Dissecting the molecular mechanisms by which Bmp8b increases thermogenesis in brown adipose tissue.

Lead Research Organisation: University of Cambridge
Department Name: Institute of Metabolic Science

Abstract

Brown adipose tissue (BAT) is a unique tissue in that whilst it resembles traditional white adipose tissue in some ways it exists to burn fat rather than store it. Evolutionarily, BAT emerged as a way of generating heat to defend body temperature in cold conditions and order to perform this role it developed a number of specialized characteristics. BAT is heavily under the control of the sympathetic nervous system (SNS), to the degree that every single brown adipocyte receives neuronal input. This is so that the tissue can respond quickly to environmental demand, increasing mitochondrial content, mobilizing stored fat and oxidising large amounts of it to generate heat. To meet the demand placed on it BAT can expand in mass incredibly quickly, doubling in size and generating new nerves and blood vessels to supply it with the nutrients and control it requires. How all of these processes are activated, regulated and maintained is not understood but the mechanisms may be relevant to the regeneration of a range of tissues, for example veins, nerves and even liver.

We have discovered a molecule that is secreted into and around active BAT, which believe plays a crucial role in a number of processes. Our preliminary evidence suggests that bone morphogenetic protein 8b (BMP8b) is able to increase BAT sensitivity to activation by the SNS whilst directly regulating the growth of neurons and vascular cells. In addition, we have reason to believe that BMP8b also acts at a central level, regulating pathways in the brain that respond to environmental and dietary changes in order to increase SNS activation of BAT at the periphery. Understanding how a secreted molecule can elicit such specific effects in diverse cell types is likely to uncover new molecular pathways that co-ordinate the remodeling of mature tissues and their metabolic activity. It is also likely to lead to the generation of new targets for drug development in a range of diseases, even those mediated by aberrant sympathetic nervous system activity.

The potential benefits that may come from understanding the functions of BMP8b are not just extremely interesting from a molecular biology perspective. Recent studies have shown unequivocally that adult humans possess substantial quantities of brown fat. It may be that endogenous mechanisms such as Bmp8b exist in humans for activating BAT and increasing energy expenditure. In the face of a widening obesity epidemic, the ability to redress the positive energy balance that causes the disease would be extremely desirable.

Technical Summary

Brown adipose tissue is unique in its high oxidative capacity, mitochondrial content, sympathetic innervation and finally its ability to undergo rapid hyperplasia. The mechanisms regulating all of these processes, in a manner which coordinates multiple cell types are largely unknown in the mature organism. Bone morphogenetic proteins (BMPs) have been characterised as developmental factors that control cell differentiation and tissue organisation in embryogenesis. Bmp8b has two important features, distinct from other BMPs acting in adipose tissue. First, it is highly cold-inducible and second, it is expressed principally in mature brown adipocytes. Our preliminary data indicate that BMP8b is induced by cold in both classical brown and white depots in proportion to their capacity to form brown adipocytes. Mice over-expressing Bmp8b have increased thermogenic genes in subcutaneous WAT and levels of Bmp8b in vivo correlate with levels of neurogenic and angiogenic markers. Also, neuronal cells cultured ex vivo display increased growth and survival when treated with Bmp8b, suggesting BMP8b drives at least 2 of the three major processes (adipogenesis, neurogenesis and angiogenesis) involved in brown adipose tissue remodeling in response to cold. Through these processes and potentially also via its central actions, Bmp8b is able to regulate global energy balance, whereby Bmp8b -/- mice are susceptible to obesity.

We aim to dissect the mechanism of action of Bmp8b by examining transctriptomic alterations in BAT and WAT of in vivo in models with altered Bmp8b expression levels. Combined with proteomic analysis in cell models in vitro we aim to identify the specific signaling pathways through which Bmp8b regulates adipocytes, neurons and endothelial cells. We will also use virally mediated, nuclei-specific manipulation of Bmp8b in the brain to assess the relative contribution of central and peripheral Bmp8b to energy balance and again aim to identify its mode of action.

Planned Impact

Medicine and Pharmaceutical Industry: Agonists of adrenergic receptors have been used successfully in the past to increase energy expenditure and treat metabolic disorders, however a lack of specificity has resulted in detrimental cardiovascular effects and the ultimate withdrawal of these drugs. Bmp8b represents a molecule that appears to act downstream of adrenergic receptors, opening up a novel molecular target (once the mechanism is better defined) for modulating the sympathetic nervous system sensitivity of specific tissues. Obviously, the role of Bmp8b in energy balance shown in our previous data makes it an attractive mechanism by which to examine the activation of human BAT, for the treatment of obesity. We already have strong links with UK based pharma companies as outlined in our proposal and as such our work could culminate in the generation of products which were of economic benefit to the UK as well as a health benefit to UK citizens.

Farmers: The ability to manipulate endogenous pathways that regulate energy balance may enable farmers to improve efficiency in terms of meat/dairy production offset to feed costs. In addition, the ability to enhance thermogenesis may improve survival and welfare in species reared outdoors in cold climates. In an increasingly competitive and highly subsidised industry, such advances would provide a economic benefit to the UK economy.

Food industry: Understanding how nutritional signals are integrated at a central level with activation/suppression of thermogenesis in BAT is likely to suggest dietary approaches to maintaining elevated energy expenditure in BAT. This is likely to be attractive to the "functional food" producers such as those making existing products enriched in omega3 fatty acids. Such products might offer a low-cost way to improve health and well-being in the UK without investment from central government. At the same time the products may themselves represent an economic benefit to the UK

Public health education: Our research could provide scientific background for public education on environmental and dietary stimulation of BAT to improve resistance to diet induced obesity. This could represent a significant benefit to public health and wellbeing.

The timescale for impact on most of the above is realistically in the order of 5-8 years for maximal effectiveness. However in the meantime the project will provide technological advances in real-time on an annual basis and provide a post-doctoral researcher (AW) with the skill necessary to advance his career to the young investigator stage. These skill would also be transferable to the private sector/pharma industry.

Publications

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Bauzá-Thorbrügge M (2019) GPER and ERa mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism. in The Journal of steroid biochemistry and molecular biology

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Carobbio S (2013) Adipogenesis: new insights into brown adipose tissue differentiation. in Journal of molecular endocrinology

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Carobbio S (2017) Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome. in Advances in experimental medicine and biology

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Carobbio S (2018) 'Basic and Applied Thermogenesis Research' Bridging the Gap. in Trends in endocrinology and metabolism: TEM

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Carobbio S (2019) Brown and beige fat: From molecules to physiology and pathophysiology. in Biochimica et biophysica acta. Molecular and cell biology of lipids

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Clemente FJ (2014) A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. in American journal of human genetics

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Huang-Doran I (2017) Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. in Trends in endocrinology and metabolism: TEM

 
Title Development of new webb for the TVP lab 
Description tvp.mrl.ims.cam.ac.uk/ 
Type Of Art Creative Writing 
Year Produced 2013 
Impact Much broader reach attracting more visitors 
URL http://www.tvp.mrl.ims.cam.ac.uk/
 
Title TVPLAB twitter 
Description Use of Social Media TVPLAB TWITTER https://twitter.com/tvplab?lang=en-gb 
Type Of Art Creative Writing 
Year Produced 2015 
Impact Creative tool to communicate our science to public 
URL https://twitter.com/tvplab?lang=en-gb
 
Description We have learned about the role of BMP8b in adipose tissue contributing to control the adipose tissue function and remodelling. In adipose tissue BMP8b has a dual role. On one hand BMP8b contributes to thermogenesis through the direct action in the adipocyte to increase the sensitivity to adrenergic stimulation. This is important because the thermogenic activity of the adipose tissue requires less activation of the sympathetic tone to exert this effect. As the sympathetic tone also result in deleterious effects at the level of blood pressure and heart rate, the sensitising effect of BMP8b results in less requirement of adrenergic stimulation and potentially improved or ameliorated side effects.

The other key observation is that BMP8b also contributes to the chronic remodelation of the beige adipose tissue by promoting the increase in vascularisation and innervation required for adipose tissue activation. The importance of this observation also is that we show that the adipocyte ad the needs imposed on it is a key determinant signalling and titrating the response of innervation and vascularisation to the functional needs of the adipose tissue. Also this research showed the concept of dormant cells differentiated to be beige cell but remaining in a dormant state waiting for the right moment to be activated when exposed to either cold or high fat diet. This opens opportunities to understand concept of programming of beiging of adipose tissue and the possibility that this may have memory.

Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue.
Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Horton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal-Puig A.
Nat Commun. 2018 Nov 26;9(1):4974. doi: 10.1038/s41467-018-07453-x.
PMID: 30478315 Free PMC Article

The project of BMP8b has evolved towards the relevance of BMP8b on the development of inflammation in fatty liver. We have a paper just accepted in Nature Metabolism highlighting the role of the inducibility of BMP8b in liver as a factor that physiologically contributes to the healing of the liver but that when continuously induced due to sustain damage contributes to sustained inflammation and exacerbated liver damage.

This awards has been also contributing to our research identifying molecular regulators of brown fat ( e.g. Thyroid hormone, Oestrogen receptor), teh contribution of specific types of fatty acids of different chain lenght (link with ELovl6), or nutrients such as Polyphenols. Simimilarly we have defined molecualr pathways regulated by lipids contributing to mitochondria activty and thermogenesis. We also idetified inactivators of brown fat such as LR11, which are potentially important to prevent excessive energy dissipation contributing patholies such as anorexia or cancer cachexia treatment.

I think this award was important for my laboratory to obtain a position of leadership in the field at international level. Also has contributed to create opinion through reviews and conferences. Finally I think the benefit to the development of the PhD students and postdocs has been important..
Exploitation Route This information is essential to consider BAT a potential therapy for obesity in the context of expanding or activating BAT. Also the knowledge generated has helped us to secure funding through ERC senbior investigator to focus on the role of human Pluripotent stem cells to differentiate into human brown fat cells and also to obtan funding from IMI Litmus project to continue work on fatty liver. Also the knowledge obtained suggests that BMP8b may also contribute to apsects of liver cancer. This is an area that will be followed by one of the Post docs when applying for his career development fellowship.

BONE MORPHOGENETIC PROTEIN 8B (BMP8B) TUNES TGFß/BMP SIGNALLING IN LIVER DISEASE CONTRIBUTING TO NON-ALCOHOLIC STEATOHEPATITIS.
Vacca et al. Nature Metabolism 2020 (in press)
Sectors Creative Economy,Healthcare,Pharmaceuticals and Medical Biotechnology

URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description Editorial Activity
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact • Editorial Advisory Board: PLoS Biol (2009-) • Editorial Board Memberships: PLoS Biology (2007-), Biochemical Journal (2008-2012), Diabetes (2012-) Trends Endocrinology and Metabolism (2008-), Biochim Biophys Acta.(2012-).Guest Editor (with RH Unger) of Special issue on lipotoxicity. Biochim Biophys Acta. 2010 Mar;1801(3):207-8.
 
Description Organisation of conferences/Courses
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact It is expected these training schemes have contributed to better care and scientifc developments. Member of the Scientific Organising Committee 1. Cambridge, United Kingdom. 30th June - 2nd July 2015. EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 2. Boston, USA. 5th - 9th June 2015. ADA Scientific Sessions Insulin Action/Molecular Metabolism. 3. Colorado, USA. 9th - 13th February 2015. Keystone Symposia - Systems Biology of Lipid Metabolism. 4. Madrid, Spain. 7th - 8th November 2014. CNIC Conference "Energy homeostasis and metabolic disease". 5. Madrid, Spain. 7th-8th November 2014. Energy homeostasis and metabolic disease. CNIC. 6. Cambridge, UK. 30th September 2014. 14th Annual Cambridge Immunology Forum Meeting. • Member of the Scientific Organising Committee Keystone meeting on Nuclear receptors. (http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=1235?Tab=travel) Austria (2013) • Member of the Scientific Organising Committee 15th European Congress of Endocrinology 27th April - 1st May 2013. Copenhagen, Denmark (http://www.ece2013.org/committees.aspx) • Director of The European Atherosclerosis Society Advanced Course IV: Murine Genetics and Cardiometabolic Phenotyping 11th - 14th July 2012. Cambridge, United Kingdom (http://www.eas-society.org/advanced-course-iv,-cambridge.aspx • Member of the Organising Scientific Committee of The Royal Society and Academy of Medical Sciences symposium on "Brown adipose tissue: a new human organ?" London (2012) (http://www.physoc.org/me2012) • Member of the Organising Scientific Committee The Obese Species Workshop Sicily, Italy. 21st - 26th October (2011) http://theobesespecies.unipr.it/. • Member of the Organising Scientific Committee for the meeting of the EAS in Hamburg. Germany (2010) • Member of the Organising Scientific Committee of the 49th International Conference on the Bioscience of Lipids. Maastrich (2008)
 
Description SAB scientific Advisory boards
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Evidence of international standing • MRC College of experts (1/10/2004-30/09/2008). • MRC Physiological Systems and Clinical Sciences Board (1/10/2004-30/09/08). • MRC Funding Schemes: Survey panel (2003-2004). • International scientific advisor Spanish Research Council, Metabolism and Nutrition Node (2003-2008). • Member of the Editorial Board of PLoS Biology, Diabetes, Biochemical Journal and Trends Endocrinology and Metabolism. • Member of PLoS Biology Advisory Board (2010-) • EAS 2010 Scientific Committee • EAS Election Committee Member • Member of the Diabetes UK Research Committee • International Scientific Committee of CIBERDEM • FP7 FLORINASH Scientific Advisory Board • Committee for Severo Ochoa Research Excellence Awards of Spanish Ministry of Innovation. • IDIBAPS Scientific Advisory Board (2012-) • EASO Scientific Advisory Board (2013-) • Member of Wellcome Trust Strategic Award [Biological determinants of ageing and late life health, and their pharmacological manipulation] Scientific Advisory Board (2013-)-) • Scientific Advisory Board of Institut d'Investigacions Biomèdiques de Girona (IDIBGI) (2013-)
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description • ERC award panel LS4 2017
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact • ERC award panel LS4 2017 Physiological sciences .
 
Description ERC Senior award
Amount € 2,500,000 (EUR)
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 01/2016 
End 12/2020
 
Description ERC senior investigator
Amount € 2,500,000 (EUR)
Funding ID StemBAT 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 01/2015 
End 12/2020
 
Description FP7 IMI Litmus "Liver Investigation: Testing Marker Utility in Steatohepatitis" (15M euro investment of EU and >15M by EFPIA). 2017-2021. £650,000
Amount € 15,000,000 (EUR)
Funding ID FP7 IMI Litmus "Liver Investigation: Testing Marker Utility in Steatohepatitis 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2017 
End 12/2021
 
Description NIH RO1
Amount $3,000,000 (USD)
Funding ID R01DK107786 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2017 
End 06/2021
 
Description The William Harvey International Translational Research Academy (WHRI-ACADEMY) -
Amount € 46,500 (EUR)
Funding ID 2017 Oct - 2018 Dec (15 month), 
Organisation Marie Curie 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 12/2018
 
Title 3D Culture of Stem cells 
Description 3D tissue culture system to study cross talk between stem cells 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Improvement in quality of results by better mimicking in vivo intercellular interactions. 
 
Title Development of methodology for microarray and lipidomic analysis 
Description We have contributed to develop methods for lipid analysis 
Type Of Material Technology assay or reagent 
Year Produced 2007 
Provided To Others? Yes  
Impact 1) Oresic M, H?nninen VA, Vidal-Puig A.Lipidomics: a new window to biomedical frontiers.Trends Biotechnol. 2008 Dec;26(12):647-52. Epub 2008 Oct 23PMID: 18951641 2)Tang J, Tan CY, Oresic M, Vidal-Puig A. Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med. 2009 Mar 30;1(3):35. [Epub ahead of print] PMID: 19341506 3) Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M. Informatics and computational strategies for the study of lipids.Mol Biosyst. 2008 Feb;4(2):121-7. Epub 2007 Dec 18. Review. 4).Oresic M, Vidal-Puig A, H?nninen V.Metabolomic approaches to phenotype characterization and applications to complex diseases.Expert Rev Mol Diagn. 2006 Jul;6(4):575-85. Review. 
URL http://europepmc.org/abstract/MED/18951641
 
Title Development of the Phenomics center 
Description Development of three core facilities, a) Murine phenotyping, b) Murine Biochemistry and c) Murine Histopathology 
Type Of Material Improvements to research infrastructure 
Year Produced 2006 
Provided To Others? Yes  
Impact Development of MRC CORD murine metabolic programme Development and expansion vreating the Cambridge Phenomics centre. 
 
Title Differentiation of ES cells 
Description Protocols do differentiation of Human PSC to brown, white and macrophage phenotype 
Type Of Material Cell line 
Provided To Others? No  
Impact Competitiveness in our research and funding acquisition e.g. ERC grant 
 
Title Hyperinsulinaemic clamps using non stable isotopes 
Description A more accurate and refined methodology to assess tissue specific insulin resistance 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2015 
Provided To Others? Yes  
Impact Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27. PMID: 26508640 Free PMC Article Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ.Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9. PMID: 25865886 Free PMC Article 
 
Title Mass Spectrometry to analyse lipids 
Description Refined technology to measure lipid composition. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2015 
Provided To Others? Yes  
Impact 1. Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. 2. Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25. 3. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. 
 
Title Microarray/lipidomic data bases 
Description Microarray and lipidomic data form in vivo experiments using animal models 
Type Of Material Biological samples 
Year Produced 2007 
Provided To Others? Yes  
Impact This material has been utilised by other EU groups focused in modelling and development of tools for nutritional research 
 
Title Phenotyping of mice; Maximal thermogenic activity 
Description Protocol tomeasure maximal thermogenic capacity 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2013 
Provided To Others? Yes  
Impact Contribution to increase accuracy of murine sudies allowing refinment, and reduction of animals 
 
Title Tools for data quatification 
Description LEM-PCR: a method for determining relative transcript isoform proportions using real-time PCR without a standard curve.Virtue S, Dale M, Sethi JK, Vidal-Puig A. Genome. 2010 Aug;53(8):637-42. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2010 
Provided To Others? Yes  
Impact Improved accuracy of data analysis 
 
Title b) Design a unique in house system for energy balance measurement. 
Description This is a new cageingsystem for metabolicphenotyping for simultaneous assessment of food inatke, energy expnditure, activity, water consumption. The equipment incorporates novel features such as having food delivery system hook to the cover of the cage. Also this is system is adapted to the cages where are normally hold which prevents measurement artifacts derived from changes in the cages when performing metabolic measurements. The new developed system to assess energy balance is a refinement because we can measure more accurately in each experiment. The addition of a 24h camera system with Visual Sonics software enables us to have secure systems to observe without disturbing measurements. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Reduction and refinement of experiments using murine models 
 
Title metabolic Cages 
Description In collaboration with Ideas Studio, we have designed new metabolic cages (SMS cages) that monitor movement, food preference and consumption, water consumption. This caging system is set for calorimetry and has its own lighting and a camera attached so the animals can be checked without having to enter the room. This equipment represents a refinement compared to the previously used CLAM system from Columbus. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact This caging system is set for calorimetry and has its own lighting and a camera attached so the animals can be checked without having to enter the room. This equipment represents a refinement compared to the previously used CLAM system from Columbus. 
 
Title Modelst for maximal termogenic capacity evaluation 
Description This is a novel technology to evaluate maximal capacity of energy expenditure and is the best method to evaluate defects in energy expenditure leading to obesity. 
Type Of Material Data analysis technique 
Year Produced 2015 
Provided To Others? Yes  
Impact Contributed to make research results reproducible and also contributes to 3R, 
 
Title Tissue bank from mice undergoing physiological challenges and specific genetic modifications 
Description This tissues and their RNA are being used for quick validation of metabolic relevance of genes identified by genomic approaches. This resourcedecreases the need of experimental groups of animals 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact identification of interesting candidate genes for metabolic disease prioritising murine work 1. Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366. 2. Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25. 3. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. 4. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.* Corresponding Author 5. Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112. Epub 2015 Oct 27 6. Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. 7. Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM. Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. Diabetologia. 2015 Jul 23. 
 
Description FAtty Liver 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Murine studies to identify NASH biomarkers and molecular mechanisms of disease
Collaborator Contribution Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship
Impact Funding 2020 Epoos and IMIM Litmus Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 2.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 3.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles
Start Year 2016
 
Description FAtty Liver 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Murine studies to identify NASH biomarkers and molecular mechanisms of disease
Collaborator Contribution Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship
Impact Funding 2020 Epoos and IMIM Litmus Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 2.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 3.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles
Start Year 2016
 
Description Plasticell: "In vivo activation of brown adipose tissue by plant-derived natural extracts", Innovation 
Organisation Plasticell Ltd
Country United Kingdom 
Sector Private 
PI Contribution Knowledge on mouse murine phenotyping
Collaborator Contribution Technology in conbinatorial optimisation of Stem cell differentiation.
Impact Multidisciplinary combining our unique expertise
Start Year 2017
 
Description Stem Cell Biology Valencia 
Organisation King Abdullah University of Science and Technology (KAUST)
Country Saudi Arabia 
Sector Academic/University 
PI Contribution Genetic engineering of human pluripotent stem cells
Collaborator Contribution Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Genetic engineering of Cells
Impact Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article
Start Year 2017
 
Description Stem Cell Biology Valencia 
Organisation Linkoping University
Department Regenerative Medicine
Country Sweden 
Sector Academic/University 
PI Contribution Genetic engineering of human pluripotent stem cells
Collaborator Contribution Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Genetic engineering of Cells
Impact Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article
Start Year 2017
 
Description Stem Cell Biology Valencia 
Organisation Microsoft Research
Department Microsoft Research Cambridge
Country United Kingdom 
Sector Private 
PI Contribution Genetic engineering of human pluripotent stem cells
Collaborator Contribution Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Genetic engineering of Cells
Impact Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article
Start Year 2017
 
Description Univerisdad de Barcelona- 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution Provide genetically modified murine models and technological support for phenotyping
Collaborator Contribution Specific knowledge in the analysis of CPT1 mutants. This is a very specific type of specialised knowledge that provides us with competitive advantage
Impact 1. P465L-PPAR? mutation confers partial resistance to the hypolipidaemic action of fibrates. Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. Epub 2018 Jun 27. PMID: 29790245 Free PMC Article Similar articles Select item 26584636 Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. PMID: 26584636 Free PMC Article Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article Trends Pharmacol Sci. 2013 Jun;34(6):347-55. doi: 10.1016/j.tips.2013.04.004. Epub 2013 May 3. Pharmacological strategies for targeting BAT thermogenesis. Whittle A1, Relat-Pardo J, Vidal-Puig A.
Start Year 2018
 
Description Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming.

PhD programme related to the German Centre of Cancer where I serve as SAAB
Year(s) Of Engagement Activity 2019
URL https://ampro.helmholtz-muenchen.de/news-events/past-events/ampro-summer-school-2019/index.html
 
Description 12th National Congress of the Spanish Society for the Study of Obesity. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 12th National Congress of the Spanish Society for the Study of Obesity.
Year(s) Of Engagement Activity 2015
 
Description Barcelona, Spain. 24th-27th May 2017. EMBO workshop meeting on BAT. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Barcelona, Spain. 24th-27th May 2017. EMBO workshop meeting on BAT. Conference lecturer
Year(s) Of Engagement Activity 2017
URL http://meetings.embo.org/event/17-brown-fat
 
Description Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Bilbao, Spain. 1st March 2017. Seminar at Biofisika, Basque Centre for Biophysics. Lecture. Networking with engineers.
Year(s) Of Engagement Activity 2017
URL http://biofisika.org/
 
Description Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. Lecture related to the role of Brown fat in metabolism.
Year(s) Of Engagement Activity 2018
URL https://www.evensi.us/adventures-metabolism-symposium-celebrate-jeffrey-flier-70th-birthday/25406324...
 
Description Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dusseldorf, Germany. 10th October 2017. Universitäts Klinikum Lecture Series - CRC1116 "master switches after myocardial infarction"
Year(s) Of Engagement Activity 2017
URL http://www.irtg1902.hhu.de/schedule/schedule-single-view.html?tx_cal_controller%5Bgetdate%5D=2017101...
 
Description EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact EAS Advanced in Cardiometabolic Phenotyping in Rodents, Cambridge, UK

Scientists from the University of Cambridge Biomedical Campus recently hosted the 2nd EAS Advanced Course in Cardiometabolic Phenotyping in Rodents. This 3-day course combines the state of the art facilities and expertise within the Disease Model Core at the WellcomeTrust-MRC Institute of Metabolic Science and the BHF Cardiovascular Centre. By integrating the expertise of these two specialized phenotyping centres, it provides a unique opportunity to learn about many of the skills required for in depth cardiometabolic phenotyping in small animals.

The 32 participants, selected from centres across Europe, were treated to a programme of lectures, phenotyping demonstrations and data analysis sessions. A further 1-day workshop at the Sanger/EBI focused on mouse genetics, genetic engineering and informatics resources, highlighting the great opportunities provided by recent advances in genetic engineering purpose-made mouse models. Participants particularly appreciated the mixture of hands-on experience, combined with opportunities to ask detailed questions on how the techniques demonstrated should be used to suit their own research priorities.

The course was sponsored by the European Atherosclerosis Society, British Heart Foundation and TSE systems, with organisation led by Prof Toni Vidal-Puig, Director of the MRC Metabolic Diseases Unit Disease Model Core.
Year(s) Of Engagement Activity 2015
URL http://tvp.mrl.ims.cam.ac.uk/events/
 
Description European Neuroendocrinology Society meeting in Vienna. . 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Sam Virtue recently presented at the prestigious European Neuroendocrinology Society meeting in Vienna. Sam's talk was focussed on metabolomics in endocrinology and was based on the past 9 years of experience in the TVP lab in the field of lipodomics. The purpose of the talk was to discuss how biologists without systems biology experience can work with groups specialising in the fields of metabolomics to design appropriate experiments and extract the maximum value from their data sets.

Dr Virtue has been invivted to give similar type of talk in other venues,
Year(s) Of Engagement Activity 2012
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Keystone Conference Lecture. Colorado, USA. 22nd - 27th January 2017.
Year(s) Of Engagement Activity 2017
URL http://healthdocbox.com/amp/69735120-Diabetes/Diabetes-january-22-26-2017-keystone-conference-center...
 
Description Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact . Colorado, USA. 22nd - 27th January 2017. Keystone Symposia on Diabetes/Obesity and Adipose Tissue Biology.
Year(s) Of Engagement Activity 2016
 
Description Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lisbon, Portugal. 11th-15th September 2017. 53rd EASD Annual Meeting. >150 attendants to symposium on Obesity associated metabolic complications.
Year(s) Of Engagement Activity 2017
URL https://d-net.idf.org/en/events/369-53rd-easd-annual-meeting-in-lisbon-portugal.html
 
Description London, UK. 24th April 2015. Royal Society of Medicine Symposium. Obesity: Epidemiology, complications and management. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This symposium provided a multidisciplinary forum for researchers and healthcare workers to discuss the most recent advances, trends and management challenges encountered in the field of obesity.

Throughout the day, delegates explored the opportunities and challenges faced by those involved in obesity medicine, together with the solutions that have currently been adopted.

The symposium aimed at all those working in the field or with an interest in obesity medicine, vascular risk medicine, PhD students, post-doctoral researchers, and clinicians of all medical specialties including medical students, foundation and core trainees, general practitioners, physicians and surgeons.
Year(s) Of Engagement Activity 2015
URL https://www.rsm.ac.uk/events/events-listing/2014-2015/sections/lipids,-metabolism-vascular-risk-sect...
 
Description Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Majorca, Spain. 16th October 2017. Seminar at Illes Balears Institute for Health Research. Research seminar. >80 attendees.
Year(s) Of Engagement Activity 2017
URL https://www.arabalears.cat/balears/Antonio-Vidal-Puig-nostres-estalviadors-lluitar_0_1892210855.html
 
Description Utah, USA. 17th - 22nd April 2015. Keystone Symposium - Beige and Brown Fat: Basic Biology and Novel Therapeutics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Beige and Brown Fat: Basic Biology and Novel Therapeutics (D5)
Organizer(s) Bruce M. Spiegelman and Sven Enerbäck
April 17-22, 2015
Snowbird Resort • Snowbird, Utah USA
The epidemic of obesity and diabetes has become a world-wide health risk. These metabolic disorders are a direct threat to the health and economic well-being of many nations. Unfortunately, education about diet and exercise are not sufficient to meet this emergency and new therapies are badly needed. Brown fat has emerged as one of the few genuinely new approaches to these problems. Brown fat exists in most or all adult humans and can dissipate caloric energy and improve both obesity and diabetes in experimental animals. This meeting will focus on new pathways controlling brown fat development and thermogenesis. We will delve into the types of brown fat cells, beige, classical brown and others. We will also put a special emphasis on emerging approaches, both biological and chemical, that can manipulate these cells for therapeutic purposes. It is our hope and belief that this meeting can nucleate expanded efforts in both academia and pharma to explore this promising research area. There has not been a Keystone Symposia conference dedicated to brown fat. While there has been a session here and there at the Obesity meeting, the science and the biomedical needs warrant this new and focused conference. Of course, this will also bridge the Obesity and Diabetes communities, and lead to pharma/academic collaborations.
Year(s) Of Engagement Activity 2015
URL http://www.keystonesymposia.org/15D5
 
Description Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Vienna, Austria. 2nd February 2018. Seminar at Vienna Biocenter. Lecture to postcs in this institute and meetings with specific students to discuss their projects
Year(s) Of Engagement Activity 2018
URL https://cluster.meduniwien.ac.at/index.php?id=3732&tx_ttnews%5Btt_news%5D=3280&tx_ttnews%5Bpointer%5...
 
Description . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact . London, UK. 11th January 2017. Seminar at the MRC Clinical Sciences Centre, Imperial College London.
Year(s) Of Engagement Activity 2016
 
Description 11/11/2014- www.teinteresa.es, Madrid Brown fat 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact La grasa marrón, clave en la lucha contra la obesidad
1456655859
11/11/2014- www.teinteresa.es, Madrid

Las compañías farmacéuticas están invirtiendo en la investigación para desarrollar un método para convertir la grasa blanca en grasa marrón.
Modificaciones de la flora bacteriana han podido ayudar a reducir la obesidad en animales, y podría aportar soluciones a la obesidad humana
Year(s) Of Engagement Activity 2014
URL http://www.teinteresa.es/salud/grasa-marron-clave-lucha-obesidad_0_1246676023.html
 
Description 15th European Congress of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 15th European Congress of Endocrinology, Copenhagen, Denmark. 27th April - 1st May 2013.

As organiser of the conference we contributed to the impact on 3000 attendees.
Year(s) Of Engagement Activity 2013
URL http://www.ece2013.org/
 
Description 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK).
Year(s) Of Engagement Activity 2018
URL https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-...
 
Description 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research"

Global forum related to Ageing from a socio scientific and multicultural perspective. Open to lay public and highly advertised.
Year(s) Of Engagement Activity 2019
URL https://www.longevityworldforum.com/tag/aging-2/
 
Description 6. Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease.

Conference at Keystone related to lipidomic analysis in the context of lipotoxicity
Year(s) Of Engagement Activity 2019
URL https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1595
 
Description 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'.
Year(s) Of Engagement Activity 2018
URL https://bscr.org/event/bscr-autumn-meeting-2018-inflammation-and-repair/
 
Description Advisory Board Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact EASO Scientific Advisory Board Meeting
18th - 19th March 2013, Brussels


redefinitionn of obesity on the baseis of body composition. BMI considered obsolete.
Year(s) Of Engagement Activity 2013
 
Description Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia. This was a conference organised by Biochemical Society where I gave the closing lecture as part of being awardee of the Sir Philip Randle Lecture, Biochemical Society
Year(s) Of Engagement Activity 2019
URL https://biochemistry.org/grants-and-awards/awards/the-sir-philip-randle-lecture/
 
Description Antalya, Turkey. 23rd-26th October 2014. Endobridge. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ENDOBRIDGE 2014, 2nd EndoBridge Meeting is one of the extensive event on Pituitary Disease, Thyroid Disorders, Obesity, Endocrinology, Endocrine, Medical, Hormone Research, Hormonal Systems, Ageing, Bone And Osteoporosis, Diabetes, Hormones, Paediatric Endocrinology, Puberty, Steroids and Testosterone segments.
2nd EndoBridge Meeting is organized annually.
Year(s) Of Engagement Activity 2014
URL http://eventegg.com/endobridge-2014/
 
Description Award Lecture in Boston, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Health professionals
Results and Impact 22nd Pat Usher Memorial Award Lecture, Harvard Medical School, Boston, USA. 18th January 2013.

-
Year(s) Of Engagement Activity 2013
 
Description BAT in Granada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Interested in Brown Adipose Tissue? Can't miss this Symposium! https://finut-en.congressus.es/symposiumbat/index @ibsGRANADA @CIBER_OBN @TVPLab @FIBAO @CanalUGR @finutibero
Year(s) Of Engagement Activity 2018
URL https://twitter.com/ruizruizjonatan/status/1024216467729010688?s=12
 
Description Barcelona, Spain. 24th-25th November 2017. AstraZeneca - Diabetter: The implications of the adipocyte in T2D 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Barcelona, Spain. 24th-25th November 2017. AstraZeneca - Diabetter: The implications of the adipocyte in T2D. Symposia organised by Astra Zeneca addressed to Spanish Endocrinologists
Year(s) Of Engagement Activity 2017
 
Description Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life.
Year(s) Of Engagement Activity 2018
URL https://www.basellife.org/basel-life-2018.html
 
Description Blog 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Fighting fat with fat
Obesity is one of the most important biomedical problems in our society and also one of the most frustrating to tackle. For this reason, the recent identification of functional brown fat in adult humans has made the obesity research community very excited. Read more here.

Sanger Institute Blog by Dr Stefania Carobbio

Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Blog BAT 2 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blog from Sanger wich bord reach where we presented our research on brown fat

From clinical studies and animal models, scientists have noticed that some obese individuals can maintain a remarkable capacity to store fat before experiencing adverse metabolic effects associated with obesity, such as insulin resistance and Type 2 diabetes. It seems that the adipose tissue of these people has developed adaptive mechanisms that allow it to preserve its functionality while adjusting its biochemical features to maintain its biophysical characteristics. Read more here.

Blog by
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events
 
Description CNN interview about LR11 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact New protein could help burn fat faster
By Meera Senthilingam, for CNN
Updated 1109 GMT (1909 HKT) February 1, 2016
(CNN)-Research has shown that the fatter your body becomes, the harder it becomes to burn that excess fat.
As people eat more fat than they burn, the body stores this excess in various parts of the body and as this storage increases, metabolism changes.

However, all is not lost: a recent study by researchers at the University of Cambridge identified one of the proteins underlying this blockage of fat burn. "[This protein] is part of the system in place to help the body store more energy," says Antonio Vidal-Puig, Professor in Molecular Nutrition and Metabolism, who worked on the study.

The culprit, called sLR11, was found to block the functioning of brown fat cells -- responsible for generating heat to keep us warm -- and instead help the body store fat more efficiently by preventing excessive heat generation.


The benefits of brown fat








There are two forms of fat cells -- brown cells and white cells -- and each plays a different role in our metabolism.



While brown cells help generate heat, the white cells are responsible for the storage of fat -- or energy -- ready for release as needed. Levels of brown fat are known to be high in children but recent findings showing the presence of brown fat in adults, restored hope to use them as targets to treat obesity.



According to Vidal-Puig, obese people have less brown fat than lean people -- and the same applies for diabetics. "If you can increase the brown fat in obese and diabetic people then you can improve their situation," says Vidal-Puig. This has been known for some time, but making it a reality has been a challenge.

The newly discovered sLR11 protein could provide the answer.


Removing the brakes


Vidal-Puig compares the protein to the brake of a car, stopping the body from accelerating its production of heat. "Obese people have more of these brakes, preventing them from creating heat and therefore losing fat," says Vidal-Puig who has seen elevated levels of the protein in the blood of obese people included in his study.

During the study, the team removed the gene producing this protein in mice and found they were able to burn calories faster.

The researchers went on to examine the protein in humans and found that levels of the protein correlated with the total fat mass in a person. What's more, investigated levels in obese patients after they underwent bariatric surgery, and their weight loss was directly proportional to the decrease in levels of the sLR11 protein.

"[Brown fat cells] are an attractive therapeutic target for weight loss, and for anti-obesity or anti-type 2 Diabetes (T2D) therapies," says Carole Sztalryd, Associate Professor of Medicine at the University of Maryland School of Medicine. Sztalryd's team also work on biological approaches to weight loss.


More brown than white on the cards


A common focus to tackle obesity has been on accelerating the production of brown fat cells so people burn more calories, but this new insight could achieve the same but through enhancing the activity -- and efficiency -- of cells. "We are stopping the brakes within the fat cells," says Vidal-Puig, as the mice in his study became protected from obesity with increased browning of their white fat cells.

The team believe controlling energy storage will be a better approach to beat the obesity epidemic than controlling people's eating habits.

But Sztalryd warns that additional studies are required to evaluate any clinical relevance,"New therapies are urgently needed for obesity. sLR11 seems promising but more work is needed to confirm if this is a relevant," she says.

In the mean time, old tactics may be the answer and the more weight gained, the more exercise to be done.
Year(s) Of Engagement Activity 2015
URL http://edition.cnn.com/2016/02/01/health/new-protein-fat-burn-feat/
 
Description Cambridge Metabolic Network/Danish Diabetes Association Course for PhD Students. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Course sponsored by NOVO foundation from Denmark, 35 PhD students from Cambridge and Denmark.
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/events/lipid-metabolism-new-methods-and-translational-aspects
 
Description Cherry Hinton Lions Under 10s Blue Football Club sponsored by IMS/TVP lab 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This is an action to promote fitness in children as a strategy to prevent orreverse obesity

Children know what is the IMS and that obesity and diabetes can be prevented by exercise.
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Communicating related to impact of our research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact News about our papers were disseminated through BBC radio, and TV ( BBC look East). Also through multiple webs and also reached internationally through links with European commision.

These media are supposed to reach out to the general public.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description DAILy MAIL ON LR11 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Why the bigger you are, the HARDER it is to lose weight: Stored fat 'fights against the body's attempts to shed the pounds'
Fat cells produce the protein sLR11 which inhibits thermogenesis
This is a process by which fat cells burn calories for energy
The more fat a person has, the more protein will be produced and the less calories burned, preventing weight loss
Experts: Finding could help treat conditions such as obesity and diabetes
By Madlen Davies for MailOnline
Published: 17:04, 24 November 2015 | Updated: 17:57, 24 November 2015
Read more: http://www.dailymail.co.uk/health/article-3331892/Why-bigger-harder-lose-weight-Stored-fat-fights-against-body-s-attempts-shed-pounds.html#ixzz41SHV7aRj
Follow us: @MailOnline on Twitter | DailyMail on Facebook
Year(s) Of Engagement Activity 2015
URL http://www.dailymail.co.uk/health/article-3331892/Why-bigger-harder-lose-weight-Stored-fat-fights-ag...
 
Description Europe press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This was an interview for Europe press news agency which has a huge diseminattion capacity. Some examples below.

http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig

http://www.europapress.es/chance/elbuenvivir/noticia-10-obesos-son-saludables-20111128124545.html

http://www.europapress.es/chance/noticias.aspx?buscar=Cambridge

http://www.enfermeriapalencia.com/modules.php?name=Noticias_enfermeras

Highewr visibility. Partients have contacted me through email with personal cases that have I have replayed so far but that if they continue to increase i may need to organise better through my web page. I am considering if i get resources to maintain in to include a page in my web for public questions and disemination.
Year(s) Of Engagement Activity 2011
URL http://www.europapress.es/chance/noticias.aspx?buscar=Antonio%2BVidal%2BPuig
 
Description GACETA MEDICA-Lilly 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gaceta Médica
Domingo, 28 de Febrero de 2016
Felipe Casanueva Freijo, presidente de la Sociedad Española para el Estudio de la Obesidad, y Manuel Puig-Domingo, presidente de la Sociedad Española de Endocrinología y Nutrición, entregaron al profesor Antonio Vidal Puig el "Premio Fundación Lilly a una Carrera Distinguida 2015" en la especialidad de Endocrinología, Nutrición y Obesidad por su contribución al conocimiento del tejido adiposo y el abordaje y prevención de la obesidad. Este galardón fue otorgado en el marco del Simposio Internacional 'Lo último en Obesidad'
Year(s) Of Engagement Activity 2016
URL http://www.gacetamedica.com/noticias-medicina/2015-12-04/en-10-minutos/premio-a-la-trayectoria-en-en...
 
Description Geneva, Switzerland. 23rd January 2018. Symposium: Neuroendocrine regulation of metabolism and dysfunctions in obesity/type 2 diabetes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Geneva, Switzerland. 23rd January 2018. Symposium: Neuroendocrine regulation of metabolism and dysfunctions in obesity/type 2 diabetes
Year(s) Of Engagement Activity 2018
URL http://www.unige.ch/medecine/diabetescentre/fr/actualites/sym/
 
Description Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Harrogate, United Kingdom. 6th-8th November 2017. Society for Endocrinology BES Conference. Lecture related to Medal award.
Year(s) Of Engagement Activity 2017
URL https://www.endocrinology.org/events/sfe-bes-conference/sfe-bes-2017/
 
Description Heidelberg, Germany. 16th - 17th October 2015. International Symposium On Diabetic Complications 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Heidelberg, Germany. 16th - 17th October 2015. International Symposium On Diabetic Complications
Event Description

HIDC 2015, 2th Heidelberg International Symposium on Diabetic Complications is going to be placed in between 16 October, 2015 and 17 October, 2015.

The Symposium place is going to be Heidelberg University Hospital.

HIDC 2015 is likely to be a stage where many notable themes are likely to be discoursed. Several of these are going to be Biology, Metabolic Diseases, Diabetes, Diabetes Research, Medical and Health Care.

2th Heidelberg International Symposium on Diabetic Complications is organized annually.
Year(s) Of Engagement Activity 2015
URL https://www.klinikum.uni-heidelberg.de/Welcome.138789.0.html
 
Description International Symposium: Latest in obesity Madrid, Spain. 1st - 2nd December 2015. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact http://www.fundacionareces.es/fundacionareces/cargarAplicacionAgendaEventos.do?idTipoEvento=1&identificador=1827?elAgenda=2
Along with obesity, diabetes is a true pandemic of the 21st century which carries a certain risk of other diseases such as cardiovascular diseases, or even cancer. It is purpose of this symposium to bring to our attention and knowledge the most recent advances on the disease and we hope to do so thanks to the remarkable roster of personalities who have accepted our invitation to share their knowledge and ideas in this INTERNATIONAL SCIENTIFIC SYMPOSIUM: LATEST IN OBESITY sponsored by the Fundación Ramón Areces and with the collaboration of the Fundación General CSIC.
Year(s) Of Engagement Activity 2015
URL http://www.fundacionareces.es/fundacionareces/cargarAplicacionAgendaEventos.do?idTipoEvento=1&identi...
 
Description Keystone Symposia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keystone Symposia - Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction. Alpbach, Austria, 3rd-8th April 2113.

Keystone Symposia - Systems Biologyof Lipid Metabolism (9th - 13th February 2015)
Colorado, USAOrganisers: Matej Orešic, Antonio Vidal-Puig, Ana Maria Cuervo

Increased applicants to the lab
Year(s) Of Engagement Activity 2013,2014
URL http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1235
 
Description LR11 in Asia 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact LR11 news disseminated in Asia
???LR11/SorLA?????????????????????BMI???????????
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
Year(s) Of Engagement Activity 2015
URL https://www.natureasia.com/ja-jp/ncomms/abstracts/71218
 
Description La obesidad está en el cerebro" Lilly Areces 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Más de 500 millones de personas en el mundo padecen obesidad.
Un simposio organizado por la Fundación Ramón Areces y la Fundación General del CSIC analiza las últimas investigaciones sobre este problema de salud pública.
Year(s) Of Engagement Activity 2015
URL http://hipertextual.com/2015/12/obesidad#
 
Description Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lisbon, Portugal. 21st-23rd May 2017. Aegerion ECE Symposium. This was a symposia with clear clinical translational implications addressed to practitioners that had implications on their practice.
Year(s) Of Engagement Activity 2017
URL http://www.ece2017.org/media/1123/ece-2017-satellite-programmes_280317.pdf
 
Description London, UK. 11th March 2015. Diabetes UK for the Adipose Plenary Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Diabetes UK Professional Conference, organized by the Diabetes UK will take place from 11th March to the 13th March 2015 at the Excel London in London, United Kingdom. The conference will cover areas like basic science, clinical science, education, clinical care management, healthcare delivery and psychological care.
Year(s) Of Engagement Activity 2015
URL http://10times.com/diabetes-uk-professional-conference
 
Description MUJER HOY Engorda La Calefaccion 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dos órganos distintos: Grasa blanca y grasa parda

1. La grasa blanca es el órgano donde se acumula el exceso de energía para que el organismo la utilice cuando la necesita. Los problemas ocurren cuando ese tejido adiposo blanco se satura y es incapaz de retener más grasa, con lo que esta empieza a acumularse en otros órganos, como el hígado o el músculo, produciendo diabetes, hígado graso y otros problemas de salud.

2. La grasa parda es un órgano diseñado para producir calor. Está presente en los recién nacidos porque son muy vulnerables frente al frío, y tienen que producir calor para mantener la temperatura corporal adecuada. Lo que se ha observado recientemente es que también la tienen algunos adultos. El equipo del profesor Vidal-Puig y otros están estudiando la posibilidad de desarrollar un fármaco capaz de estimular la producción de grasa parda. "El potencial es grande y la posibilidad de efectos secundarios, escasa", explica el experto.
Year(s) Of Engagement Activity 2013
URL http://www.mujerhoy.com/salud/consulta/engorda-calefaccion-714703022013.html
 
Description Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN)

This meeting brings all teh community of investigators on the field of obesity in Spain. It is an excellent place to identify talent.
Year(s) Of Engagement Activity 2019
URL https://www.ciberobn.es/en
 
Description Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact 9. Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology"

This was a high level scientific event organised by CSIC in Madrid attended predominantly by experts in endocrinology
Year(s) Of Engagement Activity 2019
URL https://eventos.uam.es/28633/detail/6th-symposium-on-biomedical-reserch-advances-and-perspectives-in...
 
Description Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Malaga, Spain. 19th - 21st October 2016. Congress of the Spanish Society of Endocrinology
Year(s) Of Engagement Activity 2016
 
Description Malaga, Spain. 20th-23rd March 2017. Danish Diabetes Academy Postdoc Winter School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact On March 19-24, 2017, a total of 99 Post Doc fellows, third-year PhD students and prominent national and international speakers attended Danish Diabetes Academy's 3rd Winter School in Malaga with focus on different aspects of prevention and treatment of diabetes as well as career development. Malaga, Spain. 20th-23rd March 2017. Danish Diabetes Academy Postdoc Winter School. .
Year(s) Of Engagement Activity 2017
URL https://www.danishdiabetesacademy.dk/node/1087
 
Description Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact TVP Lab members give presentations and posters at 1st ICAN conference series in Cardiometabolic Disease

Members of the TVP lab recently attended the 1st ICAN conference series in Cardiometabolic Disease in Paris. Vanessa Pellegrinelli was selected to give a presentation, and Camilla Ingvorsen, Guillaume Bidault, and Vivian Peirce were selected to present posters. Vivian Peirce was a joint-winner of Young Investigator poster award.



Projection of our lab
Year(s) Of Engagement Activity 2014
URL http://www.tvp.mrl.ims.cam.ac.uk/events/
 
Description Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Nanjing, China. 8th May 2017. Lecture at Nanjing Biomedical Research Institute. Talk at this institute in China in front of > 100 students.
Year(s) Of Engagement Activity 2017
 
Description Royal Swedish Academy of Sciences, Journal of Internal Medicine - Key Symposium "Metabolic complications of obesity" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Organisation of symposia with 150 attendants, 28 speakers from EU, USA, JAPAN, CHINA. Top symposium supported by the Swedish Academy of Sciences and the Journal of Internal Medicine.
Year(s) Of Engagement Activity 2017
URL http://www.mrl.ims.cam.ac.uk/event/metabolic-complications-obesity/
 
Description SCIENCEALERT ON LR11 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientists have figured out how your body fights your attempts to lose weight
Bummer.
DAVID NIELD
11 DEC 2015
For those of you who feel like your gym sessions aren't getting you anywhere near your target weight - scientists think they might have found a reason why. A new study has identified a protein that locks excess fat in our bodies, preventing it from being burned off easily.

And while it sucks to know that our bodies are fighting against our attempts to lose weight, the discovery could help to explain why overweight people find it so difficult to shed the additional pounds.
Year(s) Of Engagement Activity 2015
URL http://www.sciencealert.com/here-s-how-your-body-naturally-fights-your-attempts-to-lose-weight
 
Description Science News Study inMice suggests drug to turn fat brown could help fight obesity 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact https://www.sciencedaily.com/releases/2018/11/181126123416.htm
Study in mice suggests drug to turn fat 'brown' could help fight obesity
Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity.
Year(s) Of Engagement Activity 2018
URL https://www.sciencedaily.com/releases/2018/11/181126123416.htm
 
Description Suzhou, China. 1st - 5th June 2015. Cold Spring Harbor Asia (CSHA) Conference on Lipid Metabolism and Metabolic Disorders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The conference will include eight oral sessions and one poster session covering the latest findings across many topics in lipid metabolic. Many talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Alterations in lipid homeostasis play critical roles in the development of human metabolic disorders, such as obesity, type II diabetes and fatty liver. This meeting brings together world-leading experts to present and discuss latest developments in the study of lipid metabolism, as well as their implications for human health and disease. The conference will include eight oral sessions and one poster session. Additional oral presentations will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference will provide ample opportunities for scientific as well as informal interactions
Year(s) Of Engagement Activity 2015
URL https://www.csh-asia.org/2015meetings/Metabo.html
 
Description TECHTIMES 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Being Fat Makes It Harder To Lose Weight: Fatter People Produce More Protein That Inhibits Depletion Of Fat Cells
Fat people have a more difficult time of losing weight because of the increased production of a protein called sLR11. This inhibits the body's ability to burn calories and fats for heat production
Year(s) Of Engagement Activity 2015
URL http://www.techtimes.com/articles/110892/20151127/being-fat-makes-it-harder-to-lose-weight-fatter-pe...
 
Description Toulouse, France. 28th April 2017. Seminar at INSERM. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Toulouse, France. 28th April 2017. Seminar at INSERM. Dissemination of research outcomes to research commnity
Year(s) Of Engagement Activity 2017
URL https://www.stromalab.fr/actualites/pr-toni-vidal-puig-university-of-cambridge-uk/
 
Description URJC Summer University Programme: Obesity, Insulin Resistance, and Metabolic Syndrome. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact 5. Madrid, Spain. 9th-11th July 2015. URJC Summer University Programme: Obesity, Insulin Resistance, and Metabolic Syndrome.


Obesity, insulin resistance, diabetes and metabolic syndrome (Código UV-S-OBESI)

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Del 09-07-2015 al 11-07-2015

Salón de Grados, Campus de Madrid, Facultad de Ciencias Jurídicas y Sociales, Paseo de los Artilleros s/n


Organizado por Vicerrectorado de Extensión Universitaria

Teléfono de contacto: 914884762
Categorías:
Formación y docencia sanitaria

Investigación médica

Medicina general
Palabras clave:
Diabetes and metabolic syndrom...

Insulin resistance

Obesity
Year(s) Of Engagement Activity 2015
URL http://uverano.urjc.es/event_detail/2355/programme/obesity-insulin-resistance-diabetes-and-metabolic...
 
Description https://en.wikipedia.org/wiki/Antonio_Vidal-Puig 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://en.wikipedia.org/wiki/Antonio_Vidal-Puig
Year(s) Of Engagement Activity 2020
URL https://en.wikipedia.org/wiki/Antonio_Vidal-Puig
 
Description https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
November 27, 2018
Could this be a solution for the obesity crisis?
Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge
Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity?
Year(s) Of Engagement Activity 2018
URL https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283
 
Description newsweek thermogenesis 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html

In another area of Vidal-Puig's studies lies, potentially, an amazingly simple fix. In spite of all the millions spent on diets, food and exercise, it may be that something as basic as temperature is the answer. We all have two types of fat, white and brown. White fat is inert and sits in deposits. Brown fat, which regulates babies' temperatures but is much harder to pinpoint in adults, can be activated to burn calories and generate heat.

Studies show that exposure to low temperatures may encourage white fat to behave like brown fat. So while central heating ensures we move less and burn fewer calories, it's possible that lower temperatures might increase the activity of brown fat, which will burn our calories for us.
Year(s) Of Engagement Activity 2015
URL http://www.newsweek.com/2015/01/30/prepare-pill-make-you-thin-301250.html