Warwick Centre for Analytical Science
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
Analytical Science involves the development and application of new methods to measure the composition and structure of manufactured and natural substances of all types. The analytical sector in the UK underpins many vital industries (e.g. food, chemical, pharmaceutical, environmental, materials), is crucial to process and cost control, to product quality and competitiveness, to industrial compliance with environmental and safety legislation, and to the delivery of healthcare and justice. Crucially, progress in Analytical Science is also essential to advances in many key research areas including materials and life sciences. Modern analytical problems often require high spatial resolution in three dimensions, resulting in very large, complex data sets. Moreover, there is a need to combine information from multiple data sets of very different provenance. Recent official reviews have warned that, despite its central importance to the UK's economic and scientific competitiveness, Analytical Science in the UK suffers from low esteem and fragmentation, and lacks interdisciplinarity. The result is a shortage of analytical scientists, and an alarmingly low level of innovation compared to other countries. Research and innovation-led reinvigoration of this area is essential for the UK's economic and social well-being. The University of Warwick invests heavily in multidisciplinary research and education, and has a strong research base in Analytical Science in the Departments of Chemistry, Physics, Statistics, Engineering, Biological Sciences and the Medical School. Building on this philosophy, we have responded to the fourth Science and Innovation Call by proposing lectureships in three new interdisciplinary research areas (Chemometrics and Experimental Design, Chemical and Structural Characterisation of Materials, and Mass Spectrometry) that will be combined with diverse research in Analytical Science at Warwick to found a new Centre for Analytical Science, expected to boost the profile of Analytical Science in the UK and world-wide. Recognising the fact that scientific progress crucially depends on communication and collaboration between different disciplines and sectors, a central aim of the Centre will be to bring together people from academia and industry with the objective of providing a platform for identification, definition, and implementation of new Analytical Science research goals including the development of new instrumentation, and new methods for data acquisition and statistical inference. The process of innovation requires a dialogue between academia and the private sector. As stated in the Lambert report, the best forms of knowledge transfer involve human interaction . Therefore, the Centre will have an academic/industrial Advisory Board, and will develop, through its new Analytical Forum, a visitor and outreach programme, not only to enable the exchange of ideas, knowledge, and technology between developers and users of analytical tools in public and private sectors, but also to foster new collaborations.Applicants of the very highest quality will be attracted by offering excellent research facilities supported by PhD students and post-doctoral researchers in a well resourced multinational, multidisciplinary environment. The Centre will develop training programmes in Analytical Science, statistics and transferable skills. The integration of research and education in the Centre will offer a comprehensive approach to Analytical Science, helping to provide the UK with the skills base essential to remain internationally competitive.Warwick will nurture the new Centre by guaranteeing long-term support for the area, and by investing heavily in state-of-the-art equipment, purpose-built accommodation and infrastructure. There will be development of modules for CPD, PG and UG training which will help sustainability.
Publications
Wilson N
(2010)
On the structure and topography of free-standing chemically modified graphene
in New Journal of Physics
Chen JS
(2010)
Photochemistry in photonic crystal fiber nanoreactors.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Sargaeva NP
(2011)
Unusual fragmentation of ß-linked peptides by ExD tandem mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Pandey PA
(2011)
Physical vapor deposition of metal nanoparticles on chemically modified graphene: observations on metal-graphene interactions.
in Small (Weinheim an der Bergstrasse, Germany)
Qi Y
(2011)
Phase Correction of Fourier Transform Ion Cyclotron Resonance Mass Spectra Using MatLab
in Journal of the American Society for Mass Spectrometry
Lin TY
(2011)
A gain and bandwidth enhanced transimpedance preamplifier for Fourier-transform ion cyclotron resonance mass spectrometry.
in The Review of scientific instruments
Li H
(2011)
Mass spectrometry evidence for cisplatin as a protein cross-linking reagent.
in Analytical chemistry
Sargaeva NP
(2011)
Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides.
in Electrophoresis
Qi Y
(2011)
Variation of the Fourier transform mass spectra phase function with experimental parameters.
in Analytical chemistry
Sargaeva NP
(2011)
Differentiating N-terminal aspartic and isoaspartic acid residues in peptides.
in Analytical chemistry
Bichoutskaia E
(2012)
High-precision imaging of an encapsulated Lindqvist ion and correlation of its structure and symmetry with quantum chemical calculations
in Nanoscale
Li H
(2012)
Electron Capture Dissociation of Disulfide, Sulfur-Selenium, and Diselenide Bound Peptides
in Journal of the American Society for Mass Spectrometry
Kilgour DP
(2012)
Use of an artificial immune system derived method for the charge state assignment of small-molecule mass spectra.
in Analytical chemistry
Qi Y
(2012)
Absorption-mode: the next generation of Fourier transform mass spectra.
in Analytical chemistry
Minas G
(2012)
A hybrid procedure for detecting global treatment effects in multivariate clinical trials: theory and applications to fMRI studies.
in Statistics in medicine
Perez Hurtado P
(2012)
Use of High Resolution Mass Spectrometry for Analysis of Polymeric Excipients in Drug Delivery Formulations
in Analytical Chemistry
Hurtado PP
(2012)
Deamidation of collagen.
in Analytical chemistry
Li X
(2012)
Top-Down Study of ß 2 -Microglobulin Deamidation
in Analytical Chemistry
Li H
(2012)
Protein flexibility is key to cisplatin crosslinking in calmodulin.
in Protein science : a publication of the Protein Society
Páez C
(2012)
Robust signatures in the current-voltage characteristics of DNA molecules oriented between two graphene nanoribbon electrodes
in New Journal of Physics
Lopez-Clavijo AF
(2012)
Determination of types and binding sites of advanced glycation end products for substance P.
in Analytical chemistry
Kilgour DP
(2012)
Appropriate degree of trust: deriving confidence metrics for automatic peak assignment in high-resolution mass spectrometry.
in Analytical chemistry
Wills R
(2012)
Structural Characterization of Polyketides Using High Mass Accuracy Tandem Mass Spectrometry
in Analytical Chemistry
Lin TY
(2012)
A low noise single-transistor transimpedance preamplifier for Fourier-transform mass spectrometry using a T feedback network.
in The Review of scientific instruments
Qi Y
(2012)
Absorption-mode spectra on the dynamically harmonized Fourier transform ion cyclotron resonance cell.
in Rapid communications in mass spectrometry : RCM
Pandey P
(2012)
Resolving the Nanoscale Morphology and Crystallographic Structure of Molecular Thin Films: F 16 CuPc on Graphene Oxide
in Chemistry of Materials
Dyson M
(2013)
A new approach to high resolution, high contrast electron microscopy of macromolecular block copolymer assemblies
in Soft Matter
Nightingale A
(2013)
Large-scale synthesis of nanocrystals in a multichannel droplet reactor
in Journal of Materials Chemistry A
Marsden A
(2013)
Is graphene on copper doped?
in physica status solidi (RRL) - Rapid Research Letters
Qi Y
(2013)
Absorption-mode Fourier transform mass spectrometry: the effects of apodization and phasing on modified protein spectra.
in Journal of the American Society for Mass Spectrometry
Barry N
(2013)
ChemInform Abstract: Exploration of the Medical Periodic Table: Towards New Targets
in ChemInform
Pandey P
(2013)
Pd-doped reduced graphene oxide sensing films for H2 detection
in Sensors and Actuators B: Chemical
Wilson N
(2013)
Weak mismatch epitaxy and structural Feedback in graphene growth on copper foil
in Nano Research
Kilgour DP
(2013)
Autophaser: an algorithm for automated generation of absorption mode spectra for FT-ICR MS.
in Analytical chemistry
Barry NP
(2013)
Exploration of the medical periodic table: towards new targets.
in Chemical communications (Cambridge, England)
Qi Y
(2013)
Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation
in Rapid Communications in Mass Spectrometry
Pizarro A
(2013)
Comprehensive Inorganic Chemistry II
Wei J
(2013)
Structural Characterization of Chlorophyll- a by High Resolution Tandem Mass Spectrometry
in Journal of the American Society for Mass Spectrometry
Lopez-Clavijo AF
(2014)
Study of an unusual advanced glycation end-product (AGE) derived from glyoxal using mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Barry NP
(2014)
Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.
in Faraday discussions
Sun L
(2014)
Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation.
in Nature communications
Wills RH
(2014)
Structural characterization of actinomycin D using multiple ion isolation and electron induced dissociation.
in Journal of the American Society for Mass Spectrometry
Barry NP
(2014)
A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes.
in Dalton transactions (Cambridge, England : 2003)
Wei J
(2014)
D-a-tocopheryl polyethylene glycol 1000 succinate: a view from FTICR MS and tandem MS.
in Analytical chemistry
Kashtiban RJ
(2014)
Atomically resolved imaging of highly ordered alternating fluorinated graphene.
in Nature communications