ProxiMAX 2: Investigating the market for multiple, unnatural amino acids in saturation mutagenesis.

Lead Research Organisation: Aston University
Department Name: Sch of Life and Health Sciences


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Description The award primarily covered market research, which has successfully established that there is a definite market for the science that we wish to develop.

The award also provided minor funding towards key scientific milestones. 3 out of the 4 such objectives were achieved within the award and the 4th firstly via my innovator of the year award and more recently as part of the PhD research conducted by Dr Marta Ferreira Amaral. Unfortunately, a robust solution to objective 4 remains elusive, despite many approaches both from literature precedent and our own novel approaches.
Exploitation Route SInce we have been unable to create a robust and straightforward method to analyse synthetic aminoacylation, it is unlikely that we will be pursuing the award further. Findings have been distributed for use by others via conference posters and Dr Ferreira Amaral's PhD thesis, which will be published via the British Library EThOS system in due course.
Sectors Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

Description I was invited to speak in non-confidential terms about my work at the BBSRC headquarters at the BBSRC quarterly meeting. We will need development funding before more substantive impact can be achieved. Current work on the related studentship is promising. Likewise the feedback on commercial interest from the current study was promising. I anticipate application for further funding (possibly follow-on-fund) towards the end of the studentship. Update: The studentship was completed recently and although an excellent thesis, unfortunately the work therein confirmed that this process is currently far too complex for scale-up / commercial viability.
First Year Of Impact 2015
Sector Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Description Multiple poster presentations (France, UK, USA) on engineering aminoacyl synthetases 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presentation of results in the field of this grant.
Year(s) Of Engagement Activity 2018
Description Service on multiple BBSRC panels concerning impact and innovation. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact I serve / have served on the BBSRC Follow-on-fund panel, the BBSRC Excellence with Impact panel and the BBSRC Impact Acceleration Account panel.
Year(s) Of Engagement Activity 2016,2017,2018