Core Capability for Chemistry Research at the University of Liverpool
Lead Research Organisation:
University of Liverpool
Department Name: Chemistry
Abstract
This grant will underpin the Chemistry Department's core research capability by upgrading capital equipment in four key areas of Chemistry instrumentation, nuclear magnetic resonance spectroscopy, mass spectrometry, X-ray structural analysis and atomic level microscopy. These techniques provide the ability to characterise the new chemicals and materials produced in the Department of Chemistry at Liverpool, to determine their atomic structure and to examine their properties, supporting research activity across the entire Chemistry research portfolio. The new facilities will provide access to state of the art instrumentation for Chemistry academics, early career research staff, post-doctoral research workers and research students, enhancing the quality of the research carried out. Replacement of obsolete instrumentation and extending the capability of the instrumentation base will enhance sample throughput and productivity, permit unstable samples to be analysed, reduce the need for external analysis of samples and allow more complex analysis to be performed. Research programmes relying on these techniques include Materials Research, research into Green Catalysis and new Battery Materials, Drug Discovery and Drug Delivery, and the design of Functional Interfaces. Upgrading the instrument base will also ensure the training provided to research students remains compatible with the instrumentation they will meet in industry, supporting the skills needed by employers and the UK Chemical Industry.
Planned Impact
This proposal represents an ambitious project to provide an open distributed network of instrumentation and equipment across six of the N8 Research Partnership universities (Durham, Leeds, Liverpool, Manchester, Sheffield, and York) that will provide capacity to meet current and future chemistry research requirements. This will be achieved through the delivery of improved analytical facilities for chemical and materials characterisation, building on Chemistry's current capability with a co-ordinated approach to provide more specialist equipment. The funding will be used to refresh and upgrade the instrumentation available at Liverpool, leading to improvements in the capacity and levels of service that the Department of Chemistry can offer. Providing our researchers with ready access to state-of-the art analytical equipment is essential if the UK chemistry community is to continue to produce world-leading research. The research grants underpinning the bid vary from blue-skies academic research to applied and industrially co-funded projects, and the 'Pathways to Impact' that have been identified for these apply equally to this equipment bid.
Liverpool has an excellent record of bringing business interests and academic research together to drive economic and scientific success. The Department has strong funding links with many partners in the commercial sector, including Acal, Adisseo, Astrazeneca, Bayer, BP, Mristol-Myers Squibb, BNFL, GSK, Ineos Fluor, Iota Nanosolutions, Johnson Matthey, Lucite International, Merck, Millennium, Pfizer, SAFC Hitech and Sanofi-Aventis as well as with the charitable sector, including drug discovery charities, the Medicines for Malaria Venture, Wellcome Trust, the MRC and the IVCC. For example, the Centre for Materials Discovery and the recently announced Materials Innovation Factory (a £45M project jointly supported by the Government's Research Partnership Investment Fund, Unilever and the University of Liverpool) build on strong links with Unilever to provide a unique suite of facilities for Materials research, open to Industrial partners. Additional investment to provide state of the art instrumentation and equipment will strengthen these partnerships and facilitate new collaborations. In addition the Department has an extensive set of interactions with SMEs, who will benefit from the proposed equipment investment through joint research programmes, direct hosting of SME researchers and by the provision of enhanced analytical services.
A principal objective of the N8 Research Partnership is to create a culture of collaboration. The increased coordination underpinning this proposal will enable the equipment purchased to have the maximum benefit to individual departments and to the wider research community. The proposed collaboration will enable partner universities to provide cover and back-up services in the event of a major breakdown in service provision at a single university. An asset-sharing programme is being developed to create an integrated database of assets that are available for the use of researchers throughout the N8. Through this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution.
Provision of new equipment and instrumentation will have a direct impact on the quality of training given to research staff. As available equipment and associated technologies develop, there is a continued need for researchers to have access to, and be fully trained in, the latest techniques. This grant will allow us to continue to train chemists, on state of the art equipment, to a standard that enables them to compete on national and international levels and to support UK industry.
Liverpool has an excellent record of bringing business interests and academic research together to drive economic and scientific success. The Department has strong funding links with many partners in the commercial sector, including Acal, Adisseo, Astrazeneca, Bayer, BP, Mristol-Myers Squibb, BNFL, GSK, Ineos Fluor, Iota Nanosolutions, Johnson Matthey, Lucite International, Merck, Millennium, Pfizer, SAFC Hitech and Sanofi-Aventis as well as with the charitable sector, including drug discovery charities, the Medicines for Malaria Venture, Wellcome Trust, the MRC and the IVCC. For example, the Centre for Materials Discovery and the recently announced Materials Innovation Factory (a £45M project jointly supported by the Government's Research Partnership Investment Fund, Unilever and the University of Liverpool) build on strong links with Unilever to provide a unique suite of facilities for Materials research, open to Industrial partners. Additional investment to provide state of the art instrumentation and equipment will strengthen these partnerships and facilitate new collaborations. In addition the Department has an extensive set of interactions with SMEs, who will benefit from the proposed equipment investment through joint research programmes, direct hosting of SME researchers and by the provision of enhanced analytical services.
A principal objective of the N8 Research Partnership is to create a culture of collaboration. The increased coordination underpinning this proposal will enable the equipment purchased to have the maximum benefit to individual departments and to the wider research community. The proposed collaboration will enable partner universities to provide cover and back-up services in the event of a major breakdown in service provision at a single university. An asset-sharing programme is being developed to create an integrated database of assets that are available for the use of researchers throughout the N8. Through this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution.
Provision of new equipment and instrumentation will have a direct impact on the quality of training given to research staff. As available equipment and associated technologies develop, there is a continued need for researchers to have access to, and be fully trained in, the latest techniques. This grant will allow us to continue to train chemists, on state of the art equipment, to a standard that enables them to compete on national and international levels and to support UK industry.
Organisations
Publications
Inglis K
(2016)
Structure and Sodium Ion Dynamics in Sodium Strontium Silicate Investigated by Multinuclear Solid-State NMR
in Chemistry of Materials
Davidson R
(2016)
Effects of Electrode-Molecule Binding and Junction Geometry on the Single-Molecule Conductance of bis-2,2':6',2?-Terpyridine-based Complexes.
in Inorganic chemistry
Kinzhalov M
(2016)
Pd II -mediated integration of isocyanides and azide ions might proceed via formal 1,3-dipolar cycloaddition between RNC ligands and uncomplexed azide
in New Journal of Chemistry
Sprick RS
(2016)
Visible-Light-Driven Hydrogen Evolution Using Planarized Conjugated Polymer Photocatalysts.
in Angewandte Chemie (International ed. in English)
Xiao J
(2016)
A Convenient Procedure for the Oxidative Dehydrogenation of N-Heterocycles Catalyzed by FeCl2/DMSO
in Synlett
Lu S
(2016)
Base-free hydrogenation of CO 2 to formic acid in water with an iridium complex bearing a N,N'-diimine ligand
in Green Chemistry
Santibáñez-Mendieta A
(2016)
La 3 Li 3 W 2 O 12 : Ionic Diffusion in a Perovskite with Lithium on both A- and B-Sites
in Chemistry of Materials
Neri G
(2016)
Photochemical CO2 reduction in water using a co-immobilised nickel catalyst and a visible light sensitiser.
in Chemical communications (Cambridge, England)
Wang Z
(2016)
Iodide-Promoted Dehydrogenation of Formic Acid on a Rhodium Complex
in European Journal of Inorganic Chemistry
Wang XF
(2016)
BODIPY catalyzed amide synthesis promoted by BHT and air under visible light.
in Organic & biomolecular chemistry
Gülcemal S
(2016)
Acceptorless Dehydrogenative Oxidation of Secondary Alcohols Catalysed by Cp*Ir(III) -NHC Complexes.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Cheng J
(2016)
Chemoselective dehydrogenative esterification of aldehydes and alcohols with a dimeric rhodium(ii) catalyst.
in Chemical science
Guo X
(2016)
Palladium-Catalyzed Ylidyl-Carbonylation of Aryl Halides To Produce a-Acylphosphoranes.
in Organic letters
Fernández-Álvaro E
(2016)
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.
in Journal of medicinal chemistry
Coletta M
(2016)
Bis-Calix[4]arenes: From Ligand Design to the Directed Assembly of a Metal-Organic Trigonal Antiprism.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Wang X
(2016)
Acceptorless dehydrogenation and aerobic oxidation of alcohols with a reusable binuclear rhodium( ii ) catalyst in water
in Green Chemistry
Abraham RJ
(2016)
A re-investigation of (4)JFF and (5)JFF nuclear spin-spin couplings in substituted benzenes, a novel conformational tool.
in Physical chemistry chemical physics : PCCP
Maria L
(2016)
A novel samarium( ii ) complex bearing a dianionic bis(phenolate) cyclam ligand: synthesis, structure and electron-transfer reactions
in Dalton Transactions
Ahmed A
(2016)
Cu( i )Cu( ii )BTC, a microporous mixed-valence MOF via reduction of HKUST-1
in RSC Advances
Zhang J
(2016)
Potassium-mediated stereochemical assistance to form one indenonaphthacene isomer from rubrene with complementary diastereoselectivity to the acid based protocol
in Organic Chemistry Frontiers
Barday M
(2016)
Regioselective Synthesis of 3-Hydroxy-4,5-alkyl-Substituted Pyridines Using 1,3-Enynes as Alkynes Surrogates.
in Organic letters
Halat DM
(2016)
Probing Oxide-Ion Mobility in the Mixed Ionic-Electronic Conductor La2NiO4+d by Solid-State (17)O MAS NMR Spectroscopy.
in Journal of the American Chemical Society
Kinyanjui FG
(2016)
Crystal structure and proton conductivity of BaSn0.6Sc0.4O3-d : insights from neutron powder diffraction and solid-state NMR spectroscopy.
in Journal of materials chemistry. A
Al-Owaedi O
(2016)
Experimental and Computational Studies of the Single-Molecule Conductance of Ru(II) and Pt(II) trans -Bis(acetylide) Complexes
in Organometallics
Draper ER
(2016)
Self-sorted photoconductive xerogels.
in Chemical science
Postulka L
(2016)
Spin Frustration in an Organic Radical Ion Salt Based on a Kagome-Coupled Chain Structure.
in Journal of the American Chemical Society
Wang M
(2016)
Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one.
in Organic letters
Ismail HM
(2016)
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
in Angewandte Chemie (International ed. in English)
Zhang W
(2016)
Single-Molecule Conductance of Viologen-Cucurbit[8]uril Host-Guest Complexes.
in ACS nano
Grigoropoulos A
(2016)
Encapsulation of an organometallic cationic catalyst by direct exchange into an anionic MOF.
in Chemical science
Anisimova T
(2016)
1,3-Dipolar Cycloaddition of Nitrones to Gold(III)-Bound Isocyanides
in Organometallics
Tetlow DJ
(2016)
The synthesis and biological evaluation of a kabiramide C fragment modified with a WH2 consensus actin-binding motif as a potential disruptor of the actin cytoskeleton.
in Chemical communications (Cambridge, England)
Bennett TD
(2016)
Melt-Quenched Glasses of Metal-Organic Frameworks.
in Journal of the American Chemical Society
Draper E
(2017)
Nonlinear Effects in Multicomponent Supramolecular Hydrogels
in Langmuir
Darling GR
(2017)
Chiral segregation driven by a dynamical response of the adsorption footprint to the local adsorption environment: bitartrate on Cu(110).
in Physical chemistry chemical physics : PCCP
McKenna S
(2017)
The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)
in Green Chemistry
Horta P
(2017)
On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate
in Pure and Applied Chemistry
Osorio H
(2017)
Influence of surface coverage on the formation of 4,4'-bipyridinium (viologen) single molecular junctions
in Journal of Materials Chemistry C
Wang C
(2017)
Iridacycles for hydrogenation and dehydrogenation reactions.
in Chemical communications (Cambridge, England)
Kim G
(2017)
Revealing Local Dynamics of the Protonic Conductor CsH(PO 3 H) by Solid-State NMR Spectroscopy and First-Principles Calculations
in The Journal of Physical Chemistry C
Liu Y
(2017)
Reactions Catalysed by a Binuclear Copper Complex: Aerobic Cross Dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Abraham M
(2017)
A simple and facile NMR method for the determination of hydrogen bonding by amide N-H protons in protein models and other compounds
in New Journal of Chemistry
Liu Y
(2017)
Reactions catalyzed by a binuclear copper complex: selective oxidation of alkenes to carbonyls with O 2
in Catalysis Science & Technology
Colinas IR
(2017)
Anion exchange dynamics in the capture of perchlorate by a cationic Ag-based MOF.
in Dalton transactions (Cambridge, England : 2003)
Komulainen S
(2017)
Inside information on xenon adsorption in porous organic cages by NMR.
in Chemical science
Giovine R
(2017)
Study of Xenon Mobility in the Two Forms of MIL-53(Al) Using Solid-State NMR Spectroscopy
in The Journal of Physical Chemistry C
Al-Owaedi OA
(2017)
Insulated molecular wires: inhibiting orthogonal contacts in metal complex based molecular junctions.
in Nanoscale
Liu Y
(2017)
Reactions Catalysed by a Binuclear Copper Complex: Relay Aerobic Oxidation of N -Aryl Tetrahydroisoquinolines to Dihydroisoquinolones with a Vitamin B1 Analogue
in Chemistry - A European Journal
| Description | This grant upgraded the NMR, mass spectrometry and surface analysis facilities in the department of Chemistry and underpins the characterisation of all the molecular species developed in the Department. These materials have applications across all areas of the Department's research activity, ranging, for example, from the development of new anti-malarial agents and inhibitors for human alpha-methylacyl CoA reacemase (AMACR) for the treatment of prostate cancer, through to new catalysts for the hydrogenation of imines. |
| Exploitation Route | New materials developed by the Department will be investigated for commercial potential. |
| Sectors | Chemicals Pharmaceuticals and Medical Biotechnology |
| Description | The impact of this equipment grant will be on all aspects of the Department's research and impact portfolio over the next 10 years or longer. |
| First Year Of Impact | 2013 |
| Sector | Chemicals,Pharmaceuticals and Medical Biotechnology |