Ruthenium-catalysed C-H functionalization of aromatic molecules with anilinium-electrophiles
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Objective:
This project will investigate the use of anilinium-derived electrophiles as coupling partners for Ru-catalyzed C-H functionalization reactions, and their application to the synthesis or late-stage functionalization of drugs and other biologically active molecules.
Approach:
A wide variety of anilinium-derived electrophiles will be prepared and tested with a range of Ru-catalysts. Reaction conditions will be optimized, including temperature, solvent, co-additives.
Successful classes of electrophiles will be further investigated to map their scope and potential as well as their applications to industrially relevant compounds.
Remit:
This project falls within the areas of Catalysis and Synthetic Organic Chemistry.
This project will investigate the use of anilinium-derived electrophiles as coupling partners for Ru-catalyzed C-H functionalization reactions, and their application to the synthesis or late-stage functionalization of drugs and other biologically active molecules.
Approach:
A wide variety of anilinium-derived electrophiles will be prepared and tested with a range of Ru-catalysts. Reaction conditions will be optimized, including temperature, solvent, co-additives.
Successful classes of electrophiles will be further investigated to map their scope and potential as well as their applications to industrially relevant compounds.
Remit:
This project falls within the areas of Catalysis and Synthetic Organic Chemistry.
Organisations
People |
ORCID iD |
| Igor Larrosa (Primary Supervisor) | |
| Ashley Hogg (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/T517823/1 | 01/10/2020 | 30/09/2025 | |||
| 2480361 | Studentship | EP/T517823/1 | 01/10/2020 | 31/03/2024 | Ashley Hogg |