Core Capability for Chemistry Research at the University of Liverpool
Lead Research Organisation:
University of Liverpool
Department Name: Chemistry
Abstract
This grant will underpin the Chemistry Department's core research capability by upgrading capital equipment in four key areas of Chemistry instrumentation, nuclear magnetic resonance spectroscopy, mass spectrometry, X-ray structural analysis and atomic level microscopy. These techniques provide the ability to characterise the new chemicals and materials produced in the Department of Chemistry at Liverpool, to determine their atomic structure and to examine their properties, supporting research activity across the entire Chemistry research portfolio. The new facilities will provide access to state of the art instrumentation for Chemistry academics, early career research staff, post-doctoral research workers and research students, enhancing the quality of the research carried out. Replacement of obsolete instrumentation and extending the capability of the instrumentation base will enhance sample throughput and productivity, permit unstable samples to be analysed, reduce the need for external analysis of samples and allow more complex analysis to be performed. Research programmes relying on these techniques include Materials Research, research into Green Catalysis and new Battery Materials, Drug Discovery and Drug Delivery, and the design of Functional Interfaces. Upgrading the instrument base will also ensure the training provided to research students remains compatible with the instrumentation they will meet in industry, supporting the skills needed by employers and the UK Chemical Industry.
Planned Impact
This proposal represents an ambitious project to provide an open distributed network of instrumentation and equipment across six of the N8 Research Partnership universities (Durham, Leeds, Liverpool, Manchester, Sheffield, and York) that will provide capacity to meet current and future chemistry research requirements. This will be achieved through the delivery of improved analytical facilities for chemical and materials characterisation, building on Chemistry's current capability with a co-ordinated approach to provide more specialist equipment. The funding will be used to refresh and upgrade the instrumentation available at Liverpool, leading to improvements in the capacity and levels of service that the Department of Chemistry can offer. Providing our researchers with ready access to state-of-the art analytical equipment is essential if the UK chemistry community is to continue to produce world-leading research. The research grants underpinning the bid vary from blue-skies academic research to applied and industrially co-funded projects, and the 'Pathways to Impact' that have been identified for these apply equally to this equipment bid.
Liverpool has an excellent record of bringing business interests and academic research together to drive economic and scientific success. The Department has strong funding links with many partners in the commercial sector, including Acal, Adisseo, Astrazeneca, Bayer, BP, Mristol-Myers Squibb, BNFL, GSK, Ineos Fluor, Iota Nanosolutions, Johnson Matthey, Lucite International, Merck, Millennium, Pfizer, SAFC Hitech and Sanofi-Aventis as well as with the charitable sector, including drug discovery charities, the Medicines for Malaria Venture, Wellcome Trust, the MRC and the IVCC. For example, the Centre for Materials Discovery and the recently announced Materials Innovation Factory (a £45M project jointly supported by the Government's Research Partnership Investment Fund, Unilever and the University of Liverpool) build on strong links with Unilever to provide a unique suite of facilities for Materials research, open to Industrial partners. Additional investment to provide state of the art instrumentation and equipment will strengthen these partnerships and facilitate new collaborations. In addition the Department has an extensive set of interactions with SMEs, who will benefit from the proposed equipment investment through joint research programmes, direct hosting of SME researchers and by the provision of enhanced analytical services.
A principal objective of the N8 Research Partnership is to create a culture of collaboration. The increased coordination underpinning this proposal will enable the equipment purchased to have the maximum benefit to individual departments and to the wider research community. The proposed collaboration will enable partner universities to provide cover and back-up services in the event of a major breakdown in service provision at a single university. An asset-sharing programme is being developed to create an integrated database of assets that are available for the use of researchers throughout the N8. Through this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution.
Provision of new equipment and instrumentation will have a direct impact on the quality of training given to research staff. As available equipment and associated technologies develop, there is a continued need for researchers to have access to, and be fully trained in, the latest techniques. This grant will allow us to continue to train chemists, on state of the art equipment, to a standard that enables them to compete on national and international levels and to support UK industry.
Liverpool has an excellent record of bringing business interests and academic research together to drive economic and scientific success. The Department has strong funding links with many partners in the commercial sector, including Acal, Adisseo, Astrazeneca, Bayer, BP, Mristol-Myers Squibb, BNFL, GSK, Ineos Fluor, Iota Nanosolutions, Johnson Matthey, Lucite International, Merck, Millennium, Pfizer, SAFC Hitech and Sanofi-Aventis as well as with the charitable sector, including drug discovery charities, the Medicines for Malaria Venture, Wellcome Trust, the MRC and the IVCC. For example, the Centre for Materials Discovery and the recently announced Materials Innovation Factory (a £45M project jointly supported by the Government's Research Partnership Investment Fund, Unilever and the University of Liverpool) build on strong links with Unilever to provide a unique suite of facilities for Materials research, open to Industrial partners. Additional investment to provide state of the art instrumentation and equipment will strengthen these partnerships and facilitate new collaborations. In addition the Department has an extensive set of interactions with SMEs, who will benefit from the proposed equipment investment through joint research programmes, direct hosting of SME researchers and by the provision of enhanced analytical services.
A principal objective of the N8 Research Partnership is to create a culture of collaboration. The increased coordination underpinning this proposal will enable the equipment purchased to have the maximum benefit to individual departments and to the wider research community. The proposed collaboration will enable partner universities to provide cover and back-up services in the event of a major breakdown in service provision at a single university. An asset-sharing programme is being developed to create an integrated database of assets that are available for the use of researchers throughout the N8. Through this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution.
Provision of new equipment and instrumentation will have a direct impact on the quality of training given to research staff. As available equipment and associated technologies develop, there is a continued need for researchers to have access to, and be fully trained in, the latest techniques. This grant will allow us to continue to train chemists, on state of the art equipment, to a standard that enables them to compete on national and international levels and to support UK industry.
Organisations
Publications
Yahya R
(2015)
Polyisobutylene oligomer-bound polyoxometalates as efficient and recyclable catalysts for biphasic oxidations with hydrogen peroxide
in Catalysis Science & Technology
Gülcemal D
(2015)
A New Phenoxide Chelated Ir III N-Heterocyclic Carbene Complex and Its Application in Reductive Amination Reactions
in Organometallics
Mailman A
(2015)
Multiple orbital effects and magnetic ordering in a neutral radical.
in Journal of the American Chemical Society
Grisin A
(2015)
Diastereoselective construction of anti-4,5-disubstituted-1,3-dioxolanes via a bismuth-mediated two-component hemiacetal oxa-conjugate addition of ?-hydroxy-a,ß-unsaturated ketones with paraformaldehyde.
in Chemical communications (Cambridge, England)
Horta P
(2015)
Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity.
in The Journal of organic chemistry
Turnbull BW
(2015)
Stereospecific Rhodium-Catalyzed Allylic Substitution with Alkenyl Cyanohydrin Pronucleophiles: Construction of Acyclic Quaternary Substituted a,ß-Unsaturated Ketones.
in Journal of the American Chemical Society
Giri N
(2015)
Liquids with permanent porosity.
in Nature
Wallace M
(2015)
Using solution state NMR spectroscopy to probe NMR invisible gelators.
in Soft matter
Baxter EF
(2015)
Combined experimental and computational NMR study of crystalline and amorphous zeolitic imidazolate frameworks.
in Physical chemistry chemical physics : PCCP
Charoensutthivarakul S
(2015)
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties
in MedChemComm
Milan D
(2015)
Solvent Dependence of the Single Molecule Conductance of Oligoyne-Based Molecular Wires
in The Journal of Physical Chemistry C
Abraham RJ
(2015)
Conformational analysis, part 43. A theoretical and LIS/NMR investigation of the conformations of substituted benzamides.
in Magnetic resonance in chemistry : MRC
McKenna S
(2015)
Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem
in Green Chemistry
Ma W
(2015)
Carbonylative coupling of allylic acetates with aryl boronic acids.
in Chemical communications (Cambridge, England)
Evans K
(2015)
Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Kim G
(2015)
Characterization of the dynamics in the protonic conductor CsH2PO4 by ¹7O solid-state NMR spectroscopy and first-principles calculations: correlating phosphate and protonic motion.
in Journal of the American Chemical Society
Sprick RS
(2015)
Tunable organic photocatalysts for visible-light-driven hydrogen evolution.
in Journal of the American Chemical Society
Enciso-Maldonado L
(2015)
Computational Identification and Experimental Realization of Lithium Vacancy Introduction into the Olivine LiMgPO 4
in Chemistry of Materials
Zheng Z
(2015)
Influence of Functionalization of Nanocontainers on Self-Healing Anticorrosive Coatings.
in ACS applied materials & interfaces
Dervisoglu R
(2015)
Joint Experimental and Computational 17O and 1H Solid State NMR Study of Ba2In2O4(OH)2 Structure and Dynamics.
in Chemistry of materials : a publication of the American Chemical Society
Gonzalez-De-Castro A
(2015)
Green and Efficient: Iron-Catalyzed Selective Oxidation of Olefins to Carbonyls with O2.
in Journal of the American Chemical Society
Talwar D
(2015)
Regioselective Acceptorless Dehydrogenative Coupling of N-Heterocycles toward Functionalized Quinolines, Phenanthrolines, and Indoles
in Angewandte Chemie International Edition
O'Neill PM
(2015)
A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.
in Angewandte Chemie (International ed. in English)
Evans PA
(2015)
Rhodium-catalyzed [(3+2)+2] carbocyclization of alkynylidenecyclopropanes with substituted allenes: stereoselective construction of tri- and tetrasubstituted exocyclic olefins.
in Angewandte Chemie (International ed. in English)
Walsh JJ
(2015)
Improving the efficiency of electrochemical CO2 reduction using immobilized manganese complexes.
in Faraday discussions
Talwar D
(2015)
Frontispiece: A Simple Iridicycle Catalyst for Efficient Transfer Hydrogenation of N-Heterocycles in Water
in Chemistry - A European Journal
Abraham MH
(2015)
Is there an intramolecular hydrogen bond in 2-halophenols? A theoretical and spectroscopic investigation.
in Physical chemistry chemical physics : PCCP
Davidson R
(2015)
Synthesis, Electrochemistry, and Single-Molecule Conductance of Bimetallic 2,3,5,6-Tetra(pyridine-2-yl)pyrazine-Based Complexes.
in Inorganic chemistry
Vezzoli A
(2015)
Gating of single molecule junction conductance by charge transfer complex formation.
in Nanoscale
Villa-Marcos B
(2015)
Metal and organo-catalysed asymmetric hydroaminomethylation of styrenes
in Chinese Journal of Catalysis
Kewley A
(2015)
Porous Organic Cages for Gas Chromatography Separations
in Chemistry of Materials
Timofeeva S
(2015)
Application of palladium complexes bearing acyclic amino(hydrazido)carbene ligands as catalysts for copper-free Sonogashira cross-coupling
in Journal of Catalysis
Zhu M
(2015)
Transition-metal-free synthesis of quinolines from 2-nitrobenzyl alcohol in water
in Tetrahedron Letters
Yip SY
(2015)
Isomerization of Olefins Triggered by Rhodium-Catalyzed C-H Bond Activation: Control of Endocyclic ß-Hydrogen Elimination.
in Angewandte Chemie (International ed. in English)
Chen HY
(2015)
Iridicycle-Catalysed Imine Reduction: An Experimental and Computational Study of the Mechanism.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Zou Q
(2015)
Alkylation of Amines with Alcohols and Amines by a Single Catalyst under Mild Conditions.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Dunstan M
(2015)
Ion Dynamics in Li 2 CO 3 Studied by Solid-State NMR and First-Principles Calculations
in The Journal of Physical Chemistry C
Kalidindi SB
(2015)
Chemical and structural stability of zirconium-based metal-organic frameworks with large three-dimensional pores by linker engineering.
in Angewandte Chemie (International ed. in English)
O'Neil I
(2015)
Tripodal Tris-N-oxides: Synthesis and Hydrogen Bonding Capabilities
in Synlett
Auty S
(2015)
'One-pot' sequential deprotection/functionalisation of linear-dendritic hybrid polymers using a xanthate mediated thiol/Michael addition
in Polymer Chemistry
McConville M
(2015)
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
in Journal of medicinal chemistry
Draper ER
(2015)
Spatially resolved multicomponent gels.
in Nature chemistry
Martí-Gastaldo C
(2015)
Sponge-Like Behaviour in Isoreticular Cu(Gly-His-X) Peptide-Based Porous Materials.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Ahmed A
(2016)
Cu( i )Cu( ii )BTC, a microporous mixed-valence MOF via reduction of HKUST-1
in RSC Advances
Bennett TD
(2016)
Melt-Quenched Glasses of Metal-Organic Frameworks.
in Journal of the American Chemical Society
Al-Owaedi O
(2016)
Experimental and Computational Studies of the Single-Molecule Conductance of Ru(II) and Pt(II) trans -Bis(acetylide) Complexes
in Organometallics
Inglis K
(2016)
Structure and Sodium Ion Dynamics in Sodium Strontium Silicate Investigated by Multinuclear Solid-State NMR
in Chemistry of Materials
Description | This grant upgraded the NMR, mass spectrometry and surface analysis facilities in the department of Chemistry and underpins the characterisation of all the molecular species developed in the Department. These materials have applications across all areas of the Department's research activity, ranging, for example, from the development of new anti-malarial agents and inhibitors for human alpha-methylacyl CoA reacemase (AMACR) for the treatment of prostate cancer, through to new catalysts for the hydrogenation of imines. |
Exploitation Route | New materials developed by the Department will be investigated for commercial potential. |
Sectors | Chemicals,Pharmaceuticals and Medical Biotechnology |
Description | The impact of this equipment grant will be on all aspects of the Department's research and impact portfolio over the next 10 years or longer. |
First Year Of Impact | 2013 |
Sector | Chemicals,Pharmaceuticals and Medical Biotechnology |