Examining unconventional intramolecular interactions

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Chemistry


The objective of this project is to examine the physical basis of under-appreciated molecular interactions that occur within molecules, particularly those that may involve orbital mixing.

-To examine whether heterocycles can accept electron density to form bonds with partial covalency (orbital mixing) from neighbouring electron-donor sites.
-To examine the physicochemical nature of intramolecular hydrogen bonds.
-To examine whether the unusual interactions identified in the above investigations can be exploited to tune chemical reactivity, or within catalysis.

The above aims are being examined using a combination of synthetic and computational chemistry. Quantitative measurements will be made using NMR spectroscopy and compared with theoretical calculations via structure activity relationships.


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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509644/1 30/09/2016 29/09/2021
2258107 Studentship EP/N509644/1 31/08/2019 30/11/2022 Ivan Smoliar
EP/R513209/1 30/09/2018 29/09/2023
2258107 Studentship EP/R513209/1 31/08/2019 30/11/2022 Ivan Smoliar