Regulation of Infection and Biofilm Formation in Vibrio cholerae
Lead Research Organisation:
University of Birmingham
Department Name: Sch of Biosciences
Abstract
Cholera is a serious human disease caused by the gram-negative bacterium, Vibrio cholerae. It affects between 3-5 million people worldwide every year and there have been seven historical pandemics of cholera to date.
The 'seventh pandemic' of cholera is known to have been caused primarily by the O1 serogroup and the El Tor biotype of V. cholerae. The mechanisms that determine the ability of V. cholerae to infect and be transmitted by humans is still poorly understood.
Studies suggest a link between quorum-sensing and greater survival and host intestinal colonisation by Vibrio cholerae. This project aims to determine the importance of the regulation of quorum-sensing in host infection and transmission as well as bacterial survivability.
The 'seventh pandemic' of cholera is known to have been caused primarily by the O1 serogroup and the El Tor biotype of V. cholerae. The mechanisms that determine the ability of V. cholerae to infect and be transmitted by humans is still poorly understood.
Studies suggest a link between quorum-sensing and greater survival and host intestinal colonisation by Vibrio cholerae. This project aims to determine the importance of the regulation of quorum-sensing in host infection and transmission as well as bacterial survivability.
Organisations
People |
ORCID iD |
David Grainger (Primary Supervisor) | |
Lucas Walker (Student) |
Publications
Haycocks JRJ
(2019)
The quorum sensing transcription factor AphA directly regulates natural competence in Vibrio cholerae.
in PLoS genetics
Walker LM
(2023)
A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae.
in eLife
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/M01116X/1 | 30/09/2015 | 31/03/2024 | |||
1898542 | Studentship | BB/M01116X/1 | 01/10/2017 | 24/12/2021 | Lucas Walker |