Artificial Metalloenzymes
Lead Research Organisation:
University of Cambridge
Department Name: Chemistry
Abstract
Artificial metalloenzymes have been a rapidly growing field in the last few years, as they promise to become a powerful tool for augmenting and controlling the properties of classical homogeneous, inorganic catalysts. Understanding how these systems work from a bottom-up approach has the potential to unlock entire new fields, with uses spanning from medicine to industrial synthesis.
All previous studies on artificial metalloenzymes utilize non-directly co-ordinating methods to generate complexes between transition metals and peptides. However, these methods fall short in unlocking the full potential of these systems. This project examines the co-ordination sphere requirements for catalytically active metal-peptide complexes as a primary research goal. The aim is to create a true augmented active site with stereo-chemical and substrate specific activity comparable to natural metalloenzymes.
All previous studies on artificial metalloenzymes utilize non-directly co-ordinating methods to generate complexes between transition metals and peptides. However, these methods fall short in unlocking the full potential of these systems. This project examines the co-ordination sphere requirements for catalytically active metal-peptide complexes as a primary research goal. The aim is to create a true augmented active site with stereo-chemical and substrate specific activity comparable to natural metalloenzymes.
Organisations
People |
ORCID iD |
Paul Barker (Primary Supervisor) | |
Oskar Klein (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/N509620/1 | 01/10/2016 | 30/09/2022 | |||
2275908 | Studentship | EP/N509620/1 | 01/10/2019 | 30/06/2023 | Oskar Klein |
EP/R513180/1 | 01/10/2018 | 30/09/2023 | |||
2275908 | Studentship | EP/R513180/1 | 01/10/2019 | 30/06/2023 | Oskar Klein |