Regulation of the fatty acid lipidome in ageing skin: a route towards novel anti-inflammatory products

Lead Research Organisation: Aston University
Department Name: Sch of Life and Health Sciences

Abstract

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Technical Summary

N/A

Planned Impact

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Publications

10 25 50
 
Description We have developed methods that are sufficiently sensitive to characterise the regulation of the fat composition (lipid-ome) in skin cells.We have identified that a unique epigenetic signature, i.e. a mark on the DNA, is more prevalent in skin cells from older donors and can regulate the genes that control skin lipids.
We have shown that the altered lipid profile in adult compared to neonatal skin cells (lower levels of n-7, n-9 and n-10 polyunsaturated fatty acids) is driving inflammatory responses from skin cells.
Our discovery sheds new light onto the difference in normal skin barrier function, which depends on lipid content and secretion, between neonatal and adult skin. Further work is needed to understand whether DNA marking is reversible in adult skin cells. If the marks can be removed, this may increase the production of anti-inflammatory lipids in adult skin and improve older skin function and healing.
Exploitation Route The future findings may support improved skin health care during ageing.
Sectors Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description This project commenced on August 1st 2014. Our findings on existing methods and sensitivity of lipid analysis have been used by Unilever to establish a new method on site. WE have explored the potential for filing a patent. WE have identified a novel epigenetic marker associated with ageing skin it was not been possible to patent the findings and we have now published the findings C. Pararasa, D.J. Messenger, K.E. Barrett, D. Hyliands, D. Talbot, M.I. Fowler, T. Kawatra, D.A. Gunn, F.L. Lim, L.J. Wainwright, G. Jenkins, H.R. Griffiths, Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation, Biochemical and Biophysical Research Communications, Volume 601, 2022, Pages 9-15, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2022.02.055.
First Year Of Impact 2022
Sector Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology
Impact Types Economic

 
Description Ageing skin 
Organisation Unilever
Department Unilever Research and Development Vlaardingen B.V.
Country Netherlands 
Sector Private 
PI Contribution Aston has contributed methods on fatty acid analysis
Collaborator Contribution Unilever has contributed methods on skin culture
Impact C. Pararasa, D.J. Messenger, K.E. Barrett, D. Hyliands, D. Talbot, M.I. Fowler, T. Kawatra, D.A. Gunn, F.L. Lim, L.J. Wainwright, G. Jenkins, H.R. Griffiths, Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation, Biochemical and Biophysical Research Communications, Volume 601, 2022, Pages 9-15, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2022.02.055.
Start Year 2014
 
Description Heartlands Foundation Trust presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact 20 staff attended to continuing professional development about lipids during ageing. The visit sparked additional conversations about a new NIHR research grant.The stakeholders were also able to provide new contacts into primary care.
Year(s) Of Engagement Activity 2016
 
Description Talk and poster presentations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Poster presentation prize winner, British Society for REsearch on Ageing, Chathyan Pararsa Prize winner 2015, UCL London, UK
Year(s) Of Engagement Activity 2015
URL https://www.ucl.ac.uk/iha/iha-news/iha_hosts_bsra_annual_meeting