Structural Biology of Protein Nanocompartments.
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Chemistry
Abstract
Bacterial nanocompartments (BNCs) are large protein assemblies comprising a hollow icosahedral multimeric protein cage which sequesters 'cargo' protein (often enzymes) inside. This studentship will use structural biology techniques (mass spectrometry, crystallography, and electron microscopy) to determine the stoichiometry, assembly pathways, and mechanism of formation of BNCs. Understanding these fascinating underpinning systems will allow their future manipulation as potential platforms for biotechnology, synthetic biology, and drug delivery.
Organisations
People |
ORCID iD |
David Clarke (Primary Supervisor) | |
Jennifer Ross (Student) |
Publications
He D
(2019)
Conservation of the structural and functional architecture of encapsulated ferritins in bacteria and archaea.
in The Biochemical journal
Ross J
(2020)
Mass spectrometry reveals the assembly pathway of encapsulated ferritins and highlights a dynamic ferroxidase interface.
in Chemical communications (Cambridge, England)