/frontiers-in-comparative-immunology-series-t-cell-biology-virtual-conferen... |
| Description | Organiser of the Animal Genetics and Diseases conference 08 - 10 May 2019 Wellcome Genome Campus, UK. Highlighting recent advances in animal genetics and genomic technologies. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I am on the organising committee for this conference. The second conference in this series will highlight recent advances in animal genetics and genomic technologies. It will bring together specialists working on the interface of genomics, genetic engineering and infectious disease with the aims of improving animal and human health and welfare. Novel genomic technologies, mathematical modelling and quantitative genetics approaches, applied to host animals, as well as their pathogens, have transformed the understanding of animal diseases, host-pathogen interactions and epidemiology and their effects on productivity of farmed animal species and food supply chains. This year's conference will not only put the spotlight on the immune response of host animals and epidemiology but also cover the genetics and genomics of pathogens and the impact of animal-human relationships. We encourage registrations from researchers, breeders and technical specialists interested in learning and disseminating the latest cutting-edge techniques and methodologies across model species, wildlife, farmed animals and companion animals. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://coursesandconferences.wellcomegenomecampus.org/our-events/animal-genetics-diseases-2019/?dm_... |
| Description | Organiser/invited speaker - PhD course in EM, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Outreach video for BTV clinical signs and transmission 2016 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Video by Simon Carpenter and Karin Darpel intended to increase awareness regarding the potential for bluetongue virus re-emergence in the UK. Circa 2000 hits to date. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.youtube.com/watch?v=fwJ8zAxiLOE |
| Description | Oxford DTP students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | High level overview of diseases studied [at Pirbright], and the importance of our work, provided to a group of over 30 Oxford DTP students, followed by a networking lunch (29th September 2017). |
| Year(s) Of Engagement Activity | 2017 |
| Description | PDRA in my group Stacey Human attending Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | PH Filming for BBC4 programme |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview about imaging SARS2-CoV-2 in the EM |
| Year(s) Of Engagement Activity | 2021 |
| Description | PPR-Global Research and Expertise Network talk "Examining the zoonotic potential of PPRV" Vienna 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Gave a talk to the inaugural meeting of the PPR Global Research and Expertise Network (PPR GREN) at IAEA headquarters in Vienna, Austria. Participants included policy makers from the FAO and OIE. |
| Year(s) Of Engagement Activity | 2018 |
| Description | PRIDE day event TPI - HM, ND, CH, YC, MB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Stall presented describing recent research of the Coronavirus Cellular Biology group at the Pirbright Institute PRIDE event, celebrating Pirbright science and activites. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Pandemic Live (Cheltenham Science Festival) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Approximately 250 attendees at a 1 hour discussion around a simulated virus outbreak scenario (Speakers Fry; Carpenter; Beard; Hatchett). Followed by question and answer session. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.cheltenhamfestivals.com/science/whats-on/2018/pandemic-live/ |
| Description | Participant in IDEAS arboviruses workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated in discussions and breakout groups, formed contacts. Planned future meetings on minimum reporting standards in insect infection studies (now funded and scheduled for 2018). |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://ideas.princeton.edu/workshop-for-2017/ |
| Description | Participation in Understanding Animal Research Video |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviewed and filmed by Understanding Animal Research as part of their 360 degree tour of UK animal facilities (http://www.labanimaltour.org/) |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.labanimaltour.org/ |
| Description | Participation in a meeting regarding sex determination, Duesseldorf, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "Sex determination pathway in Anopheles gambiae as a target for mosquito control" during the Nothiger meeting on sex determination in insects, Duesseldorf, 11-13 March 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Participation in student day at the Pirbright Institute |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Student open day was participated by postgraduate students registered at several Universities, and scientists from Pirbright institute. Students were given a chance to discuss their research activities and future plans with senior scientists. Due to high interest from the students, the institute has decided to organize another open day. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Pasteur Institute Visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientists from Pasteur Institute in Paris visited to discuss setting up a new containment facility. They were particularly interested in having advanced microscopes in this facility so wanted to ask our advice. We had one Skype discussion (February 2020), and then they visited our site (March 2020) and went into the high containment labs. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Pathology Society talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at annual PathSoc meeting |
| Year(s) Of Engagement Activity | 2021 |
| Description | Pengxiang Chang: Talk presentation:The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines at Microbiology Society conference, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of vaccines to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://microbiologysociety.org/event/annual-conference/annual-conference.html |
| Description | Pengxiang Chang: UK-China Newton Fund (Poultry and swine) workshop at The Pirbright Institute.Oral presentation:Avian Influenza H7N9 Antigenic markers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pengxiang Chang:Influenza update meeting. The application of CRISPR/Cas9 in the development of vaccines against avian influenza virus |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques to improve and produce new effective vaccines against viral diseases of animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pig and Poultry Fair 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discussed Institute research with pig and poultry farmers, related industry and the general public. Received requests for more information related to research, business and studentships. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pigandpoultry.org.uk/ |
| Description | Pirbright Bioimaging Conference 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A small workshop on next generation imaging technologies, with collaborators from Diamond, Glasgow and other institutes. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Pirbright Dragon Fair - MZ |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Team members attended the locally held Dragon fair where the Pirbright Institute had a stand explaining the types of research that are conducted at the Institute, making our high containment science activities transparent to the local community. Approximately 60 people engaged with the stall to learn about the science happening on their doorstep. This stimulated interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pirbright Institute research teams studying characteristics of influenza virus that may alter disease outcomes in poultry. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Avian influenza, commonly known as "bird flu," is a disease caused by multiple strains of influenza virus. The viruses can infect a wide range of animals, including people and pigs, but the natural reservoir lies in populations of wild aquatic birds such as ducks and gulls, according to an announcement from The Pirbright Institute in the U.K., which is conducting research to better understand avian influenza viruses to help prevent the disease in poultry. Flu virus strains are categorized by the combination of the two proteins found on the outside of the virus: hemagglutinin (H) and neuraminidase (N) -- for example, H5N6 or H9N2. The H protein binds to cell receptors in order to initiate infection, while the N protein helps release new viruses from an infected cell, the institute explained. Strains are also classified by severity. Low-pathogenic avian influenza (LPAI) viruses cause clinical signs such as mild breathing problems, decreased egg production and growth. Some birds, particularly ducks and geese, do not display any signs of LPAI infection and are still able to spread the disease, Pirbright said. When LPAI viruses circulate in high-density poultry areas, the viruses can mutate into highly pathogenic strains. Highly pathogenic avian influenza (HPAI) viruses have severe and often fatal effects on some species of birds such as chickens, Pirbright noted, but some HPAI strains cause mild or no clinical signs of disease in wild birds and domestic waterfowl. These strains are notifiable, meaning government control measures must be put in place. Avian influenza can be carried vast distances by wild migratory birds and can infect domesticated poultry through direct contact or through contaminated droppings and bodily fluids, Pirbright said. Because of this, there is a year-round risk of avian influenza, which can increase depending on the disease status in a region and the migration season of wild aquatic birds. According to Pirbright, good biosecurity is essential in preventing poultry from being exposed to the disease and can be practiced on a commercial farm, with game birds or even with just a few backyard hens. Why is influenza so difficult to prevent? The institute explained that influenza viruses are constantly changing, and when they replicate, small errors called mutations are copied into their genome. Some of these will alter the virus's proteins, allowing the virus to escape detection by the immune system. All flu viruses also have the potential to undergo a process called reassortment, where two or more strains of influenza infect the same animal, allowing them to swap parts of their genome, Pirbright said. The resulting viruses can potentially have different characteristics than the original strains, such as the ability to replicate in different species, including people, the institute added. Avian influenza viruses such as H5N1 or H7N9 have infected people, predominantly in Southeast Asia, but in these cases, the virus has been transmitted directly from infected birds to people, with no onward spread. There is some evidence that avian influenza can be passed from person to person, and while there are no records of efficient or sustained human transmission, there is a constant risk that one of the new strains may spread easily among people, which could result in a new influenza virus pandemic, Pirbright said. Changes in the virus genetics from mutation or reassortment make it very difficult to anticipate how influenza viruses will spread through a population and whether current vaccines will be suitable for the strains that are circulating, Pirbright announced. The influenza research programs at Pirbright are progressing understanding of the virus and finding better ways to prevent its spread. Pirbright Institute group leaders Dr. Holly Shelton and professor Munir Iqbal are researching how the characteristics of influenza viruses can change the outcomes of disease. Studying flu at the molecular level allows them to find out how the virus evolves to overcome avian immunity and how changes in their genome can alter disease severity and their ability to affect different species, the announcement said. Shelton's and Iqbal's teams are working on identifying genetic markers for specific disease traits that can be used in surveillance systems to provide forewarning of strains that could cause pandemics. For example, Shelton's Influenza Viruses group is looking at which characteristics allow the viruses to become resistant to antiviral drugs that are currently used to treat human infections of influenza, allowing surveillance to provide an early warning of viruses that could cross into humans and be difficult to control, Pirbright said. The team is also investigating how long it takes for avian influenza viruses to adapt to new mammalian species. According to the institute, establishing which strains can rapidly adapt and identifying the genetic changes made to enable infection of mammalian cells will help with surveillance efforts and potentially lead to the development of techniques that will help prevent these mutations occurring. Vaccination and rapid diagnosis are very important for influenza prevention and control, but it is still not currently possible to protect against all influenza strains, Pirbright said, noting that Iqbal's Avian Influenza group is exploring which sites on the virus trigger the chicken immune system to respond quickly and fight off infection. This will better inform scientists' ability to match vaccines to strains in the field and could help to develop vaccines that are more effective. Iqbal's group is also developing multivalent vaccines that protect chickens and ducks from several avian influenza subtypes at once as well as test kits for rapid diagnosis of different subtypes at the flock-side, the announcement said. Visit Pirbright's Influenza Viruses and the Avian Influenza group pages to find out more about their research. Source: The Pirbright Institute, which is solely responsible for the information provided and is wholly owned by the source. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.feedstuffs.com/nutrition-health/protecting-poultry-avian-influenza |
| Description | Pirbright Institute stall at LEAF Open Farm Sunday |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hosting a Pirbright Institute stall at the LEAF Open Farm Sunday, held at the Leckford Estate, The Waitrose Farm, at Stockbridge in Hampshire on Sunday 11 June 2017. Open Farm Sunday is a day when farms across the country open their doors to the public to show them what it means to be a farmer and for the public to see firsthand how their food is produced. The Pirbright Institute was part of the "Science on the Farm" stand, together with BBSRC and other bioscience institutes to tell people about the work carried out and how this helps support farmers and protect the UK's food supply and the wider economy. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Pirbright Pride day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Set up a stand at the described our research, engaged with policymakers, industry and participants from other organizations and distributed leaflets. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Plenary speaker - Electron Microscopy Cryo-techniques as Tools for Elucidating Biological Processes, University of Minas Gerais, Brazil |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was personally invited to talk about imaging the cell biology of host-virus interactions. I was available throughout the associated workshop to provide advice on delegates projects relating to microscopy. These talks sparked discussions and more questions. I was able to increase my network of connections further during this visit to Brazil. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Plenary talk at 7th European Vet workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give a plenary talk on mucosal immunity at the 7th European Vet workshop. This updated the audience on the latest developments in targeting immunization to different regions and assessing immune responses. Several colleagues contacted me to conduce join stuies and established further collaborations |
| Year(s) Of Engagement Activity | 2021 |
| Description | Population Biology of Vector-Borne Diseases Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Population Immunity to ASF |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | I was contacted by a journalist from Vet Record and discussed the implication of population immunity wrt ASFV in Europe for an article they were writing. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Positive Strand Viruses Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | This was a poster presentation. There were several different poster sessions at the conference allowing a large selection of people to view each poster. The audience included world leaders in my research field and important names from groups all over the world. This gave me the opportunity to discuss my work with other scientists on a one to one basis, leading to generation of new ideas for future experiments and collaborations. |
| Year(s) Of Engagement Activity | 2010,2013,2016,2019 |
| Description | Postdocteral scientist - oral presentation at the 12th Annual meeting of Epizone (joint with 11th International Congress for Veterinary Virology, ESVV 2018) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Postdoctoral scientists abstract submission was selected for oral presentation. Project results obtained at the time were presented to a highly interested and engaging audience of more than 250 scientists, veterinarians, students and policymakers. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.epizone-eu.net/en/Home/News/show/Abstract-book-EPIZONEESVV-meeting-now-online-.htm |
| Description | Poster and flash presentation at Microscience Microscopy Congress - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | 3 minute flask presentation and poster entitled "Correlative cryo-bioimaging to study coronavirus replication organelles" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster at IMAV 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Poster presentation at IMAV 2019: INTERNATIONAL MEETING ON ARBOVIRUSES AND THEIR VECTORS 05 - 06 September 2019 "Lumpy skin disease virus: transmission to dipteran vectors using animal and ex-vivo models" Beatriz Sanz-Bernardo |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster presenation at Nipah @20 conference in Singapore |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attendance at a conference on Nipah virus, commemorating 20 years since its emergence in Malaysia and Singapore. The RA in my group presented a poster on our work developing new assays to screen the humoral response to this virus. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.nipah2019.com/ |
| Description | Poster presentation as ToScA conference - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | PP presented a poster entitled "Correlative cryo-imaging tools for the study of coronavirus replication organelles" at the ToScA conference. He discussed his data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster presentation at International Nidovirus Syposium 2023 - HM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster entitled "Cross virus comparison of coronavirus proteins involved in replication organelle formation" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at International Nidovirus Syposium 2023 - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation entitled "Coronavirus RNA synthesis occurs in membrane-bound sites" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at Microbiology Society annual conference - CH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of a poster titled "Investigating CoV Spherules Using a Replicon-based System" and discussion of data with conference participants. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Poster presentation at Microbiology Society annual conference - YC |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster entitled "Development of a CRISPR/Cas9 GeCKO library screen to identify pro-viral cellular genes in chicken cells that can be exploited to control avian endemic viruses" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at UK-ICN AGM - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a talk entitled "Coronavirus RNA synthesis occurs in membrane-bound sites" at the UK-International Coronavirus Network AGM. She answered questions and discussed her data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster presentation: European Veterinary Immunology Workshop, Utrecht, The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | David Goldeck (post-doctoral scientist) gave a poster presentation on our studies to isolate PRRSV-neutralising monoclonal antibodies from immune pigs. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Poultry Stakeholders meeting hosted by Almarai, 15 October 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engagement with Almarai Poultry. The focus of the meeting with Almarai Poultry disease control team was to share knowledge on improved vaccination and diagnostic techniques against avian influenza viruses affecting poultry production. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poultry Stakeholders meeting in Kuwait city 16 October 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prevention and control of avian influenza outbreaks in poultry. Described new vaccination and diagnostic technologies that provide more robust cross-protective immunity in emerging antigenic divergent strains of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Preclinical detection of foot-and-mouth disease |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interview with Veterinary Times about work on preclinical detection of foot-and-mouth disease and its potential impact on future control strategies |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.vettimes.co.uk/news/pre-clinical-method-a-step-closer-in-fmdv-prevention/ |
| Description | Predicting Pandemics (Panel discussion at Cheltenham Science Festival) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Preparation of presentation on African swine fever clinical signs and pathogenesis |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prepared a presentation on African swine fever clinical signs and pathogenesis aimed at making farmers and veterinary practitioners aware. Presentation made available publically on the APHA, DEFRA and Pirbright websites. A follow up video was made by APHA and training for APHA veterinary services is planned |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://apha.defra.gov.uk/documents/surveillance/diseases/african-swine-fever-images.pdf |
| Description | Presenation at the IVVN Annual Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of our Nipah and PRRSV vaccine research, which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presentation at "Vector-borne disease in the UK" conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on recent work on the transmission and control of lumpy skin disease |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.hpruezi.nihr.ac.uk/media/46429/vbd-2020-programme.pdf |
| Description | Presentation at American Society for Virology conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give a keynote talk on "Rational vaccine design for the avian coronavirus infectious bronchitis virus" at the ASV Satellite Symposium: Viral Pathogenesis and Prevention in Animals, discussed research and future plans with other researches in the field. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at Avian Diseases Symposium - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a short talk at the Avian Diseases Symposium entitled "Identification of sites of infectious bronchitis virus RNA synthesis". She discussed our data and answered questions from the audience. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at Avian Research Symposium - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a short talk at the Avian Diseases Symposium entitled "Identification of sites of infectious bronchitis virus RNA synthesis". She discussed our data and answered questions from the audience. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Avian Research Symposium - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | PP presented a talk at the Avia Research Symposium entitled "Correlative cryo-bioimaging to study avian coronavirus replication organelles". He presented data and answered questions from the audience. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Avian viruses focussed meeting - Sept 2018 ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of data as an offered paper at the molecular biology and pathogenesis of avian viruses meeting, Oxford Sept 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Imaging virus infected cells meeting - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a talk entitled "Identification of sites of infectious bronchitis virus RNA synthesis" at the Imaging Virus infected cells meeting hosted at Pirbright. She answered questions and discussed her data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Imaging virus infected cells meeting - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | PP was invited to present a talk entitled "Correlative cryo-bioimaging of coronavirus replication organelles" at the Imaging virus infected cells meeting held at Pirbright. Patrick answered questions on his presentation and discussed data with other researchers studying virus-host cell interactions using bioimaging approaches. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Inter-institute Bioimaging networking meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | An event was held to enable improved collaboration opportunities between scientists working with bioimaging techniques at the different research institutes within the UK. I presented data from the last 10 years describing our work characterising replication organelles induced by IBV, describing the different techniques and approaches we have used and the outlook for the future. The talk aimed to showcase the bioimaging facilities at Pirbright to encourage new collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at International Nidovirus Symposium 2023 - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 10 minute presentation entitled "Correlative cryo-bioimaging to study coronavirus replication organelles" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Microbiology Society Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Two presentations at Microbiology Society UK Annual Meeting Belfast April 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microbiology Society Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed our work using the pig as a preclinical model to support COVID-19 vaccine development |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation at Microbiology Society annual conference - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation at the Microbiology Society annual conference entitled "Coronavirus RNA synthesis occurs in membrane-bound sites" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Microbiology Society annual conference - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a talk entitled "Identification of sites of infectious bronchitis virus RNA synthesis" in a workshop session at the Microbiology Society annual conference. She answered questions and discussed her data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microbiology Society annual conference - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | PP presented a talk entitled "Correlative cryo-bioimaging to study avian coronavirus replication organelles" in a workshop at the Microbiology Society annual conference in Belfast. He answered questions and discussed his data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microbiology Society annual conference - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | 10 minute talk entitled "Correlative cryo-bioimaging to study coronavirus replication organelles" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Microbiology Society annual conference in Belfast |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of "The canonical stem loop RNA structure of the s2m genetic element is not required for avian coronavirus infectious bronchitis virus replication in vitro however deletion of the s2m sequence results in a 36-nucleotide insertion" and "Characterising the ion channel inactivating mutations in the E protein of Infectious Bronchitis Virus (IBV)" during the virology workshops to other research scientists and students. We also presented a poster on "Examination of in vitro cell lines and ex vivo tracheal organ cultures for the study of porcine respiratory coronavirus". Good feedback was received and ideas generated for further research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microscience Microscopy Congress - HM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster entitled "Cross virus comparison of coronavirus proteins involved in replication organelle formation" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation given on "The canonical stem loop RNA structure of the s2m genetic element in the avian coronavirus Infectious Bronchitis Virus is not required for viral replication in vitro but may play a role during in vivo infection" at the poster session of the The XVth International Nidovirus Symposium. Discussions with other researchers in the coronavirus field resulted in new ideas to take the research forwards. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at RIVR meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation of my work to other researchers at the Recently Independent Virology Researchers meeting. I discussed my data with other researchers and potential for future collaboration. |
| Year(s) Of Engagement Activity | 2016,2017,2019,2020 |
| Description | Presentation at UK-ICN ECR meeting - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 10 minute talk entitled "Structural studies of coronavirus replication organelles". |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presentation at Vaccine Innovation Forum 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation on our Nipah vaccine research, which sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presentation at the Festival of Tomorrow, Science Swindon/UKRI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation on developing livestock vaccines to prevent new/emerging diseases and the pig as a model to support COVID-19 vaccine development, which sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.scienceswindon.com |
| Description | Presentation at the International PRRS Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of our PRRSV vaccine research, which sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presentation at the Veterinary Research Club, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed our work using the pig as a preclinical model to support COVID-19 vaccine development. No known impact. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation at the World One Health Congress 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of our vaccine research, which sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presentation by Dr Anusyah Rathakrishnan at European Society for Veterinary Virology Conference Ghent Sep 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research presentation on development of live attenuated ASFV vaccine |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation of data at Microbiology Society Annual conference 2019 - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of data to scientists at the annual Microbiology Society Conference, Belfast. Following the presentation there were questions and discussion with other scientists. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation to BBSRC Executive Board |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | I presented our research to the BBSRC Executive Board when they visited The Pirbright Institute in September 2018 and discussed the impacts of our work.. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to The Pig Veterinary Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation to make pig veterinarians aware of African swine fever |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.pigvetsoc.org.uk/ |
| Description | Presentation: Culicoides as vectors of arboviruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Keynote lecture given to veterinary scientists and farmers. Performed as part of the World Buiatrics Conference 2016 and video of presentation available to members. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.wbc2016.com/ |
| Description | Presentations at Avian Research Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We have presented our research at the Avian Research Symposium organised by the National Avian Resource Facility at the Roslin Institute in 2021 (Rational vaccine design for the avian coronavirus infectious bronchitis virus) and 2023 (Disruption of the s2m RNA structure in the avian coronavirus infectious bronchitis virus results in reduced clinical disease during in vivo infection). We have engaged with other researchers to expand our network and discussed future research activities. |
| Year(s) Of Engagement Activity | 2021,2023 |
| Description | Presentations at Microbiology Society focused conference on Avian Infectious Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Microbiology Society supported a focused meeting on avian infectious disease research, bringing together scientists from all over the world to discuss their research. We gave presentations on "Characterisation of the Infectious Bronchitis Virus E Protein for Rational Vaccine Design" and "Rational vaccine design for the avian coronavirus infectious bronchitis virus", received good feedback on our work and ideas for future research. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentations at the UK International Coronavirus Network (UK-ICN) AGM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We presented research "The Genetic Stability, Replication Kinetics and Cytopathogenicity of Recombinant Avian Coronaviruses with a T16A or an A26F Mutation within the E Protein Is Cell-Type Dependent" and "A temperature sensitive recombinant of avian coronavirus infectious bronchitis virus provides complete protection against homologous challenge" and a poster on "A novel in-cell micro neutralisation assay for the human coronavirus OC-43: Allowing rapid and automated quantification of neutralising effect of antibodies and antiviral compounds" at the annual general meeting of the UK-ICN in Cambridge. We networked with other researchers working in the coronavirus field and discussed future research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press release on endemic persistence of foot-and-mouth disease in African buffalo |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Helped write press release about article appearing on cover of Science magazine |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/10/new-research-giving-insight-persistence-highly-contagious-f... |
| Description | Prevalence and Control of Avian Influenza Viruses in Poultry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presented a seminar (as an invited speaker) to poultry stakeholders including farmers and veterinarians at "Morocco Poultry Day" organised by Boehringer-Ingelheim in Tangier, Morocco. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2024 |
| Description | Preventing and controlling avian influenza infections in poultry and humans |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Project close meeting at TANUVAS, Chennai July 2018- Delivering talk on outcome of the project |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The project team held their final workshop at TANUVAS, which concluded a four year Farmed Animal Disease and Health (FADH) grant joint funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Indian Government's Department of Biotechnology (DBT). "This grant has enabled us to collaborate with four organisations across India, and ensured that our research can be applied in the field to aid the campaign for PPR global eradication", said Professor Parida.The project covered many areas of research which are essential for understanding PPR and creating tools to help control and prevent the disease. The team have now filed a patent application for their newly developed PPR vaccine, which is the first to differentiate between vaccinated and infected animals (DIVA) - a quality that enables livestock owners to protect their animals whilst continuing to trade. The team have also investigated how the PPR virus (PPRV) infects sheep and goats and how their immune systems respond. By inserting green fluorescent protein into virulent PPRV and administering the modified virus to goats, they demonstrated that PPRV primarily infects the tonsils, challenging the earlier belief that the virus first replicates in the respiratory tract epithelial cells. The collaborative project has also generated better diagnostic tests for use in the field and laboratory, and preliminary research has identified why some Indian breeds of goats and sheep are resistant to the disease, which could help scientists to create PPRV resistant breeds in the future. Project partners, scientists from the University and 40 field veterinarians have joined the meeting. An awareness training has been conducted on PPR disease and eradication for these field veterinarians. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes... |
| Description | Protecting poultry from avian influenza |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Avian influenza, commonly known as "bird flu," is a disease caused by multiple strains of influenza virus. The viruses can infect a wide range of animals, including people and pigs, but the natural reservoir lies in populations of wild aquatic birds such as ducks and gulls, according to an announcement from The Pirbright Institute in the U.K., which is conducting research to better understand avian influenza viruses to help prevent the disease in poultry. Flu virus strains are categorized by the combination of the two proteins found on the outside of the virus: hemagglutinin (H) and neuraminidase (N) -- for example, H5N6 or H9N2. The H protein binds to cell receptors in order to initiate infection, while the N protein helps release new viruses from an infected cell, the institute explained. Strains are also classified by severity. Low-pathogenic avian influenza (LPAI) viruses cause clinical signs such as mild breathing problems, decreased egg production and growth. Some birds, particularly ducks and geese, do not display any signs of LPAI infection and are still able to spread the disease, Pirbright said. When LPAI viruses circulate in high-density poultry areas, the viruses can mutate into highly pathogenic strains. Highly pathogenic avian influenza (HPAI) viruses have severe and often fatal effects on some species of birds such as chickens, Pirbright noted, but some HPAI strains cause mild or no clinical signs of disease in wild birds and domestic waterfowl. These strains are notifiable, meaning government control measures must be put in place. Avian influenza can be carried vast distances by wild migratory birds and can infect domesticated poultry through direct contact or through contaminated droppings and bodily fluids, Pirbright said. Because of this, there is a year-round risk of avian influenza, which can increase depending on the disease status in a region and the migration season of wild aquatic birds. According to Pirbright, good biosecurity is essential in preventing poultry from being exposed to the disease and can be practiced on a commercial farm, with game birds or even with just a few backyard hens. Why is influenza so difficult to prevent? The institute explained that influenza viruses are constantly changing, and when they replicate, small errors called mutations are copied into their genome. Some of these will alter the virus's proteins, allowing the virus to escape detection by the immune system. All flu viruses also have the potential to undergo a process called reassortment, where two or more strains of influenza infect the same animal, allowing them to swap parts of their genome, Pirbright said. The resulting viruses can potentially have different characteristics than the original strains, such as the ability to replicate in different species, including people, the institute added. Avian influenza viruses such as H5N1 or H7N9 have infected people, predominantly in Southeast Asia, but in these cases, the virus has been transmitted directly from infected birds to people, with no onward spread. There is some evidence that avian influenza can be passed from person to person, and while there are no records of efficient or sustained human transmission, there is a constant risk that one of the new strains may spread easily among people, which could result in a new influenza virus pandemic, Pirbright said. Changes in the virus genetics from mutation or reassortment make it very difficult to anticipate how influenza viruses will spread through a population and whether current vaccines will be suitable for the strains that are circulating, Pirbright announced. The influenza research programs at Pirbright are progressing understanding of the virus and finding better ways to prevent its spread. Pirbright Institute group leaders Dr. Holly Shelton and professor Munir Iqbal are researching how the characteristics of influenza viruses can change the outcomes of disease. Studying flu at the molecular level allows them to find out how the virus evolves to overcome avian immunity and how changes in their genome can alter disease severity and their ability to affect different species, the announcement said. Shelton's and Iqbal's teams are working on identifying genetic markers for specific disease traits that can be used in surveillance systems to provide forewarning of strains that could cause pandemics. For example, Shelton's Influenza Viruses group is looking at which characteristics allow the viruses to become resistant to antiviral drugs that are currently used to treat human infections of influenza, allowing surveillance to provide an early warning of viruses that could cross into humans and be difficult to control, Pirbright said. The team is also investigating how long it takes for avian influenza viruses to adapt to new mammalian species. According to the institute, establishing which strains can rapidly adapt and identifying the genetic changes made to enable infection of mammalian cells will help with surveillance efforts and potentially lead to the development of techniques that will help prevent these mutations occurring. Vaccination and rapid diagnosis are very important for influenza prevention and control, but it is still not currently possible to protect against all influenza strains, Pirbright said, noting that Iqbal's Avian Influenza group is exploring which sites on the virus trigger the chicken immune system to respond quickly and fight off infection. This will better inform scientists' ability to match vaccines to strains in the field and could help to develop vaccines that are more effective. Iqbal's group is also developing multivalent vaccines that protect chickens and ducks from several avian influenza subtypes at once as well as test kits for rapid diagnosis of different subtypes at the flock-side, the announcement said. Visit Pirbright's Influenza Viruses and the Avian Influenza group pages to find out more about their research. Source: The Pirbright Institute, which is solely responsible for the information provided and is wholly owned by the source. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.feedstuffs.com/nutrition-health/protecting-poultry-avian-influenza |
| Description | Protecting poultry from avian influenza through passive immunisation. Presented at Foreign Experts Seminar "New strategies and new tools for the prevention and control of major poultry diseases. Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 20-22 September 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Provided information to Podcast This week in Virology about African swine fever virus spread in wild boar |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | E-mail correspondence providing advice to presenters of TWIV This week in Virology Podcast. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.microbe.tv/twiv/twiv-532/ |
| Description | Public engagement organized at Oxford |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Set up a stand at the event, a museum at Oxford, and discussed and described research activities within the Institute with public. Set up demonstrations from some biological specimens and distributed leaflets and questionnaire. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Q&A statement on coronaviruses provided to Science Media Centre - HJM |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A Q&A statement on coronaviruses was provided to the science media centre, who distributed it to media outlets. Excerpt have been used in 1420 articles incuding the Daily Mail and syndicate articles. The Q&A was also used in a Pirbright Institute media statment. |
| Year(s) Of Engagement Activity | 2020 |
| Description | RMS EM school - invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Royal Microscopical Society Electron Microscopy School, lecture in biological sample preparation for transmission electron microscopy. Lots of questions from delegates. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | RMS Imaging Competition judge |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | RMS competition, judge |
| Year(s) Of Engagement Activity | 2021 |
| Description | Rebecca Daines: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza. Presented at Systems Immunology Workshop: Adaptive immune repertoires and beyond. 16th-17th January 2020. University of Surrey, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled "Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza" was presented at the workshop exploring new technical advances for analysis and production of antibodies for prophylaxes and treatment of animal and humans diseases. Both academics and staff linked with animal and public health industry attended this workshop. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Recombinant vaccines against avian viral diseases affecting poultry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effective: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Reddit AMA (Ask Me Anything) on vector-borne diseases |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Took part in a Reddit Ask Me Anything (AMA) on vector-borne diseases. AMAs are a question-and-answer format activity where an individual expert or panel of experts answers questions from the public for a specified duration. We received a large number of questions and the parent post received 493 upvotes, indicating an absolute minimum of 493 participants (and very probably more), so I have given the estimated audience as 500+. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.reddit.com/r/science/comments/6he8go/aaas_ama_hi_were_maria_elena_bottazzi_marcia/ |
| Description | Representing the Pirbright Institute at the UKRI Festival of Tomorrow in Swindon |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Pirbright Institute has a interactive exhibit at The UKRI Festival of tomorrow which the postdocteral scientist on the project attended to represent the overall scientific remit of the Pirbright Institute but also provide specific engagement with project specific research. The attendance and interaction of the expedition and interactive activities was excellent |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2022/03/inspiring-generation-%E2%80%93-festival-tomorrow |
| Description | Research Presentation Veterinary Research Club UK "An African Swine Fever vaccine candidate based on multiple targeted gene deletions and mutagenesis" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on African swine fever virus vaccine development |
| Year(s) Of Engagement Activity | 2022 |
| Description | Researchers at Pirbright investigate the emergence of new bird flu viruses with the potential to infect people |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Following the news brief of our research outcomes for the general public and media was published on The Pirbright Institute and widely distributed through social media platforms including Facebook, Twitter, Linkedin. Pirbright scientists have discovered that infection with two strains of avian flu can lead to the emergence of a new virus strain with the potential to jump from birds to humans. Human cases of avian influenza are extremely rare but can occur if a person comes into very close contact with an infected or dead bird. The study shows that avian influenza virus strains H9N2 and H7N9 can share genetic information to create an H9N9 strain with the potential to cause more severe disease in poultry and pose a threat to human health. Avian influenza, also known as 'bird flu', is a type of influenza that spreads among birds. The UK faces a seasonal increase in the risk of avian influenza outbreaks which are associated with the migration patterns of wild birds. Avian influenza is found across the globe, and in countries where multiple strains circulate it is important to monitor the emergence of new strains. Low virulence H9N2 and H7N9 circulate in poultry in Asia but do not cause severe disease. However, they are known to swap genetic information which can result in the emergence of an H9N9 strain, which can cause severe disease. In collaboration with the Animal and Plant Health Agency (APHA), researchers at Pirbright discovered that the H9N9 strain was able to multiply significantly better in poultry cells, indicating the potential to cause more severe disease. They also discovered that it had a higher replication rate in human cells and could bind to these cells better than H9N2. The H9N9 strain can infect and transmit between ferrets highlighting the potential to cause disease in humans. The study, published in the Journal of Virology, shows that strains already circulating in poultry populations can exchange genetic material, leading to the creation of new strains. This increases the risk of the virus jumping from avian hosts to humans and other mammals. The study concludes that H7N9 and H9N2 viruses circulating in the same regions pose a pandemic threat, which demonstrates the need for constant monitoring for the emergence of new virus strains. Professor Munir Iqbal, Head of the Avian Influenza Group at Pirbright said: "This is the first study to show that infection with circulating H9N2 and H7N9 influenza viruses could create new virus strains such as H9N9 that cause more disease in poultry and pose a greater risk to human health. If a host is infected with two different strains, there is always a chance that they will swap genetic material to create a new strain. When this happens, it could lead to many outcomes, for example, the virus becoming more or less able to cause disease in a host, or a virus acquiring the ability to jump between hosts. This leads to viruses that primarily cause disease in animals having the ability to infect humans, which is what we have observed in this study. More research is needed to determine which avian flu viruses could combine and pose a threat to poultry and human health." This study was supported by grants funded by the UK Research and Innovation Biotechnology and Biological Sciences Research Council under Newton Fund UK-China-Philippines-Thailand Swine and Poultry Research Initiative and Zoonoses and Emerging Livestock Systems (ZELS) with grants from FCDO and Dstl. The work was also funded by the GCRF One Health Poultry Hub and Defra (UK, including the Devolved Administrations of Scotland and Wales). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.pirbright.ac.uk/news/2022/01/researchers-pirbright-investigate-emergence-new-bird-flu-vi... |
| Description | Returning to STEM event - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | ND attended a workshop to discuss and exchange ideas about public engagement strategies. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Reverse genetics seminar to MSc students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A seminar was presented describing reverse genetics of viruses, including infectious bronchitis virus and the application of reverse genetics in research. The students were interested and engaged, participating in activities and asking questions. We were invited to present the seminar in subsequent years for new student intakes. |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016,2018,2019 |
| Description | Royal Institution Christmas Lectures Family Day - LA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Six Pirbright staff/students ran an all-day exhibit on gene editing and mosquitoes at the Royal Institution About 270 participants visited our stand; wide range of comments, questions, discussion and feedback |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Society Summer Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Engaged the public on the uses of genetically modified mosquitoes for preventing disease transmission, and on the drivers of viral emergence events at the Royal Society Summer Exhibition (with thousands of attendees). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://royalsociety.org/science-events-and-lectures/2022/summer-science-exhibition/ |
| Description | Royal Society Summer Fair - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | HJM attended the Pirbright stand at the Royal Society Summer Fair and presented the exhibit to visiting school children and members of the general public. The exhibit called "Disease detectives" helped visitors understand processes in identifying viruses causing disease, symptoms of infection, routes and rates of infection as well as control measures currently available and in development. The event allowed discussion of work on going in HJMs projects. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Royal Society Summer Fair - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | ND attended the Pirbright stand at the Royal Society Summer Fair and presented the exhibit to visiting school children and members of the general public. The exhibit called "Disease detectives" helped visitors understand processes in identifying viruses causing disease, symptoms of infection, routes and rates of infection as well as control measures currently available and in development. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Royal Society Summer Fair - PP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | PP attended the Pirbright stand at the Royal Society Summer Fair and presented the exhibit to visiting school children and members of the general public. The exhibit called "Disease detectives" helped visitors understand processes in identifying viruses causing disease, symptoms of infection, routes and rates of infection as well as control measures currently available and in development. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Rydal Hall Flavivirus meeting - Mathilde Laureti |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Conference to share research and break through in the Flavivirus field. Provide the opportunity for collaboration with National research groups. |
| Year(s) Of Engagement Activity | 2022 |
| Description | SEMT - Beginner's competition judge |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Head judge of RMS Beginner's Competition (presentation) |
| Year(s) Of Engagement Activity | 2021 |
| Description | STEAMfest - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A large open day event at hosted at University of Surrey for students from a number of schools in the region to explore different scientific questions and areas of work. |
| Year(s) Of Engagement Activity | 2019 |
| Description | STEAMfest - HS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Team members attended the event where a flu fighters stand was displayed demonstrating how scientists are working to rapidly detect and control avian influenza in the filed to protect food security, animal welfare and human health. Approximately 200 secondary school students engaged with the stall and this stimulated increased interest in science and research, |
| Year(s) Of Engagement Activity | 2019 |
| Description | STEM Day - Speed interviews and Careers Day 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | STEM for Society |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | KM was interviewed for the "Researcher Celebrities" video interview series on YouTube, run by STEM for Society. These videos are watched by an audience of a few hundred to a few thousand viewers from across the world. Shortly after posting the video there was already engagement in the comments section of the video. |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.youtube.com/@stemforsociety |
| Description | STEM training: Gain confidence in talking to secondary school students - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | ND attended a training event to learn effective techniques to engage with secondary school students. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Scheduled Twitter session with University of Nottingham students on professional skills for biosciences |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Hour-long Twitter chat on Friday 12th May with biotechnology students, microbiology students, animal science students interested in animal diseases and animal welfare and behaviours and agriculture students interested in livestock. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://twitter.com/search?q=%23biosciprofskills |
| Description | School Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Participated (AES) in Workshop at local school |
| Year(s) Of Engagement Activity | 2019 |
| Description | School visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Met and discussed A level students in small groups (3 students at the time) and discussed different aspects of my work as a scientist. |
| Year(s) Of Engagement Activity | 2015 |
| Description | School visit (Farnborough) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed various aspects of scientists' work. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Schools "Moving-on" Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Participated (AG) in schools "moving on" day |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Enrichment Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | HH participated in Science enrichment day in a local school |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Enrichment day at Park Mead School - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | An engagment event at a local school teachin year 5 and 6 students about mosquitos and some of the work done at Pirbright. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Update to BBSRC executives |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Visit from the BBSRC to discuss science highlights |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar at Coventry University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited seminar "One Health vaccinology to combat emerging viral zoonoses", School of Life Sciences, Coventry University, UK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Seminar at RVC Veterinary Epidemiology, Economics and Public Health group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on persistence of FMDV in African buffalo |
| Year(s) Of Engagement Activity | 2021 |
| Description | SinoPic TT |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 'SinoPic': Structural Biology of Picornaviruses meeting in China. Generating interest and collaborations in virus structural biology within China. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Sir John Kingman (UKRI) visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Visit to highlight Pirbright science to UKRI |
| Year(s) Of Engagement Activity | 2019 |
| Description | Site tour with Department of Trade and Industry |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Tour/site visit with Department of Trade and Industry (25 people attending) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Speaker UK Vector-borne Disease Meeting (Liverpool - online) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation given on 23/11/20. Major outcome was discussion around climate-related impacts on Culicoides populations. |
| Year(s) Of Engagement Activity | 2020 |
| Description | St Andrew's Catholic School visit to Pirbright |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | College students visited the Institute to learn about lab designs. They were given talks about the equipment and labs and then toured around the labs at Pirbright. Students were highly interested about our facilities and the work we are conducting at The Institute. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Supporting knowledge exchange visits and providing presentations on Estates Management Services (EMS) processes to visitors from Turkey, Chile and Brazil |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Knowledge sharing, open discussions regarding processes and procedures. |
| Year(s) Of Engagement Activity | 2023,2024 |
| Description | Surrey County Show |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Surrey County Show is an agricultural show in Guildford that is visited by the general public. The Pirbright Institute had a stand with various activities for visitors to take part in and explain our science to a wide audience. Giulia spent a day working on the stand and spoke with many children and adults about her work at Pirbright to change public attitudes and stimulate increased interest in research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Surrey County Show |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Stall at Surrey County Show, engage with the public where they can ask any questions they have about the work we do. This sparks discussions, and an increase in knowledge of the general public. I invited the Lord Lieutenant of Surrey to our stand, with whom I have built a solid relationship. This has lead to engagement of his office with the Institute, for example the visit of HRH Princess Anne to Pirbright in 2017. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Surrey County Show - Dana Perry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | DP helped run the stand located at the Surrey County Show, and fielded questions regarding our science from the general public, which stimulated discussion. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Surrey Open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Described the research activity of the Pirbright Institute for students from school, graduate and postgraduate students, and provided information on research facilities in the institute. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.surrey.ac.uk/opendays/vet |
| Description | Surrey Vet School Open Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | PH helped to run a stand representing The Pirbright institute. Fielded questions from potential vet students at Surrey, and their parents/families. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Surrey Veterinary School Open Day- AA, WM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Stimulating interest in different science career paths |
| Year(s) Of Engagement Activity | 2019 |
| Description | Surrey vet school open day - MJB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The event was an open day for prospective students for the University of Surrey vet school. The course includes a research placement, which can be conducted at Pirbright. Therefore there was a stand from Pirbright to describe the research we perform generally as well as a discussion of our specific research. The audience were generally interested and the information helped inform them when selecting a university course. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Sushant Bhat:Pirbright Dragon Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Sutton College Lecture (Enjoy your retirement) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk to group on virus outbreaks (Enjoy your retirement) - 16 people & class coordinator. Included simulation of a virus outbreak. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Symposium for WRLFMD 60th Anniversary |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | During November, the Pirbright Institute hosted a two-day symposium attended by over 100 FMD scientists to celebrate the 60-year anniversary of the establishment of the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD). The meeting was opened by Christine Middlemiss (UK, Chief Veterinary Officer), Matthew Stone (Deputy Director General of the OIE) and Keith Sumption (from FAO/EuFMD). Subsequent scientific sessions reviewed the current activities of the WRLFMD (and OIE/FAO FMD Laboratory Network: https://www.foot-and-mouth.org), and discussed new opportunities to monitor, diagnose and control FMD by applying knowledge from fundamental research projects that aim to understand the pathogenesis, host responses and epidemiology of the disease. Talks from invited speakers and WRLFMD staff were within four themes of (i) Risks & Threats, (ii) Diagnostic Innovation, (iii) Pathogenesis & Immunity and (iv) FMD Control with a Focus on Vaccination. These presentations showcased the synergy between fundamental/basic science and the on-going global surveillance activities undertaken by FMD Reference Laboratories. In the evening, the meeting delegates (including past and present members of the WRLFMD) were royally entertained at a local hotel by after-dinner "trips down memory lane" talks from Nick Knowles and Dave Rowlands that highlighted key events and personalities that have shaped the history of work at Pirbright. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.wrlfmd.org/60th-anniversary |
| Description | TV Interview Deutsche Welt |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Interview and filming at Pirbright for a programme on African swine fever virus broadcast on Deutsche Welt German TV Channel |
| Year(s) Of Engagement Activity | 2022 |
| Description | Taiwan -UK Partnering Award: Surveillance of influenza viruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended the International Flu Virus Symposium for Celebrating IPM 47th Anniversary" in Tri-Service General Hospital in Taipei, Taiwan. Tri-Service General Hospital address: No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan (R.O.C.) Invited speaker for medical staff and research scientists. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.cdc.gov.tw/rwd/english |
| Description | Talk (Christopher Sanders): Lancaster University (Culicoides and their role as vectors) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk give to academic audience through invited lecture. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk (Christopher Sanders): Virus Transmission and Vector Competence of Culiocides (Royal Entomological Society Annual Meeting) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Annual Meeting of the ROyal Entomological Society presentation. Held at LSHTM on 21st August 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk Presented at 2nd International Congress of Veterinary Microbiology, 16th -19th October 2018. Sherwood Breezes Resort-Lara, Antalya, Turkey. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed improving prevention and control of viral diseases of poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk as part of Vaccinology in Africa course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk on ASFV at 'Vaccinology in Africa' course organised by the Jenner Institute. 11th October 2021 |
| Year(s) Of Engagement Activity | 2019,2021,2022 |
| Description | Talk as part of the University of Veterinary Medicine (Vienna) doctoral school "Infectious Diseases of Pig and Poultry" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Talked about the Pirbright Institute's work on African swine fever virus to researches in Veterinary Medicine (Virology and Immunology) in Vienna. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at Human & Veterinary Vaccinology Course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented work on African swine fever vaccine design to the Human and Veterinary Vaccinology course organised by the Jenner Institute, University of Oxford |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk at IVVN Swine Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed research progress with other scientists, some discussion about a follow-up meeting on discovering T-cell antigens. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Talk at Large animal research network (LARN) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on the tools we have developed to target different parts of the respiratory tract and how to analyse local immune responses. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk at Tamil Nadu Veterinary and Animal Services University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Participated in an online webinar organised by the Tamil Nadu Veterinary and Animal Services University in Chennai India as part of their Transboundary Animal Diseases - Emerging Threats to India seminar series. I talked to around 60 participants about African swine fever and African swine fever vaccine research. There were questions on vaccine development and also control of African swine fever in India. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Talk at VIV Virtual Summit -Asia Edition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Talk to just over 100 attendees to the "Genetic Futures - Productivity, Animal Health and Clean Growth" session, part of the VIV Virtual Summit -Asia Edition. The session was organised by UK Technology for Agriculture and Genetics to showcase UK scientific expertise in the livestock sector to a Asian audience. |
| Year(s) Of Engagement Activity | 2012,2021 |
| URL | https://www.vivasia.nl/viv-virtual-summit/ |
| Description | Talk at World Vaccine Congress Europe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described research progress on ASF vaccines |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk on "Emerging Diseases" at BBSRC Cross-Institute workshop, Roslin Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Talk on Emerging Diseases in the context of a workshop on Future of Livestock in Food Production |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/future-of-livestock-production-in-the-spotlight |
| Description | Talk on "From within hosts to between farms: modelling the dynamics of foot-and-mouth disease virus across scales" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at European Conference on Mathematical and Theoretical Biology |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://ecmtb2022.org/ |
| Description | Talk on "Longitudinal animal and environmental sampling for foot-and-mouth disease virus in northern Nigeria" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at EuFMD Open Session 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.eufmd.info/os22 |
| Description | Talk on "Spread and control of lumpy skin disease virus in Europe" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at Bill & Melinda Gates Foundation workshop on lumpy skin disease, Dubai, 16-18 November 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Talk on Asfarvaridae at Virologie Fondamentale MSc course |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk on African swine fever virus family at the fundamental virology course at the Institut Pasteur |
| Year(s) Of Engagement Activity | 2023 |
| Description | Talk on Asfarvaridae at Virologie Fondamentale MSc course at Institute Pasteur |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented African swine fever virus to the Virologie Fondamentale MSc course at Institute Pasteur. This was the first time African swine fever had been included in the curriculum for this course. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Talk to students studying Animal Health and Management at Duchy College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Talk hosted at the Institute for 12 student studying Animal Health and Management at Duchy College. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk to students studying BSc in Animal Behaviour and Welfare at Merrist Wood College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Talk hosted at the Pirbright Institute for 13 undergraduate students studying Animal Behaviour and Welfare. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Targeted Antigen Delivery Vaccines: Next Generation Vaccines for Poultry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | A talk entitled "Targeted Antigen Delivery Vaccines: Next Generation Vaccines for Poultry" presented to the Executive Chair of the Biotechnology and Biological Sciences Research Council. The discussion aim was the advances approaches that can increases the strength and breath of vaccine immunity in animals and humans. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Team member presented poster 14th Annual meeting Epizone, Barcelona May 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Team member presented poster on "Novel antibody signatures in Bluetongue virus-infected ruminants improve predictions of infectious timelines". at the international 14th Annual Epizone meeting in Barcelona May 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Teentech |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The annual Teentech student science event in Guildford aims to encourage teenagers to consider science subjects and science careers. Our stand had considerable interest from the schoolchildren who were very enthusiastic. The event stimulated an increased interest in science and research. |
| Year(s) Of Engagement Activity | 2016,2019 |
| Description | Teentech Guildford - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Teentech is an event held for students from a range of local school who have an interest in science to experience the range of scientific activities that could be open to them for future careers. Students in small groups rotate around stands at the event to perform activities at each station, guided by scientists. The Pirbright stand was demonstrating the principle of genetic modification of mosquitos. The children were very interested in the exhibit and asked lots of questions. |
| Year(s) Of Engagement Activity | 2013,2019 |
| Description | Television interview Ulaanbaatar |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interviewed by UB television while on a collaborative visit to the State Central Veterinary Laboratory in Mongolia. I spoke about the collaboration between The Pirbright Institute and the SCVL, and how this benefits the Mongolian agricultural sector. |
| Year(s) Of Engagement Activity | 2017 |
| Description | The Hurst careers event - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The Hurst school held a careers event for GCSE students to attend throughout the day. The Pirbright stand contained a variety of engagement activities to demonstrate the research we perform and to stimulate discussion. The students seemed interested in the activities and those more interested in a science career asked a variety of questions about the research and entry into scientific research as a career. |
| Year(s) Of Engagement Activity | 2018 |
| Description | The Microbiology Society Annual Conference, Belfast - Poster presentation 08-11/04/2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster title: Identification of host proteins that interact with non-structural proteins-1a and -1ĂŸ of PRRSV-1 |
| Year(s) Of Engagement Activity | 2019 |
| Description | The Pirbright Village Duck Fair held on 16 June 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Local Village Fair, interaction with local residence to expanse research aims and activities of The Pirbright Institute and benefits to UK and around the globe to prevent and control infectious diseases of animals and humans. |
| Year(s) Of Engagement Activity | 2018 |
| Description | The co-Circulation of Low and High-path-AIV in the same country with sub-optimal bio-security: Virus evolution and impact on vaccine efficacy. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | The global Situation and pathobiology of Avian Influenza in different Avian Species. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019.. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | The peste des petits ruminants virus (PPRV) Global Research and Expertise Network (GREN) meeting. Presented work on the future eradication of PPRV, 13-15.11.2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | The peste des petits ruminants virus (PPRV) Global Research and Expertise Network (GREN) meeting. Presented work on the future eradication of PPRV, 13-15.11.2019 |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://rr-asia.oie.int/wp-content/uploads/2020/06/200622_ppr-gren-2-nairobi-november-2019-final-com... |
| Description | This Week In Virology Podcast 532: Morbillivirus had a little lamb |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Our research paper on morbillivirus host-range in Journal of Virology was highlighted for in-depth discussion on this episode of TWIV where they spent 30+ minutes talking about the work and its potential impact. This podcast is the number one podcast in virology and listened to across the globe. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.microbe.tv/twiv/twiv-532/ |
| Description | This week in Virology: 533: Recurring threads |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Following our paper being highlighted on the previous edition of TWIV I wrote a letter to further the discussion of this subject and clarify some technical points on The Pirbright Institute. This was read out as part of the podcast and discussed. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.microbe.tv/twiv/twiv-533/ |
| Description | Tillingborne Science Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Tillingbourne School bug hunt - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Primary school students were involved in an event to identify insects in the school grounds. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Tillingbourne School science event - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Tillingbourne School held a science event for year 3 students to explore different aspects of science including smell, acid & alkali, magnetism etc. Nicole was based at the microscopy station helping children to view samples under the microscope, explain what they were looking at and answer any questions to children asked. The children were highly engaged and interested in the exhibit. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Time for rethink on farming poultry as experts warn bird flu has slipped 'through our fingers (Sky News) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussion with Sky New UK corresponded Tom Clarke (Science and technology editor @aTomClarke) on continued avian influenza viruses are becoming endemic in bird populations in Europe and North America with some areas seeing a 600% increase in infection over the past few months in September -November 2022. In the UK, every day now, two or three new premises have been testing positive for bird flu. If they do, their flocks are culled and over 50 million birds culled in Europe this year and a similar number in North America. There is a need for an improved disease control strategies against these viruses. just culling of infected and at risk will not reduce viruses prevalence and spread, because virus in circulating in wild birds. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://news.sky.com/story/time-for-rethink-on-farming-poultry-as-experts-warn-bird-flu-has-slipped-... |
| Description | Tour of Philip Mellor Insectary (Country Land and Business Association) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Tour of Philip Mellor Insectary with Country Land and Business Association (20 people) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Transforming to Zero, MW was invited by 3PM and GXN to take part in the panel discussion on achieving Lab Net Zero (official launch of the Transforming to Zero White Paper) at the Welcome collection London. Specifically the challenges raised by High containment. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Miriam Windsor was invited to take part in the panel discussion on achieving Lab Net Zero (official launch of the Transforming to Zero White Paper) at the Welcome collection London. Specifically the challenges raised by High containment. This has lead to being invited to join the London Highers Sustainable Laboratories Working group and provided opportunities for networking with other laboratory managers, leading to the proposal to hold a laboratory management conference in Guildford (March 20th 2025). |
| Year(s) Of Engagement Activity | 2024 |
| Description | Travel to ANSES |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | a group of 12 group leaders and facility heads traveled to France, and visited the ANSES ploufragan institute to discuss possible collaborations, compare state of the heart discoveries and facilities. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Trustee tours 2021 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Tour of high containment labs to Institute trustees and science advisory board members |
| Year(s) Of Engagement Activity | 2021 |
| Description | U3A Science Forum presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk titled 'One Health' vaccines to combat emerging zoonotic viral diseases |
| Year(s) Of Engagement Activity | 2021 |
| Description | U3A talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation on influenza virus research at The Pirbright Institute for the local University of the Third Age group, approx. 50 people aged 65 years + all with an interest in science. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://cu3asandt.wordpress.com/2018/09/23/meeting-2nd-october/ |
| Description | UEA LGBT History Month article |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | I was interviewed for a student magazine feature showcasing my work as part of LGBT History month. |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK International Coronavirus Network AGM Cambridge 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Three members of the team (myself, Dr. Newman and Miss Thakur) attended the AGM of the UK-ICN - which I am a co-director of - to discuss recent data and network with other coronavirus researchers. We presented talks and DB chaired a session. |
| Year(s) Of Engagement Activity | 2022 |
| Description | UK Microbiological Society Fleming Showcase |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Described mosquito-based approaches to microbiologists and others |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/news/society-news/fleming-showcase-speaker-profile-professor-luke-al... |
| Description | UK vector meeting 2018 (Organising committee; Chair) (December; John Innes Centre, UK) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired and helped organise meeting on UK Vector-borne Diseases as part of committee. Included reviewing talks and inviting speakers. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.hpruezi.nihr.ac.uk/media/29013/master-draft-vbd-programme-with-titles-oct18_.pdf |
| Description | UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Emerging new approaches were discussed for prevention and control of infectious diseases affecting swines and poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | UKHSA - Visit from senior staff to Brooksby Building for knowledge sharing |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | UKHSA staff to visit Brooksby facility and view engineering plant |
| Year(s) Of Engagement Activity | 2025 |
| Description | UKRI Festival of Tomorrow |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and stand on viruses and engineering mosquitoes |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ukri.org/news/showcasing-incredible-discoveries-at-swindon-festival-of-tomorrow/ |
| Description | Understanding Antigenic Diversity, Zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at "UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meeting focus was to share research plans funded under "UK-China-Philippines-Thailand Swine and Poultry Research Initiative". Research projects investigate pathogens, zoonotic pathogens or "commensals" associated with food safety issues affecting poultry and swine. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bbsrc.ukri.org/funding/filter/joint-swine-poultry-initiative/ |
| Description | Understanding Evolution and Impacts of Avian Influenza Viruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Internal seminar presented at The Pirbright Institute, sharing the achievements and current ongoing research being performed within the Avian Influenza Virus and Newcastle Disease Virus Group to other colleagues throughout the site. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at UK-China-Philippines-Thailand Swine and Poultry Research Initiative: Interim Project Workshop 13th-15th January 2020 Hilton Hotel, Bracknell, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Outcomes of the research project entitled "Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry" were presented to colleagues working on prevention and control of infectious diseases affecting animals and humans. the work led to incite further research collaborations with different groups from UK, China, Thailand and Philippine. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Understanding avian influenza virus evolution and development of next generation vaccines. Presented at 459th Scientific Meeting of The Veterinary Research Club at The Farmers Club, 3 Whitehall Court London Friday 14th February 2020. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk presented entitled"Understanding avian influenza virus evolution and development of next generation vaccines". The discussion with senior staff from DEFRA and UKRI- BBSRC, researchers and veterinary professional like with control and prevention of animal diseases in United kingdom |
| Year(s) Of Engagement Activity | 2020 |
| Description | Understanding avian influenza virus evolution, antigenic diversity and vaccine failure. Presented at the 2019 Symposium on techniques for healthy breading and disease prevention & control of livestock and poultry, Golden Harbor Hotel, Beijing, 21-23 August 2019. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk and discussion on the control of infectious animal diseases including avian influenza. |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of Sao Paulo Cryo-EM workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | presentation to delegates on EM of viruses |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Surrey MSc student visit - Jennifer Simpson |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | JS organised two days of practical demonstrations on sample preparation and use of the confocal microscope. Increased visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | University of Surrey MSc student visit - Katy Moffat |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | KM organised two days of flow cytometry demonstrations. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | University of Surrey School of Veterinary Medicine Virtual Careers day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Virtual participation in both networking sessions as well as the "research and government veterinary career " panel to discuss options of a career in science and research with undergraduate Veterinary Medicine students |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.surrey.ac.uk/school-veterinary-medicine/events/vet-school-careers-fair-2021 |
| Description | University of Surrey Vet School Careers Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Careers day for veterinary students to inform about the work at The Pirbright Institute to interest future veterinarians in a research career |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of Surrey Vet School Open Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Institute stand at Surrey Vet School - introducing the institute to prospective vet students |
| Year(s) Of Engagement Activity | 2018 |
| Description | Vet School Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | University of Surrey School of Veterinary Medicine Open Day - introduced The Pirbright Institute and the research we conduct to prospective students and parents. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Vet Times |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Information on research activity of Avian Immunology group at the Pirbright Institute |
| Year(s) Of Engagement Activity | 2018 |
| Description | Veterinary Times article on morbillivirus vaccines. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was interviewed by a journalist from The Veterinary Times about our recent Journal of Virology research paper on morbillivirus host-range. This was then written up for the next edition of this publication. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.vettimes.co.uk/news/scientists-multi-purpose-ppr-vaccine-closer-to-completion/ |
| Description | Video - Being a scientist |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Outreach to primary school children, to enable them to start thinking about what it means to be a scientist and potential careers. Aimed at year 3/4 primary aged children. STEM activity. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Video on African swine fever clinical signs for APHA |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Video prepared to inform farmers and vets about African swine fever virus clinical signs |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=z4kSR-wMO4M&feature=youtu.be |
| Description | Virtual video tour of the animal facilities in Pirbright |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Contributed to public understanding of animal research by being interviewed on the virtual video tour of the animal facilities in Pirbright - one of only four such initiatives in the UK. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Visit from APHA colleagues to review HEPA installation in Plowright, led by Nik Hayward |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Tour of Plowright facility to look at HEPA engineering systems in-situ which led to some knowledge gain. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Visit to Cairo Poultry Company (CPC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Discussion and talk on prevention and control of poultry diseases (avian influenza and Newcastle Disease) and molecular factors affecting vaccine efficacy. The discussion and talk to present data, describing factors the directly influence protective efficacy of in use vaccines, and how they evaluate/ test vaccine failure. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Volunteering at Royal Society Summer Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Several members of the team volunteered to help at the Royal Society's Summer Science Festival, working on Pirbright's stand to talk about virology, zoonosis and Covid with the general public. |
| Year(s) Of Engagement Activity | 2022 |
| Description | WACCBIP Ghana (TT) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana. Workshops on cell biology of pathogens and career development. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Webinar - FMD in Indonesia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker: Molecular analyses and diagnosis of FMD. Webinar of foot-and-mouth disease: research and control. Organized by the National Research and Innovation Agency (BRIN), Indonesia, May 2022. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=mAj4FPeT02Q&t=8626s |
| Description | Webinar and roundtable on Troubleshooting Techniques for Full Genome Sequencing of African Swine Fever |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Webinar and roundtable on Troubleshooting Techniques for Full Genome Sequencing of African Swine Fever. Discussion on state of the ASFV full genome sequencing and future directions. Attended as part of the roundtable and answered questions from audience. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Why vaccines matter in the fight against zoonotic diseases |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A news story was published to increase the awareness of Zoonotic diseases and their impact on public health, food security, the economy and the environment. This was publicised at The Pirbright Institute webpage and One Health Poultry Health webpage and distributed wildly on social media including Facebook, Twitter, In Share. On World Zoonoses Day, Pirbright's Professor Munir Iqbal and Dr Joshua Sealy consider 600 years of developing technology to fight infectious diseases: The history of human and animal immunisation against infectious disease begins with the Chinese practice of variolation in the fifteenth century. Here, infectious material was taken from one patient and inoculated into a non-infected patient to initiate a mild but protective infection. Roughly 200 years later, Edward Jenner transformed the field of immunology by developing the world's first vaccine which involved immunising patients against smallpox using the closely related cowpox. Fast-forward another 200 years and the application of vaccines had transformed. On 6 July 1885, now celebrated as World Zoonoses Day, Louis Pasteur successfully administered the first vaccine against rabies - and within decades myriad other diseases had also been tackled effectively, including diphtheria, tetanus, anthrax, cholera, plague, typhoid, tuberculosis, measles, mumps, rubella, and polio. Many of these pathogens had been infecting humans for years, and continue to do so where vaccines are not deployed. Now, in the 21st century, vaccine research is undergoing another seismic shift. In 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the virus that causes COVID-19), emerged in humans which is believed to have originated in animals (known as zoonoses). It has since developed into the devastating COVID-19 pandemic and in doing so it triggered an urgent need to develop vaccines to control a virus that represents a growing problem at the human-animal interface. Pathogen evolution: Broadly speaking, humans have a naïve immune system to the many pathogens that exclusively circulate within animal reservoirs, including livestock. Most pathogens have evolved to infect specific animal species, which means that a significant barrier exists that prevents animal pathogens from causing disease in humans. However, a portion of these pathogens, including influenza viruses and coronaviruses, have the capacity to evolve such that they can overcome these barriers and be successful, especially as there is no prior immunity in the human population. This extraordinary ability to evolve also means that these pathogens have the potential to overcome vaccines. The application of vaccines and vaccine technology must progress to meet the challenge of zoonotic viruses. Vaccine variety: An impressive diversity of vaccine technologies is currently employed or in development to combat pathogens circulating in humans and animals. A vaccine needs to be effective at eliminating or reducing disease, but the diversity of pathogens means vaccines sometimes need to be equally diverse and must cater to specific challenges. Traditional inactivated pathogen vaccines are generated by 'killing' a pathogen so that it can be safely administered for immunisation. Subunit vaccines are vaccines that comprise only a fragment of the target pathogen which can be administered to generate an immune response exclusively to that fragment. Both technologies elicit protective antibody responses and have been successful for an exceptionally long time against a variety of pathogens. However, an antibody response does not provide sufficient protection against all pathogens that continually change their shapes to evade vaccines. Live attenuated vaccines typically use infectious pathogens that are modified to prevent them from causing disease but can still trigger an immune response similar to their naturally occurring counterparts. These vaccines are useful because as well as an antibody response, they can induce a cellular immune response, which targets conserved parts of the pathogens that remain the same across different strains. This means live attenuated vaccines are more effective at protecting against mutations that could allow the pathogen to escape vaccine immunity and they provide better protection against multiple pathogen strains. New vaccine technology: Viral vector vaccines are vaccines that comprise the 'backbone' of a virus that doesn't cause disease in the host animal, which expresses a piece of the target pathogen that induces an immune response. Most licensed viral vector vaccines are in use in animals, with only a single vectored vaccine (against the Ebola virus) being licensed for humans prior to the SARS-CoV-2 pandemic. Viral vector vaccines evoke a strong immune response that is specific to the pathogen, making it effective and long-lasting. DNA/RNA vaccines contain genetic material that codes for a piece of a pathogen, which the host cells process to elicit an immune response. Several mRNA vaccines are in use against SARS-CoV-2 and they are cost-effective, safe, and produced using chemicals synthetically and not from cell culture systems. As such, we now have the capacity to carefully select the target of our vaccines and the nature of the desired immune response. The importance of vaccines was brought into focus once again with the SARS-CoV-2 pandemic - and, going forward, the need for our growing arsenal of vaccines will only increase with the needs of humanity. Nutrition: As the human population increases so do its need for nutrition. A major source of human nutrition is animal-derived; thus, the population of farmed animals increases. Wild habitats are encroached upon to provide for the increasing population of farmed animals, and this facilitates interaction between farmed and wild animals. Consequently, we develop a tractable route for zoonotic diseases to enter the human population. Finally, the need for human nutrition is also met through the acquisition of wild animals. There is evidence to suggest that the West African Ebola virus epidemic was preceded by the capture of wild animals for human consumption. Likewise, SARS-CoV-2 is believed to have originated in wild animals. Zoonotic diseases clearly have far-reaching impacts. Humans and animals directly suffer pathogen-related sickness and death, and global economies incur significant losses. The current SARS-CoV-2 pandemic is a clear example of this - while avian influenza and several other emerging and re-emerging viruses carrying zoonotic infection potential circulating in farmed and wild birds are a constant reminder that the next pandemic could be around the corner. Written by Professor Munir Iqbal and Dr Joshua Sealy, members of the Avian Influenza Virus group at Pirbright. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/07/why-vaccines-matter-fight-against-zoonotic-diseases |
| Description | Why wet markets will never close - despite the global threat to human health (The Telegraph) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | This discussion was due to current enormous global spread of bird flu and widespread poultry outbreak has generated unprecedented opportunities for the virus to jump to humans and potentially even mutate to better spread between people. Since the Live bird markets have been identified as key factors in the spread, persistence and evolution of avian influenza viruses,. Therefore, there is an increased risk to public at the live birds markets and how these risks can be reduced to increase food safety, security and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.telegraph.co.uk/global-health/science-and-disease/why-wet-markets-will-never-close-despi... |
| Description | Winston Churchill Careers Fair. Winston Churchill School, Hermitage Road, St Johns, Woking, Surrey, GU21 8TL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | AS attended and presented at this event to stimulate increased interest in science and research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Winston Churchill School Career Event - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A careers event at a local school for yeat 7 to 11 students about Pirbright, what we do, the kinds of careers they can get into and routes to those careers. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Winston Churchill School Careers Fair - Jennifer Simpson |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Fielded questions from school students, stimulating increased interest in science and research. This also increased the visibility of the Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Winston Churchill School careers event - PP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Students visited a stand run by The Pirbright Institute to learn about careers in science and the work we do at Pirbright, including a microscope demonstration. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Woking High School Careers Fair -18th September 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Career fair attended by approx. 50 school aged children. Pirbright offered advice and information about the different career streams available at a research institute. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Woking School Careers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Workshop 1: Minimum Information for Reporting Arthropod Infection Studies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A workshop was held as part of the VectorBiTE RCN annual meeting at Asilomar in CA. Attendance was roughly 60 people, mostly users of data resulting from experimental arthropod infection studies or arthropod ecological datasets. AW gave a presentation describing the objectives of the grant and then we formed breakout groups to discuss potential factors to report and their importance for different categories of users. The feedback was used to review and update the draft standards document before the second workshop as ASTMH's Trop Med meeting in New Orleans in October. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Workshop 2: Minimum Information for Reporting Arthropod Infection Studies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A workshop was organised in collaboration with members of the ASTMH's Advisory Committee on Arthropod-borne Viruses (ACAV) at the start of the 2018 Trop Med annual meeting and was advertised via social media and society and project mailing lists. Around 30 people attended, mostly from the US but with representation from Asia, Europe and South America, and a mixture of senior academics, junior faculty and students. AW gave a brief introduction to the objectives of the workshop and AW, assisted by LH (a postdoc at Pirbright), helped participants pilot the questionnaire before its formal launch. Feedback was positive and used to refine the questionnaire before it was launched in November. As a result of specific points raised in the feedback, the survey was translated into French and Spanish and these versions were launched simultaneously to support involvement by a broader audience. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Workshop 3: Minimum Information for Reporting Arthropod Infection Studies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A workshop was organised during the biennial UK VBD meeting in Norwich to improve awareness of the survey and increase completion. A short presentation was given by LH, a postdoc at Pirbright who has been assisting with the development of the questionnaire and standards documentation (as AW is leaving Pirbright in December) and then breakout groups formed to discuss particular challenges and any suggested changes as well as pathways to increasing the chances of uptake of the resulting guidelines. The feedback was recorded and will influence the resulting report/manuscript. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Workshop on Ecology and Evolution of Infectious Diseases |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | NSF-BBSRC workshop on Ecology and Evolution of Infectious Diseases held at Emory University, Atlanta, U.S.A, 4-6 June 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Workshop with MSc students in Veterinary Microbiology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Both PI and postdoctoral scientists employed on projects participated in a 1 week workshop of MSc students from the University of Surrey including training activities within the high containment facilities |
| Year(s) Of Engagement Activity | 2017,2018,2019,2020 |
| Description | World Dengue Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was the inaugural World Dengue Day, an annual multi-day series of events to raise awareness of the global impact of dengue. The event raised awareness of dengue globally and sparked interest from a number of attendees in our research. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.adva.asia/world-dengue-day-2021/ |
| Description | World Vaccine Congress Talk on Nipah virus vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on our Innovate funded work on Nipah vaccines - which we have developed and tested in pigs. |
| Year(s) Of Engagement Activity | 2021 |
| Description | World Zoonosis Day 2018 - web story |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Contributed to an article from our institute on World Zoonosis Day highlighting the importance of research in this area. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pirbright.ac.uk/news/2018/07/pirbright-scientists-are-developing-vaccine-candidates-anim... |
| Description | Zeiss live cell imaging symposium - Joanna Wells |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussions with specialists in the community |
| Year(s) Of Engagement Activity | 2021 |
| Description | careers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | eMergence autumn 2019 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Article for the MSD online publication eMergence. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.emergence-msd-animal-health.com/ |