Dissecting the link between Clostridioides difficile, the intestinal microbiota and host factors to determine patient outcome.

Lead Research Organisation: University College London
Department Name: Cell and Developmental Biology

Abstract

Clostridioides difficile is the leading cause of nosocomial antibiotic-associated diarrhoea worldwide, yet little is known about colonisation of the intestinal tract and disease relapse. Treatment with antibiotics for an underlying condition alters the intestinal microbiota, which results in susceptibility to colonisation with C. difficile. Current data indicates that 20-30% of patients suffering from C. difficile infection (CDI) relapse within two months post-treatment with increasing probability of relapsing multiple times, indicating the presence of a potential reservoir of C. difficile re-seeding the intestinal tract of susceptible patients. We suggest there are there are distinct community and proteomic signatures linked to C. difficile disease.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/T008709/1 30/09/2020 29/09/2028
2397703 Studentship BB/T008709/1 30/09/2020 31/12/2024 Helen Rickard