Understanding the role of inflammation in the pathogenesis of amyotrophic lateral sclerosis
Lead Research Organisation:
University of Oxford
Department Name: Clinical Neurosciences
Abstract
DPhil will focus on understanding the role that neuroinflammation plays in the pathogenesis of ALS using a combined neuropathological approach and in vitro models
Organisations
People |
ORCID iD |
Martin Turner (Primary Supervisor) | |
Bjorn Vahsen (Student) |
Publications
Giacomelli E
(2022)
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
in Cell Stem Cell
Vahsen BF
(2021)
Non-neuronal cells in amyotrophic lateral sclerosis - from pathogenesis to biomarkers.
in Nature reviews. Neurology
Vahsen BF
(2023)
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.
in Nature communications
Vahsen BF
(2022)
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons.
in Scientific reports
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/N013468/1 | 30/09/2016 | 29/09/2025 | |||
2283992 | Studentship | MR/N013468/1 | 30/09/2019 | 29/09/2022 | Bjorn Vahsen |
Description | The role of microglia in the pathophysiology of C9orf72-related amyotrophic lateral sclerosis |
Amount | £285,000 (GBP) |
Funding ID | Talbot/Apr22/889-791 |
Organisation | Motor Neurone Disease Association (MND) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2022 |
End | 09/2025 |
Description | MND Encourage 2022 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | 2-day workshop for ECRs and PhD students working on MND to exchange and give lay talks to people living with and affected by MND |
Year(s) Of Engagement Activity | 2022 |
Description | Patient group talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Our lab gave a talk to MND patients and carers (local Oxford branch). I gave a lay talk on my DPhil project |
Year(s) Of Engagement Activity | 2022 |