Expanding Combinatorial Space in Bacterial Libraries for Synthetic Biology Applications
Lead Research Organisation:
Birkbeck, University of London
Department Name: Biological Sciences
Abstract
Although Synthetic and Systems Biology aspire to the design of biological systems,
combinatorial approaches remain efficient strategies to rapidly isolate functional designs
from a vast number of possible designs. High-quality libraries are therefore essential and
their assembly hinges on multiple practical and technical issues: (1) robustness of synthesis,
(2) stability and (3) sampling of the sequence space. Having recently developed a novel
approach to establish large multi-component in vivo libraries, we want to expand the
approach towards studying the fitness of synthetic phages and microcompartment
encapsulation of biological processes - by improving (1) and developing novel assays to
confirm (3).
combinatorial approaches remain efficient strategies to rapidly isolate functional designs
from a vast number of possible designs. High-quality libraries are therefore essential and
their assembly hinges on multiple practical and technical issues: (1) robustness of synthesis,
(2) stability and (3) sampling of the sequence space. Having recently developed a novel
approach to establish large multi-component in vivo libraries, we want to expand the
approach towards studying the fitness of synthetic phages and microcompartment
encapsulation of biological processes - by improving (1) and developing novel assays to
confirm (3).
People |
ORCID iD |
Renos Savva (Primary Supervisor) | |
Naail Kashif-Khan (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/T008709/1 | 01/10/2020 | 30/09/2028 | |||
2397286 | Studentship | BB/T008709/1 | 01/10/2020 | 30/09/2024 | Naail Kashif-Khan |