Role of fatty acid chain length in energy balance and adaptive thermogenesis

Lead Research Organisation: University of Cambridge
Department Name: Clinical Biochemistry

Abstract

Food contains different types of fat. There are some suggestions that not all the fats are equal and that there is good and bad fat with respect to their effects in the body. Not too much is known about what fat normally does in the cells of the body. We know that fat can be stored, burned, been sent from one organ to another within the body and more importantly fat are important 'bricks' to build up the different components of the cells. Interestingly not all the fats have the same size, the length of some fats is longer than others and we think that the length of the fat species may be an important determinant whether fat is stored or burn. The best organ to study this is a special type of organ known as brown fat present in children and small animals. This organ can do both, making fat and burning fat so it is the ideal organ to investigate the effect of fat length on these two processes. To study fat length we will investigate the effect of lack and/or excess of Elovl6, a molecule that elongates fat from 12 carbons to 18 carbons. Specifically we propose to investigate: 1) if making fat longer can alter the development of the brown fat organ; b) whether eliminating/increasing the capacity of elongating fat makes the animals fatter/leaner and c) less/more capable of making heat. To that end we will use cells and mice in which we will decrease or increase the capacity to make fat longer and then study the type of fat these animals make using very novel techniques that allow us to know all the types of fats that these animals will have. This information will inform us about which fats are good and which ones are bad and will allow us, for example, to modify the diets of humans and animals to ensure that they have the right type of fats to remain healthy.

Technical Summary

A fundamental question regarding the fate of cellular lipids, in particular free fatty acids, is how these lipids are targeted to various fates, either oxidation, storage, export, or incorporation into more complex membrane lipid species. In this proposal we aim to investigate if fatty acid chain length may affect the balance of oxidation vs storage in the highly metabolically active tissue, brown adipose tissue. We will primarily investigate the effect of lack of Elovl6, an enzyme responsible for elongating saturated and monounsaturated C12 and longer fatty acids up to C18. Thus the aim of this grant is to investigate the role of fatty acid chain length on control of fatty acid oxidation, focussing specifically on the fatty acid elongase Elovl6. Specifically we propose to investigate: 1) the role of Elovl6 in BAT differentiation, lipogenesis and function in vitro; b) the role of Elovl6 on energy balance and c) the effect of a lack of Elovl6 on maximal thermogenic capacity of BAT. To that end we will use both cellular and genetically modified animal models with a loss/gain of function in Elovl6 to investigate the effect of altered fatty acid chain length on fatty acid oxidation. In vivo models will be characterised using state of the art phenotyping including performing experiments at different temperatures in purposedly built facilities for thermogenic studies. Also we will use a molecular systems biology phenotyping approach using sophisticated lipidomic and transcriptomic profiling integrated into lipid metabolic networks using bioinformatic analysis.

Publications

10 25 50
 
Title Development of new webb for the TVP lab 
Description tvp.mrl.ims.cam.ac.uk/ 
Type Of Art Creative Writing 
Year Produced 2013 
Impact Much broader reach attracting more visitors 
URL http://www.tvp.mrl.ims.cam.ac.uk/
 
Title TVPLAB twitter 
Description Use of Social Media TVPLAB TWITTER https://twitter.com/tvplab?lang=en-gb 
Type Of Art Creative Writing 
Year Produced 2015 
Impact Creative tool to communicate our science to public 
URL https://twitter.com/tvplab?lang=en-gb
 
Description The purpose of this study was to determine the role, if any, of fatty acid elongation in brown adipose tissue function. To that end we utilised the elovl6 KO mouse as a model with altered fatty acid elongation. Elovl6 was well suited to this roll, as it is expressed at much higher levels in brown adipose tissue than any other tissue. Elovl6 is regulated by thermogenic challenges and is upregulated by cold exposure and reduced by thermoneutral housing. Unlike previous studies of elongation and its roll in BAT function by studying Elovl3, Elovl6 do not have an obvious skin barrier defect, removing the confounding factor of poor thermal insulation on studies of BAT function.



In line with the concept that Elovl6 was important for brown adipose tissue function we have identified that Elovl6 KO mice have a temperature dependent post natal survival. At 20oC, as reported previously, only 30% of Elovl6 KO pups survive to 3 weeks of age. However, this is not embryonic lethality as reported but instead is a temperature dependent post-natal lethality. The mendelian ratios of elovl6 KO mice can be corrected by breeding and housing pups at 24oC until weaning. This phenotype is reminiscent of other mouse models with defective BAT activity (UCP1 and PACAP). In adulthood, when housed at 24oC, mice lacking Elovl6 have a normal energy balance phenotype, with no differences in energy expenditure or food intake. However, Elovl6 was upregulated by cold exposure. In order to investigate this phenotype more fully we cold exposed Elovl6 KO mice. Mice lacking elovl6 exhibited both elevated energy expenditure and food intake (hypermetabolism). The mechanism behind this hypermetabolism remains to be elucidated but it is notable that the Elovl6 mice at both 24oC and 4oC exhibit increased expression of thermogenic markers in subcutaneous white adipose tissue (the location of so called beige adipocytes or 'Brite' cells) and to a lesser extent in canonical brown fat.



Elovl6 KO mice have shorter chain fatty acids compared to WT mice. In WT mice, cold exposure leads to significant changes in fatty acid chain length in brown adipose, white adipose and liver tissue, but not in muscle. It is possible it is a direct regulatory event in which loss of Elovl6 results in an increased thermogenic response to cold via central mechanisms. However, a second possibility is that loss of Elovl6 has actually resulted in partially defective BAT. While this would seem paradoxical the UCP1 KO mouse exhibits elevated energy at sub thermoneutral temperatures, with the biggest discrepancy between WT and UCP1 KO mice being at 4oC - the lowest temperature studied. In mice, cold exposure has been demonstrated to dramatically increase levels of stearate in brown adipose tissue mitochondria, but not in muscle mitochondria, suggesting that altered mitochondrial function may contribute to the hypermetabolic phenotype. This aspect is currently under investigation.



Finally, in addition to our specific investigations into the Elovl6 model we have carried out an extensive characterisation of adipose tissue lipid changes in various dietary and genetic models of obesity. So far, this has demonstrated that obesity and insulin resistance are associated with a lipid profile consistent with elevated SCD1 and Elovl6 activity, even after the composition of diets has been taken into account. This finding is consistent with the improved metabolic profiles of SCD1 (liver specific) and Elovl6 KO (whole organism) mouse models.
Exploitation Route Our research has potentially important implications for the functional food industry. In particular margarines and yoghurt drinks have been an area of intense focus of research and marketing by many of the major players in the FMCG world (Unilever's Flora Pro Active and Raiso group's Benecol are the leading brands in the UK with combined sales exceeding 50 million GBP). While these products have focused on cholesterol lowering, there remains a large area to exploit in the area of functional foods with modified lipid compositions and improved metabolic outcomes. Making functional food claims is increasingly difficult following EU regulations, requiring greater scientific evidence. By providing a scientific basis to support the roles of specific lipids in animal and fly models will allow a more rational and targeted design for the development of new lipid-modifying functional foods.



Whether Elongase 6 is a valid target for pharmacological agents is at present difficult to assess. Whole organism ablation of Elovl6 in mice improves insulin sensitivity, but while the mechanism remains unclear it is difficult to assess the likelihood of its efficacy and safety in humans.
The research funded by this grant will provide substantial benefit to the research community working in both metabolic science and lipid biology. By identifying unique roles for the products of Elovl6 in control of energy balance and brown adipose tissue function will enable a better understanding of the impact of modified diets and a deeper understanding of what lipid changes mean.



At present lipidomics is limited by a lack of functional information for many lipid species and on going work to improve this area of our understanding of metabolism is vital. The research related to the role of Elovl6 in regulating mitochondrial function will be invaluable to almost all areas of biology in which mitochondrial function is important. The alteration in fatty acid chain length in mouse models of obesity suggests a wider role of the elongases in the development of obesity related metabolic complications, this can potentially be targeted through dietary or pharmacological manipulation.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Editorial Activity
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact • Editorial Advisory Board: PLoS Biol (2009-) • Editorial Board Memberships: PLoS Biology (2007-), Biochemical Journal (2008-2012), Diabetes (2012-) Trends Endocrinology and Metabolism (2008-), Biochim Biophys Acta.(2012-).Guest Editor (with RH Unger) of Special issue on lipotoxicity. Biochim Biophys Acta. 2010 Mar;1801(3):207-8.
 
Description Jaime I International award panel 2017 for Clinical Medicine
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Jaime I International award panel 2017 for Clinical Medicine.
URL http://www.fprj.es/es/investigacion-medica/antoni-vidal-puig
 
Description Organisation of conferences/Courses
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact It is expected these training schemes have contributed to better care and scientifc developments. Member of the Scientific Organising Committee 1. Cambridge, United Kingdom. 30th June - 2nd July 2015. EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 2. Boston, USA. 5th - 9th June 2015. ADA Scientific Sessions Insulin Action/Molecular Metabolism. 3. Colorado, USA. 9th - 13th February 2015. Keystone Symposia - Systems Biology of Lipid Metabolism. 4. Madrid, Spain. 7th - 8th November 2014. CNIC Conference "Energy homeostasis and metabolic disease". 5. Madrid, Spain. 7th-8th November 2014. Energy homeostasis and metabolic disease. CNIC. 6. Cambridge, UK. 30th September 2014. 14th Annual Cambridge Immunology Forum Meeting. • Member of the Scientific Organising Committee Keystone meeting on Nuclear receptors. (http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=1235?Tab=travel) Austria (2013) • Member of the Scientific Organising Committee 15th European Congress of Endocrinology 27th April - 1st May 2013. Copenhagen, Denmark (http://www.ece2013.org/committees.aspx) • Director of The European Atherosclerosis Society Advanced Course IV: Murine Genetics and Cardiometabolic Phenotyping 11th - 14th July 2012. Cambridge, United Kingdom (http://www.eas-society.org/advanced-course-iv,-cambridge.aspx • Member of the Organising Scientific Committee of The Royal Society and Academy of Medical Sciences symposium on "Brown adipose tissue: a new human organ?" London (2012) (http://www.physoc.org/me2012) • Member of the Organising Scientific Committee The Obese Species Workshop Sicily, Italy. 21st - 26th October (2011) http://theobesespecies.unipr.it/. • Member of the Organising Scientific Committee for the meeting of the EAS in Hamburg. Germany (2010) • Member of the Organising Scientific Committee of the 49th International Conference on the Bioscience of Lipids. Maastrich (2008)
 
Description SAB scientific Advisory boards
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Evidence of international standing • MRC College of experts (1/10/2004-30/09/2008). • MRC Physiological Systems and Clinical Sciences Board (1/10/2004-30/09/08). • MRC Funding Schemes: Survey panel (2003-2004). • International scientific advisor Spanish Research Council, Metabolism and Nutrition Node (2003-2008). • Member of the Editorial Board of PLoS Biology, Diabetes, Biochemical Journal and Trends Endocrinology and Metabolism. • Member of PLoS Biology Advisory Board (2010-) • EAS 2010 Scientific Committee • EAS Election Committee Member • Member of the Diabetes UK Research Committee • International Scientific Committee of CIBERDEM • FP7 FLORINASH Scientific Advisory Board • Committee for Severo Ochoa Research Excellence Awards of Spanish Ministry of Innovation. • IDIBAPS Scientific Advisory Board (2012-) • EASO Scientific Advisory Board (2013-) • Member of Wellcome Trust Strategic Award [Biological determinants of ageing and late life health, and their pharmacological manipulation] Scientific Advisory Board (2013-)-) • Scientific Advisory Board of Institut d'Investigacions Biomèdiques de Girona (IDIBGI) (2013-)
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description • International Scientific Advisory Board Danish Academy of Diabetes (2018-)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact • International Scientific Advisory Board Danish Academy of Diabetes (2018-) Advice on training and research priorities.
URL https://www.danishdiabetesacademy.dk/news/dda-appoints-strong-new-international-advisory-board
 
Description 2020 Horizon Epoos
Amount € 350,000 (EUR)
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 10/2013 
End 09/2017
 
Description FP7 - IMI EMIF Joint Undertaking. PI: Dr Vidal-Puig. £300,000.
Amount € 300,000 (EUR)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 12/2014 
End 12/2016
 
Title Development of methodology for microarray and lipidomic analysis 
Description We have contributed to develop methods for lipid analysis 
Type Of Material Technology assay or reagent 
Year Produced 2007 
Provided To Others? Yes  
Impact 1) Oresic M, H?nninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers.Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23PMID: 18951641 2)Tang J, Tan CY, Oresic M, Vidal-Puig A. Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35. [Epub ahead of print] PMID: 19341506 3) Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M. Informatics and computational strategies for the study of lipids.Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. 4).Oresic M, Vidal-Puig A, H?nninen V.Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. 
URL http://europepmc.org/abstract/MED/18951641
 
Title Development of the Phenomics center 
Description Development of three core facilities, a) Murine phenotyping, b) Murine Biochemistry and c) Murine Histopathology 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact Development of MRC CORD murine metabolic programme Development and expansion vreating the Cambridge Phenomics centre. 
 
Title Differentiation of ES cells 
Description Protocols do differentiation of Human PSC to brown, white and macrophage phenotype 
Type Of Material Cell line 
Provided To Others? No  
Impact Competitiveness in our research and funding acquisition e.g. ERC grant 
 
Title Hyperinsulinaemic clamps using non stable isotopes 
Description A more accurate and refined methodology to assess tissue specific insulin resistance 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2015 
Provided To Others? Yes  
Impact Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27. PMID: 26508640 Free PMC Article Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ.Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9. PMID: 25865886 Free PMC Article 
 
Title Mass Spectrometry to analyse lipids 
Description Refined technology to measure lipid composition. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2015 
Provided To Others? Yes  
Impact 1. Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. 2. Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25. 3. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. 
 
Title Microarray/lipidomic data bases 
Description Microarray and lipidomic data form in vivo experiments using animal models 
Type Of Material Biological samples 
Year Produced 2007 
Provided To Others? Yes  
Impact This material has been utilised by other EU groups focused in modelling and development of tools for nutritional research 
 
Title Phenotyping of mice; Maximal thermogenic activity 
Description Protocol tomeasure maximal thermogenic capacity 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2013 
Provided To Others? Yes  
Impact Contribution to increase accuracy of murine sudies allowing refinment, and reduction of animals 
 
Title Tools for data quatification 
Description LEM-PCR: a method for determining relative transcript isoform proportions using real-time PCR without a standard curve.Virtue S, Dale M, Sethi JK, Vidal-Puig A. Genome. 2010 Aug;53(8):637-42. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2010 
Provided To Others? Yes  
Impact Improved accuracy of data analysis 
 
Title b) Design a unique in house system for energy balance measurement. 
Description This is a new cageingsystem for metabolicphenotyping for simultaneous assessment of food inatke, energy expnditure, activity, water consumption. The equipment incorporates novel features such as having food delivery system hook to the cover of the cage. Also this is system is adapted to the cages where are normally hold which prevents measurement artifacts derived from changes in the cages when performing metabolic measurements. The new developed system to assess energy balance is a refinement because we can measure more accurately in each experiment. The addition of a 24h camera system with Visual Sonics software enables us to have secure systems to observe without disturbing measurements. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Reduction and refinement of experiments using murine models 
 
Title Modelst for maximal termogenic capacity evaluation 
Description This is a novel technology to evaluate maximal capacity of energy expenditure and is the best method to evaluate defects in energy expenditure leading to obesity. 
Type Of Material Data analysis technique 
Year Produced 2015 
Provided To Others? Yes  
Impact Contributed to make research results reproducible and also contributes to 3R, 
 
Title Technology for lipidomic data analysis 
Description Development of tools for lipid analysis and integration with gene expressison analysis using multivariant analysis 
Type Of Material Data analysis technique 
Year Produced 2014 
Provided To Others? Yes  
Impact Fundamental for papers including lipidomic analysis which is central to our programme 
 
Title Tissue bank from mice undergoing physiological challenges and specific genetic modifications 
Description This tissues and their RNA are being used for quick validation of metabolic relevance of genes identified by genomic approaches. This resourcedecreases the need of experimental groups of animals 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact identification of interesting candidate genes for metabolic disease prioritising murine work 1. Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. 2. Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25. 3. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author 5. Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 6. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. 7. Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM. Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. Diabetologia. 2015 Jul 23. 
 
Description Flies as a disease model to study metabolic disease 
Organisation German Cancer Research Center
Country Germany 
Sector Public 
PI Contribution provide hypothesis for validation in flies and also perform experiments in mammalian systems with insights coming from flies.
Collaborator Contribution generation of genetically modified flies mimicking mouse or cell genetic modification.
Impact Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. Dietary stearic acid regulates mitochondria in vivo in humans. Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038/s41467-018-05614-6. PMID: 30087348 Free PMC Article
Start Year 2015
 
Description 12th National Congress of the Spanish Society for the Study of Obesity. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 12th National Congress of the Spanish Society for the Study of Obesity.
Year(s) Of Engagement Activity 2015
 
Description 36 Congreso Sociedad Española de Farmacología. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact http://congresosef2015.com/programa-cientifico/esquema-del-programa/
12:30 - 13:30
Sesión Plenaria.

Moderadora: Dra. Mª Jesús Sanz Ferrando
Universitat de València.
Adipose tissue expandability, lipotoxicity and the metabolic syndrome.
Prof. Antonio Vidal Puig University of Cambridge. Reino Unido.
Year(s) Of Engagement Activity 2015
URL http://congresosef2015.com/programa-cientifico/esquema-del-programa/
 
Description 5th - 9th June 2015. ADA Scientific Sessions Insulin Action/Molecular Metabolism. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture American Diabetes Association Conference 2015
Year(s) Of Engagement Activity 2015
URL http://professional2.diabetes.org/Presentations_Details.aspx?typ=10&sr=adv&cgr=238&congress=238
 
Description Alabama, USA. 19th November 2013. University of Alabama at Birmingham, Nutrition Obesity Research Center - NORC's Noon Seminar Series. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The seminar is sponsored by the Nutrition Obesity Research Center and co-sponsored by the Department of Nutrition Sciences.
Addressed the problem of adipose tissue expandability and metabolic syndrome
Year(s) Of Engagement Activity 2013
URL http://www.norc.uab.edu/courses/seminars/seminar2013#
 
Description Barcelona, Spain. 24th-27th May 2017. EMBO workshop meeting on BAT. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Barcelona, Spain. 24th-27th May 2017. EMBO workshop meeting on BAT. Conference lecturer
Year(s) Of Engagement Activity 2017
URL http://meetings.embo.org/event/17-brown-fat
 
Description Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. Lecture. Networking with engineers.
Year(s) Of Engagement Activity 2017
URL http://biofisika.org/
 
Description Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. Lecture related to the role of Brown fat in metabolism.
Year(s) Of Engagement Activity 2018
URL https://www.evensi.us/adventures-metabolism-symposium-celebrate-jeffrey-flier-70th-birthday/25406324...
 
Description British Atherosclerosis Society Meeting: 'Atherosclerosis: crossroads of metabolism and inflammation'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact British Atherosclerosis Society Meeting: 'Atherosclerosis: crossroads of metabolism and inflammation'.
British Atherosclerosis Society Autumn Meeting 2015


Atherosclerosis: Crossroads of Metabolism and Inflammation

Meeting Report

Organisers: Joseph Boyle, Ashley Miller, Martin Bennett
Date: Thursday 10th - Friday 11th September 2015
Venue: Murray Edwards College, New Hall, University of Cambridge, Cambridge
Final Programme
Sponsors: Amgen has provided unrestricted funding to support this meeting. Amgen has had no input into the programme, selection of speakers or topics.
Year(s) Of Engagement Activity 2015
URL http://www.britathsoc.org/previous-meetings/british-atherosclerosis-society-autumn-meeting-2015/
 
Description Colorado, USA. 9th - 13th February 2015. Keystone Symposia - Systems Biology of Lipid Metabolism. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keystone Symposia organiser and speaker.
Area Lipid Biochemistry
Year(s) Of Engagement Activity 2015
URL http://www.keystonesymposia.org/15B4
 
Description Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction"
Year(s) Of Engagement Activity 2017
URL http://www.irtg1902.hhu.de/schedule/schedule-single-view.html?tx_cal_controller%5Bgetdate%5D=2017101...
 
Description EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EAS Advanced in Cardiometabolic Phenotyping in Rodents, Cambridge, UK

Scientists from the University of Cambridge Biomedical Campus recently hosted the 2nd EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. This 3-day course combines the state of the art facilities and expertise within the Disease Model Core at the WellcomeTrust-MRC Institute of Metabolic Science and the BHF Cardiovascular Centre. By integrating the expertise of these two specialized phenotyping centres, it provides a unique opportunity to learn about many of the skills required for in depth cardiometabolic phenotyping in small animals.

The 32 participants, selected from centres across Europe, were treated to a programme of lectures, phenotyping demonstrations and data analysis sessions. A further 1-day workshop at the Sanger/EBI focused on mouse genetics, genetic engineering and informatics resources, highlighting the great opportunities provided by recent advances in genetic engineering purpose-made mouse models. Participants particularly appreciated the mixture of hands-on experience, combined with opportunities to ask detailed questions on how the techniques demonstrated should be used to suit their own research priorities.

The course was sponsored by the European Atherosclerosis Society, British Heart Foundation and TSE systems, with organisation led by Prof Toni Vidal-Puig, Director of the MRC Metabolic Diseases Unit Disease Model Core.
Year(s) Of Engagement Activity 2015
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Keystone Conference Lecture. Colorado, USA. 22nd - 27th January 2017.
Year(s) Of Engagement Activity 2017
URL http://healthdocbox.com/amp/69735120-Diabetes/Diabetes-january-22-26-2017-keystone-conference-center...
 
Description Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. >150 attendants to symposium on Obesity associated metabolic complications.
Year(s) Of Engagement Activity 2017
URL https://d-net.idf.org/en/events/369-53rd-easd-annual-meeting-in-lisbon-portugal.html
 
Description London, UK. 24th April 2015. Royal Society of Medicine Symposium. Obesity: Epidemiology, complications and management. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This symposium provided a multidisciplinary forum for researchers and healthcare workers to discuss the most recent advances, trends and management challenges encountered in the field of obesity.

Throughout the day, delegates explored the opportunities and challenges faced by those involved in obesity medicine, together with the solutions that have currently been adopted.

The symposium aimed at all those working in the field or with an interest in obesity medicine, vascular risk medicine, PhD students, post-doctoral researchers, and clinicians of all medical specialties including medical students, foundation and core trainees, general practitioners, physicians and surgeons.
Year(s) Of Engagement Activity 2015
URL https://www.rsm.ac.uk/events/events-listing/2014-2015/sections/lipids,-metabolism-vascular-risk-sect...
 
Description Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. Research seminar. >80 attendees.
Year(s) Of Engagement Activity 2017
URL https://www.arabalears.cat/balears/Antonio-Vidal-Puig-nostres-estalviadors-lluitar_0_1892210855.html
 
Description Mexico. 13th-14th February 2019. Nutrition Forum 2019 Danone Institute of Mexico. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on obesity and nutrition
Year(s) Of Engagement Activity 2018
URL https://www.danoneinstitute.org/nutrition-health/local-initiatives
 
Description Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter. Lecture to postcs in this institute and meetings with specific students to discuss their projects
Year(s) Of Engagement Activity 2018
URL https://cluster.meduniwien.ac.at/index.php?id=3732&tx_ttnews%5Btt_news%5D=3280&tx_ttnews%5Bpointer%5...
 
Description Wroclaw, Poland. 3rd - 7th May 2014. European Congress of Endocrinology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Here you will find all ECE 2014 information, including details of the pre-congress courses and include the oral communications that have been chosen following the abstract selection meeting in the scientific programme.

We look forward to welcoming you to Wroclaw for ECE 2014.

Paolo Beck-Peccoz
Joint Chair, Programme Organising Committee (POC)
Year(s) Of Engagement Activity 2014
URL http://www.ece2014.org/
 
Description -Conference "Metabolism in Action - Lifetime influence of genes and environment" (1-5th October) by the Copenhagen Bioscience Conferences, a Novo Nordisk Foundation initiative, in Hillerød, Denmark ---- Poster session: S Rodriguez-Cuenca*, S Carobbio*, R Dias , G Barcelo-Cobjlin, X Prieur, J Relat-Pardo, R Amat, M Campbell, M Bahri and A Vidal-Puig. P465L PPARg mutation confers partial resistance to the hypolipidaemic action of fibrates. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact -Conference "Metabolism in Action - Lifetime influence of genes and environment" (1-5th October) by the Copenhagen Bioscience Conferences, a Novo Nordisk Foundation initiative, in Hillerød, Denmark ---- Poster session: S Rodriguez-Cuenca*, S Carobbio*, R Dias , G Barcelo-Cobjlin, X Prieur, J Relat-Pardo, R Amat, M Campbell, M Bahri and A Vidal-Puig. P465L PPARg mutation confers partial resistance to the hypolipidaemic action of fibrates.
Year(s) Of Engagement Activity 2017
 
Description . Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact 4. Cambridge, UK. 11th April 2016. British Heart Foundation Cardiovascular Research Excellence Annual Event.
Year(s) Of Engagement Activity 2016
 
Description . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London.
Year(s) Of Engagement Activity 2016
 
Description 11/11/2014- www.teinteresa.es, Madrid Brown fat 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact La grasa marrón, clave en la lucha contra la obesidad
1456655859
11/11/2014- www.teinteresa.es, Madrid

Las compañías farmacéuticas están invirtiendo en la investigación para desarrollar un método para convertir la grasa blanca en grasa marrón.
Modificaciones de la flora bacteriana han podido ayudar a reducir la obesidad en animales, y podría aportar soluciones a la obesidad humana
Year(s) Of Engagement Activity 2014
URL http://www.teinteresa.es/salud/grasa-marron-clave-lucha-obesidad_0_1246676023.html
 
Description 15th European Congress of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 15th European Congress of Endocrinology, Copenhagen, Denmark. 27th April - 1st May 2013.

As organiser of the conference we contributed to the impact on 3000 attendees.
Year(s) Of Engagement Activity 2013
URL http://www.ece2013.org/
 
Description 23/01/2017 Invited Talk, Meeting "Bile Acids, Nuclear Receptors and Nutrition" (Metabolic Control of Liver Regeneration and Hepatocellular Carcinogenesis: Nuclear Receptors and Beyond), University Medical Centre Utrecht, NL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 23/01/2017 Invited Talk, Meeting "Bile Acids, Nuclear Receptors and Nutrition" (Metabolic Control of Liver Regeneration and Hepatocellular Carcinogenesis: Nuclear Receptors and Beyond), University Medical Centre Utrecht, NL
Year(s) Of Engagement Activity 2017
 
Description 28/07/2017 Faculty Speaker, NEEDPRO Summer School in Applied Human Nutrition (Diet and Fatty Liver: A Case Study), Cambridge, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 28/07/2017 Faculty Speaker, NEEDPRO Summer School in Applied Human Nutrition (Diet and Fatty Liver: A Case Study), Cambridge, UK This is an annual summer course on Nutrition
Year(s) Of Engagement Activity 2017
 
Description 29/06/2017 Faculty Speaker, University Rey Juan Carlos (URJC) Summer School for University students and Working Professionals (Molecular basis of NASH development and progression; lipids and beyond). Madrid, ES 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 29/06/2017 Faculty Speaker, University Rey Juan Carlos (URJC) Summer School for University students and Working Professionals (Molecular basis of NASH development and progression; lipids and beyond). Madrid, ES
Year(s) Of Engagement Activity 2017
 
Description 3. Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Tsukuba, Japan. 17th-19th September 2016. Tsukuba Global Science Week.
Year(s) Of Engagement Activity 2016
 
Description 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK).
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-...
 
Description Adipose tissue expandaqbility-EL COMERCIO ASTURIAS 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact <>
Antonio Vidal-Puig, catedrático en Cambridge y director adjunto del Centro de Obesidad y Enfermedades Asociadas. Premio Internacional Hipócrates 2015
<>
Year(s) Of Engagement Activity 2015
URL http://www.elcomercio.es/asturias/201511/27/puede-obeso-saludable-siempre-20151127002423-v.html
 
Description Advisory Board Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact EASO Scientific Advisory Board Meeting
18th - 19th March 2013, Brussels


redefinitionn of obesity on the baseis of body composition. BMI considered obsolete.
Year(s) Of Engagement Activity 2013
 
Description Antalya, Turkey. 23rd-26th October 2014. Endobridge. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ENDOBRIDGE 2014, 2nd EndoBridge Meeting is one of the extensive event on Pituitary Disease, Thyroid Disorders, Obesity, Endocrinology, Endocrine, Medical, Hormone Research, Hormonal Systems, Ageing, Bone And Osteoporosis, Diabetes, Hormones, Paediatric Endocrinology, Puberty, Steroids and Testosterone segments.
2nd EndoBridge Meeting is organized annually.
Year(s) Of Engagement Activity 2014
URL http://eventegg.com/endobridge-2014/
 
Description BAT in Granada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Interested in Brown Adipose Tissue? Can't miss this Symposium! https://finut-en.congressus.es/symposiumbat/index @ibsGRANADA @CIBER_OBN @TVPLab @FIBAO @CanalUGR @finutibero
Year(s) Of Engagement Activity 2018
URL https://twitter.com/ruizruizjonatan/status/1024216467729010688?s=12
 
Description Barcelona, Spain. 8th October 2016. CIBERDEM-MSD Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Barcelona, Spain. 8th October 2016. CIBERDEM-MSD Symposium
Year(s) Of Engagement Activity 2016
 
Description Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life.
Year(s) Of Engagement Activity 2018
URL https://www.basellife.org/basel-life-2018.html
 
Description Bilbao, Spain. 8th June 2018. Seminar at Biogune. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune.
Year(s) Of Engagement Activity 2018
URL https://twitter.com/CICbioGUNE
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Fighting fat with fat
Obesity is one of the most important biomedical problems in our society and also one of the most frustrating to tackle. For this reason, the recent identification of functional brown fat in adult humans has made the obesity research community very excited. Read more here.

Sanger Institute Blog by Dr Stefania Carobbio

Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by Dr Stefania Carobbio
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk
 
Description Blog BAT 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description CNN interview about LR11 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact New protein could help burn fat faster
By Meera Senthilingam, for CNN
Updated 1109 GMT (1909 HKT) February 1, 2016
(CNN)-Research has shown that the fatter your body becomes, the harder it becomes to burn that excess fat.
As people eat more fat than they burn, the body stores this excess in various parts of the body and as this storage increases, metabolism changes.

However, all is not lost: a recent study by researchers at the University of Cambridge identified one of the proteins underlying this blockage of fat burn. "[This protein] is part of the system in place to help the body store more energy," says Antonio Vidal-Puig, Professor in Molecular Nutrition and Metabolism, who worked on the study.

The culprit, called sLR11, was found to block the functioning of brown fat cells -- responsible for generating heat to keep us warm -- and instead help the body store fat more efficiently by preventing excessive heat generation.


The benefits of brown fat








There are two forms of fat cells -- brown cells and white cells -- and each plays a different role in our metabolism.



While brown cells help generate heat, the white cells are responsible for the storage of fat -- or energy -- ready for release as needed. Levels of brown fat are known to be high in children but recent findings showing the presence of brown fat in adults, restored hope to use them as targets to treat obesity.



According to Vidal-Puig, obese people have less brown fat than lean people -- and the same applies for diabetics. "If you can increase the brown fat in obese and diabetic people then you can improve their situation," says Vidal-Puig. This has been known for some time, but making it a reality has been a challenge.

The newly discovered sLR11 protein could provide the answer.


Removing the brakes


Vidal-Puig compares the protein to the brake of a car, stopping the body from accelerating its production of heat. "Obese people have more of these brakes, preventing them from creating heat and therefore losing fat," says Vidal-Puig who has seen elevated levels of the protein in the blood of obese people included in his study.

During the study, the team removed the gene producing this protein in mice and found they were able to burn calories faster.

The researchers went on to examine the protein in humans and found that levels of the protein correlated with the total fat mass in a person. What's more, investigated levels in obese patients after they underwent bariatric surgery, and their weight loss was directly proportional to the decrease in levels of the sLR11 protein.

"[Brown fat cells] are an attractive therapeutic target for weight loss, and for anti-obesity or anti-type 2 Diabetes (T2D) therapies," says Carole Sztalryd, Associate Professor of Medicine at the University of Maryland School of Medicine. Sztalryd's team also work on biological approaches to weight loss.


More brown than white on the cards


A common focus to tackle obesity has been on accelerating the production of brown fat cells so people burn more calories, but this new insight could achieve the same but through enhancing the activity -- and efficiency -- of cells. "We are stopping the brakes within the fat cells," says Vidal-Puig, as the mice in his study became protected from obesity with increased browning of their white fat cells.

The team believe controlling energy storage will be a better approach to beat the obesity epidemic than controlling people's eating habits.

But Sztalryd warns that additional studies are required to evaluate any clinical relevance,"New therapies are urgently needed for obesity. sLR11 seems promising but more work is needed to confirm if this is a relevant," she says.

In the mean time, old tactics may be the answer and the more weight gained, the more exercise to be done.
Year(s) Of Engagement Activity 2015
URL http://edition.cnn.com/2016/02/01/health/new-protein-fat-burn-feat/
 
Description Cambridge Metabolic Network/Danish Diabetes Association Course for PhD Students. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Course sponsored by NOVO foundation from Denmark, 35 PhD students from Cambridge and Denmark.
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/events/lipid-metabolism-new-methods-and-translational-aspects
 
Description Cambridge University in Nanjing. Cambridge UNiversity Anjing Centre for innovation and technology 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Cambridge University in Nanjing.
At the entrance of the Cambridge University Nanjing Centre of Technology and Innovation, with my colleague from Cambridge Prof Daping Chu, the Director of the Centre
Year(s) Of Engagement Activity 2018
 
Description Cambridge, UK. 13th April 2015. BHF Centre of Research Annual Symposium. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact http://www.cardiovascular.cam.ac.uk/
The overarching scientific objective of the Centre is to advance understanding of pathobiology, diagnosis, prevention and therapy of selected common and rare cardiovascular conditions by applying our combined expertise in generating assumption-free approaches.
Year(s) Of Engagement Activity 2015
URL http://www.cardiovascular.cam.ac.uk/research/cambridgecre
 
Description Cherry Hinton Lions Under 10s Blue Football Club sponsored by IMS/TVP lab 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This is an action to promote fitness in children as a strategy to prevent orreverse obesity

Children know what is the IMS and that obesity and diabetes can be prevented by exercise.
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Communicating related to impact of our research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact News about our papers were disseminated through BBC radio, and TV ( BBC look East). Also through multiple webs and also reached internationally through links with European commision.

These media are supposed to reach out to the general public.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description Engordar La ciencia Asturias 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Engordar la ciencia
El endocrino Antonio Vidal-Puig reivindica el valor económico de la investigación al recibir el premio del Colegio de Médicos
El endocrinólogo Antonio Vidal-Puig, catedrático de la Universidad de Cambridge y uno de los mayores expertos del mundo en obesidad, aprovechó la conferencia con la que recibió ayer en Oviedo el Premio Internacional Hipócrates Central Lechera Asturiana de la Real Academia de Medicina y Cirugía para reclamar un mayor apoyo a la actividad investigadora en España. "Los países que no tienen grandes recursos naturales dependen de la economía del conocimiento, y nosotros podemos ser económicamente más potentes gracias a la ciencia", subrayó Vidal-Puig, que pertenece a 21 comités internacionales de expertos y ha publicado 220 artículos en revistas especializadas
Year(s) Of Engagement Activity 2015
URL http://www.lne.es/asturias/2015/11/27/engordar-ciencia/1847307.html
 
Description Europe press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This was an interview for Europe press news agency which has a huge diseminattion capacity. Some examples below.

http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig

http://www.europapress.es/chance/elbuenvivir/noticia-10-obesos-son-saludables-20111128124545.html

http://www.europapress.es/chance/noticias.aspx?buscar=Cambridge

http://www.enfermeriapalencia.com/modules.php?name=Noticias_enfermeras

Highewr visibility. Partients have contacted me through email with personal cases that have I have replayed so far but that if they continue to increase i may need to organise better through my web page. I am considering if i get resources to maintain in to include a page in my web for public questions and disemination.
Year(s) Of Engagement Activity 2011
URL http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig
 
Description GACETA MEDICA-Lilly 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gaceta Médica
Domingo, 28 de Febrero de 2016
Felipe Casanueva Freijo, presidente de la Sociedad Española para el Estudio de la Obesidad, y Manuel Puig-Domingo, presidente de la Sociedad Española de Endocrinología y Nutrición, entregaron al profesor Antonio Vidal Puig el "Premio Fundación Lilly a una Carrera Distinguida 2015" en la especialidad de Endocrinología, Nutrición y Obesidad por su contribución al conocimiento del tejido adiposo y el abordaje y prevención de la obesidad. Este galardón fue otorgado en el marco del Simposio Internacional 'Lo último en Obesidad'
Year(s) Of Engagement Activity 2016
URL http://www.gacetamedica.com/noticias-medicina/2015-12-04/en-10-minutos/premio-a-la-trayectoria-en-en...
 
Description Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. Lecture related to Medal award.
Year(s) Of Engagement Activity 2017
URL https://www.endocrinology.org/events/sfe-bes-conference/sfe-bes-2017/
 
Description Heidelberg, Germany. 16th - 17th October 2015. International Symposium On Diabetic Complications 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Heidelberg, Germany. 16th - 17th October 2015. International Symposium On Diabetic Complications
Event Description

HIDC 2015, 2th Heidelberg International Symposium on Diabetic Complications is going to be placed in between 16 October, 2015 and 17 October, 2015.

The Symposium place is going to be Heidelberg University Hospital.

HIDC 2015 is likely to be a stage where many notable themes are likely to be discoursed. Several of these are going to be Biology, Metabolic Diseases, Diabetes, Diabetes Research, Medical and Health Care.

2th Heidelberg International Symposium on Diabetic Complications is organized annually.
Year(s) Of Engagement Activity 2015
URL https://www.klinikum.uni-heidelberg.de/Welcome.138789.0.html
 
Description International Congress on Obesity 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Vancouver, Canada. 1st - 4th May 2016. 13th International Congress on Obesity. 250 attendes
Year(s) Of Engagement Activity 2016
 
Description International Symposium: Latest in obesity Madrid, Spain. 1st - 2nd December 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact http://www.fundacionareces.es/fundacionareces/cargarAplicacionAgendaEventos.do?idTipoEvento=1&identificador=1827?elAgenda=2
Along with obesity, diabetes is a true pandemic of the 21st century which carries a certain risk of other diseases such as cardiovascular diseases, or even cancer. It is purpose of this symposium to bring to our attention and knowledge the most recent advances on the disease and we hope to do so thanks to the remarkable roster of personalities who have accepted our invitation to share their knowledge and ideas in this INTERNATIONAL SCIENTIFIC SYMPOSIUM: LATEST IN OBESITY sponsored by the Fundación Ramón Areces and with the collaboration of the Fundación General CSIC.
Year(s) Of Engagement Activity 2015
URL http://www.fundacionareces.es/fundacionareces/cargarAplicacionAgendaEventos.do?idTipoEvento=1&identi...
 
Description Keystone Symposia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keystone Symposia - Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction. Alpbach, Austria, 3rd-8th April 2113.

Keystone Symposia - Systems Biologyof Lipid Metabolism (9th - 13th February 2015)
Colorado, USAOrganisers: Matej Orešic, Antonio Vidal-Puig, Ana Maria Cuervo

Increased applicants to the lab
Year(s) Of Engagement Activity 2013,2014
URL http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1235
 
Description LR11 in Asia 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact LR11 news disseminated in Asia
???LR11/SorLA?????????????????????BMI???????????
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
Year(s) Of Engagement Activity 2015
URL https://www.natureasia.com/ja-jp/ncomms/abstracts/71218
 
Description La obesidad está en el cerebro" Lilly Areces 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Más de 500 millones de personas en el mundo padecen obesidad.
Un simposio organizado por la Fundación Ramón Areces y la Fundación General del CSIC analiza las últimas investigaciones sobre este problema de salud pública.
Year(s) Of Engagement Activity 2015
URL http://hipertextual.com/2015/12/obesidad#
 
Description Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. This was a symposia with clear clinical translational implications addressed to practitioners that had implications on their practice.
Year(s) Of Engagement Activity 2017
URL http://www.ece2017.org/media/1123/ece-2017-satellite-programmes_280317.pdf
 
Description London, UK. 11th March 2015. Diabetes UK for the Adipose Plenary Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Diabetes UK Professional Conference, organized by the Diabetes UK will take place from 11th March to the 13th March 2015 at the Excel London in London, United Kingdom. The conference will cover areas like basic science, clinical science, education, clinical care management, healthcare delivery and psychological care.
Year(s) Of Engagement Activity 2015
URL http://10times.com/diabetes-uk-professional-conference
 
Description MIddle EaSt obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professors Toni Vidal-Puig MD PhD FRCP FMedSci EMBA and Meis Moukayed have honoured us by writing the fascinating article, People with obesity: Their heroic battle to defeat their genes in a hostile hypercaloric sedentary environment. The professors explain why more than 50 human genes, the environment and lifestyle culture all contribute to why it is not so easy as the doctor telling the patient to lose weight. In addition to looking at the 'why' of obesity,
Year(s) Of Engagement Activity 2018
URL https://www.middleeastmedicalportal.com/product/november-december-2018/
 
Description Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology
Year(s) Of Engagement Activity 2016
 
Description Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact TVP Lab members give presentations and posters at 1st ICAN conference series in Cardiometabolic Disease

Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. Vanessa Pellegrinelli was selected to give a presentation, and Camilla Ingvorsen, Guillaume Bidault, and Vivian Peirce were selected to present posters. Vivian Peirce was a joint-winner of Young Investigator poster award.



Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. Talk at this institute in China in front of > 100 students.
Year(s) Of Engagement Activity 2017
 
Description Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Oxford, UK. 18th January 2019. Seminar in Department of Physiology, Anatomy & Genetics
Date: 18 January 2019, 13:00 (Friday, 1st week, Hilary 2019)
Venue:
Sherrington Building
off Parks Road OX1 3PT
See location on maps.ox

Details: Large Lecture Theatre
Speaker: Professor Antonio Vidal-Puig (University of Cambridge)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser contact email address: ana.domingos@dpag.ox.ac.uk
Host: Dr Ana Domingos (University of Oxford, DPAG)
Part of: DPAG Head of Department Seminar Series
Topics: Inflammation, Diabetes, Adipose tissues, Metabolic syndrome, Obesity
Year(s) Of Engagement Activity 2018
URL https://new.talks.ox.ac.uk/talks/id/f6ae26ed-6a85-4ea6-8236-0be648588540/
 
Description Royal Swedish Academy of Sciences, Journal of Internal Medicine - Key Symposium "Metabolic complications of obesity" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Organisation of symposia with 150 attendants, 28 speakers from EU, USA, JAPAN, CHINA. Top symposium supported by the Swedish Academy of Sciences and the Journal of Internal Medicine.
Year(s) Of Engagement Activity 2017
URL http://www.mrl.ims.cam.ac.uk/event/metabolic-complications-obesity/
 
Description SCIENCEALERT ON LR11 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientists have figured out how your body fights your attempts to lose weight
Bummer.
DAVID NIELD
11 DEC 2015
For those of you who feel like your gym sessions aren't getting you anywhere near your target weight - scientists think they might have found a reason why. A new study has identified a protein that locks excess fat in our bodies, preventing it from being burned off easily.

And while it sucks to know that our bodies are fighting against our attempts to lose weight, the discovery could help to explain why overweight people find it so difficult to shed the additional pounds.
Year(s) Of Engagement Activity 2015
URL http://www.sciencealert.com/here-s-how-your-body-naturally-fights-your-attempts-to-lose-weight
 
Description Science News Study inMice suggests drug to turn fat brown could help fight obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact https://www.sciencedaily.com/releases/2018/11/181126123416.htm
Study in mice suggests drug to turn fat 'brown' could help fight obesity
Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/11/181126123416.htm
 
Description Singapore2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact University of Cambridge meets with our colleagues from the National University of Singapore to strenght our collaborative cardiovascular research network.
Year(s) Of Engagement Activity 2019
 
Description Stockholm, Sweden. 28th June - 2nd July 2014. International Society for the Study of Fatty Acids and Lipids. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact http://www.issfal.org/conferences/2014-stockholm
Stockholm, Sweden. 28th June - 2nd July 2014. International Society for the Study of Fatty Acids and Lipids.
International conference focused on the role of fatty acids in disease
Year(s) Of Engagement Activity 2014
URL http://www.issfal.org/conferences/2014-stockholm
 
Description Suzhou, China. 1st - 5th June 2015. Cold Spring Harbor Asia (CSHA) Conference on Lipid Metabolism and Metabolic Disorders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The conference will include eight oral sessions and one poster session covering the latest findings across many topics in lipid metabolic. Many talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Alterations in lipid homeostasis play critical roles in the development of human metabolic disorders, such as obesity, type II diabetes and fatty liver. This meeting brings together world-leading experts to present and discuss latest developments in the study of lipid metabolism, as well as their implications for human health and disease. The conference will include eight oral sessions and one poster session. Additional oral presentations will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference will provide ample opportunities for scientific as well as informal interactions
Year(s) Of Engagement Activity 2015
URL https://www.csh-asia.org/2015meetings/Metabo.html
 
Description TECHTIMES 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Being Fat Makes It Harder To Lose Weight: Fatter People Produce More Protein That Inhibits Depletion Of Fat Cells
Fat people have a more difficult time of losing weight because of the increased production of a protein called sLR11. This inhibits the body's ability to burn calories and fats for heat production
Year(s) Of Engagement Activity 2015
URL http://www.techtimes.com/articles/110892/20151127/being-fat-makes-it-harder-to-lose-weight-fatter-pe...
 
Description Toulouse, France. 28th April 2017. Seminar at INSERM. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Toulouse, France. 28th April 2017. Seminar at INSERM. Dissemination of research outcomes to research commnity
Year(s) Of Engagement Activity 2017
URL https://www.stromalab.fr/actualites/pr-toni-vidal-puig-university-of-cambridge-uk/
 
Description Turku, Finland. 28th January 2016. Frontiers of Science Seminar Series at Biocity Turku 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact http://www.biocity.turku.fi/index.php?id=858
Thursday, January 28
Prof. Antonio Vidal-Puig, University of Cambridge, MRC Institute of Metabolic Science, Cambridge, UK
"Adipose tissue expandability, lipotoxicity and the metabolic syndrome"
Host: Matej Oresic (mtjo(at)steno.dk)
Year(s) Of Engagement Activity 2016
URL http://www.biocity.turku.fi/index.php?id=858
 
Description Tye 2 Diabetes; Atherapeutic avenue is emerging 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Date:December 5, 2018 Source:INSERM (Institut national de la santé et de la recherche médicale) Summary:Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/12/181205134014.htm
 
Description URJC Summer University Programme: Obesity, Insulin Resistance, and Metabolic Syndrome. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact 5. Madrid, Spain. 9th-11th July 2015. URJC Summer University Programme: Obesity, Insulin Resistance, and Metabolic Syndrome.


Obesity, insulin resistance, diabetes and metabolic syndrome (Código UV-S-OBESI)

La inscripción ha finalizado.





Apúntate





Del 09-07-2015 al 11-07-2015

Salón de Grados, Campus de Madrid, Facultad de Ciencias Jurídicas y Sociales, Paseo de los Artilleros s/n


Organizado por Vicerrectorado de Extensión Universitaria

Teléfono de contacto: 914884762
Categorías:
Formación y docencia sanitaria

Investigación médica

Medicina general
Palabras clave:
Diabetes and metabolic syndrom...

Insulin resistance

Obesity
Year(s) Of Engagement Activity 2015
URL http://uverano.urjc.es/event_detail/2355/programme/obesity-insulin-resistance-diabetes-and-metabolic...
 
Description https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
November 27, 2018
Could this be a solution for the obesity crisis?
Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge
Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity?
Year(s) Of Engagement Activity 2018
URL https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
 
Description newsweek thermogenesis 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html

In another area of Vidal-Puig's studies lies, potentially, an amazingly simple fix. In spite of all the millions spent on diets, food and exercise, it may be that something as basic as temperature is the answer. We all have two types of fat, white and brown. White fat is inert and sits in deposits. Brown fat, which regulates babies' temperatures but is much harder to pinpoint in adults, can be activated to burn calories and generate heat.

Studies show that exposure to low temperatures may encourage white fat to behave like brown fat. So while central heating ensures we move less and burn fewer calories, it's possible that lower temperatures might increase the activity of brown fat, which will burn our calories for us.
Year(s) Of Engagement Activity 2015
URL http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html