Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it

Lead Research Organisation: University of Manchester
Department Name: Chemistry

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
publication icon
Bester J (2015) Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS). in Oncotarget

publication icon
Esteve C (2017) Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model. in Biochimica et biophysica acta. Proteins and proteomics

publication icon
Goodacre R (2017) Commentary on "Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks". in FEMS microbiology letters

publication icon
Kell D (2015) Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology. in F1000Research

publication icon
Kell D (2016) A Dormant Microbial Component in the Development of Pre-Eclampsia

publication icon
Kell D (2016) To what extent are the terminal stages of sepsis, septic shock, SIRS, and multiple organ dysfunction syndrome actually driven by a prion/amyloid form of fibrin?

publication icon
Kell D (2015) Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology in F1000Research

publication icon
Kell DB (2015) On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death. in Integrative biology : quantitative biosciences from nano to macro

publication icon
Kell DB (2014) Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. in Metallomics : integrated biometal science

publication icon
Kell DB (2017) Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting. in Progress in biophysics and molecular biology

 
Description Discovery of amyloid formation by clotting blood. Absolutely humungous discovery.

Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications.
Exploitation Route Novel diagnostics.
Sectors Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology