Using mathematical and computational modelling to study the formation of the primitive streak
Lead Research Organisation:
University College London
Department Name: Cell and Developmental Biology
Abstract
Research theme: Experimental and personalised medicine
Humans can generate monozygotic (identical) twins and it is believed that an embryo can split right up until the time of primitive streak formation, 14 days after fertilization. The primitive streak is the first structure of cells which defines left-right symmetry, and little is known about the mechanism by which the formation of a second streak is prevented in most embryos.
Informed by on-going studies on human genetics in populations with a very high rate of twinning, and alongside recent results of embryological manipulations and molecular genetics, this project aims to use mathematical modelling in order to propose a mechanism preventing the formation of multiple primitive streaks. This method will allow the probing of the dynamics of this mechanism, and thereby inform further experiments. Later in the project, additional methods of modelling can be applied to study the formation of the primitive streak at different scales, for example using logic-based models of molecular interactions and agent models of cell movements.
Humans can generate monozygotic (identical) twins and it is believed that an embryo can split right up until the time of primitive streak formation, 14 days after fertilization. The primitive streak is the first structure of cells which defines left-right symmetry, and little is known about the mechanism by which the formation of a second streak is prevented in most embryos.
Informed by on-going studies on human genetics in populations with a very high rate of twinning, and alongside recent results of embryological manipulations and molecular genetics, this project aims to use mathematical modelling in order to propose a mechanism preventing the formation of multiple primitive streaks. This method will allow the probing of the dynamics of this mechanism, and thereby inform further experiments. Later in the project, additional methods of modelling can be applied to study the formation of the primitive streak at different scales, for example using logic-based models of molecular interactions and agent models of cell movements.
Organisations
Publications
Lee HC
(2022)
'Neighbourhood watch' model: embryonic epiblast cells assess positional information in relation to their neighbours.
in Development (Cambridge, England)
Lee H
(2024)
Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity
in Nature Communications
Lee HC
(2022)
The extra-embryonic area opaca plays a role in positioning the primitive streak of the early chick embryo.
in Development (Cambridge, England)