Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it

Lead Research Organisation: University of Manchester
Department Name: Chemistry

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Adams B (2019) Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens. in Frontiers in aging neuroscience

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Bester J (2015) Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS). in Oncotarget

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Bezuidenhout J (2020) Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency in Frontiers in Immunology

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De Villiers S (2019) A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study. in Frontiers in neurology

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De Waal GM (2018) Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes Mellitus. in Scientific reports

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Esteve C (2017) Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model. in Biochimica et biophysica acta. Proteins and proteomics

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Goodacre R (2017) Commentary on "Goodacre R, Timmins ÉM, Rooney PJ, Rowland JJ, Kell DB: Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks. FEMS Microbiol Lett 1996; 140:233-239", the most cited paper in the Journal for that year in FEMS Microbiology Letters

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Grobbelaar LM (2021) SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. in Bioscience reports

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Kell D (2015) Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology. in F1000Research

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Kell D (2016) A Dormant Microbial Component in the Development of Pre-Eclampsia 1

 
Description Discovery of amyloid formation by clotting blood. Absolutely humungous discovery.

Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications.
Exploitation Route Novel diagnostics.
Sectors Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology