RFI Phase 2
Lead Research Organisation:
Rosalind Franklin Institute
Department Name: Research
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Carter-Searjeant S
(2023)
Nanoscale LiZnN - Luminescent Half-Heusler Quantum Dots.
in ACS applied optical materials
Richards LS
(2023)
Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED.
in ACS bio & med chem Au
Chen X
(2023)
Carbon-Centered Radicals in Protein Manipulation.
in ACS central science
Giltrap AM
(2025)
Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress.
in ACS central science
Fu XP
(2023)
Stereoretentive Post-Translational Protein Editing.
in ACS central science
Devlin A
(2023)
Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State
in ACS Central Science
Moynié L
(2022)
Hijacking of the Enterobactin Pathway by a Synthetic Catechol Vector Designed for Oxazolidinone Antibiotic Delivery in Pseudomonas aeruginosa
in ACS Infectious Diseases
Datta S
(2023)
Role of the Deep Eutectic Solvent Reline in the Synthesis of Gold Nanoparticles.
in ACS sustainable chemistry & engineering
Choi J
(2024)
Thermally Drawn Shape and Stiffness Programmable Fibers for Medical Devices
in Advanced Healthcare Materials
Abdelaziz M
(2024)
Thermally Drawn Polymeric Catheters for MR-Guided Cardiovascular Intervention
in Advanced Science
Wu V
(2022)
High Resolution Ambient MS Imaging of Biological Samples by Desorption Electro-Flow Focussing Ionization.
in Analytical chemistry
Kitano ES
(2024)
Repurposed 3D Printer Allows Economical and Programmable Fraction Collection for Proteomics of Nanogram Scale Samples.
in Analytical chemistry
Strittmatter N
(2022)
Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging.
in Analytical chemistry
Lagator M
(2024)
Reactive Gas Cluster Ion Beams for Enhanced Drug Analysis by Secondary Ion Mass Spectrometry.
in Analytical chemistry
Allen C
(2023)
Super-resolution electron ptychography of low dimensional materials at 30 keV: Beyond the detector limit
in Applied Physics Letters
Eyssen L
(2025)
From Llama to Nanobody: A Streamlined Workflow for the Generation of Functionalised VHHs
in BIO-PROTOCOL
Mycroft-West C
(2025)
Structural glycobiology - from enzymes to organelles
in Biochemical Society Transactions
Kaipa J
(2023)
Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells
in Biomolecules
Naseer Khan RM
(2023)
Distributable, Metabolic PET Reporting of Tuberculosis.
in bioRxiv : the preprint server for biology
Shad M
(2024)
Structural and functional insights of starch processing a-amylase from hyperthermophilic archaeon Pyrococcusabyssi.
in Carbohydrate research
Rigby M
(2023)
Multi-synaptic boutons are a feature of CA1 hippocampal connections in the stratum oriens
in Cell Reports
Cobo I
(2022)
Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins.
in Chembiochem : a European journal of chemical biology
Griggs S
(2025)
Phenotype-directed discovery of diverse, biologically-relevant molecular scaffolds
in Chemical Communications
Hwang H
(2022)
Two-dimensional confinement for generating thin single crystals for applications in time-resolved electron diffraction and spectroscopy: an intramolecular proton transfer study.
in Chemical communications (Cambridge, England)
Giltrap A
(2024)
Late-Stage Functionalization of Living Organisms: Rethinking Selectivity in Biology
in Chemical Reviews
Chatterjee G
(2022)
Torsionally broken symmetry assists infrared excitation of biomimetic charge-coupled nuclear motions in the electronic ground state.
in Chemical science
Galan SRG
(2024)
The Minimum Protein Staple? - Towards 'bio'-Baldwin's rules via inter-phosphosite linking in the MEK1 activation loop.
in Chemical science
Chhabra M
(2022)
Structural Insights into Pixatimod (PG545) Inhibition of Heparanase, a Key Enzyme in Cancer and Viral Infections
in Chemistry - A European Journal
Parafioriti M
(2022)
Evidence for Multiple Binding Modes in the Initial Contact Between SARS-CoV-2 Spike S1 Protein and Cell Surface Glycans**
in Chemistry - A European Journal
Fritzsche M
(2022)
Author Correction: Live microscopy: cracking the challenge to image biology unfolding in cells, tissues, and organs.
in Communications biology
Fritzsche M
(2022)
Live microscopy: cracking the challenge to image biology unfolding in cells, tissues, and organs
in Communications Biology
El Omari K
(2023)
Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
in Communications chemistry
Murray C
(2024)
Project M: investigating the effect of additives on calcium carbonate crystallisation through a school citizen science program
in CrystEngComm
Huang C
(2023)
Cryo-electron ptychography: Applications and potential in biological characterisation
in Current Opinion in Structural Biology
Dumoux M
(2023)
Cryo-plasma FIB/SEM volume imaging of biological specimens.
in eLife
Yang N
(2024)
Cyclodextrin-based metal-organic frameworks transforming drug delivery
in European Journal of Medicinal Chemistry
Halfon Y
(2022)
Maintaining the momentum in cryoEM for biological discovery.
in Faraday discussions
Pennington A
(2022)
SuRVoS 2: Accelerating Annotation and Segmentation for Large Volumetric Bioimage Workflows Across Modalities and Scales.
in Frontiers in cell and developmental biology
Levitz TS
(2022)
Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation.
in Frontiers in molecular biosciences
Oltrabella F
(2022)
IPIP27A cooperates with OCRL to support endocytic traffic in the zebrafish pronephric tubule
in Human Molecular Genetics
Hudson D
(2024)
A comparison of clustering models for inference of T cell receptor antigen specificity.
in Immunoinformatics (Amsterdam, Netherlands)
Shad M
(2024)
Investigating the effect of SUMO fusion on solubility and stability of amylase-catalytic domain from Pyrococcus abyssi
in International Journal of Biological Macromolecules
Emmenegger M
(2023)
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region
in iScience
Joosten M
(2024)
Roodmus: a toolkit for benchmarking heterogeneous electron cryo-microscopy reconstructions.
in IUCrJ
Lu Y
(2024)
Ray-tracing analytical absorption correction for X-ray crystallography based on tomographic reconstructions
in Journal of Applied Crystallography
| Description | The Rosalind Franklin Institute phase 2 award covers the full scientific and research remit of this national institute. The award has taken the Institure through it's set up phase and into full operation, and has leveraged significant further funding for research, created new industry collaborations, and has seen the beginnings of an innovation and translation programme from our work. Our role is to create new techologies for life science. Within this phase 2 grant, we have pioneered the technique of cryo-epectron tomography, enabling the structures of biology to be seen within their biological context inside the cell, advanced physical sciences techniques into biology for the first time, and developed a world class laboratory for engineering biology which will bring precise control capabilities to the molecules of biology. The Institute has also been able to develop a sttdentship scheme, and now houses a cohort of ten stdents per year, in collabroation with Universities across the UK. |
| Exploitation Route | Our work can be translated into commercial products for imaging, or as theraputics. Our technolgies can be applied by academics or by industry to understand more about biological problems, and by working with instrument developers, new instruments are now on the market. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| URL | https://www.rfi.ac.uk/about/annual-reports/ |
| Description | The Franklin has a significant community and public engagement programme, linked both to the work of the institute broadly, and to specific research areas. Our work in public engagement includes a training programme availabe to all staff, created in collaboration with Science Made Simple, opportunities throughout the year to engage local schools, in partnership with the Education Business Partnership, and Citzen science programmes intrinsic to our research activity created with Zooniverse. Working closely woth industry has realised significant non academic impact, including in the bring to market of new instrumentation, leverage by the phase 2 and Wellcome funded Electirfying Life Sciences Grant (e.g. the commercial FIB SEM 'Arctis'), through core activity with Bruker, and with JEOL. Full details on our engagement and non academic impact is available in our annual reports from www.rfi.ac.uk. |
| First Year Of Impact | 2022 |
| Sector | Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal Economic |
| Description | Challenge reviewer and contributor to Nurse RDI |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | The RDI review will shape government policy. |
| URL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1140... |
| Description | Structural Biology: From Molecules to Cells. |
| Amount | £159,340 (GBP) |
| Funding ID | 099683 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 09/2016 |
| Title | SINGLE DOMAIN ANTIBODIES THAT TARGET SARS-COV-2 |
| Description | The present invention relates to improved single domain antibodies that target SARS-CoV-2, multivalent polypeptides and fusion proteins comprising the single domain antibodies. The present invention also provides coronavirus binding molecules that bind two different epitopes on the receptor binding domain of a spike protein of a coronavirus. The coronavirus binding molecules are based on joining two antigen binding molecules together via a linker. The present invention provides the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in treating and/or preventing coronavirus, as well as the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in the detection and diagnosis of coronavirus using various methods, assays and kits. |
| IP Reference | WO2022053839 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | Commercial In Confidence |
| Impact | The patent estate is in the final stages of agreement to licence. |
| Title | rosalindfranklininstitute/guanaco: |
| Description | No description provided. |
| Type Of Technology | Software |
| Year Produced | 2021 |
| Open Source License? | Yes |
| Impact | Shaping tomography practice |
| URL | https://zenodo.org/record/5185365 |
| Title | rosalindfranklininstitute/parakeet: |
| Description | Phantom generator |
| Type Of Technology | Software |
| Year Produced | 2022 |
| Open Source License? | Yes |
| Impact | Imported into major software packages |
| URL | https://zenodo.org/record/6493567 |
| Description | Media work for science media centre |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I have supplied expert commentary on the pandemic and on science policy. |
| Year(s) Of Engagement Activity | 2020,2021,2022,2023 |
| URL | https://www.sciencemediacentre.org/?s=naismith&cat= |