Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.
This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.
This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.
People |
ORCID iD |
Peter O'Connor (Primary Supervisor) | |
Tomos Morgan (Student) |
Publications
Wootton C
(2019)
Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation
in The Analyst
Lam YPY
(2020)
Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Lermyte F
(2019)
Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry.
in Journal of the American Society for Mass Spectrometry
Chiu C
(2020)
Metallocomplex-Peptide Interactions Studied by Ultrahigh Resolution Mass Spectrometry
in Journal of the American Society for Mass Spectrometry
Lermyte F
(2019)
Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches.
in Journal of the American Society for Mass Spectrometry
Floris F
(2017)
Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin
in Journal of the American Society for Mass Spectrometry
Van Agthoven MA
(2019)
Phase relationships in two-dimensional mass spectrometry.
in Journal of the American Society for Mass Spectrometry
Van Agthoven MA
(2019)
Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry.
in European biophysics journal : EBJ
Banerjee S
(2018)
New activation mechanism for half-sandwich organometallic anticancer complexes.
in Chemical science
Wootton CA
(2018)
Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.
in Chemical science
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/P510695/1 | 01/10/2016 | 31/12/2021 | |||
1837376 | Studentship | EP/P510695/1 | 01/10/2016 | 30/03/2020 | Tomos Morgan |