Methods of Microbial Control in the Clostridial ABE Fermentation Process (MiCON)
Lead Participant:
GREEN BIOLOGICS LIMITED
Abstract
Green Biologics is an industrial biotech company, currently re-commercialising the clostridial ABE
fermentation process for the production of n-butanol and acetone from renewable and sustainable
feedstocks. There are many challenges inherent in this commercialisation process, not just with the
complexities of engineering and process design but also with ensuring the clostridial strains used exhibit
robust phenotypes such as resistance to phage infections and ability to out compete microbes
indigenous to the plant environment. This project aims to use an innovative and environmentally
reponsible alternative approach to the ‘easy fix’ solution of using antibiotics by instead taking advantage
of bacteriocins: small peptides produced by a number of bacterial strains to destroy competing
microbes in an environmental space.
fermentation process for the production of n-butanol and acetone from renewable and sustainable
feedstocks. There are many challenges inherent in this commercialisation process, not just with the
complexities of engineering and process design but also with ensuring the clostridial strains used exhibit
robust phenotypes such as resistance to phage infections and ability to out compete microbes
indigenous to the plant environment. This project aims to use an innovative and environmentally
reponsible alternative approach to the ‘easy fix’ solution of using antibiotics by instead taking advantage
of bacteriocins: small peptides produced by a number of bacterial strains to destroy competing
microbes in an environmental space.
Lead Participant | Project Cost | Grant Offer |
---|---|---|
GREEN BIOLOGICS LIMITED | £212,964 | £ 106,482 |
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Participant |
||
BIOCLEAVE LIMITED | ||
INNOVATE UK |
People |
ORCID iD |
Liz Jenkinson (Project Manager) |