Understanding the novel aspects of PERK signalling and
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Neurosciences
Abstract
1. To further characterise the novel PERK non-canonical signalling protein partners which interact with PERK via its cytoplasmic domain.
2. To develop cell-based assays which can monitor these interactions
3. To use these assays to screen compound libraries to identify compounds that specifically impact the PERK non-canonical signalling pathway and to investigate their potential neuroprotective capabilities in rodent models of neurodegeneration.
2. To develop cell-based assays which can monitor these interactions
3. To use these assays to screen compound libraries to identify compounds that specifically impact the PERK non-canonical signalling pathway and to investigate their potential neuroprotective capabilities in rodent models of neurodegeneration.
Organisations
People |
ORCID iD |
| Karinder Brar (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013433/1 | 30/09/2016 | 29/04/2026 | |||
| 2251298 | Studentship | MR/N013433/1 | 30/09/2019 | 29/09/2023 | Karinder Brar |
| NE/W503204/1 | 31/03/2021 | 30/03/2022 | |||
| 2251298 | Studentship | NE/W503204/1 | 30/09/2019 | 29/09/2023 | Karinder Brar |