Modelling hormonal crosstalk - commonalities between bacterial and fungal resistance and susceptibility networks.

Lead Research Organisation: UNIVERSITY OF EXETER
Department Name: Biosciences

Abstract

Australia
 
Description A role for a jasmonic acid repressor, JAZ7, in resistance to the wheat patohgen Fusarium.
Exploitation Route CSIRO are following up the JAZ7 story to understand the underlying mechanisms.
New publication now out - added above
Sectors Agriculture

Food and Drink
 
Description Understanding the mechanism of chloroplast immunity
Amount £510,096 (GBP)
Funding ID BB/P002560/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 03/2020
 
Title JAZ mRNAseq data 
Description mRNA-seq of JAZ5/10 mutant plants responding to Pseudomonas infection 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact First mRNA-seq of a double jaz mutant. First molecular insight into a virulence phenotype of jaz mutants. 
URL http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE72461
 
Title Pseudomonas- Arabidopsis time series microarray data 
Description Large scale time series microarray data capturing the plant defence response and the pathogen virulence strategy over 13 time-points using two-colour microarrays. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact Strong interest from the wider community - resulted in a number of imvitations to speak. However, most importantly was the basis for two key pieces of work. The disucovery that jasmonate signalling, contrary to the current dogma that it functioned early in plant-bacterial interactions, was a late response and the pathogenic outcome was dictated by ABA, with the JAZ repressors protecting the plant during early infection. Secondly, analyses of these data led to the discovery of chloroplast immunity. 
URL http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE56094
 
Description Structural elucidation 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution The travel award enabled the PI to meet ad initiate a collaboration with one of the world leading structural biologists in plant defence responses - Bostjan Kobe, who is an expert in on TIR domains
Collaborator Contribution We identified a novel set of effector activated genes containing TIR domains. This counter-intuitive finding led to development of a new hypothesis we have asked Prof. Kobe to collaborate on
Impact While not directly related to the work undertaken on the grant, the ability to work in an environment where Prof. Kobe was, meant I was familiar with his work and was able to meet more recently to discuss the possibilities of collaboration (March 2017). The project is multidisciplinary - we are currently in the process of developing the constructs to pursue this. This collaboration would not have happened had the PI not been at CSIRO in Brisbane on BBSRC travel monies.
Start Year 2017