The Development of High Throughput Automated Microscopy to Investigate the Developmental Genetics of Model Organisms

Lead Research Organisation: University of Sheffield
Department Name: Biomedical Science


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Technical Summary

Developmental biology and genetics research groups in Sheffield are engaged in a broad range of research projects in the biomolecular sciences area at an internationally competitive level, and this application is a request for a state-of-the-art, high throughout, real-time epifluoresence microscope system to support this work. Projects include studies into the fundamental biology of human embryonic stem cells, genetic stability of human embryonic stem cells, lineage segregation in stem cells and organisms. All of these projects will benefit from the range of new experiments which can be performed by the instrument requested and which are not currently possible using the microscopy systems currently available in the faculty of medicine.


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Description We have used this equipment to facilitate experiments to explore the mechanisms that control the growth and differentiation of human embryonic stem cells
Exploitation Route High content clonogenic assays are becoming widespread for the study of the biology underlying pluripotent stem cells.
Sectors Pharmaceuticals and Medical Biotechnology

Description Not applicable - equipment grant
First Year Of Impact 2005
Sector Pharmaceuticals and Medical Biotechnology
Impact Types Economic