Genomic of vector borne diseases: from pathogens to mosquitoes
Lead Research Organisation:
London School of Hygiene & Tropical Medicine
Department Name: Infectious and Tropical Diseases
Abstract
Mosquito-borne diseases are a major challenge for public health. Malaria, caused by parasites transmitted by Anopheles mosquitoes, was responsible for 435 000 deaths in 2017. Arboviruses, such as Dengue, Zika and Chikungunya transmitted by Aedes mosquitos, are causing major outbreaks around the world. Insecticide resistance, with its genetic underpinning, has increased rapidly in prevalence and threatens vector control. Similarly, mutations in pathogens can lead to drug-resistance and adaptation to new vectors, affecting disease control. Genomics can be used to investigate changes in the genetic diversity of both mosquitos and pathogens and increase knowledge of their biology and evolution.
Publications
Acford-Palmer H
(2023)
Identification of two insecticide resistance markers in Ethiopian Anopheles stephensi mosquitoes using a multiplex amplicon sequencing assay.
in Scientific reports
Acford-Palmer H
(2023)
Detection of insecticide resistance markers in Anopheles funestus from the Democratic Republic of the Congo using a targeted amplicon sequencing panel.
in Scientific reports
Collins EL
(2022)
A next generation targeted amplicon sequencing method to screen for insecticide resistance mutations in Aedes aegypti populations reveals a rdl mutation in mosquitoes from Cabo Verde.
in PLoS neglected tropical diseases
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/M009513/1 | 30/09/2015 | 31/03/2024 | |||
2241712 | Studentship | BB/M009513/1 | 30/09/2019 | 29/09/2023 | Holly Acford-Palmer |