Development of new analytical tools to study the physiology/pharmacology of the ageing gastrointestinal tract.

Lead Research Organisation: University of Brighton
Department Name: Sch of Pharmacy & Biomolecular Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
 
Description The multi-site sensor has the ability to be used to explore the functioning of serotonin containing enterochromaffin cells along the lower bowel. Currently these methods are limited to recordings at one or two distinct sites. The ability to record from multiple sites has allowed us to map the spatial and temporal release of 5-HT from the enterochromaffin cells during studies in which muscle contractions are being simultaneously recorded, allowing the precise relationship between 5-HT release and motility can be studied in exquisite detail.
Exploitation Route The multi-site sensor has the ability to be used to explore the functioning of serotonin containing enterochromaffin cells along the lower bowel. This could be used by academics or members of the pharmaceutical industry or healthcare professions to explore how drug treatment is able to modulate 5-HT release and how these changes impact on lower bowel motility.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

URL https://www.brighton.ac.uk/strand/what-we-do/research-projects/effects-of-age-on-signalling-and-function-in-the-lower-bowel.aspx
 
Title Enterochromaffin isolation from murine colon 
Description Isolation and characterization of murine enterochromaffin cells from the colon 
Type Of Material Biological samples 
Provided To Others? No  
Impact None currently 
 
Title Multi-sensor array for monitoring 5-HT release from colonic mucosa 
Description Multi-sensor array for monitoring 5-HT release from colonic mucosa 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact None currently 
 
Description Development of novel tools to study the physiology and pharmacology of the ageing gastrointestinal tract 
Organisation Michigan State University
Country United States 
Sector Academic/University 
PI Contribution BBSRC ISIS award (BB/IO25409/1)
Start Year 2011
 
Description STEM Sussex event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Schools
Results and Impact We have a stand booked at STEM Sussex, Crawley for the 6th July to disseminate some of our findings on the ageing bowel to an audience of school, children aged 7-11 years old. This is a one day event designed to familiarise school children with the workings of the GI tract and the effects that age has on the function of the GI tract Large model of GI tract that school children can walk though and examine. Lab test to look at taste and how taste regulates physiological functions.

No recordable impacts
Year(s) Of Engagement Activity 2012
 
Description STEM Sussex event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Schools
Results and Impact Stimulated thought and increased knowledge in a group of school children aged 11-19 years ol

Stand was one of the most highly rated by the students in the show. Interactive and engaging.
Year(s) Of Engagement Activity 2013
 
Description STEM Sussex event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Workshop highlighting the role played by the senses in nutrition and the function of the gastrointestinal tract and how it changes with age
Year(s) Of Engagement Activity 2014
 
Description STEM Sussex event at the South of England show ground 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Schools
Results and Impact Demonstration and participation in events stimulated lots of talk with the school children about their aims and aspirations and potential future ewmployment

Stand was voted the best in show and we have been asked to return next year, with a bigger interactive stand
Year(s) Of Engagement Activity 2014