Farm animal genetic diversity and host innate immune responses to infections of global importance

Lead Research Organisation: University of Nottingham
Department Name: School of Veterinary Medicine and Sci

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Zhang X (2017) Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations. in The Journal of general virology

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Xu G (2016) Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity. in Journal of virology

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Wei W (2013) miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development. in Cell death & disease

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Wei K (2014) Influenza A virus acquires enhanced pathogenicity and transmissibility after serial passages in swine. in Journal of virology

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Sun Y (2014) Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice. in Journal of virology

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Sun H (2016) Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets. in Journal of virology

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Sun H (2014) Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses. in Journal of virology

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Slater T (2018) Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses. in Virology journal

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Seng LG (2014) High basal expression of interferon-stimulated genes in human bronchial epithelial (BEAS-2B) cells contributes to influenza A virus resistance. in PloS one

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Pu J (2017) M Gene Reassortment in H9N2 Influenza Virus Promotes Early Infection and Replication: Contribution to Rising Virus Prevalence in Chickens in China. in Journal of virology

 
Title Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets 
Description Genetic variation data derived from ferret transmission experiments of avian H3N8 influenza viruses. Supplementary Dataset 1. Genetic variation data derived from ferret transmission experiment of HN/4-10 virus. Supplementary Dataset 2. Genetic variation data derived from ferret transmission experiment of CS/1000 virus. Supplementary Dataset 3. Genetic variation data derived from ferret transmission experiment of CK/FE12 virus. Supplementary Dataset 4. Genetic variation data derived from ferret transmission experiment of CK/F0316 virus. 
Type Of Material Database/Collection of data 
Year Produced 2023 
Provided To Others? Yes  
Impact This papers identified a new zoonotic threat of avian H3N8 virus to humans. 
URL https://zenodo.org/record/8191338
 
Title Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin 
Description The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for their infection performance in single variant- and co-infections. The effectiveness of thapsigargin (TG), a recently discovered broad-spectrum antiviral, against these variants was also examined. Of the 3 viruses, the D variant exhibited the highest replication rate and was most able to spread to in-contact cells; its replication rate at 24 h post-infection (hpi) based on progeny viral RNA production was over 4 times that of variant A and 9 times more than the B variant. In co-infections, the D variant boosted the replication of its co-infected partners at the expense of its own initial performance. Furthermore, co-infection with AD or AB combination conferred replication synergy where total progeny (RNA) output was greater than the sum of corresponding single-variant infections. All variants were highly sensitive to TG inhibition. A single pre-infection priming dose of TG effectively blocked all single-variant infections and every combination (AB, AD, BD variants) of co-infection at greater than 95% (relative to controls) at 72 hpi. Likewise, TG was effective in inhibiting each variant in active preexisting infection. In conclusion, against the current backdrop of the dominant D variant that could be further complicated by co-infection synergy with new variants, the growing list of viruses susceptible to TG, a promising host-centric antiviral, now includes a spectrum of contemporary SARS-CoV-2 viruses. 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact Demonstrates that TG is a potent antiviral against SARS-CoV-2. 
URL https://tandf.figshare.com/articles/dataset/Emergent_SARS-CoV-2_variants_comparative_replication_dyn...
 
Title SRSF5-mediated alternative splicing of M gene is essential for influenza A virus replication: a host-directed target against influenza virus. 
Description Peer reviewed paper. https://doi.org/10.1002/advs.202203088 
Type Of Material Database/Collection of data 
Year Produced 2022 
Provided To Others? Yes  
Impact The paper describes a novel host factor SRSF5 that facilitates influenza virus replication. 
URL https://onlinelibrary.wiley.com/doi/10.1002/advs.202203088
 
Description MOU signing for research collaboration with China Agricultural University Nov 2011 
Organisation China Agricultural University (CAU)
Country China 
Sector Academic/University 
PI Contribution Owing to contributions from the BBSRC China Partnering Award, the University of Nottingham (UoN) made an official Global Food Security priority research mission to Beijing, China in Nov 2011. A MOU was signed between UoN and China Agricultural University (CAU), China's top agricultural university. The UoN mission was led by our Pro-vice Chancellor. The MOU has helped to cement the working relationship between the two establishments. We are developing a PhD reseach exchange programme between the two universities to facilitate joint research in veterinary diseases, including pig and poultry.
Start Year 2011