Association genetics of UK elite barley

Lead Research Organisation: Biomathematics and Statistics Scotland
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Comadran J (2011) Patterns of polymorphism and linkage disequilibrium in cultivated barley. in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

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Druka A (2011) Genetic Dissection of Barley Morphology and Development in Plant Physiology

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Moragues M (2010) Effects of ascertainment bias and marker number on estimations of barley diversity from high-throughput SNP genotype data. in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

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Rostoks N (2006) Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop varieties. in Proceedings of the National Academy of Sciences of the United States of America

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Waugh R (2009) The emergence of whole genome association scans in barley. in Current opinion in plant biology

 
Description The AGOUEB project pioneered the use of highly parallel single nucleotide polymorphism genetic markers for use in a new type of genetic analysis called Genome Wide Association Scans. It used a large collection of elite barley genotypes to identify genetic markers linked to morphological and developmental DUS traits. SInce then the marker platform has expanded from 1500 to 50000 genetic markers and this is being sed throughout the barley genetics community. Many genes have been identified using the materials and approaches pioneered in AGOUEB and links with the breeding community were significantly strengthened by their involvement.
Exploitation Route The project formed the basis of a switch to highly parallel genetic marker technology in the research and breeding communities and some of the genetic outputs (associations) have already been used to identify several genes. The populations are still being used - in fact have been expanded - for inclusion in other projects (e.g. IMPROMALT) and have a real legacy value. The databases (GERMINATE) associated with the project hold valuable genotypic and phenotypic data and are still used.
Sectors Agriculture, Food and Drink,Education

URL https://www.barleyhub.org/projects/agoueb/
 
Description Yes. we developed marker technology that is used by all barley geneticists and commercial breeding companies across the world. We also identified a number of diagnostic markers that are being used for MAS. The GWAS population has been distributed to several groups and has been used to identify a number of important barley genes. A number of high impact papers have been published based on the concepts explored in this grant and using the basic population. It has led to further direct followup funding through the ongoing 'IMPROMALT program.
Sector Agriculture, Food and Drink
Impact Types Economic

 
Description AHDB research call
Amount £65,000 (GBP)
Funding ID 21130015 Integrated platforms for barley breeding and genetic research (INTEGRA-2) 
Organisation Agricultural and Horticulture Development Board 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 03/2017
 
Title 50K SNP chip 
Description We developed a 50K SNP chip using illumina technology for use by the entire barley genetics and breeding communities. A publication describing the resource has been uploaded to the publication outputs. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The platform has had widespread uptake in the barley genetics and breeding communities with in the region of 20,000 assays (genotypes) already collected through research in the public domain. The extent of usage in the commercial sector is - we believe- considerable but accessing the specific numbers impossible. 
URL https://ics.hutton.ac.uk/50k
 
Title SNP Genotyping Platform 
Description A high multiplex SNP assay platform for cultivated barley 
Type Of Material Technology assay or reagent 
Provided To Others? Yes  
Impact Used heavily by the worldwide barley breeding and academic (genetics) sectors