Farm animal genetic diversity and host innate immune responses to infections of global importance
Lead Research Organisation:
University of Nottingham
Department Name: School of Veterinary Medicine and Sci
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
Kin-Chow Chang (Principal Investigator) | |
Paul Barrow (Co-Investigator) |
Publications
Chang P
(2015)
Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation
in Scientific Reports
Gao H
(2015)
PA-X is a virulence factor in avian H9N2 influenza virus.
in The Journal of general virology
Gao H
(2015)
Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity.
in The Journal of general virology
Gao H
(2015)
The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.
in Scientific reports
Kuchipudi SV
(2014)
Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses.
in Veterinary research
Slater T
(2018)
Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.
in Virology journal
Title | Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets |
Description | Genetic variation data derived from ferret transmission experiments of avian H3N8 influenza viruses. Supplementary Dataset 1. Genetic variation data derived from ferret transmission experiment of HN/4-10 virus. Supplementary Dataset 2. Genetic variation data derived from ferret transmission experiment of CS/1000 virus. Supplementary Dataset 3. Genetic variation data derived from ferret transmission experiment of CK/FE12 virus. Supplementary Dataset 4. Genetic variation data derived from ferret transmission experiment of CK/F0316 virus. |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | This papers identified a new zoonotic threat of avian H3N8 virus to humans. |
URL | https://zenodo.org/record/8191338 |
Title | Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin |
Description | The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for their infection performance in single variant- and co-infections. The effectiveness of thapsigargin (TG), a recently discovered broad-spectrum antiviral, against these variants was also examined. Of the 3 viruses, the D variant exhibited the highest replication rate and was most able to spread to in-contact cells; its replication rate at 24 h post-infection (hpi) based on progeny viral RNA production was over 4 times that of variant A and 9 times more than the B variant. In co-infections, the D variant boosted the replication of its co-infected partners at the expense of its own initial performance. Furthermore, co-infection with AD or AB combination conferred replication synergy where total progeny (RNA) output was greater than the sum of corresponding single-variant infections. All variants were highly sensitive to TG inhibition. A single pre-infection priming dose of TG effectively blocked all single-variant infections and every combination (AB, AD, BD variants) of co-infection at greater than 95% (relative to controls) at 72 hpi. Likewise, TG was effective in inhibiting each variant in active preexisting infection. In conclusion, against the current backdrop of the dominant D variant that could be further complicated by co-infection synergy with new variants, the growing list of viruses susceptible to TG, a promising host-centric antiviral, now includes a spectrum of contemporary SARS-CoV-2 viruses. |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | Demonstrates that TG is a potent antiviral against SARS-CoV-2. |
URL | https://tandf.figshare.com/articles/dataset/Emergent_SARS-CoV-2_variants_comparative_replication_dyn... |
Title | SRSF5-mediated alternative splicing of M gene is essential for influenza A virus replication: a host-directed target against influenza virus. |
Description | Peer reviewed paper. https://doi.org/10.1002/advs.202203088 |
Type Of Material | Database/Collection of data |
Year Produced | 2022 |
Provided To Others? | Yes |
Impact | The paper describes a novel host factor SRSF5 that facilitates influenza virus replication. |
URL | https://onlinelibrary.wiley.com/doi/10.1002/advs.202203088 |
Description | MOU signing for research collaboration with China Agricultural University Nov 2011 |
Organisation | China Agricultural University (CAU) |
Country | China |
Sector | Academic/University |
PI Contribution | Owing to contributions from the BBSRC China Partnering Award, the University of Nottingham (UoN) made an official Global Food Security priority research mission to Beijing, China in Nov 2011. A MOU was signed between UoN and China Agricultural University (CAU), China's top agricultural university. The UoN mission was led by our Pro-vice Chancellor. The MOU has helped to cement the working relationship between the two establishments. We are developing a PhD reseach exchange programme between the two universities to facilitate joint research in veterinary diseases, including pig and poultry. |
Start Year | 2011 |