Farm animal genetic diversity and host innate immune responses to infections of global importance

Lead Research Organisation: University of Nottingham
Department Name: School of Veterinary Medicine and Sci


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Gao H (2015) PA-X is a virulence factor in avian H9N2 influenza virus. in The Journal of general virology

Title Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets 
Description Genetic variation data derived from ferret transmission experiments of avian H3N8 influenza viruses. Supplementary Dataset 1. Genetic variation data derived from ferret transmission experiment of HN/4-10 virus. Supplementary Dataset 2. Genetic variation data derived from ferret transmission experiment of CS/1000 virus. Supplementary Dataset 3. Genetic variation data derived from ferret transmission experiment of CK/FE12 virus. Supplementary Dataset 4. Genetic variation data derived from ferret transmission experiment of CK/F0316 virus. 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
Impact This papers identified a new zoonotic threat of avian H3N8 virus to humans. 
Title Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin 
Description The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for their infection performance in single variant- and co-infections. The effectiveness of thapsigargin (TG), a recently discovered broad-spectrum antiviral, against these variants was also examined. Of the 3 viruses, the D variant exhibited the highest replication rate and was most able to spread to in-contact cells; its replication rate at 24 h post-infection (hpi) based on progeny viral RNA production was over 4 times that of variant A and 9 times more than the B variant. In co-infections, the D variant boosted the replication of its co-infected partners at the expense of its own initial performance. Furthermore, co-infection with AD or AB combination conferred replication synergy where total progeny (RNA) output was greater than the sum of corresponding single-variant infections. All variants were highly sensitive to TG inhibition. A single pre-infection priming dose of TG effectively blocked all single-variant infections and every combination (AB, AD, BD variants) of co-infection at greater than 95% (relative to controls) at 72 hpi. Likewise, TG was effective in inhibiting each variant in active preexisting infection. In conclusion, against the current backdrop of the dominant D variant that could be further complicated by co-infection synergy with new variants, the growing list of viruses susceptible to TG, a promising host-centric antiviral, now includes a spectrum of contemporary SARS-CoV-2 viruses. 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact Demonstrates that TG is a potent antiviral against SARS-CoV-2. 
Title SRSF5-mediated alternative splicing of M gene is essential for influenza A virus replication: a host-directed target against influenza virus. 
Description Peer reviewed paper. 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
Impact The paper describes a novel host factor SRSF5 that facilitates influenza virus replication. 
Description MOU signing for research collaboration with China Agricultural University Nov 2011 
Organisation China Agricultural University (CAU)
Country China 
Sector Academic/University 
PI Contribution Owing to contributions from the BBSRC China Partnering Award, the University of Nottingham (UoN) made an official Global Food Security priority research mission to Beijing, China in Nov 2011. A MOU was signed between UoN and China Agricultural University (CAU), China's top agricultural university. The UoN mission was led by our Pro-vice Chancellor. The MOU has helped to cement the working relationship between the two establishments. We are developing a PhD reseach exchange programme between the two universities to facilitate joint research in veterinary diseases, including pig and poultry.
Start Year 2011