RFI Phase 2
Lead Research Organisation:
Rosalind Franklin Institute
Department Name: Research
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
James Naismith (Principal Investigator) |
Publications
Alvarez-Borges F
(2022)
Comparison of Methods to Segment Variable-Contrast XCT Images of Methane-Bearing Sand Using U-Nets Trained on Single Dataset Sub-Volumes
in Methane
Berger C
(2023)
Plasma FIB milling for the determination of structures in situ.
in Nature communications
Buchanan C
(2022)
Pathogen-sugar interactions revealed by universal saturation transfer analysis
in Science
Chatterjee G
(2022)
Torsionally broken symmetry assists infrared excitation of biomimetic charge-coupled nuclear motions in the electronic ground state.
in Chemical science
Cobo I
(2022)
Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins.
in Chembiochem : a European journal of chemical biology
De Boer C
(2022)
Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.
in Proceedings of the National Academy of Sciences of the United States of America
Ding Z
(2022)
Three-dimensional electron ptychography of organic-inorganic hybrid nanostructures.
in Nature communications
Dumoux M
(2023)
Cryo-plasma FIB/SEM volume imaging of biological specimens.
in eLife
Fu XP
(2023)
Stereoretentive Post-Translational Protein Editing.
in ACS central science
Halfon Y
(2022)
Maintaining the momentum in cryoEM for biological discovery.
in Faraday discussions
Hwang H
(2022)
Two-dimensional confinement for generating thin single crystals for applications in time-resolved electron diffraction and spectroscopy: an intramolecular proton transfer study.
in Chemical communications (Cambridge, England)
Kazantsev D
(2022)
High performance Savu software for fast 3D model-based iterative reconstruction of large data at Diamond Light Source
in SoftwareX
King O
(2022)
Volume Segmantics: A Python Package for Semantic Segmentation of Volumetric Data Using Pre-trained PyTorch Deep Learning Models
in Journal of Open Source Software
Le Bas A
(2022)
Production and Crystallization of Nanobodies in Complex with the Receptor Binding Domain of the SARS-CoV-2 Spike Protein
in BIO-PROTOCOL
Levitz TS
(2022)
Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation.
in Frontiers in molecular biosciences
Li W
(2023)
Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase.
in Open biology
Mikolajek H
(2022)
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
in Proceedings of the National Academy of Sciences of the United States of America
Mollner TA
(2022)
Reductive site-selective atypical C,Z-type/N2-C2 cleavage allows C-terminal protein amidation.
in Science advances
Morimoto K
(2022)
Cysteine Reactivity Profiling to Unveil Redox Regulation in Phytopathogens.
in Methods in molecular biology (Clifton, N.J.)
Morimoto K
(2022)
Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme.
in The New phytologist
Moynié L
(2022)
Hijacking of the Enterobactin Pathway by a Synthetic Catechol Vector Designed for Oxazolidinone Antibiotic Delivery in Pseudomonas aeruginosa.
in ACS infectious diseases
Murray C
(2022)
Diamond: The Game - a board game for secondary school students promoting scientific careers and experiences
in Research for All
Nagoor O
(2022)
Sampling strategies for learning-based 3D medical image compression
in Machine Learning with Applications
Pennington A
(2022)
SuRVoS 2: Accelerating Annotation and Segmentation for Large Volumetric Bioimage Workflows Across Modalities and Scales.
in Frontiers in cell and developmental biology
Perdigão L
(2022)
Computing for Optimized Biological Microscopy Data Processing and Analysis at The Rosalind Franklin Institute
in Microscopy and Microanalysis
Description | Challenge reviewer and contributor to Nurse RDI |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | The RDI review will shape government policy. |
URL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1140... |
Description | Structural Biology: From Molecules to Cells. |
Amount | £159,340 (GBP) |
Funding ID | 099683 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 10/2012 |
End | 09/2016 |
Title | SINGLE DOMAIN ANTIBODIES THAT TARGET SARS-COV-2 |
Description | The present invention relates to improved single domain antibodies that target SARS-CoV-2, multivalent polypeptides and fusion proteins comprising the single domain antibodies. The present invention also provides coronavirus binding molecules that bind two different epitopes on the receptor binding domain of a spike protein of a coronavirus. The coronavirus binding molecules are based on joining two antigen binding molecules together via a linker. The present invention provides the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in treating and/or preventing coronavirus, as well as the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in the detection and diagnosis of coronavirus using various methods, assays and kits. |
IP Reference | WO2022053839 |
Protection | Patent / Patent application |
Year Protection Granted | 2022 |
Licensed | Commercial In Confidence |
Impact | The patent estate is in the final stages of agreement to licence. |
Title | rosalindfranklininstitute/guanaco: |
Description | No description provided. |
Type Of Technology | Software |
Year Produced | 2021 |
Open Source License? | Yes |
Impact | Shaping tomography practice |
URL | https://zenodo.org/record/5185365 |
Title | rosalindfranklininstitute/parakeet: |
Description | Phantom generator |
Type Of Technology | Software |
Year Produced | 2022 |
Open Source License? | Yes |
Impact | Imported into major software packages |
URL | https://zenodo.org/record/6493567 |
Description | Media work for science media centre |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | I have supplied expert commentary on the pandemic and on science policy. |
Year(s) Of Engagement Activity | 2020,2021,2022,2023 |
URL | https://www.sciencemediacentre.org/?s=naismith&cat= |