Aerosol Delivery of Influenza Vaccine Candidates and Role of Local Immune Response in Pigs
Lead Research Organisation:
University of Oxford
Department Name: Weatherall Inst of Molecular Medicine
Abstract
Influenza A virus is responsible for the major pandemics in the last century. Its ability to infect different hosts, such as human, pigs and birds, and the high mutation rate represents a major challenge in fighting this pathogen. Pigs are natural host of influenza A virus and play a critical role in the emergence of new viruses, being able to be infected with human and avian strains. Current vaccine strategies rely on neutralising antibodies which are strain dependent and therefore need to be updated every year. In this study new broadly protective vaccine candidates will be analysed and different routes of administration compared for their immunogenicity and protection potential. For the first time it will be possible to study the role of lung tissue resident memory T cells in pigs and their function in the context of influenza infection and protection. This project follows the BBSRC "Bioscience for Health" priority area, giving new insights into pigs' health and allowing the study of influenza A virus in a One Health perspective.
AfS, ENWW
AfS, ENWW
People |
ORCID iD |
Elma Tchilian (Primary Supervisor) |
Publications
Thakur A
(2019)
Design of Gadoteridol-Loaded Cationic Liposomal Adjuvant CAF01 for MRI of Lung Deposition of Intrapulmonary Administered Particles.
in Molecular pharmaceutics
Holzer B
(2019)
Immunogenicity and Protective Efficacy of Seasonal Human Live Attenuated Cold-Adapted Influenza Virus Vaccine in Pigs.
in Frontiers in immunology
Holzer B
(2019)
T and B Cell Immune Responses to Influenza Viruses in Pigs.
in Frontiers in immunology
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/R506448/1 | 01/10/2017 | 30/09/2021 | |||
1962255 | Studentship | BB/R506448/1 | 01/10/2017 | 30/09/2021 |
Description | We were able to qualitfy for the first time how much areosol is delivered and reaches the porcine lung. I also established a method to define tissue resident memory T cells in the lung, a lymphocyte linage response for protection against influenza |
Exploitation Route | Improve vaccine delivery for respiratory disease Establishment of the pig as a model for human disease |
Sectors | Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology |